CN103948625B - One is applicable to upper respiratory tract infection and grippal pharmaceutical composition - Google Patents
One is applicable to upper respiratory tract infection and grippal pharmaceutical composition Download PDFInfo
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Abstract
The invention discloses and a kind of new be applicable to upper respiratory tract infection and grippal pharmaceutical composition, this pharmaceutical composition per unit preparation comprises 0.04mg 0.16mg goitrin, 0.24mg 0.96mg phillyrin, 203.2mg 812.8mg Gypsum Fibrosum, 3.87mg 15.49mg reed rhizome polysaccharide；This pharmaceutical composition can contain Chinese medicine extract or the Chinese medicine extract of lung qi dispersing cough-relieving of clearing away heat and expelling pathogen in the exterior；This pharmaceutical composition can be by oral, injection or mucosa delivery, tablet, capsule, powder, granule, lozenge, suppository can be made, or the multi-medicament form such as oral liquid or aseptic parenteral suspension liquid preparation, also have the injection forms such as big or small-volume injection, freeze-dried powder or aseptic powder separation dose；There is feature quality controllable, evident in efficacy.
Description
Technical field
The present invention relates to one and be applicable to upper respiratory tract infection and grippal pharmaceutical composition.
Background technology
Flu is a kind of frequently-occurring disease, directly influences the life of people, working and learning, and especially influenza virus is to human body
Health hazard serious.But owing to the antigenic variation ability of influenza virus is strong, the difference of individual immunity power in addition, the protection of vaccine
Rate is the highest, moreover, vaccine only has preventive effect to known influenza virus sub-strain, and for by antigenic drift or antigenicity
The produced novel influenza of conversion is invalid.Chemicals tackle this original or with anthropogeny since the most altogether
The microorganism aspect of existence, also shows slightly helpless.
Chinese medicine not only has that drug resistance is low, side effect and the advantage such as untoward reaction is few, and also suppresses virus replication, tune
Saving immunologic function, improve the comprehensive effect such as blood circulation, antipyretic-antalgic and anti-inflammation, it has in terms of preventing and treating influenza virus
There are advantage and the vast potential for future development of uniqueness.Therefore, with natural drug or a combination thereof things such as traditional Chinese medicines, or it is aided with simultaneously
Other drug is treated, and becomes a kind of important Therapeutic Method.
In prior art, Chinese medicine or a combination thereof thing preparation for antiviral are the most much reported.Such as, Application No.
The Chinese patent of 03109734.0 discloses a kind of with Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Rehmanniae, Rhizoma Acori Graminei, Radix Curcumae, Herba Pogostemonis
It is the drop pill of raw material with Rhizoma Phragmitis；Also have on market by Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Rehmanniae, Rhizoma Acori Graminei, Radix Curcumae, the wide leaves of pulse plants
Fragrant and Rhizoma Phragmitis is the granule of raw material, antiviral granule as wide in Sichuan, determined curative effect.The antiviral that even Sichuan is wide
Grain confirms to may be used for treating some influenza diseases that the most conventional coldrex such as bird flu and swine flue is difficult to treat according to test.
Concrete composition between medical material batch has subtle difference, with the composition of the Chinese medicine preparation that existing means prepare
Also there will be some uncontrollable differences, in order to preferably control the quality of Chinese medicine preparation, it is ensured that drug effect curative effect, more enter
The more preferable curative effect of offer of one step, the present invention is that clinic provides and a kind of new is applicable to upper respiratory tract infection and influenza
Pharmaceutical composition.
Summary of the invention
The present invention provides a kind of and new is applicable to upper respiratory tract infection and grippal pharmaceutical composition.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
One is applicable to upper respiratory tract infection and grippal pharmaceutical composition, and wherein per unit preparation comprises
0.04mg-0.16mg goitrin, 0.24mg-0.96mg phillyrin, 203.2mg-812.8mg Gypsum Fibrosum, 3.87mg-15.49mg reed
Root polysaccharide.
