CN103919607A - Photothermal effect tissue treatment optimizing and monitoring method and device - Google Patents
Photothermal effect tissue treatment optimizing and monitoring method and device Download PDFInfo
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- CN103919607A CN103919607A CN201310663899.0A CN201310663899A CN103919607A CN 103919607 A CN103919607 A CN 103919607A CN 201310663899 A CN201310663899 A CN 201310663899A CN 103919607 A CN103919607 A CN 103919607A
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Abstract
The invention relates to a photothermal effect tissue treatment optimizing and monitoring method and device. Continuous intensive laser and pulse laser are transmitted through a flexible diffusion end multimode fiber which is inserted into tissue in a minimal invasion manner, and the same area of the tissue can be irradiated. The continuous intensive laser mainly produces the photothermal effect to cause tissue temperature to change; the pulse laser mainly produces photoacoustic signals, temperature changes of the tissue being monitored are changed according to the strength of the photoacoustic signals, dosage and irradiation time of the continuous intensity laser are regulated in time as required, and optimized photothermal effect is achieved.
Description
Technical field
The invention belongs to photo-thermal therapy technology and monitoring field, be specifically related to the photo-thermal therapy optimization of induced with laser and the method and apparatus of monitoring.
Background technology
Tumor is to affect the important disease of human health.The Chinese tumor registration of the < < 2012 annual report > > of whole nation tumor Register issue points out: national tumor mortality rate is 180.54/10 ten thousand, every year because cancer mortality case reaches 2,700,000 examples.China resident, because the probability of cancer mortality is 13%, has 1 people because of cancer death in every 7 to 8 people.The method of the photo-thermal therapy of tumor is mainly freezing method and laser immunotherapy at present.The former utilizes the high temperature coagulation of tissue is killed to tumor, and the latter utilizes photo-thermal effect to kill tumor release tumor antigen and binding immunoassay adjuvant excites the systemic antitumor immune effect in body.These two kinds of methods all require Temperature Distribution and the situation of change in the whole therapeutic process of monitoring that we must be real-time, thereby prevent wound normal surrounding tissue and reach optimum curative effect.Therefore, need to be to organizing the temperature in photo-thermal effect to monitor real-time and accurately, and can feed back rapidly and adjustment for the treatment of light source.At present, in photo-thermal effect, the detection method of temperature is mainly: ultrasonic and magnetic resonance method.Because ultrasonic penetration depth is high, it can be for monitoring the variation of temperature during photo-thermal therapy, but ultrasonic resolution is low and the low-response to variations in temperature; And the resolution of magnetic resonance method is high and highly sensitive, but magnetic resonance method heaviness and speed are slow.Therefore, the method that Development of Novel effectively organizes photo-thermal effect treatment to optimize and monitor, is still urgent and very important.This is the place of meaning of the present invention just.
Summary of the invention
The object of the invention is to develop a kind of photo-thermal effect treatment optimization and monitoring method organized.The method is integrated continuous light laser and pulse laser, light laser is for generation of the photo-thermal effect of tissue continuously, and pulse laser changes for generation of photoacoustic signal tissue temperature monitoring; The laser that two kinds of laser instrument in the method send is also input in soft disperse end multimode fibre by optical fiber transmission simultaneously, and disperse end optical fiber adopts the mode of Wicresoft to insert in organizer, and tissue is carried out to photoirradiation; The method is integrated focusing formula ultrasonic transducer also, for receiving the photoacoustic signal being produced by pulse laser, its signal can reconstruct the high-resolution photoacoustic image of organizing of high-contrast, and the variations in temperature of tissue is monitored in the change that utilizes the intensity size of photoacoustic signal, adjust in time as requested continuous light laser dosage and exposure time, to reach the photo-thermal effect of optimization.Process operation performance sensitive fast, can realize the effect of photo-thermal effect optimization and monitoring simultaneously.
A kind of device of realizing above-mentioned method employing, comprise continuous laser generator, pulse laser generator, optical fiber component, sound acquisition component, computer module, acoustical coupling assembly, sweep mechanism are connected with computer, sample fixation kit, data collecting card, ultrasonic transducer are connected with computer circuitry with data collecting card connection, data collecting card, computer.It is characterized in that: continuously light laser and pulse laser simultaneously input front end portion be in soft disperse multimode fibre, the laser that two laser instrument send sends laser by optical fiber transmission by the end face of soft dispersion fiber, and irradiation is carried out in the same region of target position tissue.Light laser is for the production of photo-thermal effect continuously, and pulse laser excites for photoacoustic signal.And adopt ultrasonic transducer to survey photoacoustic signal, the variation of the intensity by photoacoustic signal reflects the variation of organizing the temperature that photo-thermal effect causes, thereby the photo-thermal effect of Real-Time Monitoring tissue, and according to observed temperature, change dosage and the exposure time that regulates continuous laser, to reach the photo-thermal effect of optimization.
