CN103937672A - Bioreactor thermostat - Google Patents
Bioreactor thermostat Download PDFInfo
- Publication number
- CN103937672A CN103937672A CN201410118714.2A CN201410118714A CN103937672A CN 103937672 A CN103937672 A CN 103937672A CN 201410118714 A CN201410118714 A CN 201410118714A CN 103937672 A CN103937672 A CN 103937672A
- Authority
- CN
- China
- Prior art keywords
- circulating
- reactor
- circulating line
- bio
- steam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/20—Heat exchange systems, e.g. heat jackets or outer envelopes the heat transfer medium being a gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
Landscapes
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Thermal Sciences (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention belongs to the field of biotechnology and relates to a bioreactor thermostat. The bioreactor thermostat comprises a reactor, a jacket wrapping the outer wall of the reactor, a circulating hot water tank, a cooling water supply pipeline, a circulating pipeline and a drainage pipeline, wherein the jacket is connected with the circulating hot water tank through the circulating pipeline; the cooling water supply pipeline is arranged on the circulating pipeline; the circulating hot water tank is connected with a water replenishing tank through a water inlet pipeline of the circulating hot water tank; a hot water circulating pump is arranged on the circulating pipeline; a mixer is arranged on the circulating pipeline between a circulating pump and the jacket; a steam pipeline is connected onto the mixer. The bioreactor thermostat is rapid in temperature rising speed and good in heat preservation effect.
Description
Technical field
The invention belongs to biological technical field, relate to a kind of bio-reactor thermostat.
Background technology
cell suspension culture reactor is the key equipment in biotechnology, is used for cultivating various needed cells, relates generally to vaccine, monoclonal antibody etc.Because the cultivation of cell is subject to the impact of temperature very large, to the control of temperature, require very high.Therefore, thermostat is absolutely necessary to cell suspension culture.
Existing device only adopts electrically heated mode to heat up, and the heating-up time is slow, when the temperature of setting is during far above actual temperature, especially obvious.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of heat-up rate fast, the bio-reactor thermostat of high insulating effect.
Bio-reactor thermostat of the present invention, comprise reactor, be coated on chuck, circulating water-heating tank, cooling water supply pipe, circulating line, drainage pipeline on reactor outer wall, between described chuck and circulating water-heating tank, by circulating line, be connected, on described circulating line, be provided with cooling water supply pipe; Described circulating water-heating tank is connected with water supply tank by its inlet channel; On described circulating line, be provided with hot water circulating pump; On described circulating line, be provided with steam-pipe, on described steam-pipe, be provided with control valve, described steam-pipe is connected with external steam source.
On circulating line between described recycle pump and chuck, be provided with mixing tank, on described mixing tank, be connected with steam-pipe.
On the outlet conduit of described chuck and inlet channel, be respectively arranged with steam-pipe.
On described circulating line, be provided with safety valve.
Water in described water supply tank is also provided by cooling water supply pipe.
On described reactor, be provided with the temp probe of measuring inside reactor temperature.
On described circulating line, be provided with the temp probe of measuring circulating line internal temperature.
On described water supply tank, be provided with lack of water probe.
The invention has the advantages that: whole process adopts steam to combine with electrically heated, and heat-up rate is fast.Adopt steam, electric-heating water, water coolant to combine, high insulating effect.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Embodiment
As shown in the figure, a kind of bio-reactor thermostat, comprise reactor 1, be coated on chuck 2, circulating water-heating tank 3, cooling water supply pipe 8, circulating line 4, drainage pipeline on reactor 1 outer wall, between described chuck 2 and circulating water-heating tank 3, by circulating line 4, be connected, on described circulating line 4, be provided with cooling water supply pipe 8; Described circulating water-heating tank 3 is connected with water supply tank 5 by its inlet channel; On described circulating line 4, be provided with hot water circulating pump 7; On described circulating line 4, be provided with steam-pipe 6, on described steam-pipe, be provided with control valve, described steam-pipe 6 is connected with external steam source.
On circulating line 4 between described recycle pump 7 and chuck 2, be provided with mixing tank 13, on described mixing tank, be connected with steam-pipe 6.
On the outlet conduit of described chuck 2 and inlet channel, be respectively arranged with steam-pipe 6.On described circulating line 4, be provided with safety valve 9, in described safety valve, be connected with row's steam-pipe.
On described reactor 1, be provided with the temp probe 10 of measuring reactor 1 internal temperature.On described circulating line 4, be provided with the temp probe 11 of measuring circulating line 4 internal temperatures.On described water supply tank 5, be provided with lack of water probe 12.
Water in described water supply tank 5 is also provided by cooling water supply pipe 8.