Preferably, it is applicable to upper respiratory tract infection and grippal pharmaceutical composition, wherein per unit preparation described in
Comprise 0.08mg-0.12mg goitrin, 0.48mg-0.72mg phillyrin, 406.4mg-609.6mg Gypsum Fibrosum, 7.75mg-
11.62mg reed rhizome polysaccharide.
Upper respiratory tract infection and grippal pharmaceutical composition, wherein per unit system it is applicable to described in it is furthermore preferred that
Agent comprises 0.10mg goitrin, 0.6mg phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide.
One is applicable to upper respiratory tract infection and grippal pharmaceutical composition, and wherein per unit preparation comprises
0.04mg-0.16mg goitrin, 0.24mg-0.96mg phillyrin, 203.2mg-812.8mg Gypsum Fibrosum, 3.87mg-15.49mg reed
Root polysaccharide, 0.46mg-1.84mg patchouli alcohol, 0.19mg-0.77mg beta-Asarone, 0.05mg-0.20mg curcumin,
6.04mg-24.16mg timosaponin BII, 0.54mg-2.16mg catalpol.
Preferably, it is applicable to upper respiratory tract infection and grippal pharmaceutical composition, wherein per unit preparation described in
Comprise 0.08mg-0.12mg goitrin, 0.48mg-0.72mg phillyrin, 406.4mg-609.6mg Gypsum Fibrosum, 7.75mg-
11.62mg reed rhizome polysaccharide, 0.92mg-1.38mg patchouli alcohol, 0.39mg-0.58mg beta-Asarone, 0.10mg-0.15mg Rhizoma Curcumae Longae
Element, 12.0mg-18.12mg timosaponin BII, 1.08mg-1.62mg catalpol.
Upper respiratory tract infection and grippal pharmaceutical composition, wherein per unit system it is applicable to described in it is furthermore preferred that
Agent comprises 0.10mg goitrin, 0.6mg phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide, 1.15mg patchouli alcohol, 0.48mg
Beta-Asarone, 0.13mg curcumin, 15.10mg timosaponin BII, 1.35mg catalpol.
Preferably, described pharmaceutical composition can be containing the Chinese medicine extract of clearing away heat and expelling pathogen in the exterior, in described clearing away heat and expelling pathogen in the exterior
Medicament extract carries selected from Flos Lonicerae extract, Fructus Forsythiae extract, Semen phaseoli radiati extract, Herba Lophatheri extract, Folium Menthae extract, Herba Schizonepetae
Take thing, Semen Sojae Praeparatum extract, Folium Mori extract, Flos Chrysanthemi extract.
Preferably, described pharmaceutical composition can be containing the Chinese medicine extract of lung qi dispersing cough-relieving, in described lung qi dispersing cough-relieving
Medicament extract is selected from Radix Platycodonis extract, Fructus Arctii extract, apricot seed extract.
The pharmaceutical composition of the present invention can add one or more pharmaceutically acceptable carriers, agent as different in preparation
Various customary adjuvant required during type: diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer,
Surfactant, absorption carrier, lubricant etc..
The pharmaceutical composition of the present invention can by oral, injection or mucosa delivery, can make tablet, capsule, powder,
Grain, lozenge, suppository, or the multi-medicament form such as oral liquid or aseptic parenteral suspension liquid preparation, also have big or low capacity note
Penetrate the injection forms such as agent, freeze-dried powder or aseptic powder separation dose.The medicine of above-mentioned various dosage form all can be according to pharmaceutical field
Prepared by conventional method.
Above-mentioned dosage form all can be prepared according to the conventional method of pharmaceutical field.As prepared by pill: take according to the formula of the present invention
Each medicated powder, crosses 120-140 mesh sieve, and add water mixing, pill, is dried, both.
The drug effect contrast experiment (pharmacodynamic experiment) of the pharmaceutical composition that the present invention relates to
1 antiinflammatory action compares
1.1 experiment material
1.1.1 animal: SD rat, male, 180-220g, Zhongshan University provide.
