CN103947653A - Sterilization composition containing flutriafol and SYP-Z048 - Google Patents
Sterilization composition containing flutriafol and SYP-Z048 Download PDFInfo
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- CN103947653A CN103947653A CN201410117499.4A CN201410117499A CN103947653A CN 103947653 A CN103947653 A CN 103947653A CN 201410117499 A CN201410117499 A CN 201410117499A CN 103947653 A CN103947653 A CN 103947653A
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Abstract
The present invention relates to a sterilization composition containing flutriafol and SYP-Z048, wherein the active ingredient is obtained by compounding flutriafol and SYP-Z048, a mass ratio of flutriafol to SYP-Z048 is 1-50:50-1, a mass part ratio of flutriafol to SYP-Z048 in a preparation is 1-85%, and the balance is a pesticide acceptable auxiliary component. According to the present invention, the dosage forms of the sterilization composition can be emulsifiable concentrates, suspending agents, aqueous emulsions and microemulsions, and the sterilization composition is mainly used for prevention and control of plant powdery mildew, gray mold, peronospora, phytophthora and other pathogenic bacteria.
Description
Technical field
The present invention relates to agriculture chemical compounding technical field, particularly relate to a kind of bactericidal composition that contains Flutriafol and SYP-Z048.
Background technology
Flutriafol is a kind of broad spectrum activity systemic fungicide; basidiomycetes and the microbial multiple diseases of ascus are had to good protection and therapeutic action; this medicine has good systemic action; root, stem, leaf by plant absorb; upwards shifted by vascular bundle again; the mechanism of action is mainly to combine with mycoprotein pigment, and in Antifungi body, the biosynthesis of ergosterol, causes germ death.Flutriafol has eradicant action to sorus melon, powdery mildew of wheat and barley, and after dispenser 5 ~ 10 days, the scab originally forming can disappear.Can effectively prevent and treat melon, wheat crops powdery mildew, rust etc.Its chemical molecular structural formula of Flutriafol is
SYP-Z048 is the novel agrochemical kind (Chinese invention patent number: CN99113093.6) that Shenyang Chemical Engineering Inst independently formulates and develops.SYP-Z048 belongs to sterol synthetic inhibitor bactericide, has unique mechanism of action and broad-spectrum sterilization activity, and has protection and therapeutic action simultaneously, has good interior absorption, absorbs by root and base of leaf the occurrence and harm that can effectively control leaf diseases.This compound is to tomato, cucumber, grape grey mould, wheat, powdery mildew of cucumber, and scab of cucumber, rice sheath blight diseases etc. all have good control efficiency.Chemistry N-methyl-3-(4-chlorine) phenyl-5-methyl-5-pyridine-3-methyl-oxazoline by name of SYP-Z048, its chemical structural formula is
Using chemical agent is the most effectively means of controlling plant diseases.But long-term use single chemical bactericide continuously high dose, easily cause the problem such as residual, environmental pollution and resistance to pesticide resistance fungi development of medicament.Reasonably the composite or mixture of chemical bactericide has expansion fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay the positive feature such as Antifungal resistance and drug-fast generation and development, bactericide compounded is one of the effective method the most addressing the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, composite and the mixture of low toxicity, low-residual has small investment, the lead time is short and be subject to domestic and international attention, and numerous and confused increasing develops dynamics.We filter out Flutriafol and SYP-Z048 and carry out compositely on the basis of lab screening and field trial, have obvious synergistic effect.And there is no at present people about the composite bactericidal composition of Flutriafol and SYP-Z048 and application reported.
Summary of the invention
Based on above situation, the object of the invention is to provide a kind of new and effective pesticide sterilizing composite.Be mainly used in the control of the germs such as plant powdery mildew, gray mold, Peronospora, epidemic disease be mould.
Technical scheme of the present invention realizes by following measures: a kind of bactericidal composition that contains Flutriafol and SYP-Z048, and two yuan of the active ingredient Flutriafol of this bactericidal composition and SYP-Z048s are composite, and all the other are auxiliary element.In wherein said bactericidal composition, the mass ratio of active ingredient Flutriafol and SYP-Z048 is 1 ~ 50: 50 ~ 1, and described bactericidal composition of the present invention is through toxicity test experimental verification, and the mass ratio of Flutriafol and SYP-Z048 is 1 ~ 25: 25 ~ 1 o'clock, and synergistic effect is better.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, aqueous emulsion, microemulsion.Wherein active ingredient Flutriafol and the SYP-Z048 gross mass in preparation accounts for 1% ~ 85% of the whole quality of the pharmaceutical preparations, while wherein accounting for 5% ~ 65%, and toxicity and residually reach good balance, cost is also lower.
