CN103933521B - The Chinese medicine preparation for the treatment of sheep tinea circinata - Google Patents
The Chinese medicine preparation for the treatment of sheep tinea circinata Download PDFInfo
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Abstract
The Chinese medicine preparation for the treatment of sheep tinea circinata includes treating the Chinese herbal medicine for external use preparation of sheep tinea circinata and Chinese herbal medicine additive for oral administration, and Chinese herbal medicine for external use preparation is prepared from by the raw material of following mass parts: fresh ginger 30 40, Rhizoma Alpiniae Officinarum 10 15, northeast Radix Morinae Bulleyanae 10 15, Rhizoma Curcumae Longae 10 20, Rhizoma Et Radix Notopterygii 10 20, former propolis 20 30, dehydrated alcohol 120 180, distilled water 60 90, glycerol 65 90；Chinese herbal medicine additive for oral administration is prepared from by the raw material of following mass parts: Herba Artemisiae Scopariae 15 25, Radix Angelicae Pubescentis 10 20, Rhizoma Coptidis 10 15, Cortex Phellodendri 10 15, Radix Et Rhizoma Rhei 10 15, Herba Houttuyniae 15 30, Radix Isatidis 15 25, Radix Glycyrrhizae 10 30.Tinea speckle is processed once every day by the Chinese herbal medicine for external use preparation of the present invention, uses 20 days continuously, or the Chinese herbal medicine additive for oral administration of the present invention is added in mixed concentrate by the dosage of every sheep 40g every day 30, feed continuously 5 days, preferable curative effect can be played.If Chinese herbal medicine for external use preparation and the Chinese herbal medicine additive for oral administration of the present invention are used in combination, curative effect is more preferable.Invention formulation is nontoxic, harmless, noresidue.
Description
Technical field
The present invention relates to herbal medicine manufacture field, be specifically related to a kind of sheep treatment tinea circinata Chinese herbal medicine for external use preparation and Chinese herbal medicine additive for oral administration.
Background technology
In recent years, the rise that strange land is fattened, the mobility of flock of sheep strengthens, provides the approach of propagation to some infectious disease.Add the design of some Fattening Sheep field unreasonable, there is no sports ground, in closing wet environment, be more easy to cause and accelerate infectious disease from spreading.Sheep tinea circinata is a kind of by the fungus-caused skin infectious disease of Mucor, and grazing sheep and drylot feeding breeding sheep sickness rate are 0.5% ~ 3% according to statistics, Fattening in shed lamb sickness rate more than 5%.Fattening lamb pathological changes first occurs at face, and as pasting dough on the bridge of the nose, diameter is at 1 ~ 3 centimetre, and tinea speckle is rounded or oval, and dough comes off subsequently, exposes pink skin.Pathological changes is rapidly spread to lower part of eye, neck and shoulder part, back subsequently, even spreads to extremity, and adjacent speckle mutually merges, and forms large area depilation, such as treatment not in time, may cause death；The majority of morbidity is weak ill-conditioned individuality.This disease, at continuous rainy weather, is closed in sheep hurdle environment and is infected quickly, and mortality rate is higher.Prior art mainly has following two to the Therapeutic Method of this disease, one is by only smearing antifungal medicine at diseased region to sheep, but need the treatment phase longer, need to put into substantial amounts of human and material resources and financial resources, therefore produce to sheep raising and bring very burden and economic loss；Two is to take griseofulvin, i.e. to add griseofulvin over a long time in feedstuff, and the side effect of initiation is relatively big, and for short-term fattens meat sheep, the residue problem ratio of medicine is more serious.Additionally this disease is zoonosis, also can direct contagion to people, therefore, the treatment to sheep tinea circinata must cause enough attention.
Summary of the invention
The present invention provides a kind of Chinese herbal medicine for external use preparation treating sheep tinea circinata and Chinese herbal medicine additive for oral administration, and invention formulation has preferable therapeutical effect to tinea circinata, and easy to use, nontoxic, harmless, noresidue.
The Chinese herbal medicine for external use preparation of the treatment sheep tinea circinata of the present invention, is prepared from by the raw material of following mass parts: fresh ginger 30-40, Rhizoma Alpiniae Officinarum 10-15, northeast Radix Morinae Bulleyanae 10-15, Rhizoma Curcumae Longae 10-20, Rhizoma Et Radix Notopterygii 10-20, former propolis 20-30, dehydrated alcohol 120-180, distilled water 60-90, glycerol 65-90.
