CN103920030A - Compound medicine for preventing and treating postpartum hemorrhage - Google Patents

Abstract

The invention relates to a compound medicine for preventing and treating postpartum hemorrhage. The compound medicine for preventing and treating postpartum hemorrhage comprises a drug effect component and an auxiliary component. The drug effect component is prepared from the following components in parts by weight: 6-12 parts of radix rehmanniae preparata, 10-20 parts of radix rehmanniae, 10-25 parts of Gynura segetum, 10-20 parts of figwort, 9-15 parts of radix scutellariae, 5-10 parts of Fructus Forsythiae, 12-15 parts of common cephalanoplos and 9-15 parts of gardenia. The auxiliary component is prepared from the following components in parts by weight: 9-15 parts of radix sophorae subporstratae, 10-15 parts of wolfberry bark, 30-60 parts of cogongrass rhizome, 5-10 parts of savatier monochasma herb, 10-20 parts of buffalo horn, 6-12 parts of rhizoma alismatis, 10-15 parts of madder, 6-12 parts of angelica and 6-15 parts of moutan bark. Under the reasonable compatibility, effect complementation and synergetic effect of the components, the compound medicine has the advantages of short course of treatment, quick effect taking, favorable curative effect and the like in the aspects of preventing and treating postpartum hemorrhage, improves the general symptoms by regulating the yin-yang, qi and blood of the organism, and has obvious curative effect.

Description

A kind of compound medicine of prophylactic treatment postpartum hemorrhage

Technical field

The present invention relates to a kind of department of obstetrics and gynecology medicine, particularly a kind of compound medicine of prophylactic treatment postpartum hemorrhage.

Background technology

Late postpartum hemorrhage refers to that childbirth is after 24 hours, the metrorrhagia occurring within puerperal, its reason mainly contains that afterbirth is residual, infect in official, the involution of uterus is bad or cesarean section after ultrasonic on observing uterine incision bad etc.Severe loss of blood can cause serious anemia or shock, jeopardizes puerpera's life.The traditional Chinese medical science claims that primary disease is " postpartum lochiorrhea, puerperal blood faints ".Its clinical manifestation is: continue vaginal hemorrhage puerperal, a large amount of or sub minute a few days in puerperium of a small amount of, middle amount bleed profusely suddenly, cuts open palace postpartum hemorrhage and can occur in puerperium latter stage, and companion is dizzy weak, the Anemias such as pale complexion.Severe patient can cause hemorrhagic shock, threat to life.Gynecologial examination: soft birth canal not damaged, palace mouth pine, flow out in chamber, the blood White House, and uterus is large and soft, sometimes sees that residual placenta tissue or congestion piece stop up palace mouth.Often be attended by following symptom: (1) deficiency of vital energy: postpartum hemorrhage amount is many, the light matter of color is rare, without clot, lower abdomen tenesmus, shortness of breath and fatigue, pale tongue, white and thin fur, thready and weak pulse.(2) blood stasis: postpartum hemorrhage amount is many or not to the utmost dripping, the purple fine clot that has of color, abdominal pain with tenderness, clot is discharged rear alleviation of pain, and purplish tongue has ecchymosis petechiae, hesitant pulse.(3) YinXuXueRe: postpartum hemorrhage amount is many, color is scarlet or purplish red, and matter is sticky, or smelly dirty, xerostomia fever of the body, red tongue, the few Tianjin of yellow fur, thready and rapid pulse.(4) deficiency of vital energy blood prostration: postpartum hemorrhage amount is many, the light matter of color is rare, pale complexion, cold extremities due to sweating, pale tongue, tongue are white, and faint and thready pulse is wild.At present, the drug variety for the treatment of this class disease is a lot, but exists the defects such as treatment is single, curative effect slow, cure rate is lower.

Summary of the invention

The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, and a kind of compound medicine of prophylactic treatment postpartum hemorrhage is provided.

