A kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy.
Background technology
Gastropathy can very gently also can be very heavy, and modal have epigastric discomfort or pain, nausea,vomiting,diarrhea, an inappetence.The symptom of gastritis and duodenal ulcer is epigastrium burning pain, particularly, between two meals, early occurs before the meal or after drinking orange juice, coffee, and severe patient can have tarry stool, melena or hemafecia.Gastropathy is difficult to cure, but often treating one section can recur again, has a strong impact on physical and mental health.The Chinese medicine of existing treatment gastropathy generally adopts high-temperature water boiling standby, and in water cooking liquid, the biological activity of Chinese crude drug is easily destroyed, and dissolution rate is not high, and effective component content is not high, affects therapeutic effect.
Summary of the invention
The problem existing for prior art, the object of the invention is to design provides a kind of technical scheme of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, its bioactive ingredients, granularity that has retained Chinese crude drug is little, good evenness and dissolution rate high, can accelerate its dissolving, infiltration rate in vivo, improve its absorbtivity, good to the therapeutic effect of gastropathy.
Described a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, is characterized in that comprising the following steps:
1) raw material processing: percentage composition takes Semen Lablab Album 20-30%, sepiellae seu sepiae ink sac dry powder 15-20%, Semen Ziziphi Spinosae (parched) powder 20-27%, Radix Glycyrrhizae Preparata 9-12%, Rhizoma Atractylodis Macrocephalae 9-12%, Pericarpium Citri Reticulatae 10-15% by weight, for subsequent use; After Semen Lablab Album, Radix Glycyrrhizae Preparata, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae are mixed, pulverize with pulverizer, cross 30-50 mesh sieve, add sepiellae seu sepiae ink sac dry powder, Semen Ziziphi Spinosae (parched) powder to mix;
2) wall breaking pulverization: by the mixed powder in step 1), be crushed to 50-100 μ m through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding to pulverize, and the weight ratio of fine powder raw material and water is 1:3-5, and drum's speed of rotation is 200-300 rpm, passes through 2-3 hour ball milling breaking cellular wall, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added to raw material weight 5-6 water soaking 1-2h doubly, then 100 DEG C of big fire decoct 20-30min, then use little fire decoction 10-20min instead, and cold filtration, collects filtrate;
5) by filtrate at 70-80 DEG C, vacuum is 0.09 MpaMpa, feed liquor flow velocity is 200-300mL min
-1condition under carry out vacuum film concentrate drying;
6) high temperature sterilize: the dry powder that step 5) is made short time sterilizing under the high temperature of 80 DEG C-90 DEG C, fill, in sterilizing bottle, obtains finished product.
Described a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, is characterized in that in step 1): Semen Lablab Album 23-27%, sepiellae seu sepiae ink sac dry powder 16-18%, Semen Ziziphi Spinosae (parched) powder 22-25%, Radix Glycyrrhizae Preparata 10-11%, Rhizoma Atractylodis Macrocephalae 10-11%, Pericarpium Citri Reticulatae 12-13%.
Described a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, is characterized in that in step 1): Semen Lablab Album 25%, sepiellae seu sepiae ink sac dry powder 17%, Semen Ziziphi Spinosae (parched) powder 24%, Radix Glycyrrhizae Preparata 10%, the Rhizoma Atractylodis Macrocephalae 11%, Pericarpium Citri Reticulatae 13%.
Described a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, is characterized in that step 2) in: wall breaking pulverization is to 70-80 μ m.
Described a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, is characterized in that in step 3): the weight ratio of fine powder raw material and water is 1:4, drum's speed of rotation is 250 rpm.
Semen Lablab Album, is the medical material of integration of edible and medicinal herbs, and it is not only a kind of food, is also a kind of medicine, and Semen Lablab Album is flat, sweet in the mouth, effect spleen invigorating and in, the removing dampness of relieving summer heat, the nourishing the stomach therapeutic method to keep the adverse QI flowing downwards.Compendium of Material Medica is recorded: " duricrust Semen Lablab Album, its son enriches, Bai Erwei Huang, its gas raw meat perfume (or spice), it is warm in nature flat, obtains neutralization, the paddy of spleen is also ".