1.1.2 medicine
Test medicine: the pharmaceutical composition of the present invention, preparation method is with reference to description of the invention embodiment 2；
Antiviral granule: Sichuan Guangda Pharmaceutical Co., Ltd produces；
Curcumin: lark prestige Science and Technology Ltd.；
Timosaponin BII: Chengdu bass spy reagent company limited；
1.1.3 instrument: toes swelling instrument, syringe, marking pen, normal saline, 1% carrageenin, prednisone
1.2 method and result
SD rat 36, is randomly divided into 6 groups, often group rat 6, labelling is weighed, be divided into normal saline group, prednisone group,
Test medicine group, antiviral granule group, curcumin group, timosaponin BII group.
Normal saline group gavage normal saline, 3 times/day, continuous 4 days；
Prednisone group gavage prednisone 5mg/kg, 3 times/day, continuous 4 days；
Curcumin group gavage curcumin 0.2mg/kg, 3 times/day, continuous 4 days；
Timosaponin BII group gavage timosaponin BII27mg/kg, 3 times/day, continuous 4 days:
Antiviral granule group gavage antiviral granule 900mg/kg, 3 times/day, continuous 4 days；
Test medicine group gavage test medicine 900mg/kg, 3 times/day, continuous 4 days；
In last be administered after 1.5h at every Rat Right metapedes plantar subcutaneous injection 1% carrageenin, and in injection before and note
After penetrating 1,2,4,6,8h measure foot sole of the foot volume, calculate swelling percentage rate.
Measure Rat Right metapedes normal volume: lumbar injection 20% urethane 0.5ml/100g is by rat anesthesia, in every
With one horizontal line of marking penization as mark at Mus metapedes external malleolus.Use volumetric measurement method to be stretched by Mus hind leg and put into measuring instrument glass
In glass cylinder, when in inspection section, liquid water horizontal line is overlapping with Mus foot horizontal line mark, measuring instrument digital display screen display foot sole of the foot volume
Numerical value.
Volume before swelling percentage rate=100% × (volume before volume-injection after injection)/injection
Statistical analysis: use SPSS11.0 software to carry out statistical analysis.Data result analysis uses t inspection.
The results contrast of rat paw edema caused by carrageenin, is shown in Table 1.
Table 1: the results contrast of rat paw edema caused by carrageenin (N=6, %)
Test result indicate that: curcumin, timosaponin BII can suppress the rat hindleg foot caused by carrageenin slightly
Sole of the foot swelling, accelerates disappearing of inflammatory reaction to a certain extent；Antiviral granule, test medicine can significantly suppress carrageenin institute
The rat hindleg pedal swelling caused, accelerates disappearing of inflammatory reaction.With curcumin group, timosaponin BII group and antiviral granule
Group is compared, test medicine group accelerate the speed that disappears of inflammatory reaction faster, but the speed that disappears is slightly below prednisone group.Tested
Medicine group is reliable anti-inflammatory drug.
2 resisiting influenza virus effects are compared
2.1 experiment material
2.1.1 animal NIH mice, body weight 13-15g, male and female half and half, Zhongshan University provide.
2.1.2 medicine
Test medicine: the pharmaceutical composition of the present invention, preparation method is with reference to description of the invention embodiment 1；
Antiviral granule: Sichuan Guangda Pharmaceutical Co., Ltd produces；
Goitrin: the triumphant chemical Science and Technology Ltd. of Shanghai one hundred generation；
2.1.3 seed culture of viruses Influenza A1 virus FM1 Mus lung adapted strain, is identified by China's pharmaceutical biological product and is provided, through little
After Mus strengthens virulence, pass on 2 times in Embryo Gallus domesticus blister cavities, and measure its median lethal dose(LD 50) LD50.
2.1.4 reagent 2,4-DNP；Virazole；
2.1.5 instrument clinical thermometer
2.1.6 statistics with methods experiment data withRepresent, between group, compare employing t inspection.
