CN103893814B - A kind of medical sanitary shield wound application and preparation method - Google Patents
A kind of medical sanitary shield wound application and preparation method Download PDFInfo
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Abstract
The present invention provides a kind of medical sanitary shield wound application, it is made of base layer, wound protection layer and two peeling layers, wound protection layer is fitted closely in the center of base layer side, and peeling layer overlapping is covered in wound protection layer, and wound protection layer is the silk fibroin porous biomaterial prepared by ad hoc approach.It is prepared by the combined method that wound protection layer combs lapping spun lacing by shredding.The shield wound application of the present invention belongs to natural biologic material shield wound application product, has good biocompatibility, is suitable for various wounds.It can effectively antibacterial anti-inflammatory disinfection, hemostasis.Permeability is good, stick it is soft, give the surface of a wound provide an advantageous growing environment.
Description
Technical field
The invention belongs to field of medical materials, it is related to a kind of novel medical sanitary shield wound application and preparation method, it is main
Ingredient is made a living the fibroin albumen biological stephanoporate material obtained after natural silk degumming.Shield suitable for various wounds, which is created, to be used, because of its tool
There is bacteriostasis, while protecting the surface of a wound, can inhibit bacterial growth, be conducive to wound repair.
Background technology
Wherein important one of the care events of wound are that guarantee wound as much as possible is repaired in an aseptic environment.
Shield wound product mainly contains in existing medical material：Medical cotton ball, cotton swab, bandage, adhesive bandage, first-aid dressing,
Absorbent cotton, absorbent gauze, pad of cotion etc. generally have non-sterile and two kinds sterile.
Wherein, the hospital gauze of sterile manner packaging can be used directly, and the gauze packed in a manner of non-sterile is necessary
It can be used through the methods of high temperature and high pressure steam or ethylene oxide disinfection rear.Medical bandage is generally all gone out with non-sterile medical products
It sells.If using medical bandage when wound site, use should be isolated with wound.
In existing product, in terms of sterility barrier, majority be by be isolated it is extraneous in a manner of, once have bacterium intrusion, unfavorable wound
Mouth is repaired；Have plenty of the chemical antibacterial medicines of artificial addition, there are certain side effect outside, cost of manufacture is also higher.It is badly in need of a kind of tool
There is the biomaterial of natural bacteriostatic function to be used to protect the medical material of wound, while the invasion of extraneous bacterium is isolated, itself
With bacteria resistance function, raw material are easy to get, and are prepared by the technique of particular feasible, are conveniently widely used.
It is found in studying various novel medical sanitary materials, raw silk can prepare a kind of bio-medical material, and silk is
By the fibroin albumen of internal layer（Silk fibroin, SF）And the sericin of external sheath（secricin）It is formed, Qian Zhehan
Amount accounts for about 70%-80%.The study found that fibroin albumen is heavy chain（H chains）, light chain（L chains）It is combined with 6: 6: 1 with p25 molecules
Made of.Fibroin albumen has the excellent performances such as biological degradability, nontoxic, good human body compatibility and biocompatibility, and
It can be prepared into variform, such as cellular, membranaceous and tubulose, and with to its unique amino acid composition and crystalline texture etc.
Study on Physico-chemical is goed deep into, and especially silk multipurpose develops the infiltration to new and high technology in recent years, in biomedical sector
Exploration, such as using fibroin albumen come manufacture engineering material of bone tissue, artificial skin, tissue engineering bracket, slow releasing carrier of medication,
Biosensor etc., even more receives significant attention, it is shown that application potential of the fibroin albumen as bio-medical material.
Invention content
The purpose of the present invention is overcoming existing product insufficient, a kind of medical sanitary shield wound application, shield wound application tool are provided
There is biocompatibility, various wounds such as burn, scald and operative incision is suitable for, and with good flexibility, dilatancy
And permeability.Medical sanitary shield wound application of the present invention is made of base layer, wound protection layer and two peeling layers, and wound protection layer is closely pasted
Together in the center of base layer side, two peeling layer one end partly overlap and are covered in wound protection layer, are risen to wound protection layer and cover shield
Effect, two respective other ends of peeling layer are bonded with two end of base layer, are removed when easy to use, base layer is bonded with wound protection layer
A side surface have carry glue-line ripple type on-woven medical air-permeable adhesive plaster, wound protection layer be silk fibroin porous biomaterial,
Peeling layer is release paper, such as Ge Laxin paper.The silk fibroin porous biomaterial is prepared using the method for the present invention.
