CN103919701A - Sunscreen spray containing solid lipid microparticles and preparation method of sunscreen spray - Google Patents
Sunscreen spray containing solid lipid microparticles and preparation method of sunscreen spray Download PDFInfo
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Abstract
The invention discloses a sunscreen spray containing solid lipid microparticles and a preparation method of the sunscreen spray. The sunscreen spray containing solid lipid microparticles consists of 1-20% of solid grease, 1-20% of liquid grease, 3-15% of a solid emulsifier, 1-15% of a solid sun-screening agent, 3-25% of a liquid sun-screening agent, 0.05-10% of a wetting agent, 0.2-5.0% of a rheolobic modifier, 0.2-2.0% of a preservative, 0.1-0.5% of essence and the balance of deionized water. The preparation method comprises the following steps: dispersing an oil phase system consisting of the solid grease, the liquid grease, the solid emulsifier, the solid sun-screening agent and the liquid solid sun-screening agent with the wetting agent to an aqueous phase formed by deionized water, and mixing and homogenizing for 4 minutes to obtain a system; carrying ultrasonic treatment on the system for 6-15 minutes; then, adding the rheolobic modifier while stirring, and cooling to 40-60 DEG C and adding the preservative and essence; and then stirring and cooling to room temperature to obtain the sunscreen spray containing solid lipid microparticles.
Description
Technical field
The present invention relates to a kind of sun-proof spray containing solid lipid microgranule and preparation method thereof, belong to cosmetics technical field.
Background technology
Sun-proof is the topic that cosmetic field is paid close attention to always, and the stability of sunscreen, safety, effectiveness are the sun-proof problems that must solve.Conventional sunscreen mainly contains chemical sunscreen and physical sunscreen agent according to mechanism.Chemistry sunscreen is by absorbing ultraviolet, reaches sun-proof effect after making it be converted into thermal release; Physical sunscreen agent is by reaching anti-sunlight function after reflection shielding ultraviolet rays.On market, common sun care preparations has sunscreen cream, sunscreen and sun-proof spraying.Compare with other two product, sun-proof spraying is easy to carry; Owing to being vaporific, do not need to smear with hands, be directly sprayed on skin, therefore can reduce the loss; Easy to use, can supplement fast; Salubrious control oil, tack-free.And existing sun-proof spraying also exists a lot of problems, if main component is liquid sunscreen, solid-state sunscreen is as little in the content of butyl methoxydibenzoylmethise, and easily occurs chap and the separating of oil phenomenon of water in storage and centrifugal process; Directly be scattered in spraying, directly contact with skin, may penetrate into skin surface; Shear shinning effect is bad, is difficult to smear evenly.
At present, have much about the research of sun-proof spraying, but there is not yet open containing the spray of the sun-proof grain of solid lipid nano.
Summary of the invention
The object of the present invention is to provide a kind of sun-proof spray containing solid lipid microgranule.
Two of object of the present invention is the preparation method of a kind of sun-proof spray containing solid lipid microgranule that provides above-mentioned.
Know-why of the present invention
Solid lipid nanoparticle (SLN) be again solid liposome, is the solid particle that solid grease solidifies in cooling or phase separation and crystallization forms.As a kind of novel carrier, solid lipid nanoparticle possesses that physiological compatibility is good, biodegradable, Drug loading capacity is strong, physical chemistry stable storage, cost are low, be beneficial to the advantages such as large-scale production.Act in cosmetics, permeability, targeting that can enhanced activity composition, improve closure function and hydration, can improve the stability of active component as coated carrier simultaneously.
And the spraying that contains solid lipid sun-prevention microparticle has many good qualities compared with common spraying.First, sunscreen is coated on solid lipid nanoparticle rear stability and improves, and zest reduces, and secondly because the common sun-proof spraying of its size ratio is little, can improve the closure function of spraying and the adhesion with skin.Solid lipid nanoparticle can play the effect of physics spinning solarization agent simultaneously, has strengthened sun-proof property.