2.2 method and result
2.2.1 antivirus action
Take seed culture of viruses physiological saline solution before experiment and be diluted to every 0.05ml containing 8 LD50, put in frozen water and preserve.Take NIH
Mice 80, is randomly divided into 5 groups.Under ether light anesthesia, infecting with influenza virus drop nose, every Mus drips 4, about
0.05ml.5 groups of mices are divided into: virus control group, virazole group, test medicine group, antiviral granule group and goitrin group.
Virus control group gavage equal-volume distilled water, 3 times/day, continuous 12 days；
Virazole group gavage virazole 250mg/kg, 3 times/day, continuous 12 days；
Test medicine group gavage test medicine 1.8g/kg, 3 times/day, continuous 12 days；
Antiviral granule group gavage antiviral granule thing 1.8g/kg, 3 times/day, continuous 12 days；
Goitrin group gavage goitrin 0.45mg/kg, 3 times/day, continuous 12 days；
Infecting in virus starts by measuring gastric infusion for first 1 day, continuous 12 days.Day by day animal disease symptom is observed with dead
Number, observes 15 days altogether, and experimental result is shown in Table 2.
Table 2: resisiting influenza virus effect compare (N=16, %)
Test result indicate that: virazole group, test medicine group, antiviral granule group and goitrin group survival rate are above disease
Poison matched group, and the survival rate of test medicine group is higher than virazole group, antiviral granule group and goitrin group, medicine of the present invention
The antiviral activity of compositions is better than virazole group, antiviral granule and goitrin.
Specific embodiment
Referring to specific embodiment, the present invention is described.Only it will be appreciated by those skilled in the art that these embodiments
For the present invention is described, it limits the scope of the present invention never in any form.
Embodiment 1:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure reed rhizome polysaccharide in Rhizoma Phragmitis clear paste by HPLC method to contain
Amount.
In 0.10g goitrin, 0.6g phillyrin, 9.68g reed rhizome polysaccharide ratio, weigh three of the above clear paste, mixing, continues
It is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin appropriate, mixing, make
Grain, sieves, makes 4000g, subpackage, every bag of 4g, the pharmaceutical composition obtained, and wherein every bag comprises 0.10mg goitrin, 0.6mg
Phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide.
Embodiment 2:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.10g goitrin, 0.6g phillyrin, 9.68g reed rhizome polysaccharide, 1.15g patchouli alcohol, 0.48g beta-Asarone,
0.13g curcumin, 15.10g timosaponin BII, 1.35g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into
Relative density is the clear paste of 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make granule, sieve,
Add the volatile oil of above-mentioned collection, mixing, make 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, the most often
Bag comprises 0.10mg goitrin, 0.6mg phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide, 1.15mg patchouli alcohol, 0.48mg
Beta-Asarone, 0.13mg curcumin, 15.10mg timosaponin BII, 1.35mg catalpol.
Embodiment 3:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure reed rhizome polysaccharide in Rhizoma Phragmitis clear paste by HPLC method to contain
Amount.
In 0.04g goitrin, 0.24g phillyrin, 3.87g reed rhizome polysaccharide ratio, weigh three of the above clear paste, mixing, continues
Continuous it is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make
Grain, sieves, and makes 4000g, subpackage, every bag of 4g, the pharmaceutical composition obtained, wherein every bag comprise 0.04mg goitrin,
0.24mg phillyrin, 203.2mg Gypsum Fibrosum, 3.87mg reed rhizome polysaccharide.
Embodiment 4:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure reed rhizome polysaccharide in Rhizoma Phragmitis clear paste by HPLC method to contain
Amount.
In 0.16g goitrin, 0.96g phillyrin, 15.49g reed rhizome polysaccharide ratio, weigh three of the above clear paste, mixing, continues
Continuous it is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make
Grain, sieves, and makes 4000g, subpackage, every bag of 4g, the pharmaceutical composition obtained, wherein every bag comprise 0.16mg goitrin,
0.96mg phillyrin, 812.8mg Gypsum Fibrosum, 15.49mg reed rhizome polysaccharide.