It is a further object to provide the preparation methods that the medical sanitary protects wound protection layer in wound application product, lead to
Following key step is crossed to realize：
（1）Raw natural silk degumming：1% soap water lotion is configured, the NaHCO for being 0.5% containing mass concentration3, by raw silk
It impregnates wherein, silk is with solution weight than 1：25, the temperature of immersion is 70 DEG C -90 DEG C, and the time of immersion is 40-60 minutes, is gone
Ionized water cleans, 70 DEG C -90 DEG C of water temperature, and constant temperature impregnates 40-60 minutes, loose wire, and room temperature air-dries, with spare；
（2）It is prepared by biological stephanoporate biomaterial：By step（1）Obtained material is handled through thick shredding；Speed is 0.20-
0.40Hz feeds transmission mode mixed cotton；Speed is 0.20-0.40Hz essence shreddings；It is shifted by the vacuum diversion box containing metering pump,
Control vacuum diversion box condition be：Main cylinder speed is 20-30Hz, and doffer speed 20-30Hz, mixed and disorderly speed is 14-
19Hz；Bilayer combs, and it is 0.2-0.4Hz that carding condition, which is to cotton speed, and coaster speed is 8-10Hz；Through bilayer or multilayer, hand over
Fork or lay-up lapping, the oblique curtain speed of lapping are 10.0-15.0Hz, thickness 3-5mm；Transfer conveying, bottom curtain is defeated in transfer conveying
It is 0.80-1.50Hz to go out speed；Spun lacing, spun lacing mesh version version thickness are 0.8mm, and pressure of prewetting is 20-30bar, and main thorn pressure is
25-35bar, a counter-pressure are 35-45bar, and two counter-pressures are 40-50 bar, and three counter-pressures are 45-55 bar, draw condition
For：It is 2-4 Hz that drawing-off 1, which is closed, and it is 2-4Hz that drawing-off 2, which is closed, and it is 2-4Hz that drawing-off 3, which is closed,；Vacuum drying, pressure are 25-50 atmospheric pressure；
Thick trimming, is frittered at the conveying of rolled system tumbler；
（3）By step（2）The specification of biological stephanoporate biomaterial as required is obtained to cut, it is spare to be made to make wound protection layer
Apply finished product.
By nonwoven medical air-permeable adhesive plaster, step（3）Obtain wound protection layer, two panels peeling layer is sequentially placed from top to bottom in compound
On the material shelf of roller, wherein wound protection layer is placed in nonwoven, through air adhesive plaster center, and two panels peeling layer has fraction overlapping, San Zhejin
Row is compound, and the medical sanitary shield wound application finished product of the present invention is made.
The present invention uses the fibroin albumen biological stephanoporate material that specific technique is prepared, and has better antibacterial effect
Fruit, and it is applied to medical sanitary shield wound application product.This application product can be used for general skin injury wound, it is also possible to
In the systemic wound of large area, it can also be used to wound hemostasis, promotion wound healing after wound suture.Reduce clinic
Multiple links during shield wound have been saved the time especially for the wound care of Emergency Patients, and Clinical practice is more convenient.
The present invention has effects that following and advantage：（1）Belong to natural biologic material shield wound application product, there is good biological
Compatibility is suitable for various wounds；（2）It can effectively antibacterial anti-inflammatory disinfection, hemostasis；（3）Permeability is good, stick it is soft, to wound
Face provides an advantageous growing environment.（4）The group technology of shredding-combing-lapping-spun lacing of use, according to preferred work
Skill parameter, silk fibroin porous material obtained have compared with common process fibroin albumen as made from electrospinning process
Stronger bacteriostasis.
Description of the drawings
Fig. 1 is medical sanitary of the present invention shield wound application structure schematic diagram.
Fig. 2 is fibroin albumen biological stephanoporate material electronics flying-spot microscope prepared by 2-4 of the embodiment of the present invention（SEM）Structure
Characterization.
Fig. 3 is In Vitro Bacteriostasis effect contrast figure.
Specific implementation mode
The present invention in conjunction with the accompanying drawings and embodiments, is further described.
Embodiment 1
Referring to Fig. 1, a kind of medical sanitary shield wound application is made of, shield wound base layer 1, wound protection layer 2 and two peeling layers 3
Layer 2 is fitted closely in the center of 1 side of base layer, and one end of two peeling layers 3, which partly overlaps, to be covered in wound protection layer 2,
Wound protection layer is served and covers shield, two 3 respective other ends of peeling layer are bonded with 1 two end of base layer, are removed when easy to use, base
It is to adopt that the side surface that body layer 1 is bonded with wound protection layer 2, which has the ripple type on-woven medical air-permeable adhesive plaster for carrying glue-line, wound protection layer 2,
The silk fibroin porous biomaterial prepared with the method for the present invention, peeling layer 3 is release paper, such as Ge Laxin paper.
