CN103908565A - Traditional Chinese medicinal veterinary granules for preventing and treating atypical newcastle disease and preparation method thereof - Google Patents
Traditional Chinese medicinal veterinary granules for preventing and treating atypical newcastle disease and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicinal veterinary preparations, and relates to traditional Chinese medicinal veterinary granules for preventing and treating the atypical newcastle disease and a preparation method thereof. The traditional Chinese medicinal veterinary granules for preventing and treating atypical newcastle disease are prepared from the following traditional Chinese medicinal materials: honeysuckle, fructus forsythiae, cyrtomium fortunei, gypsum, rhizoma anemarrhenae, raw rehmannia root, cornu bubali, astragalus membranaceus, rhizoma atractylodis macrocephalae, adenophora stricta, platycodon grandiflorum, thunberg fritillary bulb, ephedra, radix paeoniae rubra, moutan bark, dried tangerine peel, cape jasmine fruit and liquorice. The preparation method of the traditional Chinese medicinal veterinary granules for preventing and treating the atypical newcastle disease comprises the steps of extracting, concentrating, granulating and the like. The medicinal effective ingredients of the preparation can be easily absorbed by poultry, and has a remarkable curative effect on the atypical newcastle disease, the total effective rate of the traditional Chinese medicinal veterinary granules is over 95 percent, and the cure rate is over 89 percent. The traditional Chinese medicinal veterinary granules do not have drug residues, toxic or side effects.
Description
Technical field
The invention belongs to herbal medicine formulation art, relate to a kind of for preventing and treating herbal medicine granular preparation of atypical Newcastle disease and preparation method thereof.
Background technology
Newcastle disease is that the one being caused by Avian pneumo-encephalitis virus is acute, height contagious infection disease, has and distributes extensively, propagates fast, mortality rate high.Typical Newcastle disease clinically main manifestations is that the septicemia such as fervescence, dyspnea, severe diarrhea, nervous disorder and mucosa, serous coat are hemorrhage change.At present, along with constantly improving and raising of immune system, vaccine quality, the extensive popular seldom generation of newcastle disease epidemic disease that typical case, speed are sent out, but atypical Newcastle Disease but constantly occurs and rises year by year.Atypical newcastle disease mainly occurs in the chicken group that vaccine immunity is crossed, and its harm object is mainly chickling and laying hen, and has a strong impact on the growth promoter of chickling, often because of immunity of organisms decline susceptible other diseases; Laying hen group infects this virus and often causes egg production and eggs ' quality sharp fall thereof, causes huge economic loss to poultry husbandry.For the chicken group that atypical newcastle disease the occurs modes that adopt urgent prevention and Drug therapy to combine more, antibiotic, antibiotics to atypical newcastle without therapeutical effect, thereby and take for a long time and easily cause dysbacteriosis initiation autogenous infection in intestinal.Veterinary drug granules is in Chinese veterinarian's theoretical basis, in conjunction with modern pharmaceutical technology, have quality controllable, determined curative effect, be convenient to absorb, easy to use, the advantages such as bioavailability height.
Summary of the invention
Technical problem to be solved by this invention is; provide a kind of for preventing and treating the technical scheme of herbal medicine granular preparation of atypical Newcastle disease and preparation method thereof for the deficiencies in the prior art; this veterinary drug granules is evident in efficacy; noresidue; have no side effect, can not cause dysbacteriosis in poultry intestinal tract, the preparation method of said preparation is simple; quality controllable, be suitable for modern large-scale production.
Provided by the invention a kind of for preventing and treating the herbal medicine granular preparation of atypical Newcastle disease, it is characterized in that, it is to be formed by the Chinese drug preparation of following weight portion: Flos Lonicerae 15～30 weight portions, Fructus Forsythiae 15～30 weight portions, Rhizoma Osmundae 15～20 weight portions, Gypsum Fibrosum 40～50 weight portions, the Rhizoma Anemarrhenae 20～25 weight portions, the Radix Rehmanniae 10～20 weight portions, Cornu Bubali 20～25 weight portions, the Radix Astragali 10～20 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, Radix Adenophorae (Radix Glehniae) 10～20 weight portions, Radix Platycodonis 15～25 weight portions, Bulbus Fritillariae Thunbergii 15～25 weight portions, Herba Ephedrae 10～20 weight portions, Radix Paeoniae Rubra 30～45 weight portions, Cortex Moutan 25～35 weight portions, Pericarpium Citri Reticulatae 25～35 weight portions, Fructus Gardeniae 10～20 weight portions, Radix Glycyrrhizae 10～20 weight portions.
