CN103911240A - Grape wine - Google Patents

Abstract

The invention provides a grape wine, and relates to a healthcare grape wine capable of preventing high blood glucose. The healthcare grape wine capable of preventing high blood glucose, provided by the invention, is characterized by comprising the following raw materials, lycopodium clavatum traditional Chinese medicine powder and grape wine, wherein the proportion of the lycopodium clavatum traditional Chinese medicine powder and the grape wine is 20-200g/L, and the lycopodium clavatum traditional Chinese medicine powder is prepared from the following raw materials in parts by weight: 10-20 parts of lycopodium clavatum, 8-20 parts of plumeria rubra, 3-10 parts of liquorice, 5-10 parts of semen cuscutae, 10-20 parts of tuckahoe and 5-10 parts of dwarf lilyturf root. The grape wine has the advantages that the plumeria rubra, the semen cuscutae, the tuckahoe, the dwarf lilyturf root and juncus roemerianus are used for conditioning the balance of five internal organs, namely heart, liver, spleen, lung and kidney of a human body, dispersing blood stasis, clearing turbid qi and quenching thirst, the lycopodium clavatum is used for relaxing the muscles, stimulating the blood circulation, reinforcing qi and dredging collaterals, so that the purpose of decreasing blood sugar is achieved, the appropriate alcohol power of the grape wine is used for promoting the effect of blood sugar decreasing, and the grape wine is suitable for patients with high blood sugar and diabetes.

Description

A kind of grape wine

Technical field

The present invention relates to a kind of health wine, especially a kind of health wine of preventing and treating hyperglycemia.

Background technology

The mankind's healthy living, closely related with stablizing of external environment (as air, water source) and interior environment (as blood, tissue juice).The too high interior environment that has destroyed just human body of blood sugar, cause a series of biochemical pathological changes, affect the function of each internal organs, long-term hyperglycemia can make each histoorgan generation pathology of whole body, cause the generation of acute and chronic complication, as pancreas function exhaustion, dehydration, electrolyte disturbance, nutritive deficiency, resistibility decline, impaired renal function, DPN, ocular fundus pathology etc., therefore prevent and to treat hyperglycemia very important.

Prior art is not applied Herba Lycopodii and is prevented and treated hyperglycemia, does not apply Herba Lycopodii preparation yet and prevents and treats the health wine of hyperglycemia, and the single and nourishing function of taste has its limitation.As the invention that is 200710056888.0 at the number of patent application of Chinese patent information center announcement---regulate blood sugar health preserving wine and preparation method thereof, this disclosure of the invention a kind of adjusting blood sugar health preserving wine, comprise white wine and puerarin, astragalus polysaccharides, jasminoidin, one or more in ursolic acid, the health factor of maximum saturation solubleness containing from 1mg to white wine in every 500ml wine, its beneficial effect is: blood sugar reducing health wine has retained colourless or micro-yellow of original white wine, thoroughly clear, free from extraneous odour, there is the sweet-smelling of wine, health factor contained in wine is clear and definite, stable and controllable for quality, the health factor adding, containing any chemical additive, is not green food and the healthcare products of environment-friendly type, and the content of active Chinese drug component material wherein has the effect that suppresses or prevent hyperglycemia.

Summary of the invention

In order to solve prior art problem, the object of the invention is to provide a kind of health wine of preventing and treating hyperglycemia.

Technical scheme: a kind of health wine of preventing and treating hyperglycemia, is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10.

Preparation method: Herba Lycopodii Chinese medicine powder is added in grape wine in proportion, after mixing, then be finished product through sterilizing, filtration, encapsulation.

As optimization, a kind of health wine of preventing and treating hyperglycemia of the present invention, is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, and both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10, Rush 3-5, dark plum 3-10.

Herba Lycopodii, toil temperature, expelling wind and cold, dehumidifying are subsided a swelling, are stimulated the circulation of the blood and cause the muscles and joints to relax." Hunan medicine will " records Herba Lycopodii: sweet, flat.Nontoxic, enter the heart, kidney two warps, relax the muscles and stimulate the blood circulation, invigorating qi and dredging collateral.

Flower of Mexican Frangipani, cool in nature, taste is sweet, light; Return large intestine, stomach warp, there is effect of moistening lung removing toxic substances, clearing heat and expelling damp, laxation.

Radix Glycyrrhizae taste is sweet, flat.The thoughts of returning home, lung, spleen, stomach warp.Function cures mainly: invigorates the spleen and benefits qi, and clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

South Dodder Seed Chinese Dodder Seed acrid-sweet flavor, property is flat, enters liver, kidney two warps.There is tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity, antiabortive effect.

Poria cocos taste is sweet, light, property is flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of beneficial spleen and stomach, tranquillizing by calming the heart.Modern medicine study: Poria cocos energy enhancing body immunologic function, Pachymose has significantly antitumor and protect the liver dirty effect.

