CN103908416A - Skincare active factor composition - Google Patents
Skincare active factor composition Download PDFInfo
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- CN103908416A CN103908416A CN201410162368.8A CN201410162368A CN103908416A CN 103908416 A CN103908416 A CN 103908416A CN 201410162368 A CN201410162368 A CN 201410162368A CN 103908416 A CN103908416 A CN 103908416A
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Abstract
The invention discloses a skincare active factor composition, including a solvent, as well as 10-100 pg of EGF, 5-80pg of aFGF, 5-80 pg of bFGF and 10-100pg of KGF relative to 1ml of the solvent. The skincare active factor composition disclosed by the invention is added in cosmetics to effectively interact with skin cells, to promote the nutrition metabolism of epithelial cells, protect the skin and prevent and treat skin injury caused by various reasons.
Description
Technical field
The present invention relates to cosmetics technical field, be specifically related to a kind of skin care activity factor composition.
Background technology
Skin is the organ of human body maximum, is also the first natural cover for defense of skin.Skin surface has the natural sebum film of one deck, and sebum film is the weakly acidic protecting film that the sebum of the perspiration drained by sweat gland and smegma forms through the emulsifying of air at skin surface.Its effect is mainly the effects such as moisturizing, antibacterial, sterilization.Skin aging is the skin aging phenomenon being caused by natural cause or non-natural cause.
After people is born, skin histology is day by day flourishing, and function is active gradually, will start to degenerate when certain age of arrival, and this degeneration is often slowly carried out unconsciously people.The growth stage of skin histology generally ended at about 25 years old, had this phase of person for " bent angle of skin ", carried out with aging from after this growth simultaneously, and Elastic fibers is chap gradually.The reason that affects skin aging has a lot, as improper in age, health, spirit, nutrition, living habit, endocrine regulation, skin care etc., except the age is unique inevitable factor, all the other factors all can change.So various cosmetics (as oral health product, skin care item, cosmetics etc.) emerge in an endless stream.
Nowadays skin protection has become the women's that likes to be beautiful required course, this wherein cosmetics and skin care item be definitely the staple product of skin protection, and these product categories are various, quality and effect are also all uneven.Traditional skin nursing is only confined to oil film and covers and keep the physical methods such as moisture.In recent years, biology gene engineering technology tremendous development and had influence on the every aspect of life sciences, all brought brand-new opportunity to develop also to cosmetics industry, cosmetics are from traditional chemistry beauty treatment, plant beauty to biological beauty and gene beauty treatment development simultaneously.
Summary of the invention
Of the present inventionly be to provide a kind of skin care activity factor composition, add in cosmetics, can effectively have an effect with Skin Cell, promote epithelial cell Nutrition and Metabolism, protection skin, the skin injury that prevention and treatment cause due to a variety of causes.
For achieving the above object, the technical solution adopted in the present invention is as follows:
A kind of skin care activity factor composition, it comprises solvent, and following component taking solvent as benchmark:
EGF 10-100pg/ml
aFGF 5-80pg/ml
bFGF 5-80pg/ml
KGF 10-100pg/ml。
As the preferred embodiment of one of the present invention, described skin care activity factor composition comprises solvent, and following component taking solvent as benchmark:
EGF 10-50pg/ml
aFGF 5-50pg/ml
bFGF 5-40pg/ml
KGF 10-50pg/ml。
As the preferred embodiment of one of the present invention, described skin care activity factor composition comprises solvent, and following component taking solvent as benchmark:
EGF 40-60pg/ml
aFGF 20-50pg/ml
bFGF 20-50pg/ml
KGF 40-60pg/ml。
On the basis of such scheme, as the preferred embodiment of one of the present invention, described skin care activity factor composition also comprises the VEGF 1-10pg/ml taking solvent as benchmark.
On the basis of such scheme, as the preferred embodiment of one of the present invention, described skin care activity factor composition also comprises insulin-like growth factor IGF-1, and the addition of insulin-like growth factor IGF-1 is taking the volume of solvent as benchmark is as 5-15 pg/ml.
" EGF " in the present invention refers to epidermal growth factor; EGF can promote body epidermis cell, epithelial cell, fibroblastic growth, division and metabolism, promotes microvascular growth, improves the microenvironment of Growth of Cells.Therefore it has good reparation, nursing role to damaged skin, sensitive skin, trauma skin and reconstruction property skin.Although the epidermal growth factor of separate sources structurally has difference slightly, their effect and effect are very close.
" aFGF " in the present invention refers to acid fibroblast somatomedin; AFGF can promote fibroblastic growth, has improved the ability of the synthetic collagen protein of skin, from improving in essence the situation of skin, and the effect such as there is efficient reparation skin injury, smooth away wrinkles.BFGF in the present invention refers to basic fibroblast growth factor; It has skin protection, repair, improves the microenvironment of Growth of Cells, promotes the synthetic of elastic fiber and collagen protein, make skin high resilience, make skin in sliding tender state, can promote fibroblastic growth promoter, constantly replace aged cells with new cell; BFGF can also reduce the content of melanin and coloured corpuscle in Skin Cell, alleviates the calmness of skin pigment, has whitening, effect of dispelling spots; In addition bFGF also has the effect of repairing skin and cicatrix.