Veterinary drug granules involved in the present invention is realized as follows: herbal medicine preparation involved in the present invention is to take and obtain Traditional Chinese drug mixture by described weight portion proportioning, through invading profit, extraction, concentrate and granulating process step is prepared from.
The invention has the beneficial effects as follows, this herbal medicine preparation combines Traditional Chinese Medicine with modern veterinary theory, have not sick diseases prevention, preventing exacerbation after being taken ill, effect for the treatment of both the principal and secondary aspects of a disease.This preparation medicine effective ingredient is easy to poultry and absorbs, and remarkable to the therapeutic effect of atypical newcastle disease, effective percentage is more than 95%, and cure rate is more than 89%, and noresidue, has no side effect., medicine short for poultry digestive tract optimized preparation technology in physiological characteristicies such as the enteral time of staying are few, and preparation method is simple, quality controllable, is suitable for modern large-scale production, and the medicament of making has the advantages such as oral administration convenience.
The specific embodiment
With specific embodiment, content of the present invention is described further below.
embodiment 1
For preventing and treating a herbal medicine granular preparation for atypical Newcastle disease, it is to be formed by the Chinese drug preparation of following weight: 15 kilograms of Flos Loniceraes, 15 kilograms of Fructus Forsythiaes, 15 kilograms of Rhizoma Osmundae, 40 kilograms of Gypsum Fibrosum, 20 kilograms of the Rhizoma Anemarrhenaes, 10 kilograms, the Radix Rehmanniae, 20 kilograms of Cornu Bubalis, 10 kilograms of the Radixs Astragali, 20 kilograms of the Rhizoma Atractylodis Macrocephalaes, 10 kilograms of Radix Adenophorae (Radix Glehniae), 15 kilograms of Radix Platycodoniss, 15 kilograms of Bulbus Fritillariae Thunbergiis, 10 kilograms, Herba Ephedrae, 30 kilograms of Radix Paeoniae Rubra, 25 kilograms of Cortex Moutans, 25 kilograms of Pericarpium Citri Reticulataes, 10 kilograms of Fructus Gardeniaes, 10 kilograms, Radix Glycyrrhizae.
The preparation method that the present invention relates to above-mentioned granular preparation, comprises the following steps:
(1) extract: take all Chinese medicine dropping into successively in Chinese medicine extracting tank by above-mentioned weight proportion, to the purification water enchroachment (invasion) profit that adds 8 times of each Chinese medicine gross weights in extraction pot, invade profit and after 4～5 hours, carry out reflux, extract, and within 4 hours, make active constituents of medicine extracting solution;
(2) concentrated: adopt concentrating under reduced pressure method to concentrate extracting solution, being concentrated in temperature is 60 ℃ of ointment that the density under condition is 1.26～1.30g/cm3;
(3) granulate: to the auxiliary materials and mixing that adds ointment weight 45～55% in above-mentioned ointment, described adjuvant is dextrin, sucrose or anhydrous glucose, the weight ratio of dextrin and sucrose or anhydrous glucose is 1:5, add 2% ethanol moistening of ointment weight, through granulating, drying, then obtain this herbal medicine granular preparation through granulate again under 70 ℃ of conditions.
Described herbal medicine granule adds consumption by 0.1～0.2% of chicken amount of drinking water.
This preparation lung-heat clearing and detoxification, dispersing and lowering lung-QI, can be used for the ill chicken group of early stage atypical Newcastle disease, and total effective rate is 95%, and cure rate is 89%.
embodiment 2
For preventing and treating a herbal medicine granular preparation for atypical Newcastle disease, it is to be formed by the Chinese drug preparation of following weight: 30 kilograms of Flos Loniceraes, 30 kilograms of Fructus Forsythiaes, 20 kilograms of Rhizoma Osmundae, 50 kilograms of Gypsum Fibrosum, 25 kilograms of the Rhizoma Anemarrhenaes, 20 kilograms, the Radix Rehmanniae, 25 kilograms of Cornu Bubalis, 20 kilograms of the Radixs Astragali, 30 kilograms of the Rhizoma Atractylodis Macrocephalaes, 20 kilograms of Radix Adenophorae (Radix Glehniae), 25 kilograms of Radix Platycodoniss, 25 kilograms of Bulbus Fritillariae Thunbergiis, 20 kilograms, Herba Ephedrae, 45 kilograms of Radix Paeoniae Rubra, 35 kilograms of Cortex Moutans, 35 kilograms of Pericarpium Citri Reticulataes, 20 kilograms of Fructus Gardeniaes, 20 kilograms, Radix Glycyrrhizae.