Radix Ophiopogonis, the micro-sugariness hardship of property, cold, there is nourishing Yin and moistening lung, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, reinforcing yin essence benefit essence, five viscera settling effect.

Medulla Junci, is slightly cold; Sweet, light; The thoughts of returning home; Lung; Small intestine; Urinary bladder channel.Effect: relieving stranguria by diuresis; Clearing heart fire.Dark plum acid, puckery, flat, returns liver, spleen, lung, large intestine channel.[function cures mainly] astringes the lung, and puckery intestines, promote the production of body fluid, claming ascaris.For chronic cough of deficiency lung, protracted dysentery laxation, abnormal heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract (" Chinese Pharmacopoeia ").

The traditional Chinese medical science thinks, diabetes are mainly that the five internal organs are weak due to the plain body deficiency of Yin, multiple because of eating and drinking without temperance, overfeeding delicious food, and disorder of emotion, labor is wanted excessively, and causes deficiency of kidney-YIN, and lung stomach is scorching; Interpretation of the cause, onset and process of an illness emphasis is that the deficiency of Yin is scorching, and take the deficiency of Yin as this, scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of Yin is scorching, and the bright liquid in consumption Tianjin makes blood viscous, the not smooth stasis of blood that forms of blood; Deficiency of YIN affecting YANG, the deficiency of yang is cold solidifying, also can cause sun in hemostasis.

Advantage of the present invention: 1, Herba Lycopodii Xin Wenyi impairment of yin blood of the present invention, therefore adapted Flower of Mexican Frangipani, Radix Glycyrrhizae are in harmonious proportion, make its institute partially, its taste is glycol, fresh and sweet, has channels sootheing and network vessel quickening, function of promoting blood circulation to disperse blood clots.

2, South Dodder Seed Chinese Dodder Seed tonifying kidney and benefiting sperm, Poria cocos promoting diuresis to eliminate damp pathogen, beneficial spleen and stomach, Radix Ophiopogonis is nourishing Yin and moistening lung, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, and Medulla Junci clearing heart fire, dark plum are quenched one's thirst and are brought down a fever, and more contribute to promoting blood circulation and removing blood stasis hypoglycemic.

3, the present invention is by the balance of Flower of Mexican Frangipani, South Dodder Seed Chinese Dodder Seed, Poria cocos, Radix Ophiopogonis, Medulla Junci conditioning human body-centered liver spleen lung kidney the five internal organs, stagnation resolvation is pure and impure quenches one's thirst, relax the muscles and stimulate the blood circulation with Herba Lycopodii again, thereby invigorating qi and dredging collateral reaches hypoglycemic object, relend making every effort to promote into blood sugar decreasing effect of grape wine appropriateness alcohol, be applicable to the patient such as hyperglycemia, diabetes.

4, the present invention has significant hypoglycemic activity to suprarenin hyperglycemia mouse and tetraoxypyrimidine hyperglycemia mouse.Each 20 of male and female mice is selected in experiment; Adopt respectively suprarenin and tetraoxypyrimidine to set up hyperglycemia mouse model, then give Chinese medicine powder of the present invention, U26452, phenformin and treat and survey glucose level.In the hyperglycemia mouse of bringing out at suprarenin, the present invention can make fasting serum glucose [(16. 58 ± 3. 92) mmol/L] be reduced to (7. 56 ± 2. 63) mmol/L, effect and U26452 comparison, no significant difference (P>0.05); In the hyperglycemia mouse of model induced by alloxan, the present invention is reduced to fasting serum glucose [(15. 56 ± 1. 83) mmol/L] (7. 55 ± 1.65) mmol/L, blood sugar reducing function is significantly better than phenformin (P<0 05), and causes hypoglycemic side effect without U26452.Conclusion: the present invention can significantly reduce the glucose level (P <0. 001) of 2 kinds of modeling animals, and makes blood sugar be down to normal level.

5, the present invention shows through more than the 60 routine sugared dung patients' that make a definite diagnosis clinical observation on the therapeutic effect, and the present invention has remarkable reduction glycosuria patient's glucose level, makes blood sugar recovery normal.

Clinical observation result of the present invention:

1.1 physical data: select the People's Hospital of city outpatient service diabetes B patient 60 examples, be divided at random two groups.Treatment group 30 examples, male 16 examples, female's 14 examples, 30～70 years old age, average (50 ± 1.5) year, the course of disease 6 months～15 years, average (8.0 ± 1.2) year; Control group 30 examples, male 18 examples, female's 12 examples, 29～70 years old age.Two groups of physical data comparing difference not statistically significants (P>0.05), have comparability.