For solving the problems of the technologies described above, the compound medicine of this prophylactic treatment postpartum hemorrhage comprises active ingredient and assists a ruler in governing a country composition, wherein said active ingredient by following component according to shown in weight ratio scope formulated, Radix Rehmanniae Preparata 6～12, the Radix Rehmanniae 10～20, Radix gynurae segeti 10～25, Radix Scrophulariae 10～20, Radix Scutellariae 9～15, Fructus Forsythiae 5～10, Herba Cirsii 12～15, Fructus Gardeniae 9～15.

As optimization, described assist a ruler in governing a country composition by following component according to shown in weight ratio scope formulated, Radix Sophorae Tonkinensis 9～15, Cortex Lycii 10～15, Rhizoma Imperatae 30～60, Herba monochasmatis 5～10, Cornu Bubali 10～20, Rhizoma Alismatis 6～12, Radix Rubiae 10～15, Radix Angelicae Sinensis 6～12, Cortex Moutan 6～15.

As optimum ratio, described compound medicine by following component according to shown in weight ratio scope formulated, Radix Rehmanniae Preparata 8～10, the Radix Rehmanniae 14～16, Radix gynurae segeti 18～20, Radix Scrophulariae 14～16, Radix Scutellariae 11～13, Fructus Forsythiae 7～9, Herba Cirsii 12～14, Fructus Gardeniae 9～11, Radix Sophorae Tonkinensis 13～15, Cortex Lycii 12～14, Rhizoma Imperatae 44～46, Herba monochasmatis 8～10, Cornu Bubali 15～17, Rhizoma Alismatis 8～10, Rhizoma dioscoreae (parched) 17～19, Radix Rubiae 11～13, Radix Angelicae Sinensis 8～10, Cortex Moutan 9～11.

As best proportioning, described compound medicine by following component according to shown in weight ratio formulated, Radix Rehmanniae Preparata 9, the Radix Rehmanniae 15, Radix gynurae segeti 19, Radix Scrophulariae 15, Radix Scutellariae 12, Fructus Forsythiae 8, Herba Cirsii 13, Fructus Gardeniae 10, Radix Sophorae Tonkinensis 14, Cortex Lycii 13, Rhizoma Imperatae 45, Herba monochasmatis 9, Cornu Bubali 16, Rhizoma Alismatis 9, Rhizoma dioscoreae (parched) 18, Radix Rubiae 12, Radix Angelicae Sinensis 9, Cortex Moutan 10.

The preparation method of the compound medicine of this prophylactic treatment postpartum hemorrhage comprises the following steps,

Step 1) takes each component of each active ingredient according to above-mentioned formula, dry, pulverize into fine powder at 80 ℃～95 ℃, crosses 50 mesh sieves; According to above-mentioned formula, take and respectively assist a ruler in governing a country each component of composition, at 60 ℃～70 ℃, dry, pulverize into fine powder, cross 80 mesh sieves;

Step 2) each component of each active ingredient through step 1) gained is sieved fine powder adds 10～14 times of quality decoctings and boils, to decocting liquid filter, filtrate is concentrated into the ointment that density is 1.35g/mL～1.40g/mL;

Step 3) is sieved fine powder at 70 ℃～80 ℃, with water dissolution by each component of each auxiliary element through step 1) gained.

Step 4) is by through step 2) ointment of gained smashs to pieces, at 20 ℃～40 ℃, adds in the mixed industry suspension of step 3) gained and mixes, and obtains the compound medicine of this prophylactic treatment postpartum hemorrhage.

Pharmacology analysis:

1, active ingredient

Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, returns liver, kidney channel; Effect: Radix Rehmanniae Preparata sweet in the mouth tepor matter profit, the YIN nourishing of both having enriched blood, vital essence replenishing and marrow benifiting again, for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, the disease such as also can be used for hectic fever hectic fever due to YIN-deficiency, night sweat that deficiency of kidney yin causes, pass out semen and quench one's thirst.

The Radix Rehmanniae: sweet in the mouth, cool in nature, enter the heart, liver, kidney channel; Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid, and has clearing away heat and cooling blood effect: for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat, quench one's thirst, haematemesis, epistaxis, send out the diseases such as speckle dermexanthesis.

