CN103948839B - A kind of Semen Coicis legal system decoction pieces and preparation method thereof - Google Patents
A kind of Semen Coicis legal system decoction pieces and preparation method thereof Download PDFInfo
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- CN103948839B CN103948839B CN201410217356.0A CN201410217356A CN103948839B CN 103948839 B CN103948839 B CN 103948839B CN 201410217356 A CN201410217356 A CN 201410217356A CN 103948839 B CN103948839 B CN 103948839B
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Abstract
The present invention relates to prepared slices of Chinese crude drugs field, particularly to a kind of Semen Coicis legal system decoction pieces and preparation method thereof.It is made up of following material composition: Semen Coicis and edible oil.The preparation method of a kind of Semen Coicis legal system decoction pieces, by Semen Coicis Ex-all, by 30～40 mesh sieve holes, enters 1～5L drinking water swelling 24～48h；Pick up the Semen Coicis of swelling, drain surface moisture, add edible oil and mix thoroughly, steam 3～4h with moderate heat, to the well-done heart, take out and dry to surface-brightening, color transparent, put under the sun micro-solarization to holding tool hardness；With moderate heat stir-baking with sand 2～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.The rapid dissolution of intracellular effective ingredient of Semen Coicis decoction pieces can be made, strengthen clinical effect such as blood sugar lowering, antitumor, and reduce zest, reach the advantages such as method italian-jobi jen process of preparing process efficient, specification, standard, energy-saving and environmental protection.
Description
Technical field
The present invention relates to prepared slices of Chinese crude drugs field, particularly to a kind of Semen Coicis legal system decoction pieces and preparation method thereof.
Background technology
Modern study shows: Semen Coicis has the effects such as blood sugar lowering, antitumor, raising immunity, is mainly used in water clinically
Swollen, tinea pedis, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, the disease such as cancerous protuberance.
The existing concocting method of Semen Coicis is to take clean Semen Coicis, put into parch container wheat bran stir rapidly, fry to surface in
Slightly yellow, to obtain final product.But by after said method parch, in use, effect that Semen Coicis has been given play to is faint, it is difficult to reach
Expected Results.
Summary of the invention
It is an object of the invention to provide a kind of Semen Coicis legal system decoction pieces and preparation method thereof, it is possible to be effectively improved Semen Coicis
The content of interior effective ingredient triolein so that it is in the application, what the effect of Semen Coicis played becomes apparent from.
The object of the present invention is achieved like this, a kind of Semen Coicis legal system decoction pieces, is made up of following material composition:
Semen Coicis and edible oil.
Count by weight, described Semen Coicis 150-300 part, described edible oil 2.5～6 parts.
Preferably, described Semen Coicis 200 parts, described edible oil 4～6 parts.
The preparation method of a kind of Semen Coicis legal system decoction pieces, comprises the following steps:
Step 1, by Semen Coicis Ex-all, by 30～40 mesh sieve holes, enters 1～5L drinking water swelling 24～48h；
Wherein, soak time according to the difference in season difference, it is preferable that soaking winter 46-50 hour, summer soaks
Steep 20-28 hour.
Preferably, every 1g Semen Coicis adds 1～5mL drinking water.
Step 2, picks up the Semen Coicis of swelling, drains surface moisture, adds edible oil and mixes thoroughly, steams 3～4h with moderate heat, to well-done
The heart, takes out and dries to surface-brightening, color transparent, put under the sun micro-solarization to holding tool hardness；
Wherein it is preferred to, the addition of described edible oil is that every 100kg Semen Coicis edible oil 1～3kg is mixed thoroughly.
The time dried is preferably 1～2 day.
Step 3, with moderate heat stir-baking with sand 3～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.Wherein, final
Rate is 60%～70%.
A kind of Semen Coicis legal system decoction pieces and preparation method thereof that the present invention provides, it is possible to make that Semen Coicis decoction pieces is intracellular to be had
The effect rapid dissolution of composition, strengthens clinical effect such as blood sugar lowering, antitumor, and reduces zest, reach method italian-jobi jen process of preparing work
The advantages such as skill is efficient, specification, standard, energy-saving and environmental protection.Meanwhile, Three factors-levels L9 (3 is used4) orthogonal test carrys out laws for criterion
Preparation method of semen coicis and technical parameter, set up its normalized processing procedure, make conventional process techniques and modern scientific theory
Organically combine, and make effective ingredient triolein significantly raised, play due curative effect, it is ensured that the safety of common people's medication has
Effect.