Technical scheme of the present invention
Containing a sun-proof spray for solid lipid microgranule, to calculate by mass percentage, its composition is that content is as follows:
Solid grease 1～20%
Liquid fat 1～20%
Solid state emulsifying agent 3～15%
Solid-state sunscreen 1～15%
Liquid sunscreen 3～25%
Wetting agent 0.05～10%
Rheology control agent 0.2～5.0%
Antiseptic 0.2～2.0%
Essence 0.1～0.5%
Surplus is deionized water;
Wherein solid lipid is saturated fat acids, steroid, glyceride type or waxiness class;
Described saturated fat acids is stearic acid, Palmic acid, capric acid or behenic acid;
Described steroid is cholesterol;
Described glyceride type is glyceryl monostearate, glyceryl tristearate or trilaurin;
Described waxiness class is cetyl palmitate;
Described liquid fat is that one or more of Vegetable oil lipoprotein, mineral grease and synthetic ester oil are composite;
Wherein said Vegetable oil lipoprotein is Jojoba oil, macadimia nut oil, olive oil, Semen pruni armeniacae oil, Oleum Cocois, Oleum Ricini, the young oil of Helianthi or Semen Tritici aestivi germ oil;
Described mineral grease is white oil;
Described synthetic ester oil is isomery hexadecane hydrocarbon, iso-octyl palmitate, isopropyl palmitate, sad capric acid triglyceride, dimethicone, squalane, ethyl oleate, stearic acid 13 esters or the different monooctyl ester of isostearic acid etc.;
Described solid state emulsifying agent is ceteareth-25, ceteareth-6, ceteareth-12, ceteareth-20, ceteareth-30, stearyl alcohol polyethers-2, stearyl alcohol polyethers-21, polyglycereol-6 pair stearate, three cetearyl alcohol ether-4 phosphate esters, PEG-20 tri-Glyceryl Behenates, PEG-8 Cera Flava, PEG-stearate or PEG-32 stearate etc.;
Described solid-state sunscreen is butyl methoxydibenzoylmethise, BP-4, two ethyl hexyl oxy phenol p-methoxyphenyl triazines, Uvinul T 150, diethylamino oxybenzene formoxyl hexyl-benzoate, aluminium hydroxide/hydrogenation polydimethylsiloxane, 2-cyano group-3,3 diphenylacrylate monooctyl esters, the combination of one or more in 4-methyl-4-ethoxybenzene formyl methane;
Described liquid sunscreen is octyl methoxycinnamate, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, N, N-octyl dimethyl p-aminobenzoic acid, N, N-amyl dimethyl paraaminobenzoic acid, diethylamino oxybenzene formoxyl hexyl-benzoate, Antisolaire, phenyl salicytate, benzyl salicylate, menthyl salicylate, para-amino benzoic acid, para-amino benzoic acid glyceride, N, N-amyl dimethyl paraaminobenzoic acid, two (hydroxypropyl) Aminobenzoates of ethyl-4-and N, the combination of one or more in N-octyl dimethyl p-aminobenzoic acid,
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer, acrylic compounds/acrylamide copolymer/white mineral oil/polysorbate 85, PEG-120 methyl glucose dioleate, PEG-120 methyl glucose trioleate, acrylate copolymer, polyacrylate-1 cross linked polymer, carbomer-U10, carbomer-U20, carbomer-ETD 2050, carbomer-934, carbomer-980, Carbomer-940, carbomer-941, carbomer-981, acrylic copolymer sodium salt/mineral oil/PPG-1 tridecanol polyethers-6, polyacrylate 13/ polyisobutylene gathers three pears acid esters 20, sodium acrylate/dimethyl acrylamide sodium acyl taurine copolymer and different hexadecane gather three pears acid esters 80, the combination of one or more in xanthan gum,
Described wetting agent is the biochemical class of polyalcohols, nature moisturizing factor, amino acids or macromolecule; Wherein polyalcohols is glycerol, 1,3 butylene glycol, Polyethylene Glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol or Sorbitol;
Nature moisturizing factor carbamide, amino acid etc.;
Amino acids is animal proteinum, hydrolyzed protein or soybean protein etc.;
The biochemical class of macromolecule mainly contains collagen protein, hyaluronate sodium or glycoprotein etc.;