Radix gynurae segeti: sweet in the mouth, hardship, warm in nature; Removing blood stasis dissipating blood stasis, hemostasis, detumescence.For traumatic injury, wound hemorrhage, spit blood, puerperal abdominalgia with blood stasis.

Radix Scrophulariae: sweet in the mouth, hardship, cold in nature, be included into lung, stomach, kidney channel; There is the effects such as clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, eliminating fire and detoxication and hard masses softening and resolving.

Radix Scutellariae: bitter in the mouth, cold in nature, return lung, gallbladder, spleen, large intestine, small intestine meridian; There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis and the effect such as antiabortive; Clinical practice shows that Radix Scutellariae antibacterial effect is not worse than Rhizoma Coptidis, and does not develop immunity to drugs.

Fructus Forsythiae: bitter in the mouth, be slightly cold, return lung, the heart, gallbladder meridian, tool heat-clearing and toxic substances removing, dispelling wind and heat pathogens effect.

Herba Cirsii: bitter in the mouth, sweet, cool in nature, GUIXIN, Liver Channel, have the effect of cooling blood for hemostasis.

Fructus Gardeniae: cold in nature, bitter in the mouth; Enter the heart, liver, lung, stomach, tri-jiao channel; There is the effects such as pathogenic fire purging relieving restlessness, removing pathogenic heat from blood and toxic substance from the body, eliminating damp-heat.

2, assist a ruler in governing a country composition

Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, poisonous, attach to the lung and stomach meridians; Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; For diseases such as laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, jaundice due to damp-heat, cough due to lung-heat and carbuncle sore tumefacting virus.

Cortex Lycii: sweet in the mouth, cold in nature, return lung, kidney channel; For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat; There is removing heat from blood, heat clearing away, remove the effects such as rash, lung heat clearing pathogenic fire reducing and resisting pathogenic microbes.

Rhizoma Imperatae: sweet in the mouth, cold, return lung, stomach, urinary bladder channel; Cure mainly removing heat from blood, hemostasis, heat clearing away, removing toxic substances, diuresis; The diseases such as the sound of vomiting and cough of vomitting for haematemesis, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, gastric heat; Rhizoma Imperatae energy lung heat clearing gastric heat, therefore be applicable to above-mentioned all diseases.

Herba monochasmatis: bitter in the mouth, cool in nature; For cough, spit blood, bloody dysentery, leukorrhagia, gingivitis, mastitis, furuncle and phyma, the effect of getting its cooling blood for hemostasis, heat-clearing and toxic substances removing.

Cornu Bubali: nature and flavor, bitter salty, cold; Heat clearing away, removing heat from blood, removing toxic substances, for calentura headache, high fever coma, macule, tell the diseases such as nosebleed, infantile convulsion and sore throat pharyngeal swelling.

Rhizoma Alismatis: sweet in the mouth, cold in nature, enter kidney, bladder two warps; Cure mainly promoting diuresis to eliminate damp pathogen, this product slightly sweet flavor and cold in nature, the cold diarrhea of heat type water that can win, it is light that to ooze diuretic wet; Expel the heat-evil, Rhizoma Alismatis is cold in nature, cold can heat clearing away, enter kidney channel, can rush down kidney channel fire mutually, can be used for seminal emission, tinnitus, the disease such as dizzy.

Radix Rubiae: cold in nature, bitter in the mouth, returns liver, the heart, kidney, spleen, stomach, pericardium channel; Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling; Cure mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore and the disease such as hemorrhoid are swollen.

Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent, returns liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For diseases such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down and ulcer sores.

Cortex Moutan: acrid in the mouth, hardship, cool in nature; Enter the heart, liver, kidney three warps; Cure mainly clearing away heat and cooling blood, Cortex Moutan acrid in the mouth, hardship, cool in nature, be the good medicine of clearing away heat and cooling blood, is usually used in all diseases of heat in blood, is used for the treatment of heat and enters the diseases such as nutrient blood, infantile convulsion, headache due to pathogenic wind-heat, heat in blood are hemorrhage, osteopyrexia and fever; Dissipating blood stasis and reducing the stagnation, Cortex Moutan acrid in the mouth, hardship, cool in nature, Xin Nenghang can fall apart, circulation of qi promoting promoting the circulation of blood, hardship can dampness, expel the heat-evil, dredging collateral, its cool can heat clearing away, therefore be used for the treatment of the disease causing because of blood stasis, the stagnation of QI, be used for the treatment of the diseases such as carbuncle, traumatic injury, blood stasis amenorrhea, wind heat numbness.