Simultaneously can improve Semen Coicis process of preparing technological level so that it is to realizing efficiently, specification, standard, energy-saving and environmental protection
Modern pharmaceutical technology stride forward major step.
The present invention uses Three factors-levels L9 (34) orthogonal test comes laws for criterion preparation method of semen coicis and technical parameter,
Set up its normalized processing procedure, make conventional process techniques organically combine with modern scientific theory, and make effective ingredient glycerol
Trioleate is significantly raised, plays due curative effect.
Accompanying drawing explanation
The preparation method flow chart of a kind of Semen Coicis legal system decoction pieces that Fig. 1 provides for the present invention.
Detailed description of the invention
Below by specific embodiment and combine accompanying drawing the present invention is described in further detail.
A kind of Semen Coicis legal system decoction pieces, is made up of following material composition:
Semen Coicis and edible oil.
Count by weight, described Semen Coicis 150-300 part, described edible oil 2.5～6 parts.
Preferably, described Semen Coicis 200 parts, described edible oil 4～6 parts.
A kind of preparation method of Semen Coicis legal system decoction pieces, as it is shown in figure 1, comprise the following steps:
Step 1, by Semen Coicis Ex-all, by 30～40 mesh sieve holes, enters 1～5L drinking water swelling 24～48h；
Wherein, soak time according to the difference in season difference, it is preferable that soaking winter 46-50 hour, summer soaks
Steep 20-28 hour.
Preferably, every 1g Semen Coicis adds 1～5mL drinking water.
Step 2, picks up the Semen Coicis of swelling, drains surface moisture, adds edible oil and mixes thoroughly, steams 3～4h with moderate heat, to well-done
The heart, takes out and dries to surface-brightening, color transparent, put under the sun micro-solarization to holding tool hardness；
Wherein it is preferred to, the addition of described edible oil is that every 100kg Semen Coicis edible oil 1～3kg is mixed thoroughly.
The time dried is preferably 1～2 day.
Step 3, with moderate heat stir-baking with sand 3～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.Wherein, final
Rate is 60%～70%.
A kind of Semen Coicis legal system decoction pieces and preparation method thereof that the present invention provides, it is possible to make that Semen Coicis decoction pieces is intracellular to be had
The effect rapid dissolution of composition, strengthens clinical effect such as blood sugar lowering, antitumor, and reduces zest, reach method italian-jobi jen process of preparing work
The advantages such as skill is efficient, specification, standard, energy-saving and environmental protection.Meanwhile, Three factors-levels L9 (3 is used4) orthogonal test carrys out laws for criterion
Preparation method of semen coicis and technical parameter, set up its normalized processing procedure, make conventional process techniques and modern scientific theory
Organically combine, and make effective ingredient triolein significantly raised, play due curative effect, it is ensured that the safety of common people's medication has
Effect.
Simultaneously can improve Semen Coicis process of preparing technological level so that it is to realizing efficiently, specification, standard, energy-saving and environmental protection
Modern pharmaceutical technology stride forward major step.
The present invention uses Three factors-levels L9 (34) orthogonal test comes laws for criterion preparation method of semen coicis and technical parameter,
Set up its normalized processing procedure, make conventional process techniques organically combine with modern scientific theory, and make effective ingredient glycerol
Trioleate is significantly raised, plays due curative effect.
The content balance table of the effective ingredient triolein in the Semen Coicis that below the most different concocting methods are made:
Result Semen Coicis is after distinct methods is concocted, and the content of triolein is the most inconsistent, it may be assumed that method Semen Coicis ＞
Fry the Semen Coicis ＞ parching with earth Semen Coicis ＞ clean Semen Coicis of Semen Coicis (parched with bran) ＞, and method Semen Coicis is higher than it with frying content increments
Its concocting method, embodies legal system Semen Coicis with the obvious advantage.
Embodiment 1
Take Semen Coicis 200g, Ex-all, by 30～40 mesh sieve holes, enter 3L drinking water swelling 24～48h.Pick up and drain surface
Moisture, adds edible oil 6g and mixes thoroughly, steams 3～4h with moderate heat, to the well-done heart, take out dry to surface-brightening, color transparent, micro-solarization.With
140 DEG C-190 DEG C moderate heat stir-baking with sand 3～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.
Detecting finished product according to process of preparation method quality standard, concrete detection is as follows:
[discriminating]
(1) the light off-white color of microscopical identification this product powder or yellow-white.Main is gelatinized starch grain, oil seen from parenchyma cell surface
Drip, accidental stone cell.