When the temperature of setting is during far above actual temperature, under the control of program, start steam and circulating water-heating tank 3, open corresponding valve, circulating water-heating tank 3 starts heating, the in good time moisturizing of water supply tank 5, hot water circulating pump 7 beats water to chuck 2, arrive after the temperature of setting, in conjunction with water coolant, guarantee homo(io)thermism.
Claims (8)
1. a bio-reactor thermostat, comprise reactor (1), be coated on chuck (2), circulating water-heating tank (3), cooling water supply pipe (8), circulating line (4), drainage pipeline on reactor (1) outer wall, between described chuck (2) and circulating water-heating tank (3), by circulating line (4), be connected, on described circulating line (4), be provided with cooling water supply pipe (8); Described circulating water-heating tank (3) is connected with water supply tank (5) by its inlet channel; On described circulating line (4), be provided with hot water circulating pump (7); It is characterized in that: on described circulating line (4), be provided with steam-pipe (6), on described steam-pipe, be provided with control valve, described steam-pipe (6) is connected with external steam source.
2. bio-reactor thermostat according to claim 1, is characterized in that: on the circulating line (4) between described recycle pump (7) and chuck (2), be provided with mixing tank (13), be connected with steam-pipe (6) on described mixing tank.
3. bio-reactor thermostat according to claim 1, is characterized in that: on the outlet conduit of described chuck (2) and inlet channel, be respectively arranged with steam-pipe (6).
4. bio-reactor thermostat according to claim 1, is characterized in that: on described circulating line (4), be provided with safety valve (9).
5. bio-reactor thermostat according to claim 1, is characterized in that: the water in described water supply tank (5) is also provided by cooling water supply pipe (8).
6. bio-reactor thermostat according to claim 1, is characterized in that: on described reactor (1), be provided with the temp probe (10) of measuring reactor (1) internal temperature.
7. bio-reactor thermostat according to claim 1, is characterized in that: on described circulating line (4), be provided with the temp probe (11) of measuring circulating line (4) internal temperature.
8. bio-reactor thermostat according to claim 1, is characterized in that: on described water supply tank (5), be provided with lack of water probe (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410118714.2A CN103937672A (en) | 2014-03-27 | 2014-03-27 | Bioreactor thermostat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410118714.2A CN103937672A (en) | 2014-03-27 | 2014-03-27 | Bioreactor thermostat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103937672A true CN103937672A (en) | 2014-07-23 |
Family
ID=51185551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410118714.2A Pending CN103937672A (en) | 2014-03-27 | 2014-03-27 | Bioreactor thermostat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103937672A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688775A (en) * | 2016-04-26 | 2016-06-22 | 河北工业大学 | Reactor with temperature control device |
| CN106318864A (en) * | 2016-08-23 | 2017-01-11 | 成都慧信实验设备有限公司 | Electric heating culture medium |
| CN115121202A (en) * | 2022-09-02 | 2022-09-30 | 江苏飞宇医药科技股份有限公司 | Reaction kettle temperature control method and production process of cyclopropyl ethyl amide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201386102Y (en) * | 2009-03-27 | 2010-01-20 | 北京天和瑞生物科技有限公司 | Bioreactor |
| CN201396935Y (en) * | 2009-03-31 | 2010-02-03 | 北京天和瑞生物科技有限公司 | Heating system |
| CN203319996U (en) * | 2013-05-10 | 2013-12-04 | 佛山金葵子植物营养有限公司 | Fermentation tank |
| CN203474776U (en) * | 2013-08-07 | 2014-03-12 | 国家电网公司 | Fermented fuel reactor |
-
2014
- 2014-03-27 CN CN201410118714.2A patent/CN103937672A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201386102Y (en) * | 2009-03-27 | 2010-01-20 | 北京天和瑞生物科技有限公司 | Bioreactor |
| CN201396935Y (en) * | 2009-03-31 | 2010-02-03 | 北京天和瑞生物科技有限公司 | Heating system |
| CN203319996U (en) * | 2013-05-10 | 2013-12-04 | 佛山金葵子植物营养有限公司 | Fermentation tank |
| CN203474776U (en) * | 2013-08-07 | 2014-03-12 | 国家电网公司 | Fermented fuel reactor |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688775A (en) * | 2016-04-26 | 2016-06-22 | 河北工业大学 | Reactor with temperature control device |
| CN105688775B (en) * | 2016-04-26 | 2018-03-16 | 河北工业大学 | A kind of reactor with temperature regulating device |
| CN106318864A (en) * | 2016-08-23 | 2017-01-11 | 成都慧信实验设备有限公司 | Electric heating culture medium |
| CN115121202A (en) * | 2022-09-02 | 2022-09-30 | 江苏飞宇医药科技股份有限公司 | Reaction kettle temperature control method and production process of cyclopropyl ethyl amide |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140723 |