Summary of the invention
The invention provides one and treat tonsillitic Traditional Chinese medicine lozenge and preparation method; The selected medical material compatibility of Traditional Chinese medicine lozenge of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of reducing swelling and alleviating pain, expelling wind and clearing away heat, promoting blood circulation and detoxication, the symptom such as pharyngitis enlargement, pain causing for tonsillitis has significant curative effect, short treating period, instant effect, safe without toxic side effect, period in a medicine can normally be worked and live, treating both the principal and secondary aspects of a disease, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
One is treated tonsillitic Traditional Chinese medicine lozenge, and raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:
Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:
Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:
Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:
Treat a preparation method for tonsillitic Traditional Chinese medicine lozenge, comprise following processing step:
(1) Herba Polygoni cymosi, Herba Bidentis Bipinnatae and Radix Tinosporae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Herba Thesii, Radix Aerio Fici Microcarpae and Herba Bulbophylli inconspicui are cleaned, immersed 80% the alcohol solution dipping 1~2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 DEG C of simmer down tos, relative density is 1.12~1.16 is for subsequent use;
(3) catechu, Herba Macleayae Cordatae, Uroctea compatilis Koch., Herba Asplenii Incisi and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) Radix Clerodenri Cyrtophylli, Caulis Arcangelisiae, Herba aeginetiae indicae, Cortex Ilicis Rotundae and Herba Excoecariae cochinchinensis are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 DEG C, relative density is 1.10~1.13, for subsequent use;
(5) above-mentioned steps (1)~(4) prepared juice, thick paste and fine powder are mixed, make tablet, obtain the tonsillitic Traditional Chinese medicine lozenge for the treatment of of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Polygoni cymosi: sour in the mouth, cold nature.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For upper respiratory tract infection, tracheitis, pertussis, acute tonsillitis, enteritis, dysentery, oedema due to nephritis; Herpes zoster is controlled in external, eczema, carbuncle furuncle and phyma poison, venom.
Herba Thesii: acrid in the mouth, hardship, puckery, property is flat.Heat clearing away, removing toxic substances, separates administration.For enteritis, lung abscess, tonsillitis, middle administration, acute mastitis, tuberculous lymphadenitis, acute cystitis, upper respiratory tract infection, lumbago due to renal deficiency, giddy, seminal emission, spermatorrhea." Guizhou side's medicine among the people collection " carries: " control giddy weak, lumbago, seminal emission, spermatorrhea.”
Catechu: bitter in the mouth, puckery, cold nature.Removing heat-phlegm, sore hemostasis.For cough due to lung-heat, spitting of blood, diarrhoea, infantile dyspepsia, external is controlled skin infection and is not closed up for a long time, skin eczema, aphtha, tonsillitis.
Herba Macleayae Cordatae: bitter in the mouth, cold in nature, very toxic.The removing toxic substances of dispeling the wind, dissipating blood stasis for subsidence of swelling.For traumatic injury, rheumatic arthritis, carbuncle furuncle and phyma poison, ulcer of the lower limb, furuncle of finger, abscess, acute tonsillitis, otitis media, trichomonal vaginitis, scalds stubborn dermatitis." Jiangxi traditional herbal medicine " carries: " control ecthyma, stubborn dermatitis, white baldhead, soaks in vinegar seven, eight with leaf, and the rotten deposited affected part of pestle, changes for one day one." modern medicine study confirmation, three kinds of alkaloids in Herba Macleayae Cordatae have nematocidal effect, and some antibacterial and fungus are also had to inhibition effect.
Radix Aerio Fici Microcarpae: bitter in the mouth, property are put down; Return lung, spleen, kidney channel.Expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease stomachache, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " clearing away heat and expelling pathogen in the exterior, diaphoresis rash.Control influenza, flu, tonsillitis, eye conjunctivitis, malaria, pertussis, measles without adequate eruption.”
Radix Clerodenri Cyrtophylli: bitter in the mouth, cold in nature; GUIXIN, Liver Channel.Heat clearing away, removing toxic substances, removing heat from blood.Main encephalitis b, epidemic encephalitis, the high heat of flu, epidemic encephalitis, parotitis, heat in blood is sent out class, measles pneumonia, icteric tripe inflammation, diarrhea of heat type hematodiarrhoea, rheumatism pyretic arthralgia, headache, laryngopharynx swelling and pain, acute toothache, orchitis.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, dissipating blood stasis hemostasis.Control enteritis, bacillary dysentery, pharyngolaryngitis, tonsillitis, parotitis, cold, fever, gingiva bleeding gingival hemorrhage.”