Embodiment 5:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.04g goitrin, 0.24g phillyrin, 3.87g reed rhizome polysaccharide, 0.46g patchouli alcohol, 0.19g beta-Asarone,
0.05g curcumin, 6.04g timosaponin BII, 0.54g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into phase
Being the clear paste of 1.23-1.30 (65 DEG C) to density, qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, makes granule, sieves, adds
Enter the volatile oil of above-mentioned collection, mixing, make 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, wherein every bag
Comprise 0.04mg goitrin, 0.24mg phillyrin, 203.2mg Gypsum Fibrosum, 3.87mg reed rhizome polysaccharide, 0.46mg patchouli alcohol,
0.19mg beta-Asarone, 0.05mg curcumin, 6.04mg timosaponin BII, 0.54mg catalpol.
Embodiment 6:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.16g goitrin, 0.96g phillyrin, 15.49g reed rhizome polysaccharide, 1.84g patchouli alcohol, 0.77g beta-Asarone,
0.20g curcumin, 24.16g timosaponin BII, 2.16g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into
Relative density is the clear paste of 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make granule, sieve,
Add the volatile oil of above-mentioned collection, mixing, make 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, the most often
Bag comprise 0.16mg goitrin, 0.96mg phillyrin, 812.8mg Gypsum Fibrosum, 15.49mg reed rhizome polysaccharide, 1.84mg patchouli alcohol,
0.77mg beta-Asarone, 0.20mg curcumin, 24.16mg timosaponin BII, 2.16mg catalpol.
Embodiment 7:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.08g goitrin, 0.48g phillyrin, 7.75g reed rhizome polysaccharide, 0.92g patchouli alcohol, 0.39g beta-Asarone,
0.10g curcumin, 12.0g timosaponin BII, 1.08g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into phase
Being the clear paste of 1.23-1.30 (65 DEG C) to density, qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, makes granule, sieves, adds
Enter the volatile oil of above-mentioned collection, mixing, make 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, wherein every bag
Comprise 0.08mg goitrin, 0.48mg phillyrin, 406.4mg Gypsum Fibrosum, 7.75mg reed rhizome polysaccharide, 0.92mg patchouli alcohol,
0.39mg beta-Asarone, 0.10mg curcumin, 12.0mg timosaponin BII, 1.08mg catalpol.
Embodiment 8:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.12g goitrin, 0.72g phillyrin, 11.62g reed rhizome polysaccharide, 1.38g patchouli alcohol, 0.58g beta-Asarone,
0.15g curcumin, 18.12g timosaponin BII, 1.62g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into
Relative density is the clear paste of 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make granule, sieve,
Add the volatile oil of above-mentioned collection, mixing, make 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, the most often
Bag comprise 0.12mg goitrin, 0.72mg phillyrin, 609.6mg Gypsum Fibrosum, 11.62mg reed rhizome polysaccharide, 1.38mg patchouli alcohol,
0.58mg beta-Asarone, 0.15mg curcumin, 18.12mg timosaponin BII, 1.62mg catalpol.
Embodiment 9:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
In 0.08g goitrin, 0.48g phillyrin, 7.75g reed rhizome polysaccharide ratio, weigh above 3 kinds of clear paste, mixing, continues
It is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin appropriate, mixing, make
Grain, sieves, makes 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, wherein every bag comprise 0.08mg goitrin,
0.48mg phillyrin, 406.4mg Gypsum Fibrosum, 7.75mg reed rhizome polysaccharide.
Embodiment 10:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
In 0.12g goitrin, 0.72g phillyrin, 11.62g reed rhizome polysaccharide ratio, weigh above eight kinds of clear paste, mixing, continues
Continuous it is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds cane sugar powder and dextrin is appropriate, mixing, make
Grain, sieves, makes 1000g, subpackage, every bag of 4g, to obtain final product.The pharmaceutical composition obtained, wherein every bag comprise 0.12mg goitrin,
0.72mg phillyrin, 609.6mg Gypsum Fibrosum, 11.62mg reed rhizome polysaccharide.