The preparation method of the Chinese herbal medicine for external use preparation that the present invention treats sheep tinea circinata is:
(1) fresh ginger purchased, Rhizoma Alpiniae Officinarum, northeast Radix Morinae Bulleyanae, Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii being preserved at the shady and cool ventilation place of being dried, former propolis is saved in-20 DEG C of refrigerators:
(2) weigh 10-15 part Rhizoma Alpiniae Officinarum, 10-15 part northeast Radix Morinae Bulleyanae, 10-20 part Rhizoma Curcumae Longae and 10-20 part Rhizoma Et Radix Notopterygii by mass parts, be crushed to 10-40 mesh respectively；Weigh the fragment of fresh ginger 30-40 part chopping to about 2 cubic millimeters；Weigh former propolis 20-30 part and be crushed to 10-20 mesh, then by wrapping up with gauze after all raw material mix homogeneously, put into hermetic container；
(3) dehydrated alcohol 120-180 part and distilled water 60-90 part are weighed by mass parts, add in hermetic container described in (2), after after soaking 72-96 hour, mentioning from container solution, draining gauze medicated bag, take out, make Chinese medicine ethanol extraction；
(4) weigh glycerol 65-90 part by mass parts, add in ethanol extraction prepared by (3), after stirring and evenly mixing, be the Chinese herbal medicine for external use preparation for the treatment of sheep tinea circinata.
The Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention, is prepared from by the raw material of following mass parts: Herba Artemisiae Scopariae 15-25, Radix Angelicae Pubescentis 10-20, Rhizoma Coptidis 10-15, Cortex Phellodendri 10-15, Radix Et Rhizoma Rhei 10-15, Herba Houttuyniae 15-30, Radix Isatidis 15-25, Radix Glycyrrhizae 10-30.
The preparation method of the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention is: (1) purchases Herba Artemisiae Scopariae, Radix Angelicae Pubescentis, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Herba Houttuyniae, Radix Isatidis and Radix Glycyrrhizae, preserves at the shady and cool ventilation place of being dried；(2) weigh various Chinese herbal medicine by above-mentioned mass parts, be crushed to 20-40 mesh, mix homogeneously the most respectively.
The present invention treats the Chinese herbal medicine for external use preparation using method of sheep tinea circinata: the Chinese herbal medicine for external use preparation present invention prepared pours in the watering can of 500ml ~ 1000ml, ill sheep is cut off the Pilus Caprae seu Ovis around tinea speckle, scrape off the dough sample mildew being pasted onto skin surface, the Chinese herbal and crude drugs preparations of the present invention is sprayed directly on skin surface, fountain height is till medicinal liquid complete wetting surface, and every day processes once.Use 5 days continuously, the diffusion of basic controlling tinea speckle；After using 10 days, at tinea speckle, skin surface has virgin wool fiber to grow；After using 15 days, substantially cure；After using 20 days, cure rate is more than 90%.
The Chinese herbal medicine additive using method of the treatment sheep tinea circinata of the present invention is: by the present invention orally ill sheep is taken Chinese herbal medicine additive and adds in mixed concentrate by the dosage of every sheep 30-40g every day, stir, disposably it is fed for when being sooner or later fed at twice or early raise, use 5 days continuously, be used in combination with Chinese herbal and crude drugs preparations.To ill sheep only, coordinating and feed Chinese herbal medicine additive while spraying Chinese herbal medicine for external use preparation, using effect is more preferable.Chinese herbal medicine additive is disposably fed for when being sooner or later fed at twice or early raise, and uses 5 days continuously, and after sprinkling Chinese herbal medicine for external use preparation uses 15 days continuously, cure rate just reaches more than 90%.
The present invention is specific to the Chinese herbal medicine for external use preparation of sheep tinea circinata preparation and Chinese herbal medicine additive for oral administration, and in this Chinese herbal medicine for external use preparation, fresh ginger and northeast Radix Morinae Bulleyanae ethanol propose liquid has killing action to the Mucor fungus of skin；Rhizoma Alpiniae Officinarum, Rhizoma Curcumae Longae and Rhizoma Et Radix Notopterygii have obvious inhibiting effect to 8 ~ 13 kinds of funguses of skin superficial part；Propolis ethanol extract has stronger inhibitory action to the pathogenic moulds of common skin superficial part；Dehydrated alcohol, as solvent, extracts the effective ingredient in above-mentioned Chinese medicine.Mycete has sensitivity to glycerol, adds glycerol and adds the therapeutic effect of this Chinese medicine preparation.
