CN103948732B - A kind of Chinese medicine composition treating allergic rhinitis - Google Patents

A kind of Chinese medicine composition treating allergic rhinitis Download PDF

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Publication number
CN103948732B
CN103948732B CN201410209536.4A CN201410209536A CN103948732B CN 103948732 B CN103948732 B CN 103948732B CN 201410209536 A CN201410209536 A CN 201410209536A CN 103948732 B CN103948732 B CN 103948732B
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allergic rhinitis
chinese medicine
medicine composition
radix
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CN103948732A (en
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谯凤英
马融
杨仕蕊
魏国威
朱慧贤
樊凌杉
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FIRST AFFILIATED HOSPITAL OF TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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FIRST AFFILIATED HOSPITAL OF TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Abstract

The present invention provides a kind of Chinese medicine composition treating allergic rhinitis, is made up of each raw material of following weight portion: Flos Magnoliae 2��18 parts, the Radix Angelicae Dahuricae 2��18 parts, Herba Menthae 1��11 part, Radix Saposhnikoviae 2��18 parts, Fructus Schisandrae Chinensis 2��18 parts, Radix Paeoniae Rubra 2��18 parts, Rhizoma Chuanxiong 2��18 parts, Borneolum Syntheticum 0.01��0.3 part. The Chinese medicine composition of the present invention is when treatment, the efficacy of a drug is made to go directly focus by wearing medicated gauze mask, effect is concentrated, curative effect is reliable, clinical symptoms and the sign of Allergic Rhinitis can be significantly improved, without the generation of obvious toxic-side effects and untoward reaction, and the drug medication of the present invention is convenient, is suitable at clinical application.