Herba Bidentis Bipinnatae: bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and detumescence.Cure mainly malaria, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, acute appendicitis, laryngopharynx swelling and pain, traumatic injury, snake bite and insect sting.Modern medicine study confirmation, the ethanol immersion of Herba Bidentis Bipinnatae has bacteriostasis to gram-positive bacterium in vitro, and flower, stem also have bacteriostasis to staphylococcus aureus.
Herba Bulbophylli inconspicui: sweet in the mouth, light, cool in nature; Enter lung, stomach two warps.Nourishing YIN and clearing away heat, preventing phlegm from forming and stopping coughing.For xeropulmonary cough, hemoptysis of pulmonary tuberculosis, calentura excessive thirst, tonsillitis.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " moistening the lung and resolving phlegm, tonifying-Yin and nourishing-stomach.Control pulmonary tuberculosis cough, spitting of blood, cough due to chronic tracheitis, pneumonia convalescent period, chronic pharyngalgia, chronic gastritis, achlorhydria, inappetence, seminal emission.”
Uroctea compatilis Koch.: salty in the mouth, hardship, cold in nature.Heat clearing away, removing toxic substances, hemostasis.For pharyngolaryngitis, tonsillitis, oral cavity, gingival ulcer, epistaxis and incised wound are hemorrhage.Supplement to the Herbal carries: " main epistaxis and incised wound, hematochezia are more than.Right-falling stroke is got in worm juice point skin ulcer and in nose.Also treat outfield fowl disease hematochezia.”
Caulis Arcangelisiae: bitter in the mouth, cold in nature; GUIXIN, lung, large intestine channel.Clearing away heat-damp and promoting diuresis, removing toxic substances pain relieving.Be used for preventing influenza, leptospirosis, control acute gastroenteritis, bacillary dysentery, tonsillitis, bronchitis, malaria; Eye conjunctivitis is controlled in external, skin eczema, impetigo, vaginitis.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing.Control enteritis, bacillary dysentery, tonsillitis, bronchitis, furuncle and phyma, malaria, dermatitis, eczema, impetigo, tinea pedis infects.”
Herba aeginetiae indicae: bitter in the mouth, cool in nature, slightly poisonous.Removing toxic substances and promoting subsidence of swelling, clearing away heat and cooling blood.For tonsillitis, pharyngolaryngitis, urinary tract infection, osteomyelitis; Venom is controlled in external, furuncle.The doctor of Soviet Union " Chinese herbal medicine handbook " is carried: " heat-clearing and toxic substances removing.Treating tonsillitis, pharyngolaryngitis, urinary tract infection.”
Radix Tinosporae: bitter in the mouth, cold in nature; Return lung, large intestine channel.Heat-clearing and toxic substances removing, relieving sore throat and pain.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, relieving sore throat and pain.Control diphtheria, acute pharyngolaryngitis, tonsillitis, heat syndrome cough aphonia, bacillary dysentery, traumatic injury, snakebite.”
Herba Asplenii Incisi: bitter in the mouth, micro-sweet, cool in nature.Heat-clearing and toxic substances removing, cough-relieving sore-throat relieving, inducing diuresis and reducing edema, hemostasis and pain-relieving.For influenza, cold cough, tonsillitis, parotitis, conjunctival congestion and swelling pain, enteritis, dysentery, agalactia; The swollen furunculosis of skin ulcer is controlled in external, traumatic injury, and eczema, burn and scald, knife injury is hemorrhage." conventional glossary of Herbs and Drugs among the people " carries: " control cough, spit blood, remove lung-heat.”
Cortex Ilicis Rotundae: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, dampness removing pain relieving.The heating that cures cold, tonsillitis, laryngopharynx swelling and pain, acute, chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic arthritis, traumatic injury, burn.Carry in Jiangxi " medical herbs handbook ": " clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.The heating that cures cold, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, gastric and duodenal ulcers, traumatic injury, rheumatism." modern medicine study confirmation, Cortex Ilicis Rotundae is applicable to suppurative illness (as skin sore and furuncle, cellulitis, deep abscess etc.), upper respiratory tract infection, acute tonsillitis, acute gastroenteritis, bacillary dysentery, burn infection and hands postoperative infection prevention etc.