Chinese herbal medicine additive Herba Artemisiae Scopariae for oral administration, Herba Houttuyniae, Radix Isatidis have heat-clearing and toxic substances removing, removing heat from blood, antibacterial and anti-inflammation functions；Rhizoma Coptidis, Cortex Phellodendri and Radix Et Rhizoma Rhei have heat clearing and damp drying, eliminating fire and detoxication etc. act on, and Mucor fungus and trichophyton purpureatum etc. are had stronger bacteriostasis, and Chinese herbal medicine additive for oral administration plays the immunologic function strengthening sheep body, improve the resistance against diseases of sheep body, sheep tinea circinata is had good preventive and therapeutic action.
The present invention and the comparative test of existing drug treatment
(1) experimental animal and packet: choose the sheep 40 suffering from tinea circinata from raiser, it is randomly divided into 4 groups, often group 10, being assigned randomly to (A) invention formulation group, (B) griseofulvin group, (C) clotrimazole ointment group and (D) 3% iodine glycerol group, experimental period is 20 days.
(2) test method:
A tests Ration Compound: prepare with reference to U.S. NRC (version in 2007) sheep feeding standard.
(A) invention formulation group makes additive group daily ration of the present invention according to every sheep 30 grams of interpolation Chinese herbal medicine additive of the present invention every day in TRM；
(B) griseofulvin group makes griseofulvin group daily ration according to every sheep 200 milligrams of interpolation griseofulvin every day in TRM；
(C) clotrimazole ointment group and (D) 3% iodine glycerol group all feed the TRM without adding medicine.
B external used medicine using method:
(A) ill sheep is cut off the Pilus Caprae seu Ovis around tinea speckle by invention formulation group, scrape off the dough sample mildew being pasted onto skin surface, the Chinese herbal medicine for external use preparation of the present invention is sprayed directly on skin surface, and fountain height is till medicinal liquid complete wetting surface, and every day processes once.Use 5 days continuously；
(B) griseofulvin group processes without medicine for external use；
(C) ill sheep is cut off the Pilus Caprae seu Ovis around tinea speckle by clotrimazole ointment group, scrapes off the dough sample mildew being pasted onto skin surface, and clotrimazole ointment is coated directly on skin surface, and every day processes once.Use 20 days continuously；
(D) ill sheep is cut off the Pilus Caprae seu Ovis around tinea speckle by 3% iodine glycerol group, scrapes off the dough sample mildew being pasted onto skin surface, and 3% iodine glycerol is coated directly on skin surface, and every day processes once.Use 20 days continuously；
(3) curative effect statistical method: have virgin wool fiber to grow with skin surface at tinea speckle and be considered as using this method effective,
Effectively cure rate (%)=effectively sheep number of elements ÷ 10 × 100%；
Relapse rate (%)=recurrence sheep number of elements ÷ effective sheep number of elements × 100%.
(4) result of the test
After test shows that Chinese herbal and crude drugs preparations of the present invention and additive are used in combination, effective cure rate is significantly higher than griseofulvin group, clotrimazole ointment group and 3% iodine glycerol group, without death, without recurrence.Refer to table 1
The different medicine cure rate effective to tinea circinata of table 1
Beneficial effects of the present invention
The present invention is the Chinese medicine preparation of special for treating sheep tinea circinata, it is divided into Chinese herbal medicine for external use preparation and two kinds of dosage forms of Chinese herbal medicine additive for oral administration, wherein Chinese herbal medicine for external use preparation is mainly used for killing and suppress pathomycete effect on skin, Chinese herbal medicine additive for oral administration is mainly used in heat-clearing and toxic substances removing, anti-inflammation, to strengthen the immunologic function suffering from sheep, improve resistance against diseases.Chinese herbal and crude drugs preparations using effect of the present invention is good, and cure rate is high, without recurrence；Compared with griseofulvin group, invention formulation has and has no side effect, and has no adverse reaction, and noresidue can ensure the safety in production of Carnis caprae seu ovis；Compared with clotrimazole process group, it is fast that invention formulation has the sick sheep speed of process, easy to use.Statistics uses Chinese herbal and crude drugs preparations of the present invention and 5 raisers of additive, suffers from tinea circinata disease sheep 210, after using 15 days, and cure rate 85%；After using 20 days, cure rate 91.2%；After using 30 days, cure rate 95.3%；Occur without death.
Embodiment
1
Certain raiser's house feed fattening sheep 360, suffers from tinea circinata disease sheep only 22, and the preparation 500-1000ml present invention treats the Chinese herbal and crude drugs preparations of external sheep tinea circinata every time.Specifically comprise the following steps that
(1) fresh ginger 60 grams, Rhizoma Alpiniae Officinarum 20 grams, northeast Radix Morinae Bulleyanae 30 grams, 30 grams of Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii 20 grams, former propolis 40 grams, dehydrated alcohol 320 grams, distilled water 120 grams, glycerol 130 grams are weighed.