Through clinical practice, verify that this preparation has no adverse reaction, toxicity is less, safe and reliable.

The compound medicine of a kind of prophylactic treatment postpartum hemorrhage of the present invention,, synergism complementary with reasonable compatibility, the effect of assisting a ruler in governing a country each component of composition by active ingredient, with " supplementing QI to revive YANG, rescuing contrary solid de-, replenishing YIN and removing heat hemostasis, activating blood circulation to dissipate blood stasis; oxytocin bleeding, nourishing qi to stop ", it is formula selection direction, it is aspect prophylactic treatment postpartum hemorrhage, there is the advantages such as short treating period, instant effect, good effect, by adjusting body yang blood and qi, improve General Symptoms, evident in efficacy.

The specific embodiment

Embodiment 1: the preparation method of the compound medicine of this prophylactic treatment postpartum hemorrhage comprises the following steps,

Step 1), according to weight ratio, is got Radix Rehmanniae Preparata 9, the Radix Rehmanniae 15, Radix gynurae segeti 19, Radix Scrophulariae 15, Radix Scutellariae 12, Fructus Forsythiae 8, Herba Cirsii 13, Fructus Gardeniae 10, takes each component of each active ingredient, dry, pulverize into fine powder at 80 ℃～95 ℃, crosses 50 mesh sieves; According to weight ratio, get Radix Sophorae Tonkinensis 12, Cortex Lycii 13, Rhizoma Imperatae 45, Herba monochasmatis 8, Cornu Bubali 13, Rhizoma Alismatis 9, Radix Rubiae 12, Radix Angelicae Sinensis 10, Cortex Moutan 10, at 60 ℃～70 ℃, dry, pulverize into fine powder, cross 80 mesh sieves;

Step 2) each component of each active ingredient through step 1) gained is sieved fine powder adds 12 times of quality decoctings and boils, to decocting liquid filter, filtrate is concentrated into the ointment that density is 1.35g/mL;

Step 3) is sieved fine powder at 70 ℃～80 ℃, with water dissolution by each component of each auxiliary element through step 1) gained.

Step 4) is by through step 2) ointment of gained smashs to pieces, at 20 ℃～40 ℃, adds in the mixed industry suspension of step 3) gained and mixes, and obtains the compound medicine A of this prophylactic treatment postpartum hemorrhage.

Embodiment 2: the preparation method of the compound medicine of this prophylactic treatment postpartum hemorrhage comprises the following steps,

Step 1), according to weight ratio, is got Radix Rehmanniae Preparata 6, the Radix Rehmanniae 20, Radix gynurae segeti 10, Radix Scrophulariae 20, Radix Scutellariae 9, Fructus Forsythiae 10, Herba Cirsii 12, Fructus Gardeniae 15, takes each component of each active ingredient, dry, pulverize into fine powder at 80 ℃～95 ℃, crosses 50 mesh sieves; According to weight ratio, get Radix Sophorae Tonkinensis 9, Cortex Lycii 15, Rhizoma Imperatae 30, Herba monochasmatis 10, Cornu Bubali 10, Rhizoma Alismatis 12, Rhizoma Dioscoreae 15, Radix Rubiae 15, Radix Angelicae Sinensis 6, Cortex Moutan 15, at 60 ℃～70 ℃, dry, pulverize into fine powder, cross 80 mesh sieves;

Step 2) each component of each active ingredient through step 1) gained is sieved fine powder adds 14 times of quality decoctings and boils, to decocting liquid filter, filtrate is concentrated into the ointment that density is 1.35g/mL;

Step 3) is sieved fine powder at 70 ℃～80 ℃, with water dissolution by each component of each auxiliary element through step 1) gained.