Description

A kind of Chinese medicine composition treating allergic rhinitis
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition treating allergic rhinitis.
Background technology
Allergic rhinitis is to occur at the allergic disease of nasal mucosa, and the prevalence general population is 10%-40%, cardinal symptom rhinocnesmus, sneeze, watery nasal discharge, nasal obstruction. It is characterized in that onset is anxious, makes a return journey rapidly; After symptom eliminates, then such as normality, but the normal recurrent exerbation of the state of an illness, therefore the course of disease is general longer, has a strong impact on quality of life and the work efficiency of patient. At present, what integrative therapy allergic rhinitis was primary is a bit to try to avoid contact with anaphylactogen, then row opinion is controlled again, primary treatments has several as follows: 1, western medicine therapy: oral or nose spray antihistaminic, mast cell membrane stabilizer, anti-leukotriene medicine, 17-hydroxy-11-dehydrocorticosterone etc., it is administered orally with antiallergic class or hormones Western medicine or spray nose instant effect, controlling symptom effective, but easily recur after drug withdrawal, Reusability is easily generated drug resistance; 2, Chinese medicine decoction treatment: according to entire patient's symptom determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, interior can adjust the five internal organs, get rid of evils outward gas, fundamentally treating allergic rhinitis, Chinese medicine decoction can fundamentally treat allergic rhinitis, but due to Chinese medicine bitter in the mouth, decoct trouble, many patients can not adhere to medication or the just abandoning cure that wins initial success, it is impossible to reaches good therapeutic purposes; 3. acupuncture and moxibustion treatment: choose acupuncture point a surname's clearing the nasal passage such as Yingxiang, according to entire patient's situation differentiation of symptoms and signs for classification of syndrome, coordinate its cave to dispel the wind and dissipate heresy, tonification lung spleen kidney, but many patients fear due to psychology, refusal adopts this therapy, and this therapy needs go to hospital for treatment every day, working clan has no time condition, it is impossible to accept this treatment.
Summary of the invention
The problem that the invention to solve is to provide and a kind of treats bitterness rapid, painless, has no side effect and treat the Chinese medicine composition treating easily allergic rhinitis.
For solving above-mentioned technical problem, the invention the technical scheme is that a kind of Chinese medicine composition treating allergic rhinitis, is made up of each raw material of following weight portion: Flos Magnoliae 2��18 parts, the Radix Angelicae Dahuricae 2��18 parts, Herba Menthae 1��11 part, Radix Saposhnikoviae 2��18 parts, Fructus Schisandrae Chinensis 2��18 parts, Radix Paeoniae Rubra 2��18 parts, Rhizoma Chuanxiong 2��18 parts, Borneolum Syntheticum 0.01��0.3 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 5��15 parts, the Radix Angelicae Dahuricae 5��15 parts, Herba Menthae 2��10 parts, Radix Saposhnikoviae 5��15 parts, Fructus Schisandrae Chinensis 5��15 parts, Radix Paeoniae Rubra 5��15 parts, Rhizoma Chuanxiong 5��15 parts, Borneolum Syntheticum 0.05��0.2 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 7��13 parts, the Radix Angelicae Dahuricae 7��13 parts, Herba Menthae 4��8 parts, Radix Saposhnikoviae 7��13 parts, Fructus Schisandrae Chinensis 7��13 parts, Radix Paeoniae Rubra 7��13 parts, Rhizoma Chuanxiong 7��13 parts, Borneolum Syntheticum 0.06��0.14 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 9��11 parts, the Radix Angelicae Dahuricae 9��11 parts, Herba Menthae 5��7 parts, Radix Saposhnikoviae 9��11 parts, Fructus Schisandrae Chinensis 9��11 parts, Radix Paeoniae Rubra 9��11 parts, Rhizoma Chuanxiong 9��11 parts, Borneolum Syntheticum 0.08��0.12 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Chuanxiong 10 parts, Borneolum Syntheticum 0.1 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 9 parts, the Radix Angelicae Dahuricae 9 parts, Herba Menthae 5 parts, Radix Saposhnikoviae 9 parts, Fructus Schisandrae Chinensis 9 parts, Radix Paeoniae Rubra 9 parts, Rhizoma Chuanxiong 9 parts, Borneolum Syntheticum 0.09 part.
Preferably, it is made up of each raw material of following weight portion: Flos Magnoliae 11 parts, the Radix Angelicae Dahuricae 11 parts, Herba Menthae 7 parts, Radix Saposhnikoviae 11 parts, Fructus Schisandrae Chinensis 11 parts, Radix Paeoniae Rubra 11 parts, Rhizoma Chuanxiong 11 parts, Borneolum Syntheticum 0.11 part.
The specification of each taste crude drug used by Chinese medicine composition of the present invention all meets country's medical standards, can be commercially available at pharmacy. Wherein Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Menthae clearly profit the head, a surname clearing the nasal passage; Radix Saposhnikoviae delivers scattered wind, removing dampness to relieve pain, modern medicine study, containing volatile oil, mannitol etc., can eliminate nasal cavity edema; Fructus Schisandrae Chinensis convergence only tears; Radix Paeoniae Rubra, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling strengthen sensible effect; Add Borneolum Syntheticum refreshment sensible. All medicines share, and play awakening consciousness, the effect holding back tears inducing diuresis and reducing edema, antipruritic altogether. In each herbal medicine used in the present invention, except Fructus Schisandrae Chinensis, all the other medicines all contain volatile oil.
Present invention also offers a kind of method preparing the Chinese medicine composition treating allergic rhinitis as above, each raw material components is pulverized, crosses 100 mesh sieves, mix.
Present invention provides the Chinese medicine composition for the treatment of allergic rhinitis as above purposes in treatment allergic rhinitis medicine.