Described antiseptic is benzoic acids, Pyrusussuriensis acids, parabens, germall class, Kazon class and dihydroxymethyl glycolylurea, 1, 2-benzisothiazole-3-ketone, essence of Niobe, Methylisothiazolinone, trichloro-symmetrical diphenyl urea, 2-bromo-2-nitro-1.3-propylene glycol (Bronopol), glyceryl monolaurate, diazonium ureine, bromo-5 nitro-1 of propylene glycol-5-, 3-bis-Evil alkane, dehydroacetic acid, bromo-5 nitro-1 of propylene glycol-5-, 3-bis-Evil alkane, propylene glycol-bis-imidazolidinyl urea, two imidazolidinyl urea/methyl hydroxybenzoate/propylene glycol, two imidazolidinyl urea, the combination of one or more in iodo propinyl butyl carbamate,
Described parabens is preferably methyl hydroxybenzoate;
Described essence is spice mixt used for cosmetic, is preferably jasmin essence or Flos Gardeniae essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, specifically comprises and is prepared as follows step:
(1), the preparation of oil-based system
Solid lipid, liquid fat, solid state emulsifying agent, solid-state sunscreen and liquid sunscreen 75-95 DEG C of melting and be uniformly dispersed, are obtained to finely dispersed oil phase;
(2), the preparation of aqueous phase system
Wetting agent and deionized water mixing post-heating, to 75-95 DEG C, are formed to water;
(3), emulsifying water and oil phase
With the water of power homogenizing step (2) gained of 7200-240000W, add the oil phase of step (1) gained simultaneously, continue homogenizing 2-10min, obtain emulsification system;
(4), ultrasonic promotion emulsifying
The emulsification system that step (3) is obtained is with the power ultrasonic 4-20min of 80-800W;
(5), stir cooling
Emulsification system after ultrasonic step (4) is stirred with the speed of 200-800r/min, add while stirring rheology control agent, in the time that temperature is 50 DEG C of left and right, add antiseptic, essence, stir 20～60min with rotating speed 200～1000r/min, be cooled to room temperature and obtain the sun-proof spray containing solid lipid microgranule.
Above-mentioned a kind of sun-proof spray containing solid lipid microgranule, when extruding, system has overcome yield value, forms vaporificly, can adhere to skin surface;
The particle diameter of above-mentioned a kind of sun-proof spray containing solid lipid microgranule is in 200-400nm left and right, due to solid lipid particle encapsulation solid-state sunscreen and liquid sunscreen, being sprayed in 290nm～400nm wave-length coverage of therefore forming has anti-sunlight function.
Beneficial effect of the present invention
A kind of sun-proof spray containing solid lipid microgranule of the present invention, owing to having avoided sunscreen directly to contact with skin after the coated sunscreen of solid lipid, reduces the stimulation of sunscreen to skin; By controlling solid lipid diameter of particle within the scope of 200-400nm, reduced the infiltration of sunscreen to skin simultaneously.There is a yield value in the system of gained, leaving standstill or firmly existing with the form of stable solid lipid particle encapsulation sunscreen compared with hour system, in the process of extruding, overcome the yield value of system, system can instantaneous shear shinning, and sunscreen can be attached on skin uniformly.
Further, a kind of sun-proof spray containing solid lipid microgranule of the present invention, owing to adopting ultrasonic dispersion technology in preparation process, the solid lipid microgranule preparing wraps up sunscreen, has improved the centrifugal and low-temperature stability of sunscreen.
Brief description of the drawings
The scanning electron microscope (SEM) photograph of the sun-proof spray containing solid lipid microgranule of Fig. 1, embodiment 1 gained.
Detailed description of the invention
Also by reference to the accompanying drawings the present invention is further set forth below by specific embodiment, but do not limit the present invention.