The specific embodiments of the formulations of pesticide that bactericidal composition of the present invention is mixed with is as follows: described bactericidal composition is cream preparation, and the mass fraction of component is: 1 ~ 50 part of Flutriafol; 1 ~ 50 part of SYP-Z048; 10 ~ 30 parts of conventional emulsifiers; 20 ~ 50 parts of conventional solvents; 1 ~ 5 part of conventional synergist.The concrete production stage of this cream preparation is first active ingredient Flutriafol and SYP-Z048 to be added in solvent to the oily liquids that becomes transparent and homogeneous after adding again emulsifier, synergist to stir after dissolving completely, filling, can be made into the cream preparation of the present composition.
Described bactericidal composition is suspending agent, and the mass fraction of component is: 1 ~ 50 part of Flutriafol; 1 ~ 50 part of SYP-Z048; 5 ~ 20 parts of dispersants; 1 ~ 5 part of antifreezing agent; 0.1 ~ 2 part of thickener; 0.1 ~ 0.8 part of defoamer; 0.1 ~ 10 part of penetrating agent; 0.1 ~ 5 part of pH value conditioning agent; Water, surplus.The concrete production stage of this suspending agent is for first mixing other auxiliary agents, mix through high speed shear, add active ingredient Flutriafol and SYP-Z048, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all below 5mm, can be made into the suspending agent preparation of the present composition.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is: 1 ~ 50 part of Flutriafol; 1 ~ 50 part of SYP-Z048; 3 ~ 30 parts of emulsifier; 5 ~ 15 parts of solvents; 2 ~ 15 parts of stabilizing agents; 1 ~ 5 part of antifreezing agent; 0.1 ~ 8 part of defoamer; 0.2 ~ 2 part of thickener; Water, surplus.The concrete production stage of this aqueous emulsion is: first Flutriafol and SYP-Z048, solvent and emulsifier, cosolvent are added together, make to be dissolved into uniform oil phase; By part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes into uniform water; When reactor high speed stirs, oil phase is added to water, slowly add water until reach phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type, can be made into the aqueous emulsion of the present composition.
Described bactericidal composition is microemulsion, and the mass fraction of component is: 1 ~ 50 part of Flutriafol; 1 ~ 50 part of SYP-Z048; 10 ~ 30 parts of emulsifier, 1 ~ 8 part of antifreezing agent, 0.5 ~ 10 part of stabilizing agent, 20 ~ 50 parts of conventional solvent cosolvents.Flutriafol and SYP-Z048 are dissolved completely with cosolvent, then add other compositions such as emulsifier, antifreezing agent stabilizing agent, evenly mix, finally add water, after fully stirring, can be made into microemulsion.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, any or more than one any mixtures than forming in polyoxyethylene aliphatic alcohol ether.
Described solvent is dimethylbenzene or biodiesel, toluene, and diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine-based vegetable oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), one or more in water equal solvent are arbitrarily than the mixture of composition.
Described dispersant is selected from polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene methyl ether condensate sulfate, alkylsulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, one or more in fatty acid glyceride APEO.
Described wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX, moistening bleeding agent, alkylbenzenesulfonate polyoxyethylene triphen phosphenylic acid salt dimly, spaonin powder, silkworm excrement, one or more in soapberry powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, one or more in sodium bicarbonate.
Described thickener is selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, in polyvinyl alcohol one or more.
Described stabilizing agent is selected from sodium citrate, the one in resorcinol.
Described antifreezing agent is selected from ethylene glycol, propane diols, one or more in glycerine.
Described defoamer is selected from silicone oil, silicone compound, C10-20 saturated fat acid compounds, one or more of C8-10 fatty alcohol.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, one or more in precipitated calcium carbonate.
The present invention has obvious synergistic effect taking Flutriafol and SYP-Z048 as the composite bactericide of active ingredient, delay the drug-fast generation in key, and reduced to become to produce cost and use cost, be mainly used in the control of plant botrytis, Peronospora, epidemic disease mycin germ, banded sclerotial blight.