1.2 case selections: with reference to the World Health Organization's (WHO) diabetes diagnosis in 1999 and somatotype standard [1]: diabetic symptom+random time plasma glucose levels >=11.1mmol/L(200mg/dl).The patient's random packet that meets above-mentioned standard is carried out to observational study, and the patient that part takes traditional Chinese medicine stops former Chinese medicine and includes observation in after 2 weeks, and the patient's to be directly brought into not taking traditional Chinese medicine is observed.Two groups of patients all give diabetes Primary Care, comprise dietary control, kinesitherapy and orally-taken blood sugar reducing Western medicine, and hypoglycemic Western medicine adopts N1,N1-Dimethylbiguanide, carries out drug usage and dose adjustment according to blood sugar situation.

1.3 methods for the treatment of: treatment group is taken Chinese medicine powder of the present invention on the basis of taking N1,N1-Dimethylbiguanide.Basic side is made up of the composition of raw materials of following weight part: Herba Lycopodii 10, Flower of Mexican Frangipani 10, Radix Glycyrrhizae 3, South Dodder Seed Chinese Dodder Seed 5, Poria cocos 10, Radix Ophiopogonis 5; Every natural gift are taken for three times, each 4 grams.Control group routine is taken N1,N1-Dimethylbiguanide.Two groups are consistent in dietary control, kinesitherapy, and be 2 months two groups of courses for the treatment of.

1.4 observation index: measure respectively fasting plasma glucose (FPG), postprandial blood sugar (2hBG), glycolated hemoglobin (HbA1c), fasting insulin (FINS), blood fat (TC, TG, HDL-C, LDL-C) before and after treatment, blood sugar determination of glucose oxidase, Regular Insulin is measured with putting the method for exempting from, blood fat is measured with automatic clinical chemistry analyzer, HOMA-IR employing Haffner etc. [3,4] in Homa model, calculate the formula of IR, be HOMA-IR=FPG × FINS/22.5 (FPG unit is mmol/L, and FINS unit is mU/L).

1.5 statistical methods: adopt SPSS 14.0 statistical analysis softwares to carry out statistical procedures.Measurement data adopts t check, enumeration data χ2-test,chi-square test.

2 results: before and after two groups of treatments, the variation of FPG, 2hBG, HbAIc, FINS and HOMA-IR refers to table 1.By in table 1, we can see, treat front two groups of patient FPG, 2hBG, HbAlc, FINS, the horizontal comparing difference not statistically significant of HOMA-IR (P>0.05); After treating, two groups of FPG, 2hBG, HbAlc, FINS, HOMA-IR levels have statistical significance (P<0.05 or P<0.01) with the front comparing differences for the treatment of, before treatment group patient's These parameters and treatment, relatively have significant difference (P<0.01).Prompting treatment group and control group all can reduce diabetes blood sugar, but it is more obvious to improve blood sugar with treatment group.

The variation of FPG, 2hBG, HbAlc, FINS and HOMA-IR before and after table 1 liang group patient treatment

Note: indices is compared with before treatment: * P<0.05, * * P<0.01; The rear two groups of FINS for the treatment of and HOMA-IR compare ^P<0.05, ^^P<0.01.

Before and after two groups of patient treatments, the variation of TC, TG, HDL-C, LDL-C is in table 2.From table 2, we can see the front two groups of patients' for the treatment of the horizontal comparing difference not statistically significant of TC, TG, HDL-C, LDL-C (P>0.05); After treatment, TC, TG, HDL-C, the LDL-C level of two groups have considerable change, wherein TC, TG, LDL-C level have statistical significance (P<0.05) with the front comparing difference for the treatment of, and relatively have significant difference (P<0.01) before treatment group HDL-C level and treatment.Illustrate that treatment group and control group all can improve diabetic subject's blood lipid level, and more remarkable with treatment group effect.

The variation of TC, TG, HDL-C, the horizontal content of LDL-C before and after table 2 liang group patient treatment

Note: indices is compared with before treatment: * P<0.05, * * P<0.01; After treatment, two groups of indices are compared ^P<0.05, ^^P<0.01.

Embodiment

Embodiment 1: a kind of health wine of preventing and treating hyperglycemia, is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10.

Preparation method: Herba Lycopodii Chinese medicine powder is added in grape wine in proportion, after mixing, then be finished product through sterilizing, filtration, encapsulation.

Embodiment 2: a kind of health wine of preventing and treating hyperglycemia, is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10, Rush 3-5, dark plum 3-10.

Preparation method is with embodiment 1.

Claims (2)

1. prevent and treat a health wine for hyperglycemia, it is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10.

2. prevent and treat a health wine for hyperglycemia, it is characterized in that comprising following raw material: Herba Lycopodii Chinese medicine powder and grape wine, both proportionings are 20-200g/L; Described Herba Lycopodii Chinese medicine powder is made up of the composition of raw materials of following weight part: Herba Lycopodii 10-20, Flower of Mexican Frangipani 8-20, Radix Glycyrrhizae 3-10, South Dodder Seed Chinese Dodder Seed 5-10, Poria cocos 10-20, Radix Ophiopogonis 5-10, Rush 3-5, dark plum 3-10.