A kind of mask using the Chinese medicine composition treating allergic rhinitis as above, is placed on each raw material components mix homogeneously in the medicated bag that non-woven fabrics is made, then is sewn in disposable breathing mask by medicated bag. The Chinese medicine composition powder for the treatment of allergic rhinitis provided by the invention is placed in mask interlayer, wear use, in treatment allergic rhinitis, can effectively reduce anaphylactogen and enter respiratory tract, make Chinese medicine ingredients act on the effective acupuncture point of the noses such as Yingxiang simultaneously, through Nasal Mucosa Absorption, can directly improving sniffle again, treatment is rapidly, and it is simple to operate, painless bitterness, it is easy to carry, it is possible to accepted by extensive patients.
The invention has the advantage that and has the benefit effect that the Chinese medicine composition of the present invention is when treatment, by wearing the through focus of the medicated gauze mask efficacy of a drug, effect is concentrated, curative effect is reliable, clinical symptoms and the sign of Allergic Rhinitis can be significantly improved, and without the generation of obvious toxic-side effects and untoward reaction, and the drug medication of the present invention is convenient, is suitable at clinical application.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this embodiment following is merely to illustrate the present invention and the present invention is not limited.
Embodiment one
Flos Magnoliae 10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Chuanxiong 10 parts, Borneolum Syntheticum 0.1 part.
Embodiment two
Flos Magnoliae 9 parts, the Radix Angelicae Dahuricae 9 parts, Herba Menthae 5 parts, Radix Saposhnikoviae 9 parts, Fructus Schisandrae Chinensis 9 parts, Radix Paeoniae Rubra 9 parts, Rhizoma Chuanxiong 9 parts, Borneolum Syntheticum 0.09 part
Embodiment three
Flos Magnoliae 11 parts, the Radix Angelicae Dahuricae 11 parts, Herba Menthae 7 parts, Radix Saposhnikoviae 11 parts, Fructus Schisandrae Chinensis 11 parts, Radix Paeoniae Rubra 11 parts, Rhizoma Chuanxiong 11 parts, Borneolum Syntheticum 0.11 part.
Embodiment four
Flos Magnoliae 3 parts, the Radix Angelicae Dahuricae 3 parts, Herba Menthae 1 part, Radix Saposhnikoviae 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Chuanxiong 3 parts, Borneolum Syntheticum 0.03 part.
Embodiment five
Flos Magnoliae 15 parts, the Radix Angelicae Dahuricae 15 parts, Herba Menthae 10 parts, Radix Saposhnikoviae 15 parts, Fructus Schisandrae Chinensis 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Chuanxiong 15 parts, Borneolum Syntheticum 0.15 part.
By the medicine in embodiment one��embodiment five, pulverize respectively, cross 100 mesh sieves, mix, be then charged in the medicated bag that non-woven fabrics is made, then medicated bag is sewn in disposable breathing mask. Patient is with and muzzles, and makes medicated bag just to living nostril and fragrant cave, and 5 days courses for the treatment of, general 1��3 course for the treatment of can cure, and every day changed one by mask.
Clinical experimental data
Treatment group: the medicine in embodiment one��embodiment five is prepared into mask, is respectively used to 50 example patients. 5 days courses for the treatment of, treating for 1 course for the treatment of, every day changed one by mask.
Matched group: 50 example patients wear common medical mask, 5 days courses for the treatment of, wears a course for the treatment of, and every day changed one by mask.
Wherein the sex of patient in each treatment group and matched group, the age, the course of disease, there was no significant difference through statistical procedures, there is comparability.
Efficacy assessment standard: with reference to Chinese Journal of Otorhinolaryngology Head And Neck Surgery " principle of diagnosis and treatment of allergic rhinitis and suggested design (2004, Lanzhou) "
1, Syndrome Scale and standards of grading
Rhinocnesmus: 0 point: nothing; 1 point: be interrupted; 2 points: ant row sense, but can stand; 3 points: ant row sense, unbearably.
Sneeze: 0 point: nothing; 1 point: one-time continuous 3��5; 2 points: one-time continuous 6��10; 3 points: one-time continuous >=11.
Watery nasal discharge: 0 point: nothing; 1 point: blowing the nose every day number of times��5 time; 2 points: every day blowing the nose number of times 5��9 times; 3 points: blowing the nose every day number of times >=10 time.
Nasal obstruction: 0 point: nothing; 1 point: feel during air-breathing consciously; 2 points: intermittent or interactivity; 3 points: almost whole day mouth breathing.
2, sign classification and standards of grading
The pale edema situation of nasal mucosa: 0 point: normal; 1 point: pale edema that concha nasalis is slight, nasal septum, middle nasal concha are still visible; 2 points: concha nasalis inferior and nasal septum (or at the bottom of nose) against, have small gap therebetween; 3 points: at the bottom of concha nasalis and nose, nasal septum against, can not see middle nasal concha, or middle nasal concha mucosal polyp sample become, polyp is formed.
Therapeutic index (n)=[(treatment before symptom, somatic feature score and-treatment after symptom, somatic feature score and) �� treatment before symptom, somatic feature score and] �� 100%
Effective: therapeutic index >=66%.
Effective: therapeutic index >=26%, and < 66%.
Invalid: therapeutic index < 26%.
(note: effective and effective sum is total effective rate)
Therapeutic outcome
Clinical observation on the therapeutic effect is it is shown that Chinese medicine composition of the present invention has significant curative effect and instant effect for allergic rhinitis; Safety observations finds, it does not have observe any clinical adverse, it was shown that Chinese medicine composition clinical practice of the present invention is safe and free of toxic and side effects.
Above embodiments of the invention are described in detail, but described content has been only presently preferred embodiments of the present invention, it is impossible to be considered the practical range for limiting the present invention. All equalizations made according to the scope of the invention change and improvement etc., all should still belong within this patent covering scope.