Step 4) is by through step 2) ointment of gained smashs to pieces, at 20 ℃～40 ℃, adds in the mixed industry suspension of step 3) gained and mixes, and obtains the compound medicine B of this prophylactic treatment postpartum hemorrhage.

Embodiment 3: the preparation method of the compound medicine of this prophylactic treatment postpartum hemorrhage comprises the following steps,

Step 1), according to weight ratio, is got Radix Rehmanniae Preparata 12, the Radix Rehmanniae 10, Radix gynurae segeti 25, Radix Scrophulariae 10, Radix Scutellariae 9, Fructus Forsythiae 10, Herba Cirsii 12, Fructus Gardeniae 15, takes each component of each active ingredient, dry, pulverize into fine powder at 80 ℃～95 ℃, crosses 50 mesh sieves; According to weight ratio, get Radix Sophorae Tonkinensis 9～15, Cortex Lycii 10～15, Rhizoma Imperatae 30, Herba monochasmatis 10, Cornu Bubali 10, Rhizoma Alismatis 12, Rhizoma Dioscoreae 15, Radix Rubiae 15, Radix Angelicae Sinensis 6, Cortex Moutan 15, at 60 ℃～70 ℃, dry, pulverize into fine powder, cross 80 mesh sieves;

Step 2) each component of each active ingredient through step 1) gained is sieved fine powder adds 10 times of quality decoctings and boils, to decocting liquid filter, filtrate is concentrated into the ointment that density is 1.35g/mL;

Step 3) is sieved fine powder at 70 ℃～80 ℃, with water dissolution by each component of each auxiliary element through step 1) gained.

Step 4) is by through step 2) ointment of gained smashs to pieces, at 20 ℃～40 ℃, adds in the mixed industry suspension of step 3) gained and mixes, and obtains the compound medicine C of this prophylactic treatment postpartum hemorrhage.

Clinical data:

(1) physical data: the inventor in 2008 so far, carries out clinical observation treatment to 160 routine patients.Age 18, to 45 years old, is all late puerperal hemorrhage patient, and has the deficiency of vital energy, blood stasis, YinXuXueRe, deficiency of vital energy blood prostration symptom in various degree.

(2) Therapeutic Method: sooner or later each once, 3 days is a course for the treatment of, according to the state of an illness and do not recover speed treatment 3 days to 15 days not etc.For the special person of some state of an illness, assisted surgery treatment: be suspected to have the residual person of afterbirth, should go and examine erasion, scrape thing and send pathologic finding; Consider that uterine incision infects the person of splitting, answer laparotomy exploration, hysterectomize if desired.

(3) efficacy assessment standard: the present invention is mainly used in treating late Xiang postpartum hemorrhage patient, therefore the every symptom of hemorrhagic disease is improved situation as curative effect judging standard, is divided into following four kinds: cure: clinical symptoms and sign are all eliminated, and efficacy consolidation.Effective: though clinical symptoms is eliminated, curative effect is consolidated not.Effective: clinical symptoms and sign make moderate progress.Invalid: unchanged before treatment.

(4) therapeutic effect: clinical cure 137 examples, effective 10 examples, effective 8 examples, invalid 5 examples, all cases all have no adverse reaction.

(5) toxic and side effects: apply none example of 160 routine patients of the present invention and occur discomfort, the toxic and side effects such as swelling.Experimental check hematuria, just conventional, liver, renal function are all without abnormal change.Illustrate that the present invention is safety Chinese medicine without any side effects.

(6) sum up: clinical time: 13 years, curative effect: 3 days are effectively, the course for the treatment of: general patient 3-9 days, recover normal, patient with severe symptoms: within 9 days, disease disappears, within 15 days, recover normal.Effective percentage 96.9%, cure rate 85.6%.

Above-mentioned embodiment is intended to illustrate the present invention and can be professional and technical personnel in the field's realization or use; it will be apparent for those skilled in the art that above-mentioned embodiment is modified; therefore the present invention includes but be not limited to above-mentioned embodiment; any these claims or description of meeting described; meet and principle disclosed herein and novelty, the method for inventive features, technique, product, within all falling into protection scope of the present invention.

