CN103933010A - Process for manufacturing enteric plant hollow capsule - Google Patents
Process for manufacturing enteric plant hollow capsule Download PDFInfo
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- CN103933010A CN103933010A CN201410139370.3A CN201410139370A CN103933010A CN 103933010 A CN103933010 A CN 103933010A CN 201410139370 A CN201410139370 A CN 201410139370A CN 103933010 A CN103933010 A CN 103933010A
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- glue
- enteric
- hollow capsule
- cellulose
- plant hollow
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Abstract
The invention belongs to the field of medicines, and in particular relates to a process for manufacturing an enteric plant hollow capsule. According to the process for manufacturing the enteric plant hollow capsule, more than one time of glue dipping operation is performed in the process of manufacturing a plant hollow capsule frame. The manufacturing process is a simple method, can be used for improving the baking efficiency of the plant hollow capsule frame by multiple baking operations through multiple times of glue dipping on the premise that a baking device is not lengthened, basis is laid to drying enteric coating in a subsequent process, and the production speed of the enteric plant hollow capsule can be improved.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of processing technology of enteric plant hollow capsule.
Background technology
Enteric hollow capsule refers to that capsule is insoluble in gastric juice, but can be in intestinal juice disintegrate or dissolving and medicine in release capsule, Capsules is the major auxiliary burden of processing medicament capsule preparation, and the enteric hollow capsule using is at present by gelatin machine-shaping and then at the coating material of the coated anti-gastric acid of appearance.But the processing of capsule needs multistep operation, complex operation, pharmagel is to select animal skins, bone and muscle tendon, the senior glue product that the fat-free high protein making through complicated physics and chemistry processing is easily absorbed by the body.Have viscosity high, freeze that power is high, the easy physical characteristics such as congeal.But the easy dehydration embrittlement of gelatin Capsules, water suction is softening, meets aldehyde material the defects such as cross-linking reaction easily occur, and affects the therapeutic effect of medicine.In addition, along with the continuous enhancing of people's self health consciousness, the impact of the factors such as the popular and religions belief of vegetarianism, the plant enteric hollow capsule product of pure natural has become next step developing direction.
In Capsules preparation process, need to dry operation, but while using plant cellulose to prepare capsule skeleton, be difficult for drying, in order to improve the effect of oven dry, often need to increase the length of drying plant, but increased the floor space of equipment.
Summary of the invention
For solving the above-mentioned defect of prior art, the invention provides a kind of enteric plant the processing technology of carrying out capsule, this processing technology can improve the drying rate of enteric coated capsule skeleton.
The present invention is achieved through the following technical solutions:
A processing technology for enteric plant hollow capsule operates through dipping in glue more than 1 time in the manufacturing process of enteric coated capsule skeleton.
A kind of processing technology of enteric plant hollow capsule, comprise the following steps, (1), preparation glue: extracting cellulose ether 10-20 part, Gellan gum 0.1-0.5 part, chelating agen 0.05-0.2 part, add in the hot water of 80-90 part and carry out dissolved dilution, add as required opacifier appropriate, use 120 object gauzes to filter out impurity, be prepared into glue, add glue groove; (2), use mould dip in glue, then at 20-30 DEG C of temperature, dry, make moisture evaporation; (3), then mould is stretched into and in glue groove, carry out secondary and dip in glue, and then dry; (4), enteric coating liquid preparation: get enteric coating powder 10-20 part, plasticizer 2-4 part, add in the organic solvent of 75-85 part and carry out dissolved dilution, use 120 object gauzes to filter out impurity, be prepared into enteric liquid, add glue groove; (5) the plant hollow capsule skeleton, after dipping in glue for twice, drying carries out enteric coating (can one or many), after organic solvent volatilization, carries out the demoulding, cutting, fit again, makes finished product;
Described cellulose ether is one or more in methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethylmethyl-cellulose, hydroxypropyl emthylcellulose; Chelating agen is the one in potassium chloride, potassium citrate;
Opacifier is titanium dioxide; Enteric coating powder is one or more in polyacrylic resin, cellulose acetate-phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropyl methyl cellulose succinate; Plasticizer is one or more in triethyl citrate, Oleum Ricini, glyceryl triacetate, glycerol, Polyethylene Glycol, sorbic acid; Organic solvent is one or more in methanol, ethanol, acetone, dichloromethane.
Beneficial effect of the present invention: the process for making that the present invention provides is simple, in the situation that not lengthening equipment drying unit, by repeatedly dipping in glue, repeated drying can be accelerated the drying efficiency of Capsules, has improved the speed of production of enteric plant hollow capsule.
Detailed description of the invention
Embodiment 1
A processing technology for enteric plant hollow capsule operates through dipping in glue more than 1 time in the manufacturing process of Capsules.
A kind of processing technology of enteric plant hollow capsule, comprise the following steps, (1), preparation glue: extracting cellulose ether 10-20 part, Gellan gum 0.1-0.5 part, chelating agen 0.05-0.2 part, add in the hot water of 80-90 part and carry out dissolved dilution, add as required opacifier appropriate, use 120 object gauzes to filter out impurity, be prepared into glue, add glue groove; (2), use mould dip in glue, then at 20-30 DEG C of temperature, dry, make moisture evaporation; (3), then mould is stretched into and in glue groove, carry out secondary and dip in glue, and then dry; (4), enteric coating liquid preparation: get enteric coating powder 10-20 part, plasticizer 2-4 part, add in the organic solvent of 75-85 part and carry out dissolved dilution, use 120 object gauzes to filter out impurity, be prepared into enteric liquid, add glue groove; (5) the plant hollow capsule skeleton, after repeatedly dipping in glue, drying carries out enteric coating (can one or many), after organic solvent volatilization, carries out the demoulding, cutting, fit again, makes finished product;
Described cellulose ether is one or more in methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethylmethyl-cellulose, hydroxypropyl emthylcellulose; Chelating agen is the one in potassium chloride, potassium citrate;
Opacifier is titanium dioxide; Enteric coating powder is one or more in polyacrylic resin, cellulose acetate-phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropyl methyl cellulose succinate; Plasticizer is one or more in triethyl citrate, Oleum Ricini, glyceryl triacetate, glycerol, Polyethylene Glycol, sorbic acid; Organic solvent is one or more in methanol, ethanol, acetone, dichloromethane.