Embodiment 1
Containing a sun-proof spraying for solid lipid microgranule, by the total of 100g, its composition is that content is as follows:
Solid grease 1g (1%)
Liquid fat 1g (1%)
Solid state emulsifying agent 3g (3%)
Solid-state sunscreen 1g (1%)
Liquid sunscreen 3g (3%)
Wetting agent 0.05g (0.05%)
Rheology control agent 0.2g (0.2%)
Antiseptic 2g (2%)
Essence 0.1g (0.1%)
Surplus is deionized water;
Wherein solid lipid is the glyceryl monostearate in glyceride type;
Described liquid fat is the caprylic/capric triglyceride in synthetic ester oil;
Described solid state emulsifying agent is ceteareth-25;
Described solid-state sunscreen is butyl methoxydibenzoylmethise;
Described liquid sunscreen is octyl methoxycinnamate;
Described rheology control agent is carbomer-U20;
Described wetting agent is the hyaluronate sodium of the biochemical apoplexy due to endogenous wind of macromolecule;
Described antiseptic is two imidazolidinyl urea/methyl hydroxybenzoate/propylene glycol;
Described essence is jasmin essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, specifically comprises and is prepared as follows step:
(1), the preparation of oil-based system
Solid lipid, liquid fat, solid state emulsifying agent, solid-state sunscreen and liquid sunscreen 75-95 DEG C of melting and be uniformly dispersed, are obtained to finely dispersed oil phase;
(2), the preparation of aqueous phase system
Wetting agent and deionized water mixing post-heating, to 75-95 DEG C, are formed to water;
(3), emulsifying water and oil phase
With the water of power homogenizing step (2) gained of 7200-240000W, add the oil phase of step (1) gained simultaneously, continue homogenizing 2-10min, obtain emulsification system;
(4), ultrasonic promotion emulsifying
The emulsification system that step (3) is obtained is with the power ultrasonic 4-20min of 80-800W;
(5), stir cooling
Emulsification system after ultrasonic step (4) is stirred with the speed of 200-800r/min, add while stirring rheology control agent, controlling temperature is 50 DEG C, add antiseptic, essence, stir 20～60min with rotating speed 200～1000r/min, be cooled to room temperature and obtain the sun-proof spray containing solid lipid microgranule.
Adopt scanning electron microscope instrument (FEI company, Quanta200 FEG, Holland) the sun-proof spray containing solid lipid microgranule of above-mentioned gained is scanned, the scanning electron microscope (SEM) photograph of gained as shown in Figure 1, as can be seen from Figure 1 solid lipid particle alignment is tight, uniform particles, has good coating function to sunscreen.
Embodiment 2
Containing a sun-proof spraying for solid lipid microgranule, by the total of 100g, its composition is that content is as follows:
Solid grease 5g (5%)
Liquid fat 5g (5%)
Solid state emulsifying agent 7g (7%)
Solid-state sunscreen 3g (3%)
Liquid sunscreen 4g (4%)
Wetting agent 5g(5%)
Rheology control agent 0.25g (0.25%)
Antiseptic 0.2g (0.2%)
Essence 0.2g (0.2%)
Surplus is deionized water;
Wherein solid lipid is the Palmic acid of satisfied fatty acid apoplexy due to endogenous wind;
Described liquid fat is the macadimia nut oil in Vegetable oil lipoprotein;
Described solid state emulsifying agent is stearyl alcohol polyethers-21;
Described solid-state sunscreen is butyl methoxydibenzoylmethise;
Described liquid sunscreen is octyl methoxycinnamate;
Described rheology control agent is xanthan gum;
Described wetting agent is glycerol;
Described antiseptic is two imidazolidinyl urea;
Described essence is jasmin essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, concrete steps are with embodiment 1.