The preparation method that the present invention relates to above-mentioned granular preparation, comprises the following steps:
(1) extract: take all Chinese medicine dropping into successively in Chinese medicine extracting tank by above-mentioned weight proportion, to the purification water enchroachment (invasion) profit that adds 8 times of each Chinese medicine gross weights in extraction pot, invade profit and after 4～5 hours, carry out reflux, extract, and within 4 hours, make active constituents of medicine extracting solution;
(2) concentrated: adopt concentrating under reduced pressure method to concentrate extracting solution, being concentrated in temperature is 60 ℃ of ointment that the density under condition is 1.26～1.30g/cm3;
(3) granulate: to the auxiliary materials and mixing that adds ointment weight 45～55% in above-mentioned ointment, described adjuvant is dextrin, sucrose or anhydrous glucose, the weight ratio of dextrin and sucrose or anhydrous glucose is 1:5, add 2% ethanol moistening of ointment weight, through granulating, drying, then obtain this herbal medicine granular preparation through granulate again under 70 ℃ of conditions.
Described herbal medicine granule adds consumption by 0.3～0.5% of chicken amount of drinking water.
This preparation heat-clearing and toxic substances removing, the blood stasis dispelling of eliminating the phlegm, removing heat from blood is regulated the flow of vital energy, and can be used for the ill chicken group of the atypical Newcastle disease of middle and advanced stage, and total effective rate is 96%, and cure rate is 90%.
embodiment 3
For preventing and treating a herbal medicine granular preparation for atypical Newcastle disease, it is to be formed by the Chinese drug preparation of following weight: 25 kilograms of Flos Loniceraes, 20 kilograms of Fructus Forsythiaes, 18 kilograms of Rhizoma Osmundae, 45 kilograms of Gypsum Fibrosum, 20 kilograms of the Rhizoma Anemarrhenaes, 15 kilograms, the Radix Rehmanniae, 25 kilograms of Cornu Bubalis, 18 kilograms of the Radixs Astragali, 25 kilograms of the Rhizoma Atractylodis Macrocephalaes, 15 kilograms of Radix Adenophorae (Radix Glehniae), 20 kilograms of Radix Platycodoniss, 20 kilograms of Bulbus Fritillariae Thunbergiis, 18 kilograms, Herba Ephedrae, 45 kilograms of Radix Paeoniae Rubra, 30 kilograms of Cortex Moutans, 30 kilograms of Pericarpium Citri Reticulataes, 15 kilograms of Fructus Gardeniaes, 18 kilograms, Radix Glycyrrhizae.
The preparation method that the present invention relates to above-mentioned granular preparation, comprises the following steps:
(1) extract: take all Chinese medicine dropping into successively in Chinese medicine extracting tank by above-mentioned weight proportion, to the purification water enchroachment (invasion) profit that adds 8 times of each Chinese medicine gross weights in extraction pot, invade profit and after 4～5 hours, carry out reflux, extract, and within 4 hours, make active constituents of medicine extracting solution;
(2) concentrated: adopt concentrating under reduced pressure method to concentrate extracting solution, being concentrated in temperature is 60 ℃ of ointment that the density under condition is 1.26～1.30g/cm3;
(3) granulate: to the auxiliary materials and mixing that adds ointment weight 45～55% in above-mentioned ointment, described adjuvant is dextrin, sucrose or anhydrous glucose, the weight ratio of dextrin and sucrose or anhydrous glucose is 1:5, add 2% ethanol moistening of ointment weight, through granulating, drying, then obtain this herbal medicine granular preparation through granulate again under 70 ℃ of conditions.
Described herbal medicine granule adds consumption by 0.2～0.5% of chicken amount of drinking water.
This preparation heat-clearing and toxic substances removing, the blood stasis dispelling of eliminating the phlegm, removing heat from blood is regulated the flow of vital energy, and can be used for the ill chicken group of the atypical Newcastle disease of middle and advanced stage, and total effective rate is 97%, and cure rate is 92%.