" KGF " in the present invention refers to keratinocyte growth factor; KGF strengthens epithelium function by the expression that promotes propagation, migration, differentiation, survival, DNA reparation and the induction of cell to have the enzyme of function of detoxification to active oxygen; thereby protective epithelium avoids the damage of toxicant, it can have mitosis promoting effect, cell migration effect, regulating cell differentiation, anti-apoptotic effect, cytoprotection etc.
" VEGF " in the present invention refers to VEGF, VEGF can effectively improve local vascular permeability, thereby abundant blood fortune is fibroblastic propagation and collagen syntheticly provides sufficient nutrient substance and other somatomedin, further promote division, the propagation of cell, improve skin microcirculation, make wax yellow, matt, unsound skin become ruddy glossy.
In the present invention, solvent used is acceptable any solvent in cosmetics, skin care field, and preferred, the solvent that adopted is in the present invention one or more mixing in glycerol, deionized water or triethanolamine aqueous solution.
Inventor finds that in research process the combination of above-mentioned several somatomedin can promote effect each other, but the consumption of these somatomedin can not arbitrarily add, the inconsistent situation that appearance effect declines on the contrary in the time that addition is too much of the dose-effect relationship between them and peak concentration.This may be the biological characteristics difference to some extent due to cytokine, interactional complicated mechanism between somatomedin, also there is no at present clear and definite mechanism of action, therefore between these somatomedin, except the effect of mutually promoting, also may have an effect of cancelling out each other.So proportioning addition how to control these somatomedin is only the key of controlled quentity controlled variable effect relationship.
Compared to existing technology, beneficial effect of the present invention is:
1. skin care activity factor composition of the present invention is brought into play biological regulation effect in conjunction with multiple somatomedin to epidermis cell physiological function and metabolic activity, affect directly or indirectly growth, division, differentiation, propagation and the migration of polytype cell, accelerate the generation of cell collagen, thereby reach antidotal effect;
2. skin care activity factor composition of the present invention can effectively be repaired injured skin, alleviate the calmness of skin pigment, has whitening, effect of dispelling spots;
3. skin care activity factor composition of the present invention can be separately uses as skin care item, also can be used as raw material and adds in skin care item or cosmetics and use.
Below in conjunction with concrete embodiment, the present invention is described in further detail.
Detailed description of the invention
It is below specific embodiment of the present invention.
Embodiment 1
A kind of skin care activity factor composition, it comprises solvent, and following component taking solvent as benchmark:
EGF 10pg/ml
aFGF 80pg/ml
bFGF 5pg/ml
KGF 10pg/ml; Described solvent is glycerol.
Embodiment 2
A kind of skin care activity factor composition, it comprises solvent, and following component taking solvent as benchmark:
EGF 100pg/ml
aFGF 5pg/ml
bFGF 80pg/ml
KGF 100pg/ml, described solvent is deionized water.
Embodiment 3
A kind of skin protection group active factors compositions comprises solvent, and following component taking solvent as benchmark:
EGF 40pg/ml
aFGF 50pg/ml
bFGF 20pg/ml
KGF 60pg/ml; Described solvent is deionized water.
Embodiment 4
A kind of skin care activity factor composition comprises solvent, and following component taking solvent as benchmark:
EGF 60pg/ml
aFGF 20pg/ml
bFGF 50pg/ml
KGF 40pg/ml, described solvent is deionized water.
Embodiment 5
A kind of skin care activity factor composition comprises solvent, and following component taking solvent as benchmark:
EGF 40pg/ml
aFGF 50pg/ml
bFGF 20pg/ml
KGF 60pg/ml
VEGF 5 pg/ml; Described solvent is glycerol.
Embodiment 6
A kind of skin care activity factor composition comprises solvent, and following component taking solvent as benchmark:
EGF 60pg/ml
aFGF 20pg/ml
bFGF 50pg/ml
KGF 40pg/ml
VEGF 5pg/ml
IGF-1 125pg/ml; Described solvent is glycerol.
Compositions of the present invention meets the indices in national " cosmetics health specification 2007 " of promulgating, said composition, containing any noxious substance, does not have no side effect.By product of the present invention to 20-45 year skin exist the women of variety of issue on probation, user is 100 people altogether, after using 14-28 days, skin all improves significantly, and due to can not be exhaustive, have only enumerated several Application Examples below with description effect.