Embodiment 3
Containing a sun-proof spraying for solid lipid microgranule, by the total of 100g, its composition is that content is as follows:
Solid grease 5g (5.0%)
Liquid fat 8g (8.0%)
Solid state emulsifying agent 7g (7.0%)
Solid-state sunscreen 5g (5.0%)
Liquid sunscreen 8g (8.0%)
Wetting agent 10g (10.0%)
Rheology control agent 0.4g (0.4%)
Antiseptic 0.3g (0.3%)
Essence 0.4g (0.4%)
Surplus is deionized water;
Wherein solid lipid is the cetyl palmitate of waxiness apoplexy due to endogenous wind;
Described liquid fat is the iso-octyl palmitate in synthetic ester oil;
Described solid state emulsifying agent is PEG-20 tri-Glyceryl Behenates;
Described solid-state sunscreen is BP-4;
Described liquid sunscreen is benzyl salicylate;
Described rheology control agent is polyacrylate-1 cross linked polymer;
Described wetting agent is propylene glycol;
Described antiseptic is two imidazolidinyl urea;
Described essence is Flos Gardeniae essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, concrete steps are with embodiment 1.
Embodiment 4
Containing a sun-proof spray for solid lipid microgranule, by the total of 100g, its composition is that content is as follows:
Solid grease 10g (10%)
Liquid fat 10g (10%)
Solid state emulsifying agent 10g (10%)
Solid-state sunscreen 10g (10%)
Liquid sunscreen 12g (12%)
Wetting agent 10g (10%)
Rheology control agent 2.5g (2.5%)
Antiseptic 0.3g (0.3%)
Essence 0.2g (0.2%)
Surplus is deionized water;
Described solid lipid is the glyceryl tristearate in glyceride type;
Described liquid fat is the isopropyl palmitate in synthetic ester oil;
Described solid state emulsifying agent is PEG-8 Cera Flava;
Described solid-state sunscreen is two ethyl hexyl oxy phenol p-methoxyphenyl triazines;
Described liquid sunscreen is benzyl salicylate;
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer;
Described wetting agent is propylene glycol;
Described antiseptic is two imidazolidinyl urea;
Described essence is jasmin essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, concrete steps are with embodiment 1.
Embodiment 5
Containing a sun-proof spray for solid lipid microgranule, by the total of 100g, its composition and content are as follows:
Solid grease 20g (20%)
Liquid fat 20g (20%)
Solid state emulsifying agent 15g (15%)
Solid-state sunscreen 15g (15%)
Liquid sunscreen 10g (10%)
Wetting agent 10g (10%)
Rheology control agent 5g (5%)
Antiseptic 0.3g (0.3%)
Essence 0.5g (0.5%)
Surplus is deionized water;
Described solid lipid is the behenic acid of satisfied fatty acid apoplexy due to endogenous wind;
Described liquid fat is the olive oil in Vegetable oil lipoprotein;
Described solid state emulsifying agent is PEG-8 Cera Flava;
Described solid-state sunscreen is Uvinul T 150;
Described liquid sunscreen is N, N-octyl dimethyl p-aminobenzoic acid;
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer;
Described wetting agent is glycerol;
Described antiseptic is methyl hydroxybenzoate;
Described essence is jasmin essence.
Embodiment 6
Containing a sun-proof spray for solid lipid microgranule, by the total of 100g, its composition is that content is as follows:
Solid grease 20g (20%)
Liquid fat 15g (15%)
Solid state emulsifying agent 15g (15%)
Solid-state sunscreen 5g (5%)
Liquid sunscreen 25g (25%)
Wetting agent 10g (10%)
Rheology control agent 5g (5%)
Antiseptic 0.3g (0.3%)
Essence 0.5g (0.5%)
Surplus is deionized water;
Described solid lipid is the cholesterol in steroid;
Described liquid fat is the white oil in mineral grease;
Described solid state emulsifying agent is PEG-20 tri-Glyceryl Behenates;
Described solid-state sunscreen is 2-cyano group-3,3 diphenylacrylate monooctyl esters;
Described liquid sunscreen is ethylhexyl salicylate;
Described rheology control agent is carbomer-980;
Described wetting agent is 1,3 butylene glycol;
The described antiseptic azanyl urea of attaching most importance to;
Described essence is jasmin essence.
The preparation method of above-mentioned a kind of sun-proof spray containing solid lipid microgranule, concrete steps are with embodiment 1.