Embodiment
For making technical scheme of the present invention, object and advantage are clearer, and the present invention describes with following specific embodiment, but the present invention is not limited to these examples.The mode that effect experiment of the present invention adopts indoor biometrics and field trial to combine, if no special instructions, the ratio of below mentioning is all ratio of quality and the number of copies.
Embodiment 1: Flutriafol proportioning co-toxicity experiments different from SYP-Z048.
1.1 reagent agent
The former medicine of 95% Flutriafol, the former medicine of 96% SYP-Z048.
1.2 test targets
Never executed Flutriafol and SYP-Z048 from Yan Tang town, Guichi District of Chizhou City, Anhui Province and cucumber of the same type gathers and separates potted plantly, for examination cucumber variety: grind No. one in Tianjin.
1.3 test method
1.3.1 medicament preparation
First use the former medicine of acetone solution, according to the result of preliminary experiment, two appropriate former medicines are made into several different proportionings, then it is stand-by with acetone, each processing to be diluted to respectively to several concentration gradients.
Susceptible cucumber variety Chang Chun Mi Ci is cultivated in pot for growing seedlings, be placed in greenhouse and cultivate, plant grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of botrytis cinerea pers.
1.3.2 the cultivation of botrytis cinerea pers and the preparation of spore suspension
Botrytis cinerea pers adopts plants method to cultivate under 20 DEG C, the condition of 12h alternation of light and darkness, and every 30d turns culture 1 time.When inoculation, with the conidium on sterile water wash-out incidence of leaf, being mixed with spore concentration is l × 10
6the suspension of individual/ML.
1.3.3 strains tested sensitivity testing
Adopt leaf dish moisturizing method to carry out toxicity test.First the blade of collection is prepared into the leaf dish that diameter is 1.5cm, mix at random, be placed in respectively the series concentration liquid configuring and soak lh, 50 leaf dishes of each concentration, test is with the blank that is treated to of adding medicine not, after immersion finishes, leaf faces up and puts on the wetting blotting paper of identical liquor strength, liquid on leaf dish is blotted, the spore suspension l0L preparing is inoculated in to leaf dish central authorities, and room temperature is placed after 5min, is placed under 20 DEG C, the condition of 12h alternation of light and darkness and cultivates, after 10d, measure the onset area on leaf dish, calculate LC
50.
2 toxicity tests
On the basis of preliminary experiment, respectively single dose Flutriafol and SYP-Z048 are carried out to toxicity test in order to upper method, the two LC
50value is respectively 5.9331mg/L and 4.8561mg/L.
2.1 percentage that account for leaf disc area according to lesion area are divided sick level
0 grade: anosis;
1 grade: sorus area accounts for below 5% of whole leaf area;
3 grades: sorus area accounts for below 6% ~ 10% of whole leaf area;
5 grades: sorus area accounts for below 11% ~ 20% of whole leaf area;
7 grades: sorus area accounts for below 21% ~ 50% of whole leaf area;
9 grades: sorus area accounts for the more than 50% of whole leaf area;
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.Taking the logarithm value of drug concentration (mg/L) as independent variable X, taking the probability value of corrected mortality as dependent variable Y, set up respectively virulence regression equation formula, adopt DPS software to calculate the LC of single dose and each proportioning mixture
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
Co-toxicity coefficient CTC computing formula is as follows: (taking SYP-Z048 as standard medicament, its toxicity index is 100):
The LC of toxicity index (TI) the=SYP-Z048 of Flutriafol
50the LC of ∕ Flutriafol
50× 100
The LC of actual measurement toxicity index (ATI) the=SYP-Z048 of M
50the LC of ∕ M
50× 100
TI × P SYP-Z048+Flutriafol TI × P Flutriafol of theoretical toxicity index (TTI) the=SYP-Z048 of M
TTI × 100 of the ATI ∕ M of co-toxicity coefficient (CTC)=M of M
In formula: M is SYP-Z048 and the mixture of the different proportionings of Flutriafol
P SYP-Z048 is SYP-Z048 shared ratio in mixture
P Flutriafol is Flutriafol shared ratio in mixture
2.2 toxicity test results:
table one, Flutriafol and the SYP-Z048 toxicity test result table to gray mold of cucumber
As can be seen from Table 1, the result of the test of different proportion proportioning shows, dilute respectively and all show stronger synergistic effect in active ingredient ratio, wherein taking Flutriafol and SYP-Z048 as 1:50 ~ 50:1 time synergistic effect good, suggestion is carried out further field control effectiveness test to suitable proportion 1:20 ~ 20:1 left and right mixture preparation, to evaluate its field practical application effect.