(2) indentification by TLC takes this product powder 1g, adds petroleum ether (60～90 DEG C) 10mL, supersound process 30 minutes, filter
Crossing, filtrate is evaporated, and residue adds petroleum ether (60～90 DEG C) 1mL makes dissolving, as need testing solution.Separately take Semen Coicis control medicinal material
1g, is made in the same way of control medicinal material solution.Test according to thin layer chromatography, draw each 10 μ L of above two solution, put respectively in same
On silica gel g thin-layer plate, with petroleum ether (60～90 DEG C)-ethyl acetate-acetic acid (10:3:0.1) as developing solvent, launch, take out, dry in the air
Dry, put and inspect under ultra-violet lamp (365nm).In test sample chromatograph, on position corresponding with control medicinal material chromatograph, micro-aobvious identical
The fluorescence speckle of color.
(3) high performance liquid chromatography differentiates to take Semen Coicis oil reference extract, triolein reference substance, adds (containing measuring
Calmly) flowing under item is respectively prepared every 1mL solution containing 1mg, 0.14mg, mutually as reference extract, reference substance solution.According to
Chromatographic condition test under (assay) item, draw respectively the need testing solution under (assay) item, reference substance solution and
The each 10 μ L of above-mentioned reference extract, reference substance solution, inject chromatograph of liquid.Test sample chromatogram and reference substance retention time one
The chromatographic peak caused；And present 7 the main chromatographic peaks consistent with reference extract chromatographic peak retention time.
[extractum] is according to the hot dipping under ethanol-soluble extractives algoscopy (Chinese Pharmacopoeia one annex Ⅹ A of version in 2010) item
Measuring, make solvent with dehydrated alcohol, result is 7.4%.
[assay] measures according to high performance liquid chromatography (annex VI D).
Chromatographic condition and system suitability are with octadecylsilane chemically bonded silica as filler；With acetonitrile-dichloromethane
Alkane (65:35) is flowing phase；Evaporative light scattering detector detects.Number of theoretical plate is calculated should be not less than by triolein peak
5000。
It is appropriate that the preparation of reference substance solution takes triolein reference substance, accurately weighed, adding flowing and making every 1ml mutually and contain
The solution of 0.14mg, to obtain final product.
The preparation of need testing solution takes this product powder (crossing No. three sieves) about 0.6g, accurately weighed, puts in tool plug conical flask, essence
Close addition flowing phase 50ml, weighed weight, soak 2 hours, supersound process (power 300W, frequency 50kHz) 30 minutes, let cool,
The most weighed weight, supplies the weight of less loss mutually, shakes up with flowing, filters, takes subsequent filtrate, to obtain final product.
Algoscopy precision respectively draws reference substance solution 5 μ l, 10 μ l, need testing solution 5～10 μ l, injects liquid chromatograph
Instrument, measures, and calculates with external standard two-point method logarithmic equation, to obtain final product.
This product is pressed dry product and is calculated, containing triolein (C57H104O6) it is 0.90%.
Embodiment 2
Take Semen Coicis 250g, Ex-all, by 30～40 mesh sieve holes, enter 4L drinking water swelling 24～48h.Pick up and drain surface
Moisture, adds edible oil 5g and mixes thoroughly, steams 3～4h with moderate heat, to the well-done heart, take out dry to surface-brightening, color transparent, micro-solarization.With
Moderate heat (140 DEG C-190 DEG C) stir-baking with sand 3～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.
Detection (detection method is same as in Example 1).
[discriminating] (1) microscopical identification light off-white color of this product powder or yellow-white.Main for gelatinized starch grain, parenchyma cell surface
Visible oil droplet, accidental stone cell.
(2) Semen Coicis control medicinal material inspection: in test sample chromatograph, on position corresponding with control medicinal material chromatograph, micro-aobvious
The fluorescence speckle of same color.
(3) Semen Coicis oil reference extract, the inspection of triolein reference substance: test sample chromatogram retains with reference substance
The chromatographic peak of time consistency；And present 7 the main chromatographic peaks consistent with reference extract chromatographic peak retention time.
[extractum] is according to the hot dipping under ethanol-soluble extractives algoscopy (Chinese Pharmacopoeia one annex Ⅹ A of version in 2010) item
Measuring, make solvent with dehydrated alcohol, result is 7.8%.
[assay] this product is pressed dry product and is calculated, containing triolein (C57H104O6) it is 0.92%.