(2) Rhizoma Alpiniae Officinarum, northeast Radix Morinae Bulleyanae, Rhizoma Curcumae Longae and the Rhizoma Et Radix Notopterygii Chinese medicine powder that (1) are weighed are broken to 20 mesh, fresh ginger is switched to the fragment of about 2 cubic millimeters, former propolis is crushed to 20 mesh, then by wrapping up with gauze after all raw material mix homogeneously, put in 1000ml wide mouth glass bottle；
(3) (1) is weighed dehydrated alcohol and distilled water adds wide mouth glass bottle, shake up；Every day shakes up 5-8 time, after after extracting 3 days, mentioning from wide mouth glass bottle, draining gauze medicated bag, takes out, and adds the glycerol mixing that (1) weighs, standby after labelling.
(4) the Chinese herbal medicine for external use preparation that (3) prepare is poured in the little water sprager of 500-1000ml.Cutting off the Pilus Caprae seu Ovis around tinea speckle, scrape off and be pasted onto the dough sample mildew of skin surface, the Chinese herbal and crude drugs preparations of the present invention is sprayed directly on skin surface, fountain height is till medicinal liquid complete wetting surface.
The present invention takes the preparation of Chinese herbal medicine additive orally, specifically comprises the following steps that
(1) purchase Herba Artemisiae Scopariae, Radix Angelicae Pubescentis, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Herba Houttuyniae, Radix Isatidis and Radix Glycyrrhizae, preserve at the shady and cool ventilation place of being dried；
(2) according to sheep 40g every day every, use 5 days continuously, 22 ill sheep need the consumption of additive 4.4kg of the present invention altogether, weigh Herba Artemisiae Scopariae 508 grams, Radix Angelicae Pubescentis 338 grams, Rhizoma Coptidis 338 grams, Cortex Phellodendri 508 grams, Radix Et Rhizoma Rhei 508 grams, Herba Houttuyniae 677 grams, Radix Isatidis 846 grams, 677 grams of Radix Glycyrrhizae, it is crushed to 30 mesh, mix homogeneously the most respectively；Being divided into 5 parts, pack labelling is standby；
(3) every day 1 part of Chinese herbal medicine of the present invention is added in mixed concentrate, be disposably fed for when early raising.
After Chinese herbal and crude drugs preparations and additive use 10 days continuously, at tinea speckle, skin surface has virgin wool fiber to grow；After using 15 days, suffer from sheep for 20 and substantially cure, other two basic controlling state of an illness, tinea speckle goes out just has wool fiber to grow, until 2 sheep rehabilitations after using 30 days.
Embodiment
2
(1) prepare the Chinese herbal medicine for external use preparation of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: fresh ginger 30, Rhizoma Alpiniae Officinarum 10, northeast Radix Morinae Bulleyanae 10, Rhizoma Curcumae Longae 10, Rhizoma Et Radix Notopterygii 10, former propolis 20, dehydrated alcohol 120, distilled water 60, glycerol 60.
The present invention treats the preparation method of the Chinese herbal medicine for external use preparation of sheep tinea circinata with embodiment 1.
(2) prepare the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: Herba Artemisiae Scopariae 15, Radix Angelicae Pubescentis 10, Rhizoma Coptidis 10, Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10, Herba Houttuyniae 15, Radix Isatidis 15, Radix Glycyrrhizae 10.
The preparation method of the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention is with embodiment 1.
Embodiment
3
(1) prepare the Chinese herbal medicine for external use preparation of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: fresh ginger 40, Rhizoma Alpiniae Officinarum 15, northeast Radix Morinae Bulleyanae 15, Rhizoma Curcumae Longae 20, Rhizoma Et Radix Notopterygii 20, former propolis 30, dehydrated alcohol 180, distilled water 90, glycerol 90.
The present invention treats the preparation method of the Chinese herbal medicine for external use preparation of sheep tinea circinata with embodiment 1.
(2) prepare the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: Herba Artemisiae Scopariae 25, Radix Angelicae Pubescentis 20, Rhizoma Coptidis 15, Cortex Phellodendri 15, Radix Et Rhizoma Rhei 15, Herba Houttuyniae 30, Radix Isatidis 25, Radix Glycyrrhizae 30.
The preparation method of the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention is with embodiment 1.
Embodiment
4
(1) prepare the Chinese herbal medicine for external use preparation of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: fresh ginger 35, Rhizoma Alpiniae Officinarum 12, northeast Radix Morinae Bulleyanae 13, Rhizoma Curcumae Longae 15, Rhizoma Et Radix Notopterygii 15, former propolis 25, dehydrated alcohol 150, distilled water 75, glycerol 80.