Embodiment 11:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
In 0.12g goitrin, 0.72g phillyrin, 11.62g reed rhizome polysaccharide ratio, weigh above eight kinds of clear paste, mixing, continues
Continue and be concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, addition betacyclodextrin, sodium cyclamate, dextrin,
Starch and cane sugar powder are appropriate, and mixing uses marumerization, makes granule, add appropriate magnesium stearate, and 33 rush rotary tablet compression
Machine tabletting, subpackage, to obtain final product.The pharmaceutical composition obtained, wherein every bag comprise 0.12mg goitrin, 0.72mg phillyrin,
609.6mg Gypsum Fibrosum, 11.62mg reed rhizome polysaccharide.
Embodiment 12:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
In 0.08g goitrin, 0.48g phillyrin, 7.75g reed rhizome polysaccharide ratio, weigh above 3 kinds of clear paste, mixing, continues
It is concentrated into the clear paste that relative density is 1.23-1.30 (65 DEG C), qinghuo reagent, adds betacyclodextrin, sodium cyclamate, dextrin, form sediment
Powder and cane sugar powder are appropriate, and mixing uses marumerization, makes granule, add appropriate magnesium stearate, and 33 rush rotary tablet machine
Tabletting, subpackage, to obtain final product.The pharmaceutical composition obtained, wherein every bag comprises 0.08mg goitrin, 0.48mg phillyrin, 406.4mg
Gypsum Fibrosum, 7.75mg reed rhizome polysaccharide.
Embodiment 13:
(1) Radix Isatidis 400g, Gypsum Fibrosum 59g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure goitrin in clear paste of Radix Isatidis by HPLC method to contain
Amount.
(2) Fructus Forsythiae 400g, Gypsum Fibrosum 163g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure phillyrin in Fructus Forsythiae clear paste by HPLC method to contain
Amount.
(3) Rhizoma Phragmitis 400g, Gypsum Fibrosum 125g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filter
Crossing, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Reed rhizome polysaccharide in Rhizoma Phragmitis clear paste is measured by HPLC method
Content.
(4) Rhizoma Anemarrhenae 400g pulverizes, and adds 80%-95% alcohol heating reflux and extracts 3 times, each 3 hours, filters, and filtrate is returned
Receive ethanol and be concentrated into the clear paste that relative density is 1.03-1.10 (65 DEG C).Timosaponin in Rhizoma Anemarrhenae clear paste is measured by HPLC method
BII content.
(5) Radix Rehmanniae 400g, boiling three times, 1 hour for the first time, second and third time each 0.5 hour, filters, and filtrate concentrates
To the clear paste that relative density is 1.05-1.15 (65 DEG C).Catalpol content in Radix Rehmanniae clear paste is measured by HPLC method.
(6) Herba Pogostemonis 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Herba Pogostemonis clear paste by HPLC method
Patchouli alcohol content.
(7) Rhizoma Acori Graminei 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time each 0.5
Hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Measure in Rhizoma Acori Graminei clear paste by HPLC method
Beta-Asarone content.
(8) Radix Curcumae 400g, boiling three times, collect volatile oil simultaneously, 1 hour for the first time, second and third time was each 0.5 little
Time, filtering, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (65 DEG C).Rhizoma Curcumae Longae in Radix Curcumae clear paste is measured by HPLC method
Cellulose content.
By 0.12g goitrin, 0.72g phillyrin, 11.62g reed rhizome polysaccharide, 1.38g patchouli alcohol, 0.58g beta-Asarone,
0.15g curcumin, 18.12g timosaponin BII, 1.62g catalpol ratio, weigh above eight kinds of clear paste, mixing, continues to be concentrated into
Relative density is the clear paste of 1.23-1.30 (65 DEG C), and qinghuo reagent adds betacyclodextrin, sodium cyclamate, dextrin, starch and sucrose
Powder is appropriate, mixing, uses marumerization, makes granule, dries, 20 mesh sieve granulate, adds the volatile oil of above-mentioned collection with hard
Fatty acid magnesium, mixing, fill capsule, to obtain final product.The pharmaceutical composition obtained, wherein every bag comprises 0.12mg goitrin, 0.72mg even
Stick up glycosides, 609.6mg Gypsum Fibrosum, 11.62mg reed rhizome polysaccharide, 1.38mg patchouli alcohol, 0.58mg beta-Asarone, 0.15mg curcumin,
18.12mg timosaponin BII, 1.62mg catalpol.