Claims (5)

1. the compound medicine of a prophylactic treatment postpartum hemorrhage, it is characterized in that: this compound medicine comprises active ingredient and assists a ruler in governing a country composition, wherein said active ingredient by following component according to shown in weight ratio scope formulated, Radix Rehmanniae Preparata 6～12, the Radix Rehmanniae 10～20, Radix gynurae segeti 10～25, Radix Scrophulariae 10～20, Radix Scutellariae 9～15, Fructus Forsythiae 5～10, Herba Cirsii 12～15, Fructus Gardeniae 9～15.

2. the compound medicine of prophylactic treatment postpartum hemorrhage according to claim 1, it is characterized in that: described in assist a ruler in governing a country composition by following component according to shown in weight ratio scope formulated, Radix Sophorae Tonkinensis 9～15, Cortex Lycii 10～15, Rhizoma Imperatae 30～60, Herba monochasmatis 5～10, Cornu Bubali 10～20, Rhizoma Alismatis 6～12, Rhizoma Dioscoreae 15～20, Radix Rubiae 10～15, Radix Angelicae Sinensis 6～12, Cortex Moutan 6～15.

3. the compound medicine of prophylactic treatment postpartum hemorrhage according to claim 2, it is characterized in that: described compound medicine by following component according to shown in weight ratio scope formulated, Radix Rehmanniae Preparata 8～10, the Radix Rehmanniae 14～16, Radix gynurae segeti 18～20, Radix Scrophulariae 14～16, Radix Scutellariae 11～13, Fructus Forsythiae 7～9, Herba Cirsii 12～14, Fructus Gardeniae 9～11, Radix Sophorae Tonkinensis 13～15, Cortex Lycii 12～14, Rhizoma Imperatae 44～46, Herba monochasmatis 8～10, Cornu Bubali 15～17, Rhizoma Alismatis 8～10, Rhizoma dioscoreae (parched) 17～19, Radix Rubiae 11～13, Radix Angelicae Sinensis 8～10, Cortex Moutan 9～11.

4. the compound medicine of prophylactic treatment postpartum hemorrhage according to claim 3, it is characterized in that: described compound medicine by following component according to shown in weight ratio formulated, Radix Rehmanniae Preparata 9, the Radix Rehmanniae 15, Radix gynurae segeti 19, Radix Scrophulariae 15, Radix Scutellariae 12, Fructus Forsythiae 8, Herba Cirsii 13, Fructus Gardeniae 10, Radix Sophorae Tonkinensis 14, Cortex Lycii 13, Rhizoma Imperatae 45, Herba monochasmatis 9, Cornu Bubali 16, Rhizoma Alismatis 9, Rhizoma dioscoreae (parched) 18, Radix Rubiae 12, Radix Angelicae Sinensis 9, Cortex Moutan 10.

5. according to the compound medicine of the arbitrary described prophylactic treatment postpartum hemorrhage of claim 1 to 4, it is characterized in that: the preparation method of this medicine comprises the following steps,

Step 1) takes each component of each active ingredient according to formula described in claim 1,3,4, dry, pulverize into fine powder at 80 ℃～95 ℃, crosses 50 mesh sieves; According to formula described in claim 2,3,4, take and respectively assist a ruler in governing a country each component of composition, at 60 ℃～70 ℃, dry, pulverize into fine powder, cross 80 mesh sieves;

Step 2) each component of each active ingredient through step 1) gained is sieved fine powder adds 10～14 times of quality decoctings and boils, to decocting liquid filter, filtrate is concentrated into the ointment that density is 1.35g/mL～1.40g/mL;

Step 3) is sieved fine powder at 70 ℃～80 ℃, with water dissolution by each component of each auxiliary element through step 1) gained.

Step 4) is by through step 2) ointment of gained smashs to pieces, at 20 ℃～40 ℃, adds in the mixed industry suspension of step 3) gained and mixes, and obtains the compound medicine of this prophylactic treatment postpartum hemorrhage.