The present invention treats the preparation method of the Chinese herbal medicine for external use preparation of sheep tinea circinata with embodiment 1.
(2) prepare the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention, each raw material of following mass parts be prepared from: Herba Artemisiae Scopariae 20, Radix Angelicae Pubescentis 15, Rhizoma Coptidis 12, Cortex Phellodendri 13, Radix Et Rhizoma Rhei 12, Herba Houttuyniae 22, Radix Isatidis 20, Radix Glycyrrhizae 20.
The preparation method of the Chinese herbal medicine additive of the treatment sheep tinea circinata of the present invention is with embodiment 1.
Claims (1)
1. treat a Chinese medicine preparation for sheep tinea circinata, including Chinese herbal medicine for external use preparation and the Chinese herbal medicine additive for the treatment of sheep tinea circinata for the treatment of sheep tinea circinata, it is characterised in that
The Chinese herbal medicine for external use preparation for the treatment of sheep tinea circinata is prepared from by the raw material of following mass parts: fresh ginger 30-40, Rhizoma Alpiniae Officinarum 10-15, northeast Radix Morinae Bulleyanae 10-15, Rhizoma Curcumae Longae 10-20, Rhizoma Et Radix Notopterygii 10-20, former propolis 20-30, dehydrated alcohol 120-180, distilled water 60-90, glycerol 65-90；
The preparation method of the Chinese herbal medicine for external use preparation for the treatment of sheep tinea circinata is:
(1) fresh ginger purchased, Rhizoma Alpiniae Officinarum, northeast Radix Morinae Bulleyanae, Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii being preserved at the shady and cool ventilation place of being dried, former propolis is protected
Exist in-20 DEG C of refrigerators:
(2) 10-15 part Rhizoma Alpiniae Officinarum, 10-15 part northeast Radix Morinae Bulleyanae, 10-20 part Rhizoma Curcumae Longae and 10-20 part Rhizoma Et Radix Notopterygii are weighed by mass parts,
It is crushed to 10-40 mesh respectively；Weigh the fragment of fresh ginger 30-40 part chopping to about 2 cubic millimeters；Weigh former propolis 20-30
Part is crushed to 10-20 mesh, then by wrapping up with gauze after all raw material mix homogeneously, puts into hermetic container；
(3) weigh dehydrated alcohol 120-180 part and distilled water 60-90 part by mass parts, add the hermetic container described in (2)
In, after after soaking 72-96 hour, mentioning from container solution, draining gauze medicated bag, taking-up, make Chinese medicine ethanol extraction；
(4) weigh glycerol 65-90 part by mass parts, add in ethanol extraction prepared by (3), after stirring and evenly mixing, be treatment
The Chinese herbal medicine for external use preparation of sheep tinea circinata；
The Chinese herbal medicine additive for the treatment of sheep tinea circinata is prepared from by the raw material of following mass parts: Herba Artemisiae Scopariae 15-25, Radix Angelicae Pubescentis 10-20, Rhizoma Coptidis 10-15, Cortex Phellodendri 10-15, Radix Et Rhizoma Rhei 10-15, Herba Houttuyniae 15-30, Radix Isatidis 15-25, Radix Glycyrrhizae 10-30；
The preparation method of the Chinese herbal medicine additive for the treatment of sheep tinea circinata is:
(1) purchase Herba Artemisiae Scopariae, Radix Angelicae Pubescentis, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Herba Houttuyniae, Radix Isatidis and Radix Glycyrrhizae, protect at the shady and cool ventilation place of being dried
Deposit；
(2) weigh various Chinese herbal medicine by above-mentioned mass parts, be crushed to 20-40 mesh, mix homogeneously the most respectively.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062361A (en) * | 2007-05-29 | 2007-10-31 | 赵素兰 | Chinese traditional medicine for treating dermatosis and its preparation method |
| CN101480445A (en) * | 2008-01-07 | 2009-07-15 | 北京科技桥科贸有限公司 | Medicine for treating dermatitis |
| CN102727635A (en) * | 2011-03-31 | 2012-10-17 | 吕维学 | Chinese medicinal formula for treatment of ringworm |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062361A (en) * | 2007-05-29 | 2007-10-31 | 赵素兰 | Chinese traditional medicine for treating dermatosis and its preparation method |
| CN101480445A (en) * | 2008-01-07 | 2009-07-15 | 北京科技桥科贸有限公司 | Medicine for treating dermatitis |
| CN102727635A (en) * | 2011-03-31 | 2012-10-17 | 吕维学 | Chinese medicinal formula for treatment of ringworm |
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