Herba Excoecariae cochinchinensis: acrid in the mouth, micro-hardship, property is flat, slightly poisonous; Return Liver Channel.Stimulate the menstrual flow, active, pain relieving.Cure mainly measles, parotitis, tonsillitis, angina pectoris, renal colic, lumbar muscle strain." Xinhua's book on Chinese herbal medicine outline " carries: " dredge the meridian passage, pain relieving, for measles, parotitis, tonsillitis, angina pectoris, renal colic; Lumbar muscle strain.”
Folium Callicarpae Formosanae: bitter in the mouth, puckery, property is flat.Hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn." middle traditional Chinese medicines are planted illustrated handbook " carries: " hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, wound hemorrhage, pneumorrhagia and the hemorrhage good effect that all has of having tooth pulled out.”
The present invention compared with prior art, has following beneficial effect:
The selected medical material compatibility of Traditional Chinese medicine lozenge of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of reducing swelling and alleviating pain, expelling wind and clearing away heat, promoting blood circulation and detoxication, the symptom such as pharyngitis enlargement, pain causing for tonsillitis has significant curative effect, short treating period, instant effect, safe without toxic side effect, period in a medicine can normally be worked and live, treating both the principal and secondary aspects of a disease, wide popularization and application on clinic.Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of Traditional Chinese medicine lozenge effective ingredient of the present invention are:
The preparation method of Traditional Chinese medicine lozenge of the present invention, comprises following processing step:
(1) Herba Polygoni cymosi, Herba Bidentis Bipinnatae and Radix Tinosporae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Herba Thesii, Radix Aerio Fici Microcarpae and Herba Bulbophylli inconspicui are cleaned, immersed 80% the alcohol solution dipping 1~2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 DEG C of simmer down tos, relative density is 1.12~1.16 is for subsequent use;
(3) catechu, Herba Macleayae Cordatae, Uroctea compatilis Koch., Herba Asplenii Incisi and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) Radix Clerodenri Cyrtophylli, Caulis Arcangelisiae, Herba aeginetiae indicae, Cortex Ilicis Rotundae and Herba Excoecariae cochinchinensis are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 DEG C, relative density is 1.10~1.13, for subsequent use;
(5) above-mentioned steps (1)~(4) prepared juice, thick paste and fine powder are mixed, make tablet, obtain the tonsillitic Traditional Chinese medicine lozenge for the treatment of of the present invention.
Usage and dosage: oral, buccal after meal, every day 3 times, each 1 time sooner or later, each 1 (every 0.5g); Within 5 days, be 1 course for the treatment of, can fully recover 3~5 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
Raw material composition and the weight of Traditional Chinese medicine lozenge effective ingredient of the present invention are:
Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of Traditional Chinese medicine lozenge effective ingredient of the present invention are:
Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of Traditional Chinese medicine lozenge effective ingredient of the present invention are:
Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
Raw material composition and the weight of Traditional Chinese medicine lozenge effective ingredient of the present invention are:
Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the tonsillitic Traditional Chinese medicine lozenge for the treatment of, select the routine clinical observation of tonsillitis patient 532 of making a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups at random, treatment group 266 examples, wherein male's 132 examples, women's 134 examples, 11~46 years old age, 28.5 years old mean age, average 5.6 years of the course of disease; Matched group 266 examples, wherein male's 133 examples, women's 133 examples, 10~45 years old age, 27.5 years old mean age, average 5.2 years of the course of disease.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Traditional Chinese medicine lozenge of the present invention, oral, buccal after meal, every day 3 times, each 1 time sooner or later, each 1 (every 0.5g); Within 5 days, be 1 course for the treatment of, take continuously 3~5 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken prednisone acetate tablets, oral, one time 1~2, one day 2~12, the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: the symptom symptom such as pharyngitis enlargement, pain that tonsillitis causes all disappears, it is normal that bottleneck throat recovers.
(2) effective: above-mentioned symptom obviously alleviates, throat feels to be clearly better.
(3) effective: symptom alleviates to some extent, throat's sensation takes a turn for the better to some extent.