Operation principle of the present invention: when the surrounding tissue of optical fiber disperse end is subject to continuous Irradiation of High, absorb the energy of continuous light, cause that the temperature in this region raises; Meanwhile, the surrounding tissue of disperse end is subject to pulsed laser irradiation, produces photoacoustic signal.There is one-to-one relationship in temperature and the photoacoustce signal intensity of tissue.Therefore, by measuring photoacoustic signal, can be finally inversed by the temperature of organizing measured region.This not only can, for detection of the temperature of the photo-thermal effect of organizing, can also optimize light dosage and the exposure time of photo-thermal therapy.The method is convenient and swift, can realize photo-thermal effect optimization and monitoring integration.
The invention has the advantages that:
1, the inventive method can directly be utilized the temperature of photoacoustic signal reflection tissue, so can accomplish the variation of temperature in accurately real-time monitoring photo-thermal effect.
2, the tissue temperature that the inventive method utilization monitors, adjusts light dosage and the irradiation time of continuous laser in time, and optimizing tissue photo-thermal effect is to reach temperature requirement in photo-thermal therapy.
3, in the present invention, continuous laser and pulse laser are input in the optical fiber with disperse end, effectively realize treatment optimization and the monitoring integration of organizing photo-thermal effect, for clinical research provides a kind of method easily.
4, in the present invention, adopt the mode of Wicresoft that disperse end optical fiber direct is patched in organizer, need not adopt optothermal material, avoid toxic action.
Accompanying drawing explanation
Fig. 1 is the structural representation of apparatus of the present invention.
Fig. 2 be the inventive method photoacoustic signal different luminous powers (2,3,4W) with the relation of tissue temperature.
Fig. 3 is the relation of CW Laser time and tissue temperature (a) and photoacoustic signal (b).
The specific embodiment
As seen from Figure 1, apparatus of the present invention are by pulse laser 1, continuous wave laser 2, optical fiber component 3, acoustical signal acquisition component 4, calculating unit sample 5, sample fixation kit 6, coupling assembly 7, and scan components 8 forms.Wherein continuous wave laser 1 is selected continuous conductor laser (810nm), pulse laser 2 is selected Nd:YAG laser instrument, it goes out optical wavelength is 532nm, pulse is 5ns, repetitive rate is 10Hz, optical fiber component 3 is input to continuous laser and pulse laser in the optical fiber with disperse end simultaneously, and acoustical signal acquisition component 4 amplifies 4-2 by water immersion focusing formula ultrasonic transducer 4-1 through signal amplifier, after oscillograph 4-3 is average, by the computer 5 with GPIB card, by controlling software, completes collection.Sample fixation kit 6 is with utilizing three-dimensional adjustable sample stage to fix the position of sample, keeping sample position and the coupling assembly close contact of wish observation; Coupling assembly 7 adopts the bottom of little tank to seal with preservative film, holds the water in tank, and the surface of sample and tank coupling effect are better, can reduce the serious signal attenuation that acoustical signal causes because of impedance mismatch between different medium.Scan components 8 by computer by digital I/O card and the translation of relay controller control step driven by motor scanning bracket.
Said apparatus is applied to, in a Pig Liver, open pulse laser, gathers the photoacoustic signal of tissue, by Hilbert transform, extract the intensity of photoacoustic signal, and form optoacoustic tomographic map.Then, will between ultrasonic transducer focal zone, be fixed on the center of optical fiber disperse end, thermocouple is directly placed on to the organizer surface of optical fiber disperse end center, for the tissue temperature of alignment light sound measurement simultaneously.Open continuous laser, select different power, within every 30 seconds in photo-thermal effect process, gather a photoacoustic signal, extract the temperature of the intensity inverting tissue of photoacoustic signal.As shown in Figure 2, show in the method photoacoustic signal different luminous powers (2,3,4W) become one-to-one relationship with tissue temperature.Fig. 3 shows, along with the increase of CW Laser time, the temperature of its optical fiber disperse end surrounding tissue and photoacoustic signal increase, and after irradiation 600s, the temperature of tissue and photoacoustic signal are tending towards saturated.This shows feasibility and effectiveness that photoacoustic signal monitor temperature changes.Then according to the temperature of photoacoustic signal actual measurement, adjust light dosage and the exposure time of optimizing continuous laser.
Claims (4)
1. organize photo-thermal effect treatment to optimize and monitoring method, it is characterized in that: the method is integrated continuous light laser and pulse laser, by soft disperse end multimode fibre, transmit, disperse end optical fiber adopts the mode of Wicresoft to insert in organizer, can carry out photoirradiation to the same area of tissue; Wherein, light laser mainly produces photo-thermal effect and causes that tissue temperature changes continuously, and pulse laser mainly produces photoacoustic signal, and by the variations in temperature of the change monitoring tissue of the intensity size of photoacoustic signal, adjust in time as required continuous light laser dosage and exposure time to reach the photo-thermal effect of optimization.