Sepiellae seu sepiae ink sac dry powder adopts sepiellae seu sepiae ink sac to make, and can directly buy from the market.Sepiellae seu sepiae also claims black sepiellae seu sepiae fish, cuttle fish, and Sepiida marine products cephalopod, with Octopus and the nearly edge of squid.Sepiellae seu sepiae is distributed in each ocean, the world, mainly lives in the littoral shallow water in the torrid zone and temperate zone, and often adjourn to compared with territory, deep-sea winter.Sepiellae seu sepiae can say that whole body is precious, and not only sense of taste is fresh and crisp tasty and refreshing, has higher nutritive value, and is rich in medical value.The every hectogram meat of sepiellae seu sepiae is containing 13 grams, protein, and only 0.7 gram, fat, also contains the necessary materials of human body such as carbohydrate and vitamin A, vitamin B group and calcium, phosphorus, ferrum, is a kind of high protein and low fat nourishing food.Be worth mentioning, it is the desirable health food that women moulds build and maintenance skin.Sepiellae seu sepiae shell is containing calcium carbonate, conchiolin, phlegmatic temperament and a small amount of sodium chloride, calcium phosphate, magnesium salt etc.Cuttle-fish bone juice contains a kind of mucopolysaccharide, and experiment confirms that mice is had to certain cancer suppressing action.According to theory of Chinese medical science, sepiellae seu sepiae salty in the mouth, property are put down, and enter liver, kidney channel; Have nourish blood, stimulate the menstrual flow, effect of lactogenic, spleen reinforcing, kidney tonifying, YIN nourishing, regulating menstruation, leukorrhagia stopping; Be used for the treatment of the diseases such as women's irregular menstruation, edema, arthralgia chiefly caused by damp pathogen, hemorrhoid, beriberi.Cuttlefish meat, spine (Chinese medicine is called Endoconcha Sepiae) all can be used as medicine.Li Shizhen (1518-1593 A.D.) claims that cuttlefish is " blood system medicine ", is the good medicine for the treatment of woman anemia, blood deficiency amenorrhea.Sepiellae seu sepiae combines the cuisines function of food and medicines and health protection function.Sepiellae seu sepiae ink sac dry powder is good to the therapeutic effect of gastropathy.
Semen Ziziphi Spinosae (parched) powder adopts Semen Ziziphi Spinosae to make, Semen Ziziphi Spinosae, and another name Semen Ziziphi Spinosae, Fructus Choerospondiatis, jujube nucleus, Zizyphus jujuba is Rhamnaceae jujube.In " book on Chinese herbal medicine converges and says ", say Semen Ziziphi Spinosae: astringing QI is calmed the nerves, and flourish muscle is supported marrow, stomach function regulating activating the spleen.Semen Ziziphi Spinosae contains volume fatty oil and protein, and containing sterol, triterpenes, Semen Ziziphi Spinosae saponin, volume vitamin C, sweet in the mouth, acid, property is flat, and stomach function regulating activating the spleen, can nourish conscience, calms the nerves, arresting sweating.
Radix Glycyrrhizae Preparata, is leguminous plant, and Radix Glycyrrhizae Preparata is with the honey Radix Glycyrrhizae of smoking, and is commonly called as the process of preparing Chinese medicine, Mel is put in pot and is smelt middle honey exactly, uses slow fire instead and adds Radix Glycyrrhizae sheet and stir evenly, takes the dish out of the pot, and puts barn or baking oven and is dried to taking-up when tack-free, cools.Modern study, Radix Glycyrrhizae Preparata contains the number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, has antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect.Therefore main effect of Radix Glycyrrhizae Preparata is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Be usually used in weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison.
The Rhizoma Atractylodis Macrocephalae, another name: small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis, Compositae, [WTBX herbaceos perennial, root stock nodositas.Stem is upright, the long branch from middle and lower part conventionally, all Glabrous.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.There is spleen reinforcing, stomach reinforcing, dampness, and in, antiabortive; Control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.
Pericarpium Citri Reticulatae, sweet-bitter flavor, but have the delicate fragrance of Fructus Citri tangerinae, is the dryness peel of making after the peel drying of Fructus Citri tangerinae is processed, this peel, as under the condition keeping dry, can be placed storage for a long time, therefore claim Pericarpium Citri Reticulatae.Regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Temperature can circulation of qi promoting, and pungent can dispersing is bitter and sluice.Therefore Pericarpium Citri Reticulatae has three major types effect, the one, lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three greatly on, Main Function is row QI of the spleen and stomach.