Embodiment 3
Take Semen Coicis 300g, Ex-all, by 30～40 mesh sieve holes, enter 5L drinking water swelling 24～48h；Pick up and drain surface
Moisture, adds edible oil 4g and mixes thoroughly, steams 3～4h with moderate heat, to the well-done heart, take out dry to surface-brightening, color transparent, micro-solarization；With
Moderate heat (140 DEG C-190 DEG C) stir-baking with sand 3～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product.
Detection (detection method is same as in Example 1).
[discriminating] (1) microscopical identification light off-white color of this product powder or yellow-white.Main for gelatinized starch grain, parenchyma cell surface
Visible oil droplet, accidental stone cell.
(2) Semen Coicis control medicinal material inspection: in test sample chromatograph, on position corresponding with control medicinal material chromatograph, micro-aobvious
The fluorescence speckle of same color.
(3) Semen Coicis oil reference extract, the inspection of triolein reference substance: test sample chromatogram retains with reference substance
The chromatographic peak of time consistency；And present 7 the main chromatographic peaks consistent with reference extract chromatographic peak retention time.
[extractum] is according to the hot dipping under ethanol-soluble extractives algoscopy (Chinese Pharmacopoeia one annex Ⅹ A of version in 2010) item
Measuring, make solvent with dehydrated alcohol, result is 8.0%.
[assay] this product is pressed dry product and is calculated, containing triolein (C57H104O6) it is 0.97%.
This concocting method former concocting method product quality comparison sheet:
Learning from upper table result, the decoction pieces product of concocting method of the present invention is every detection compared with former concocting method product
Mesh all reaches requirement, and effective ingredient triolein content is apparently higher than former concocting method.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, that is made any repaiies
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (5)
1. the preparation method of a Semen Coicis legal system decoction pieces, it is characterised in that comprise the following steps:
Step 1, by Semen Coicis Ex-all, by 30～40 mesh sieve holes, enters 1～5L drinking water swelling 24～48h；
Step 2, picks up the Semen Coicis of swelling, drains surface moisture, adds edible oil and mixes thoroughly, steams 3～4h with moderate heat, to the well-done heart,
Taking-up is dried to surface-brightening, color transparent, puts under the sun micro-solarization to holding tool hardness；
Step 3, with moderate heat stir-baking with sand 2～5min, flower-shaped to rice krispies, take out, sieve shakeout, cool, to obtain final product；Wherein, by weight
Meter, in described preparation method, Semen Coicis consumption be 150-300 part, described amount of edible oil be 2.5～6 parts.
The preparation method of a kind of Semen Coicis legal system decoction pieces the most according to claim 1, it is characterised in that: in described step 1,
Every 1g Semen Coicis adds 1～5mL drinking water.
The preparation method of a kind of Semen Coicis legal system decoction pieces the most according to claim 1, it is characterised in that: in described step 2,
The addition of described edible oil is that every 100kg Semen Coicis edible oil 1～3kg is mixed thoroughly.
The preparation method of a kind of Semen Coicis legal system decoction pieces the most according to claim 3, it is characterised in that: in described step 2,
The time dried is 1～2 day.
The preparation method of a kind of Semen Coicis legal system decoction pieces the most according to claim 1, it is characterised in that: described step 2 and
In step 3, the temperature of described moderate heat is 140 DEG C-190 DEG C.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105105020B (en) * | 2015-09-18 | 2018-08-17 | 福建农林大学 | A kind of Job's tears fast food piece rich in EGCG and coix seed grease |
| CN108992601B (en) * | 2018-09-13 | 2021-10-29 | 江西景德中药股份有限公司 | Decoction pieces prepared from Coicis semen and its preparation method |
| CN108982741A (en) * | 2018-09-13 | 2018-12-11 | 江西景德中药股份有限公司 | The discrimination method of method semen coicis based on thin-layer chromatography |
| CN108939031A (en) * | 2018-09-20 | 2018-12-07 | 江西景德中药股份有限公司 | Chinese medicine composition of strengthening spleen and nourishing blood and its preparation method and application |
| CN108969688A (en) * | 2018-09-20 | 2018-12-11 | 江西景德中药股份有限公司 | Invigorating spleen for diuresis, Chinese medicine composition of detumescence and apocenosis and its preparation method and application |
| CN110151930A (en) * | 2019-05-27 | 2019-08-23 | 王茂泓 | A kind of processing method of Chinese medicine preparation |
| CN110063497A (en) * | 2019-06-04 | 2019-07-30 | 四川星河云海科技有限公司 | A kind of semen coicis food and its processing method |
| CN113058008B (en) * | 2021-04-09 | 2022-05-20 | 建昌帮药业有限公司 | Fried semen coicis and preparation method thereof |
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