Claims (10)

1. the Chinese medicine composition treating allergic rhinitis, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 2��18 parts, the Radix Angelicae Dahuricae 2��18 parts, Herba Menthae 1��11 part, Radix Saposhnikoviae 2��18 parts, Fructus Schisandrae Chinensis 2��18 parts, Radix Paeoniae Rubra 2��18 parts, Rhizoma Chuanxiong 2��18 parts, Borneolum Syntheticum 0.01��0.3 part.
2. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 5��15 parts, the Radix Angelicae Dahuricae 5��15 parts, Herba Menthae 2��10 parts, Radix Saposhnikoviae 5��15 parts, Fructus Schisandrae Chinensis 5��15 parts, Radix Paeoniae Rubra 5��15 parts, Rhizoma Chuanxiong 5��15 parts, Borneolum Syntheticum 0.05��0.2 part.
3. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 7��13 parts, the Radix Angelicae Dahuricae 7��13 parts, Herba Menthae 4��8 parts, Radix Saposhnikoviae 7��13 parts, Fructus Schisandrae Chinensis 7��13 parts, Radix Paeoniae Rubra 7��13 parts, Rhizoma Chuanxiong 7��13 parts, Borneolum Syntheticum 0.06��0.14 part.
4. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 9��11 parts, the Radix Angelicae Dahuricae 9��11 parts, Herba Menthae 5��7 parts, Radix Saposhnikoviae 9��11 parts, Fructus Schisandrae Chinensis 9��11 parts, Radix Paeoniae Rubra 9��11 parts, Rhizoma Chuanxiong 9��11 parts, Borneolum Syntheticum 0.08��0.12 part.
5. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Chuanxiong 10 parts, Borneolum Syntheticum 0.1 part.
6. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 9 parts, the Radix Angelicae Dahuricae 9 parts, Herba Menthae 5 parts, Radix Saposhnikoviae 9 parts, Fructus Schisandrae Chinensis 9 parts, Radix Paeoniae Rubra 9 parts, Rhizoma Chuanxiong 9 parts, Borneolum Syntheticum 0.09 part.
7. the Chinese medicine composition for the treatment of allergic rhinitis according to claim 1, it is characterised in that: it is made up of each raw material of following weight portion: Flos Magnoliae 11 parts, the Radix Angelicae Dahuricae 11 parts, Herba Menthae 7 parts, Radix Saposhnikoviae 11 parts, Fructus Schisandrae Chinensis 11 parts, Radix Paeoniae Rubra 11 parts, Rhizoma Chuanxiong 11 parts, Borneolum Syntheticum 0.11 part.
8. the method for the Chinese medicine composition of the treatment allergic rhinitis that a kind is prepared as described in any one of claim 1��7, it is characterised in that: each raw material components is pulverized, crosses 100 mesh sieves, mix.
9. the Chinese medicine composition of the treatment allergic rhinitis according to any one of claim 1��7 purposes in preparation treatment allergic rhinitis medicine.
10. the mask of the Chinese medicine composition of the treatment allergic rhinitis used as described in any one of claim 1��7, it is characterised in that: each raw material components mix homogeneously is placed in the medicated bag that non-woven fabrics is made, then medicated bag is sewn in disposable breathing mask.
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105521021A (en) * 2015-08-07 2016-04-27 陈自明 Rhinitis treating formula and preparation method thereof
CN107582656A (en) * 2017-08-29 2018-01-16 成都泠汐尚品科技有限公司 A kind of Chinese medicine composition for being used to treat allergic rhinitis
CN108186829B (en) * 2018-03-13 2021-02-23 广西中医药大学附属瑞康医院 Chinese herbal medicine composition for treating chronic rhinitis and preparation method thereof
CN109172639A (en) * 2018-09-18 2019-01-11 李同信 Nasal cavity allergen barrier and its preparation method and application
CN112451602A (en) * 2020-12-29 2021-03-09 黄海兵 Production method of traditional Chinese medicine nasal wash and traditional Chinese medicine nasal wash

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1480189A (en) * 2003-07-10 2004-03-10 姜延德 Medication for treating rhinitis
CN101642500A (en) * 2008-08-04 2010-02-10 王军 Medicament for treating rhinitis
CN103655936A (en) * 2012-09-18 2014-03-26 青岛信立德中药技术研究开发有限公司 Traditional Chinese medicine for treating allergic rhinitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1480189A (en) * 2003-07-10 2004-03-10 姜延德 Medication for treating rhinitis
CN101642500A (en) * 2008-08-04 2010-02-10 王军 Medicament for treating rhinitis
CN103655936A (en) * 2012-09-18 2014-03-26 青岛信立德中药技术研究开发有限公司 Traditional Chinese medicine for treating allergic rhinitis

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