The thickness needing according to Capsules and the viscosity of glue, regulate the number of times that dips in glue, and gelatin viscosity is less, dips in glue thickness of film forming on mould less at every turn, and the speed of oven dry is faster, and only needing increases the number of times that dips in glue, reaches applicable Capsules thickness.
This manufacture method is applicable to the making of other enteric plant hollow capsules.
Claims (3)
1. a processing technology for enteric plant hollow capsule, is characterized in that, in the manufacturing process of plant hollow capsule skeleton, operates through dipping in glue more than 1 time.
2. the processing technology of a kind of enteric plant hollow capsule according to claim 1, it is characterized in that, comprise the following steps, (1), preparation glue: extracting cellulose ether 10-20 part, Gellan gum 0.1-0.5 part, chelating agen 0.05-0.2 part, add in the hot water of 80-90 part and carry out dissolved dilution, add as required opacifier appropriate, use 120 object gauzes to filter out impurity, be prepared into glue, add glue groove; (2), use mould dip in glue, then at 20-30 DEG C of temperature, dry, make moisture evaporation; (3), then mould is stretched into and in glue groove, carry out secondary and dip in glue, and then dry; (4), enteric coating liquid preparation: get enteric coating powder 10-20 part, plasticizer 2-4 part, add in the organic solvent of 75-85 part and carry out dissolved dilution, use 120 object gauzes to filter out impurity, be prepared into enteric liquid, add glue groove; (5) the plant hollow capsule skeleton, after dipping in glue for twice, drying carries out enteric coating, after organic solvent volatilization, carries out the demoulding, cutting, fit again, makes finished product.
3. a kind of processing technology of enteric plant hollow capsule according to claim 2, wherein (1), cellulose ether are one or more in methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethylmethyl-cellulose, hydroxypropyl emthylcellulose; (2), chelating agen is the one in potassium chloride, potassium citrate; (3), opacifier is titanium dioxide; (4), enteric coating powder is one or more in polyacrylic resin, cellulose acetate-phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropyl methyl cellulose succinate; (5), plasticizer is one or more in triethyl citrate, Oleum Ricini, glyceryl triacetate, glycerol, Polyethylene Glycol, sorbic acid; (6), organic solvent is one or more in methanol, ethanol, acetone, dichloromethane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410139370.3A CN103933010A (en) | 2014-04-09 | 2014-04-09 | Process for manufacturing enteric plant hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410139370.3A CN103933010A (en) | 2014-04-09 | 2014-04-09 | Process for manufacturing enteric plant hollow capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103933010A true CN103933010A (en) | 2014-07-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410139370.3A Pending CN103933010A (en) | 2014-04-09 | 2014-04-09 | Process for manufacturing enteric plant hollow capsule |
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| CN (1) | CN103933010A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105475942A (en) * | 2015-12-18 | 2016-04-13 | 湖南尔康制药股份有限公司 | Freeze-dried bee product capsule |
| CN105595242A (en) * | 2015-12-18 | 2016-05-25 | 湖南尔康制药股份有限公司 | Freeze-dried scallion filling capsule |
| CN105767957A (en) * | 2015-12-21 | 2016-07-20 | 湖南尔康制药股份有限公司 | Odorless freeze-dried garlic powder capsule product |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN108992417A (en) * | 2018-09-27 | 2018-12-14 | 宁波大红鹰药业股份有限公司 | A kind of capsule shells and preparation method thereof preventing adherency oral cavity |
| CN112641121A (en) * | 2020-10-10 | 2021-04-13 | 广州启键生物科技有限公司 | Preparation method of filling hollow capsules of hydroxypropyl methylcellulose and algal polysaccharide |
-
2014
- 2014-04-09 CN CN201410139370.3A patent/CN103933010A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105475942A (en) * | 2015-12-18 | 2016-04-13 | 湖南尔康制药股份有限公司 | Freeze-dried bee product capsule |
| CN105595242A (en) * | 2015-12-18 | 2016-05-25 | 湖南尔康制药股份有限公司 | Freeze-dried scallion filling capsule |
| CN105767957A (en) * | 2015-12-21 | 2016-07-20 | 湖南尔康制药股份有限公司 | Odorless freeze-dried garlic powder capsule product |
| CN105767957B (en) * | 2015-12-21 | 2017-09-29 | 湖南尔康制药股份有限公司 | A kind of odorless freezes garlic powder capsule product |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
| CN108992417A (en) * | 2018-09-27 | 2018-12-14 | 宁波大红鹰药业股份有限公司 | A kind of capsule shells and preparation method thereof preventing adherency oral cavity |
| CN108992417B (en) * | 2018-09-27 | 2021-08-31 | 宁波大红鹰药业股份有限公司 | Capsule shell for preventing oral cavity adhesion and preparation method thereof |
| CN112641121A (en) * | 2020-10-10 | 2021-04-13 | 广州启键生物科技有限公司 | Preparation method of filling hollow capsules of hydroxypropyl methylcellulose and algal polysaccharide |
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Application publication date: 20140723 |