2. a device of realizing the method described in right 1, comprises continuous laser generator, pulse laser generator, optical fiber component, sound acquisition component, computer module, acoustical coupling assembly, sweep mechanism is connected with computer, sample fixation kit, data collecting card, ultrasonic transducer and data collecting card connection, data collecting card is connected with computer circuitry, computer, it is characterized in that: continuous light laser and pulse laser simultaneously input front end portion are in soft disperse multimode fibre, the laser that two laser instrument send sends laser by optical fiber transmission by the end face of soft dispersion fiber, light laser is for the production of photo-thermal effect continuously, pulse laser excites for photoacoustic signal, and adopt ultrasonic transducer to survey photoacoustic signal, the variation of the intensity by photoacoustic signal reflects the variation of organizing the temperature that photo-thermal effect causes, thereby the photo-thermal effect of Real-Time Monitoring tissue, and according to observed temperature, change dosage and the exposure time that regulates continuous laser, to reach the photo-thermal effect of optimization.
3. according to the method and apparatus described in claim 1 and 2, it is characterized in that: continuous laser and pulse laser are organized by the end face irradiation of same dispersion fiber.
4. according to the method and apparatus described in claim 1 and 2, it is characterized in that: continuous laser and pulse laser are directly inputted in the optical fiber with disperse end by optical fiber component simultaneously, are irradiated to tissue to be monitored.
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| CN201310663899.0A CN103919607A (en) | 2013-12-11 | 2013-12-11 | Photothermal effect tissue treatment optimizing and monitoring method and device |
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| CN201310663899.0A CN103919607A (en) | 2013-12-11 | 2013-12-11 | Photothermal effect tissue treatment optimizing and monitoring method and device |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105181169A (en) * | 2015-05-12 | 2015-12-23 | 中国科学院苏州生物医学工程技术研究所 | Temperature measuring method and system and temperature obtaining device |
| US20170014186A1 (en) * | 2015-07-13 | 2017-01-19 | University of Central Oklahoma | Device and a method for imaging-guided photothermal laser therapy for cancer treatment |
| CN108283487A (en) * | 2017-01-10 | 2018-07-17 | 衍全生物科技（太仓）有限公司 | Cancer photo-thermal ultrasonography device and technology |
| CN108888238A (en) * | 2018-05-11 | 2018-11-27 | 南京大学深圳研究院 | A kind of photoacoustic microscope and imaging method based on ultrasonic reflection plate with holes |
| CN109008966A (en) * | 2018-07-02 | 2018-12-18 | 哈尔滨工业大学（威海） | Photo-thermal therapy system based on the measurement of optoacoustic temperature |
| WO2019219996A1 (en) * | 2018-05-18 | 2019-11-21 | Joaquin Sabaris Vilas | System for locating a probe or fibre laser for internal surgery, in real time for surgical interventions in minimal light |
| CN112842519A (en) * | 2021-01-22 | 2021-05-28 | 上海科技大学 | Photoacoustic detection device for guiding laser therapy |
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| CN1422597A (en) * | 2002-12-31 | 2003-06-11 | 华南师范大学 | Focusing supersonic modulation reflection type optical chromatography imaging method and its apparatus |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181169A (en) * | 2015-05-12 | 2015-12-23 | 中国科学院苏州生物医学工程技术研究所 | Temperature measuring method and system and temperature obtaining device |
| CN105181169B (en) * | 2015-05-12 | 2019-01-15 | 中国科学院苏州生物医学工程技术研究所 | Thermometry, temperature measurement system and temperature acquisition device |
| US20170014186A1 (en) * | 2015-07-13 | 2017-01-19 | University of Central Oklahoma | Device and a method for imaging-guided photothermal laser therapy for cancer treatment |
| US9987089B2 (en) * | 2015-07-13 | 2018-06-05 | University of Central Oklahoma | Device and a method for imaging-guided photothermal laser therapy for cancer treatment |
| CN108283487A (en) * | 2017-01-10 | 2018-07-17 | 衍全生物科技（太仓）有限公司 | Cancer photo-thermal ultrasonography device and technology |
| CN108888238A (en) * | 2018-05-11 | 2018-11-27 | 南京大学深圳研究院 | A kind of photoacoustic microscope and imaging method based on ultrasonic reflection plate with holes |
| WO2019219996A1 (en) * | 2018-05-18 | 2019-11-21 | Joaquin Sabaris Vilas | System for locating a probe or fibre laser for internal surgery, in real time for surgical interventions in minimal light |
| CN109008966A (en) * | 2018-07-02 | 2018-12-18 | 哈尔滨工业大学（威海） | Photo-thermal therapy system based on the measurement of optoacoustic temperature |
| CN112842519A (en) * | 2021-01-22 | 2021-05-28 | 上海科技大学 | Photoacoustic detection device for guiding laser therapy |
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Application publication date: 20140716 |