Application Example 1
Lee, 25 years old, company clerk, because occupation needs, often made up, and causes xerosis cutis, tarnish, has obvious hydropenia stricture of vagina; After every day makeup removing, wash one's face product of the present invention is directly clapped on the skin of face, once a day, use after one week, facial skin hydropenia stricture of vagina obviously reduces, after 3 weeks, xerosis cutis be improved significantly.
Application Example 2
Week certain, 45 years old, skin was dark yellow, crows-feet, wrinkles on one's forehead, decree stricture of vagina are obvious, there is speckle in many places.After washing one's face every day, product of the present invention is directly clapped on the skin of face, once a day, used after 5 weeks, the dark yellow mistake that fades of facial skin, the microgroove at canthus fades away, also desalination gradually of darker wrinkle before.
Application Example 3
Chen 30 years old, face's red blood streak is obvious, sensitive skin, easily irritated, face is general red throughout the year.Wash one's face every day product of the present invention directly clapped on the skin of face, once a day, uses after 3 weeks, skin red blood streak be improved significantly, continue to use after 5 weeks red blood streak disappearance.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, the variation of any unsubstantiality that those skilled in the art does on basis of the present invention and replacement all belong to the present invention's scope required for protection.
Claims (6)
1. a skin care activity factor composition, is characterized in that, it comprises solvent, and following component taking solvent as benchmark:
EGF 10-100pg/ml
aFGF 5-80pg/ml
bFGF 5-80pg/ml
KGF 10-100pg/ml。
2. skin care activity factor composition according to claim 1, is characterized in that, it comprises solvent, and following component taking solvent as benchmark:
EGF 10-50pg/ml
aFGF 5-50pg/ml
bFGF 5-40pg/ml
KGF 10-50pg/ml。
3. skin care activity factor composition according to claim 1, is characterized in that, it comprises solvent, and following component taking solvent as benchmark:
EGF 40-60pg/ml
aFGF 20-50pg/ml
bFGF 20-50pg/ml
KGF 40-60pg/ml。
4. skin care activity factor composition according to claim 1, is characterized in that: it also comprises the VEGF 1-10pg/ml taking solvent as benchmark.
5. skin care activity factor composition according to claim 1, is characterized in that: it also comprises the insulin-like growth factor IGF-1:5-15 pg/ml taking solvent as benchmark.
6. according to the skin care activity factor composition described in claim 1-5 any one, it is characterized in that, described solvent is one or more mixing in glycerol, deionized water or triethanolamine aqueous solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410162368.8A CN103908416A (en) | 2014-04-22 | 2014-04-22 | Skincare active factor composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410162368.8A CN103908416A (en) | 2014-04-22 | 2014-04-22 | Skincare active factor composition |
Publications (1)
| Publication Number | Publication Date |
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| CN103908416A true CN103908416A (en) | 2014-07-09 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410162368.8A Pending CN103908416A (en) | 2014-04-22 | 2014-04-22 | Skincare active factor composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105708724A (en) * | 2015-06-09 | 2016-06-29 | 广州艾玫格生物科技有限公司 | Cosmetic composition for repairing skin |
| CN106344427A (en) * | 2016-10-13 | 2017-01-25 | 珠海美逸生物科技有限公司 | Polypeptide composition for facial care and preparation method of polypeptide composition |
| CN107213030A (en) * | 2016-12-20 | 2017-09-29 | 林彩霞 | A kind of cell repair formula mildy wash and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102811704A (en) * | 2010-01-06 | 2012-12-05 | 奥夫莱夫塔埃克尼公司 | Method of use of stabilized plant-derived growth factor in skin care |
| CN103271837A (en) * | 2013-06-07 | 2013-09-04 | 王迎峰 | Formula and preparation method for bioactive cosmetic |
-
2014
- 2014-04-22 CN CN201410162368.8A patent/CN103908416A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102811704A (en) * | 2010-01-06 | 2012-12-05 | 奥夫莱夫塔埃克尼公司 | Method of use of stabilized plant-derived growth factor in skin care |
| CN103271837A (en) * | 2013-06-07 | 2013-09-04 | 王迎峰 | Formula and preparation method for bioactive cosmetic |
Non-Patent Citations (1)
| Title |
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| 李校堃等: "细胞生长因子在美容护肤中的应用", 《实用美容整形外科杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105708724A (en) * | 2015-06-09 | 2016-06-29 | 广州艾玫格生物科技有限公司 | Cosmetic composition for repairing skin |
| CN106344427A (en) * | 2016-10-13 | 2017-01-25 | 珠海美逸生物科技有限公司 | Polypeptide composition for facial care and preparation method of polypeptide composition |
| CN106344427B (en) * | 2016-10-13 | 2019-05-07 | 珠海美逸生物科技有限公司 | Polypeptide complex and preparation method thereof for facial-care |
| CN107213030A (en) * | 2016-12-20 | 2017-09-29 | 林彩霞 | A kind of cell repair formula mildy wash and preparation method thereof |
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Application publication date: 20140709 |