Described atomizer, ball mill can be by directly buying on market.
Above-mentioned a kind of Chinese medicine super-micro wall-broken fine powder for the treatment of gastropathy, adopt have invigorating spleen and reinforcing stomach natural food materials and medical material Semen Lablab Album, sepiellae seu sepiae ink sac dry powder, Semen Ziziphi Spinosae (parched) powder, Radix Glycyrrhizae Preparata, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae is composite makes, and gastropathy is had to synergistic function; And adopt super-micro wall-broken to be made into fine powder, reduce the destruction of the course of processing to contained nutrient substance and functional component in product, original bioactive ingredients and functional component are greatly retained, its granularity is little, good evenness and dissolution rate high, can accelerate its dissolving, infiltration rate in vivo, improve its absorbtivity, good to the therapeutic effect of gastropathy, cure rate reaches more than 98%.
The percentage composition relating in present specification unless otherwise indicated, is weight percentage.
Detailed description of the invention
Now, in conjunction with embodiments of the invention and correlation test, the invention will be further described.
Embodiment 1
1) raw material processing: percentage composition takes Semen Lablab Album 20%, sepiellae seu sepiae ink sac dry powder 15%, Semen Ziziphi Spinosae (parched) powder 27%, Radix Glycyrrhizae Preparata 12%, the Rhizoma Atractylodis Macrocephalae 12%, Pericarpium Citri Reticulatae 14% by weight, for subsequent use; After Semen Lablab Album, Radix Glycyrrhizae Preparata, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae are mixed, pulverize with pulverizer, cross 30 mesh sieves, add sepiellae seu sepiae ink sac dry powder, Semen Ziziphi Spinosae (parched) powder to mix;
2) wall breaking pulverization: by the mixed powder in step 1), be crushed to 50 μ m through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding to pulverize, and the weight ratio of fine powder raw material and water is 1:3, and drum's speed of rotation is 200 rpm, through 2 hours ball milling breaking cellular walls, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added to the water soaking 1h of 5 times of raw material weights, then 100 DEG C of big fire decoct 20min, then use little fire instead and decoct 10min, and cold filtration, collects filtrate;
5) by filtrate at 70 DEG C, vacuum is 0.09 MpaMpa, feed liquor flow velocity is 200mL min
-1condition under carry out vacuum film concentrate drying;
6) high temperature sterilize: the dry powder that step 5) is made is short time sterilizing under the high temperature of 80 DEG C, fill, in sterilizing bottle, obtains finished product.
Embodiment 2
1) raw material processing: percentage composition takes Semen Lablab Album 30%, sepiellae seu sepiae ink sac dry powder 20%, Semen Ziziphi Spinosae (parched) powder 20%, Radix Glycyrrhizae Preparata 9%, the Rhizoma Atractylodis Macrocephalae 9%, Pericarpium Citri Reticulatae 12% by weight, for subsequent use; After Semen Lablab Album, Radix Glycyrrhizae Preparata, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae are mixed, pulverize with pulverizer, cross 50 mesh sieves, add sepiellae seu sepiae ink sac dry powder, Semen Ziziphi Spinosae (parched) powder to mix;
2) wall breaking pulverization: by the mixed powder in step 1), be crushed to 100 μ m through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding to pulverize, and the weight ratio of fine powder raw material and water is 1:5, and drum's speed of rotation is 300 rpm, through 3 hours ball milling breaking cellular walls, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added to the water soaking 2h of 6 times of raw material weights, then 100 DEG C of big fire decoct 30min, then use little fire instead and decoct 20min, and cold filtration, collects filtrate;
5) by filtrate at 80 DEG C, vacuum is 0.09 MpaMpa, feed liquor flow velocity is 300mL min
-1condition under carry out vacuum film concentrate drying;
6) high temperature sterilize: the dry powder that step 5) is made is short time sterilizing under the high temperature of 90 DEG C, fill, in sterilizing bottle, obtains finished product.