3, the compound composition during with Flutriafol and SYP-Z048 2:1 is prevented and treated powdery mildew of cucumber and is carried out field trial
3.1 field trials are prevented and treated powdery mildew of cucumber
3.1.1 test method
Test is on Guichi District of Chizhou City Qiu Jiang office cucumber ground, and 4 points of every community investigation, investigate 2 strains at every, record occurring degree by staging, and grade scale is as follows:
0 grade: anosis;
1 grade: sorus area accounts for below 5% of whole leaf area;
3 grades: sorus area accounts for below 6% ~ 10% of whole leaf area;
5 grades: sorus area accounts for below 11% ~ 20% of whole leaf area;
7 grades: sorus area accounts for below 21% ~ 50% of whole leaf area;
9 grades: sorus area accounts for the more than 50% of whole leaf area.
3.1.2 control time and number of times
Test is investigated 4 times altogether, and radix investigation before medicine is investigated after 7 days, 7 days for the second time and medicine after medicine for the first time for 15 days.
3.1.3 drug effect computational methods
The total number of sheets × 100 of sick leaf rate (%)=sick number of sheets/investigate
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 100
Control efficiency (%)=(disease index after the front disease index × treatment region medicine of 1-(blank district medicine)/(the front disease index of disease index × treatment region medicine after blank district medicine)) × 100.
3.1.4 poisoning investigation method
After dispenser, whether 15d range estimation medicament has poisoning to crop continuously.
3.1.5 result of the test and analysis
Each effect of preventing and treating powdery mildew of cucumber of processing.
As shown in Table 2 Flutriafol SYP-Z048 with the composite bactericide of 2:1 for powdery mildew of cucumber control successful higher than Flutriafol and two kinds of single doses of SYP-Z048, bactericidal effect increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Advise that the bactericide different from the mechanism of action mixes use to delay the drug-fast generation of germ.
table 2, Flutriafol SYP-Z048 composite bactericide various dose are prevented and treated the effect of powdery mildew of cucumber
In sum, the bactericidal composition that the present invention contains Flutriafol and SYP-Z048, has good control efficiency to powdery mildew of cucumber, gray mold, and it is to target crop safety.Complex preparation has not only improved preventive effect, and has expanded fungicidal spectrum, widens the scope of application, reduces costs, and multiple diseases is played to the double effect of controlling of a medicine, alleviates manpower and materials, improves productivity effect.So the invention of this complex preparation is of great significance social tool with popularization.
Claims (4)
1. a bactericidal composition that contains Flutriafol and SYP-Z048, it is characterized in that: the active ingredient of this bactericidal composition is Flutriafol and SYP-Z048 binary built, all the other are auxiliary element, and wherein the mass ratio of active ingredient Flutriafol and SYP-Z048 is 1 ~ 50: 50 ~ 1.
2. bactericidal composition according to claim 1, is characterized in that: Flutriafol and the SYP-Z048 gross weight in preparation accounts for 1% ~ 85% of the whole quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, is characterized in that: Flutriafol and the SYP-Z048 gross weight in preparation accounts for 5% ~ 55% of the whole quality of the pharmaceutical preparations.
4. according to the bactericidal composition described in claim 1 or 2 or 3, it is characterized in that: the formulation of this bactericidal composition is missible oil, suspending agent, aqueous emulsion, microemulsion.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012140212A2 (en) * | 2011-04-15 | 2012-10-18 | Syngenta Participations Ag | Pesticidal compositions |
| CN103651338A (en) * | 2012-09-24 | 2014-03-26 | 宜德雅(北京)科技有限公司 | Sterilization and synergism composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012140212A2 (en) * | 2011-04-15 | 2012-10-18 | Syngenta Participations Ag | Pesticidal compositions |
| CN103651338A (en) * | 2012-09-24 | 2014-03-26 | 宜德雅(北京)科技有限公司 | Sterilization and synergism composition |
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Application publication date: 20140730 |