Above said content is only the basic explanation of the present invention under conceiving, and according to any equivalent transformation that technical scheme of the present invention is done, all should belong to protection scope of the present invention.
Claims (9)
1. containing a sun-proof spray for solid lipid microgranule, it is characterized in that the described sun-proof spray containing solid lipid microgranule, calculate by mass percentage, its composition and content are as follows:
Solid grease 1～20%
Liquid fat 1～20%
Solid state emulsifying agent 3～15%
Solid-state sunscreen 1～15%
Liquid sunscreen 3～25%
Wetting agent 0.05～10%
Rheology control agent 0.2～5.0%
Antiseptic 0.2～2.0%
Essence 0.1～0.5%
Surplus is deionized water;
Described solid lipid is saturated fat acids, steroid, glyceride type or waxiness class;
Wherein saturated fat acids is stearic acid, Palmic acid, capric acid or behenic acid;
Steroid is cholesterol;
Glyceride type is glyceryl monostearate, glyceryl tristearate or trilaurin;
Waxiness class is cetyl palmitate;
Described liquid fat is that one or more of Vegetable oil lipoprotein, mineral grease and synthetic ester oil are composite;
Wherein Vegetable oil lipoprotein is Jojoba oil, macadimia nut oil, olive oil, Semen pruni armeniacae oil, Oleum Cocois, Oleum Ricini, the young oil of Helianthi or Semen Tritici aestivi germ oil;
Mineral grease is white oil;
Synthetic ester oil is isomery hexadecane hydrocarbon, iso-octyl palmitate, isopropyl palmitate, caprylic/capric triglyceride, dimethicone, squalane, ethyl oleate, stearic acid 13 esters or the different monooctyl ester of isostearic acid;
Described solid state emulsifying agent is ceteareth-25, ceteareth-6, ceteareth-12, ceteareth-20, ceteareth-30, stearyl alcohol polyethers-2, stearyl alcohol polyethers-21, polyglycereol-6 pair stearate, three cetearyl alcohol ether-4 phosphate esters, PEG-20 tri-Glyceryl Behenates, PEG-8 Cera Flava, PEG-stearate or PEG-32 stearate;
Described solid-state sunscreen is butyl methoxydibenzoylmethise, BP-4, two ethyl hexyl oxy phenol p-methoxyphenyl triazines, Uvinul T 150, diethylamino oxybenzene formoxyl hexyl-benzoate, aluminium hydroxide/hydrogenation polydimethylsiloxane, 2-cyano group-3,3 diphenylacrylate monooctyl esters, the combination of one or more in 4-methyl-4-ethoxybenzene formyl methane;
Described liquid sunscreen is octyl methoxycinnamate, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, N, N-octyl dimethyl p-aminobenzoic acid, N, N-amyl dimethyl paraaminobenzoic acid, diethylamino oxybenzene formoxyl hexyl-benzoate, Antisolaire, phenyl salicytate, benzyl salicylate, menthyl salicylate, para-amino benzoic acid, para-amino benzoic acid glyceride, N, N-amyl dimethyl paraaminobenzoic acid, two (hydroxypropyl) Aminobenzoates of ethyl-4-and N, the combination of one or more in N-octyl dimethyl p-aminobenzoic acid,
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer, acrylic compounds/acrylamide copolymer/white mineral oil/polysorbate 85, PEG-120 methyl glucose dioleate, PEG-120 methyl glucose trioleate, acrylate copolymer, polyacrylate-1 cross linked polymer, carbomer-U10, carbomer-U20, carbomer-ETD 2050, carbomer-934, carbomer-980, Carbomer-940, carbomer-941, carbomer-981, acrylic copolymer sodium salt/mineral oil/PPG-1 tridecanol polyethers-6, polyacrylate 13/ polyisobutylene gathers three pears acid esters 20, sodium acrylate/dimethyl acrylamide sodium acyl taurine copolymer and different hexadecane gather three pears acid esters 80, the combination of one or more in xanthan gum,