Embodiment 3
1) raw material processing: percentage composition takes Semen Lablab Album 25%, sepiellae seu sepiae ink sac dry powder 17%, Semen Ziziphi Spinosae (parched) powder 24%, Radix Glycyrrhizae Preparata 10%, the Rhizoma Atractylodis Macrocephalae 11%, Pericarpium Citri Reticulatae 13% by weight, for subsequent use; After Semen Lablab Album, Radix Glycyrrhizae Preparata, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae are mixed, pulverize with pulverizer, cross 30-50 mesh sieve, add sepiellae seu sepiae ink sac dry powder, Semen Ziziphi Spinosae (parched) powder to mix;
2) wall breaking pulverization: by the mixed powder in step 1), be crushed to 80 μ m through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding to pulverize, and the weight ratio of fine powder raw material and water is 1:4, and drum's speed of rotation is 250 rpm, through 2.5 hours ball milling breaking cellular walls, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added to the water soaking 1.5h of 5.5 times of raw material weights, then 100 DEG C of big fire decoct 25min, then use little fire instead and decoct 15min, and cold filtration, collects filtrate;
5) by filtrate at 75 DEG C, vacuum is 0.09 MpaMpa, feed liquor flow velocity is 250mL min
-1condition under carry out vacuum film concentrate drying;
6) high temperature sterilize: the dry powder that step 5) is made is short time sterilizing under the high temperature of 85 DEG C, fill, in sterilizing bottle, obtains finished product.
Instructions of taking: 3 times on the one, a 4-5 gram, warm water is dissolved and is taken, and anemia of pregnant woman, infant are avoided clothes.Take 8-10 days: flatulence, stomachache, symptom of diarrhea alleviate, have appetite sense.Take 15-20 days: have the hiccups, heartburn, nauseating, pantothenic acid, tripe is swollen, and phenomenon disappears substantially.Take 30 days: gastroenteritic ulcer face heals substantially, new gastrointestinal mucosa generates, and it is normal that gastrointestinal function recovers substantially.Within 30 days, be a course for the treatment of, take 2-3 the course for the treatment of: gastric mucosal immunity power, gastrointestinal function obviously strengthen, gastropathy curative effect is remarkable.
Further illustrate beneficial effect of the present invention by curing case below.
Cure case 1: Zhang, female, 30 years old, clinical diagnosis bile reflux gastritis, upper abdomen persistence burning pain, pain increases the weight of after the meal, remission after drug administration, but often recurrence, cannot cure, and does not feel like oneself more than 2 years, take after 2 courses for the treatment of of above-mentioned super-micro wall-broken fine powder (embodiment 1), subjective symptoms disappears, and drug withdrawal is after 6 months, without uncomfortable sensation.
Cure case 2: Lee, man, 45 years old, clinical diagnosis is gastric ulcer, and epigastrium pain is burning property, nibbling property or hunger property dull pain, distending pain or dull pain, remission after drug administration, but often recurrence, cannot cure, and does not feel like oneself more than 1 year, take after 3 courses for the treatment of of above-mentioned super-micro wall-broken fine powder (embodiment 2), subjective symptoms disappears, and drug withdrawal is after 4 months, without uncomfortable sensation.
Cure case 3: Liu, female, 60 years old, suffer from chronic superficial gastritis for many years, the conscious dull pain of upper abdomen sometimes, loss of appetite, glutted, acid regurgitation etc. after the meal, take 2 courses for the treatment of of above-mentioned super-micro wall-broken fine powder (embodiment 3), and subjective symptoms disappears.
Cure case 4: thank certain, man, 36 years old, suffer from atrophic gastritis, often recurrence, cannot cure, and the 4-5 that does not feel like oneself took after 3 courses for the treatment of of above-mentioned super-micro wall-broken fine powder (embodiment 2), and subjective symptoms disappears, and drug withdrawal is after 9 months, without uncomfortable sensation.
The invention will be further described below to pass through microbiological indicator and content of beary metal test, in table 1.
Above-mentioned test determination result shows, microorganism, the content of beary metal of super-micro wall-broken fine powder prepared by embodiment 1 are humble, meet green industry standard and green food standard.Carry out same test with embodiment 2-3, its microorganism, content of beary metal also meet green industry standard and green food standard.