(4) invalid: by treating rear symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of medicine of the present invention, cure 178 examples, effective 49 examples, effective 35 examples, invalid 4 examples, cure rate 66.9%, total effective rate 98.5%.
In matched group, cure 67 examples, effective 36 examples, effective 20 examples, invalid 143 examples, cure rate 25.2%, total effective rate 46.2%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Peng, man, 12 years old, people from Liaoyuan, Jilin.Patient's nasal obstruction, hypopnea 2 years, and had obviously and increase the weight of at recent three months, repeatedly there is inflammation, pain in throat, AD is the slight pure chronic rhinitis of chronic tonsillitis, take antibiotic without obvious therapeutic effect, to our hospital upon somebody's introduction, take Traditional Chinese medicine lozenge treatment of the present invention, take after 1 course for the treatment of, symptom takes a turn for the better to some extent, continues to take after 1 course for the treatment of transference cure, recovery from illness, follows up a case by regular visits to after 1 year without recurrence.
2, revive certain, female, 17 years old, Liaoning people from Huludao City.Patient suffers from tonsillitis for many years, the i.e. morbidity of each flu, laryngopharynx swelling and pain, fever with chills, Western medicine " antibiotic " has been used a lot, still has more afterwards recurrence, repeatedly show effect more than ten years, rear employing Traditional Chinese medicine lozenge treatment of the present invention, took after 1 course for the treatment of, symptom takes a turn for the better to some extent, body temperature is normal, continues to take after 2 courses for the treatment of transference cure, cure, follow up a case by regular visits to so far without recurrence.
3, Jiang, man, 23 years old, people from Huangpu District, Shanghai.Patient suffers from tonsillitis 5 years, has throughout the year generation, when outbreak, generates heat, laryngopharynx swelling and pain, aversion to cold is heavy when light when symptom, Western medicine " antibiotics " is oral, injection, and Chinese patent medicine " LIUSHEN WAN ", containing changing, can not be fully recovered, after take Traditional Chinese medicine lozenge of the present invention treatment, take after 1 course for the treatment of, swell and ache and be clearly better, continue to take after 2 courses for the treatment of, the disappearance of swelling and ache, body temperature is normal, reach clinical cure object, after 1 year, follow up a case by regular visits to not recurrence.
4, Xue, man, 31 years old, people from Beijing Shunyi.Pharyngeal and the congested redness of tonsil of patient, above has pus point or microabscess, red tongue, yellow fur, slippery and rapid pulse, takes Traditional Chinese medicine lozenge treatment of the present invention, takes after 1 course for the treatment of, and symptom alleviates to some extent, take after 3 courses for the treatment of, transference cure, it is normal that physiological function recovers, and follows up a case by regular visits to without recurrence after half a year.
5, Cai, female, 45 years old, Tsuen Wan, Hong Kong people from district.Ill 3 years of patient, there is the feature of throat disease pathological change: pharyngeal congestion, lymph foilicie hyperplasia, lateral pharyngeal band plumpness, tonsil is large, epiglottis is congested, it is tired etc. to swell and ache, often speak.Remove hospital admission, pharyngeal congestion is obvious, and lymph foilicie hyperplasia is obvious, and lateral pharyngeal band is obviously plump, and tonsil slightly increases, and epiglottis is slightly congested.Patient is pharyngeal to swell and ache, perceptual image numbness the same, babble is clear, does not even want to speak, doctor recommends to take after 1 course for the treatment of, symptom takes a turn for the better to some extent, continue to take after 1 course for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to without recurrence.
6, the Yan, female, 33 years old, Distributions in Liaocheng of Shandong Province people.Patient is after a heavy cold, there is acute tonsillitis, the little pus point of adularescent on tonsil, in throat, there is foreign body sensation, the medicine of taking treatment flu has no recovery from illness, and local hospital takes medicine to eat, although symptom is controlled to some extent, but the indistinct pain of tonsil is not eliminated, there is little pus point in tonsil, pain increases the weight of again, and removing hospital admission is chronic tonsillitis, patient takes Traditional Chinese medicine lozenge treatment of the present invention, take after 1 course for the treatment of, symptom takes a turn for the better to some extent, continues to take after 2 courses for the treatment of, transference cure, did not recur call-on back by phone after 2 years.