Described wetting agent is the biochemical class of polyalcohols, nature moisturizing factor, amino acids or macromolecule;
Wherein polyalcohols is glycerol, 1,3 butylene glycol, Polyethylene Glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol or Sorbitol;
Nature moisturizing factor is carbamide or amino acid;
Amino acids is animal proteinum, hydrolyzed protein or soybean protein;
The biochemical class of macromolecule mainly contains collagen protein, hyaluronate sodium or glycoprotein etc.;
Described antiseptic is benzoic acids, Pyrusussuriensis acids, parabens, germall class, Kazon class and dihydroxymethyl glycolylurea, 1, 2-benzisothiazole-3-ketone, essence of Niobe, Methylisothiazolinone, trichloro-symmetrical diphenyl urea, the bromo-2-nitro-1.3-of 2-propylene glycol, glyceryl monolaurate, diazonium ureine, bromo-5 nitro-1 of propylene glycol-5-, 3-bis-Evil alkane, dehydroacetic acid, bromo-5 nitro-1 of propylene glycol-5-, 3-bis-Evil alkane, propylene glycol-bis-imidazolidinyl urea, two imidazolidinyl urea/methyl hydroxybenzoate/propylene glycol, two imidazolidinyl urea, the combination of one or more in iodo propinyl butyl carbamate,
Described essence is spice mixt used for cosmetic.
2. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 1, is characterized in that described essence is jasmin essence or Flos Gardeniae essence.
3. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 1%
Liquid fat 1%
Solid state emulsifying agent 3%
Solid-state sunscreen 1%
Liquid sunscreen 3%
Wetting agent 0.05%
Rheology control agent 0.2%
Antiseptic 2%
Essence 0.1%
Surplus is deionized water;
Wherein solid lipid is tristerin;
Described liquid fat is caprylic/capric triglyceride;
Described solid state emulsifying agent is ceteareth-25;
Described solid-state sunscreen is butyl methoxydibenzoylmethise;
Described liquid sunscreen is octyl methoxycinnamate;
Described rheology control agent is carbomer-U20;
Described wetting agent is hyaluronate sodium;
Described antiseptic is two imidazolidinyl urea/methyl hydroxybenzoate/propylene glycol;
Described essence is jasmin essence.
4. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 5%
Liquid fat 5%
Solid state emulsifying agent 7%
Solid-state sunscreen 3%
Liquid sunscreen 4%
Wetting agent 5%
Rheology control agent 0.25%
Antiseptic 0.2%
Essence 0.2%
Surplus is deionized water;
Wherein solid lipid is Palmic acid;
Described liquid fat is macadimia nut oil;
Described solid state emulsifying agent is stearyl alcohol polyethers-21;
Described solid-state sunscreen is butyl methoxydibenzoylmethise;
Described liquid sunscreen is octyl methoxycinnamate;
Described rheology control agent is xanthan gum;
Described wetting agent is glycerol;
Described antiseptic is two imidazolidinyl urea;
Described essence is jasmin essence.
5. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 5.0%
Liquid fat 8.0%
Solid state emulsifying agent 7.0%
Solid-state sunscreen 5.0%
Liquid sunscreen 8.0%
Wetting agent 10.0%
Rheology control agent 0.4%
Antiseptic 0.3%
Essence 0.4%
Surplus is deionized water;
Wherein solid lipid is cetyl palmitate;
Described liquid fat is iso-octyl palmitate;
Described solid state emulsifying agent is PEG-20 tri-Glyceryl Behenates;
Described solid-state sunscreen is BP-4;
Described liquid sunscreen is benzyl salicylate;
Described rheology control agent is polyacrylate-1 cross linked polymer;
Described wetting agent is propylene glycol;
Described antiseptic is two imidazolidinyl urea;
Described essence is Flos Gardeniae essence.
6. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 10%
Liquid fat 10%
Solid state emulsifying agent 10%
Solid-state sunscreen 10%
Liquid sunscreen 12%
Wetting agent 10%
Rheology control agent 2.5%
Antiseptic 0.3%
Essence 0.2%
Surplus is deionized water;
Described solid lipid is glyceryl tristearate;
Described liquid fat is isopropyl palmitate;
Described solid state emulsifying agent is PEG-8 Cera Flava;
Described solid-state sunscreen is two ethyl hexyl oxy phenol p-methoxyphenyl triazines;
Described liquid sunscreen is benzyl salicylate;
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer;
Described wetting agent is propylene glycol;
Described antiseptic is two imidazolidinyl urea;
Described essence is jasmin essence.
7. a kind of sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 20%
Liquid fat 20%
Solid state emulsifying agent 15%
Solid-state sunscreen 15%
Liquid sunscreen 10%
Wetting agent 10%
Rheology control agent 5%
Antiseptic 0.3%
Essence 0.5%
Surplus is deionized water;
Described solid lipid is behenic acid;
Described liquid fat is Vegetable oil lipoprotein olive oil;
Described solid state emulsifying agent is PEG-8 Cera Flava;
Described solid-state sunscreen is Uvinul T 150;
Described liquid sunscreen is N, N-octyl dimethyl p-aminobenzoic acid;
Described rheology control agent is acrylic compounds/C10-30 alkylol acrylamide acid esters cross linked polymer;
Described wetting agent is glycerol;
Described antiseptic is methyl hydroxybenzoate;
Described essence is jasmin essence.
8. the sun-proof spray containing solid lipid microgranule as claimed in claim 2, is characterized in that calculating by mass percentage, and its composition and content are as follows:
Solid grease 20%
Liquid fat 15%
Solid state emulsifying agent 15%
Solid-state sunscreen 5%
Liquid sunscreen 25%
Wetting agent 10%
Rheology control agent 5%
Antiseptic 0.3%
Essence 0.5%
Surplus is deionized water;
Described solid lipid is cholesterol;
Described liquid fat is white oil;
Described solid state emulsifying agent is PEG-20 tri-Glyceryl Behenates;
Described solid-state sunscreen is 2-cyano group-3,3 diphenylacrylate monooctyl esters;
Described liquid sunscreen is ethylhexyl salicylate;
Described rheology control agent is carbomer-980;
Described wetting agent is 1,3 butylene glycol;
The described antiseptic azanyl urea of attaching most importance to;
Described essence is jasmin essence.
9. the preparation method of the sun-proof spray containing solid lipid microgranule as described in as arbitrary in claim 1-7, is characterized in that specifically comprising the steps:
(1), the preparation of oil-based system
Solid lipid, liquid fat, solid state emulsifying agent, solid-state sunscreen and liquid sunscreen 75-95 DEG C of melting and be uniformly dispersed, are obtained to finely dispersed oil phase;
(2), the preparation of aqueous phase system
Wetting agent and deionized water mixing post-heating, to 75-95 DEG C, are formed to water;
(3), emulsifying water and oil phase
With the water of power homogenizing step (2) gained of 7200-240000W, add the oil phase of step (1) gained simultaneously, continue homogenizing 2-10min, obtain emulsification system;
(4), ultrasonic promotion emulsifying
The emulsification system that step (3) is obtained is with the power ultrasonic 4-20min of 80-800W;
(5), stir cooling
Emulsification system after ultrasonic step (4) is stirred with the speed of 200-800r/min, add while stirring rheology control agent, when temperature is 50 DEG C, add antiseptic, essence, stir 20～60min with rotating speed 200～1000r/min, be cooled to room temperature and obtain the sun-proof spray containing solid lipid microgranule.
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| CN201410142082.3A CN103919701A (en) | 2014-04-10 | 2014-04-10 | Sunscreen spray containing solid lipid microparticles and preparation method of sunscreen spray |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410142082.3A CN103919701A (en) | 2014-04-10 | 2014-04-10 | Sunscreen spray containing solid lipid microparticles and preparation method of sunscreen spray |
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| CN201410142082.3A Pending CN103919701A (en) | 2014-04-10 | 2014-04-10 | Sunscreen spray containing solid lipid microparticles and preparation method of sunscreen spray |
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Application publication date: 20140716 |