Claims (6)
1. one kind is applicable to upper respiratory tract infection and grippal pharmaceutical composition, it is characterised in that described pharmaceutical composition
By 0.04mg-0.16mg goitrin, 0.24mg-0.96mg phillyrin, 203.2mg-812.8mg Gypsum Fibrosum, 3.87mg-15.49mg
Reed rhizome polysaccharide forms.
Pharmaceutical composition the most according to claim 1, it is characterised in that described pharmaceutical composition is accused by 0.08mg-0.12mg
According to spring, 0.48mg-0.72mg phillyrin, 406.4mg-609.6mg Gypsum Fibrosum, 7.75mg-11.62mg reed rhizome polysaccharide composition.
Pharmaceutical composition the most according to claim 2, it is characterised in that described pharmaceutical composition by 0.10mg goitrin,
0.6mg phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide form.
4. one kind is applicable to upper respiratory tract infection and grippal pharmaceutical composition, it is characterised in that described pharmaceutical composition
By 0.04mg-0.16mg goitrin, 0.24mg-0.96mg phillyrin, 203.2mg-812.8mg Gypsum Fibrosum, 3.87mg-15.49mg
Reed rhizome polysaccharide, 0.46mg-1.84mg patchouli alcohol, 0.19mg-0.77mg beta-Asarone, 0.05mg-0.20mg curcumin,
6.04mg-24.16mg timosaponin BII, 0.54mg-2.16mg catalpol forms.
Pharmaceutical composition the most according to claim 4, it is characterised in that described pharmaceutical composition is accused by 0.08mg-0.12mg
According to spring, 0.48mg-0.72mg phillyrin, 406.4mg-609.6mg Gypsum Fibrosum, 7.75mg-11.62mg reed rhizome polysaccharide, 0.92mg-
1.38mg patchouli alcohol, 0.39mg-0.58mg beta-Asarone, 0.10mg-0.15mg curcumin, 12.0mg-18.12mg Rhizoma Anemarrhenae soap
Glycosides BII, 1.08mg-1.62mg catalpol forms.
Pharmaceutical composition the most according to claim 5, it is characterised in that described pharmaceutical composition by 0.10mg goitrin,
0.6mg phillyrin, 508mg Gypsum Fibrosum, 9.68mg reed rhizome polysaccharide, 1.15mg patchouli alcohol, 0.48mg beta-Asarone, 0.13mg Rhizoma Curcumae Longae
Element, 15.10mg timosaponin BII, 1.35mg catalpol composition.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101285812A (en) * | 2008-03-06 | 2008-10-15 | 广州中医药大学 | Antivirus compound formulation quality control method |
| CN101919959A (en) * | 2009-06-16 | 2010-12-22 | 丽珠医药集团股份有限公司 | Drug composition for preventing and treating swine influenza and preparation method and application thereof |
| KR101266180B1 (en) * | 2010-11-29 | 2013-05-21 | 주식회사 리안 | Vegetable antibacterial composition and cosmetic composition for improving skin using the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101285812A (en) * | 2008-03-06 | 2008-10-15 | 广州中医药大学 | Antivirus compound formulation quality control method |
| CN101919959A (en) * | 2009-06-16 | 2010-12-22 | 丽珠医药集团股份有限公司 | Drug composition for preventing and treating swine influenza and preparation method and application thereof |
| KR101266180B1 (en) * | 2010-11-29 | 2013-05-21 | 주식회사 리안 | Vegetable antibacterial composition and cosmetic composition for improving skin using the same |
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