Claims (3)
1. one kind for preventing and treating the herbal medicine granular preparation of atypical Newcastle disease, it is characterized in that, it is to be formed by the Chinese drug preparation of following weight portion: Flos Lonicerae 15～30 weight portions, Fructus Forsythiae 15～30 weight portions, Rhizoma Osmundae 15～20 weight portions, Gypsum Fibrosum 40～50 weight portions, the Rhizoma Anemarrhenae 20～25 weight portions, the Radix Rehmanniae 10～20 weight portions, Cornu Bubali 20～25 weight portions, the Radix Astragali 10～20 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, Radix Adenophorae (Radix Glehniae) 10～20 weight portions, Radix Platycodonis 15～25 weight portions, Bulbus Fritillariae Thunbergii 15～25 weight portions, Herba Ephedrae 10～20 weight portions, Radix Paeoniae Rubra 30～45 weight portions, Cortex Moutan 25～35 weight portions, Pericarpium Citri Reticulatae 25～35 weight portions, Fructus Gardeniae 10～20 weight portions, Radix Glycyrrhizae 10～20 weight portions.
2. a kind ofly it is characterized in that for preventing and treating the preparation method of herbal medicine granular preparation of atypical Newcastle disease for the preparation of claimed in claim 1, comprise the following steps:
(1) extract: take all Chinese medicine dropping into successively in Chinese medicine extracting tank by above-mentioned weight proportion, to the purification water enchroachment (invasion) profit that adds 8 times of each Chinese medicine gross weights in extraction pot, invade profit and after 4～5 hours, carry out reflux, extract, and within 4 hours, make active constituents of medicine extracting solution;
(2) concentrated: adopt concentrating under reduced pressure method to concentrate extracting solution, being concentrated in temperature is 60 ℃ of ointment that the density under condition is 1.26～1.30g/cm3;
(3) granulate: to the auxiliary materials and mixing that adds ointment weight 45～55% in above-mentioned ointment, described adjuvant is dextrin, sucrose or anhydrous glucose, the weight ratio of dextrin and sucrose or anhydrous glucose is 1:5, add 2% ethanol moistening of ointment weight, through granulating, drying, then obtain this herbal medicine granular preparation through granulate again under 70 ℃ of conditions.
3. according to claim 1 a kind of for preventing and treating the herbal medicine granular preparation of atypical Newcastle disease, it is characterized in that, it is to be formed by the Chinese drug preparation of following weight: 25 kilograms of Flos Loniceraes, 20 kilograms of Fructus Forsythiaes, 18 kilograms of Rhizoma Osmundae, 45 kilograms of Gypsum Fibrosum, 20 kilograms of the Rhizoma Anemarrhenaes, 15 kilograms, the Radix Rehmanniae, 25 kilograms of Cornu Bubalis, 18 kilograms of the Radixs Astragali, 25 kilograms of the Rhizoma Atractylodis Macrocephalaes, 15 kilograms of Radix Adenophorae (Radix Glehniae), 20 kilograms of Radix Platycodoniss, 20 kilograms of Bulbus Fritillariae Thunbergiis, 18 kilograms, Herba Ephedrae, 45 kilograms of Radix Paeoniae Rubra, 30 kilograms of Cortex Moutans, 30 kilograms of Pericarpium Citri Reticulataes, 15 kilograms of Fructus Gardeniaes, 18 kilograms, Radix Glycyrrhizae.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168357A (en) * | 2015-09-10 | 2015-12-23 | 重庆布尔动物药业有限公司 | Effect of stephania terandra and radix astragali oral liquor on common infectious diseases serum antibody titers of chicken |
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| CN101690810A (en) * | 2009-10-21 | 2010-04-07 | 张勇飞 | Tetravalent inactivated vaccine adjuvant against Newcastle Disease, infectious bronchitis, egg drop syndrome and bird flu and preparation method thereof |
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| CN101690810A (en) * | 2009-10-21 | 2010-04-07 | 张勇飞 | Tetravalent inactivated vaccine adjuvant against Newcastle Disease, infectious bronchitis, egg drop syndrome and bird flu and preparation method thereof |
| CN102100835A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Plague-removing and cystoma-treating traditional veterinary medicament and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168357A (en) * | 2015-09-10 | 2015-12-23 | 重庆布尔动物药业有限公司 | Effect of stephania terandra and radix astragali oral liquor on common infectious diseases serum antibody titers of chicken |
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