The preparation method of wound protection layer, has main steps that in 2 product of the present invention of embodiment：
（1）Raw natural silk degumming：1% soap water lotion is configured, the NaHCO for being 0.5% containing mass concentration3, by raw silk
It impregnates wherein, silk is with solution weight than 1：25, the temperature of immersion is 70 DEG C, and the time of immersion is 40 minutes, and deionized water is clear
It washes, 70 DEG C of water temperature, constant temperature impregnates 40 minutes, loose wire, and room temperature air-dries, with spare；
（2）It is prepared by silk fibroin porous biomaterial：By step（1）Obtained material is handled through thick shredding；Speed is
0.20 feeding transmission mode mixed cotton；Speed is 0.20 smart shredding；By the vacuum diversion box transfer containing metering pump, control vacuum turns
Move case condition be：Main cylinder speed：20Hz, doffer speed：20Hz, mixed and disorderly speed：14Hz；Bilayer combs, and carding condition is
It is 0.2Hz to cotton speed, coaster speed is 8Hz；Through the double-deck cross lapping, the oblique curtain speed of lapping is 10.0Hz, thickness 5mm；
Transfer conveying, bottom curtain output speed is 0.80Hz in transfer conveying；Spun lacing, spun lacing mesh version version thickness are 0.8mm, and pressure of prewetting is
20bar, main thorn pressure are 25bar, and a counter-pressure is 35bar, and two counter-pressures are 40bar, and three counter-pressures are 45bar, traction item
Part is：It is 2Hz that drawing-off 1, which is closed, and it is 2Hz that drawing-off 2, which is closed, and it is 2Hz that drawing-off 3, which is closed,；Vacuum drying, pressure are 25 atmospheric pressure；Thick trimming, warp
The conveying of reel system tumbler is frittered；
（3）By step（2）It obtains silk fibroin porous material and is cut to wide 2cm long 6cm, it is spare to be made to make wound protection layer
Apply finished product.
Porous material obtained uses electron scanning（SEM）Microscope figure carries out structural characterization, such as the A in Fig. 2..
The preparation method of wound protection layer, has main steps that in 3 product of the present invention of embodiment：
（1）Raw natural silk degumming：1% soap water lotion is configured, the NaHCO for being 0.5% containing mass concentration3, by raw silk
It impregnates wherein, silk is with solution weight than 1：25, the temperature of immersion is 90 DEG C, and the time of immersion is 60 minutes, and deionized water is clear
It washes, 90 DEG C of water temperature, constant temperature impregnates 60 minutes, loose wire, and room temperature air-dries, with spare；
（2）It is prepared by silk fibroin porous biomaterial：By step（1）Obtained material is handled through thick shredding；Speed is
0.40Hz feeds transmission mode mixed cotton；Speed is 0.40Hz essence shreddings；By the vacuum diversion box transfer containing metering pump, control is true
The condition of empty diversion box is：Main cylinder speed is 30Hz, and doffer speed 30Hz, mixed and disorderly speed is 19 Hz；Bilayer combs, comb
It is 0.4Hz that manage bar part, which is to cotton speed, and coaster speed is 10Hz；Through multilayer, lay-up lapping, the oblique curtain speed of lapping is 15.0Hz,
Thickness is 5mm；Transfer conveying, bottom curtain output speed is 0.80-1.50Hz in transfer conveying；Spun lacing, spun lacing mesh version version thickness are
0.8mm, pressure of prewetting are 30bar, and main thorn pressure is 35bar, and a counter-pressure is 45bar, and two counter-pressures are 50bar, three back-pressures
Power is 55 bar, and traction condition is：It is 4 Hz that drawing-off 1, which is closed, and it is 4Hz that drawing-off 2, which is closed, and it is 4Hz that drawing-off 3, which is closed,；Vacuum drying, pressure are
50 atmospheric pressure；Thick trimming, is frittered at the conveying of rolled system tumbler；
（3）By step（2）It is 5cm long 60cm to obtain biological stephanoporate material cutting width, spare that application is made to make wound protection layer
Finished product.
Porous material obtained uses electron scanning（SEM）Microscope figure carries out structural characterization, such as the B in Fig. 2.
The preparation method of wound protection layer, has main steps that in 4 product of the present invention of embodiment：
（1）Raw natural silk degumming：1% soap water lotion is configured, the NaHCO for being 0.5% containing mass concentration3, by raw silk
It impregnates wherein, silk is with solution weight than 1：25, the temperature of immersion is 80 DEG C, and the time of immersion is 50 minutes, and deionized water is clear
It washes, 80 DEG C of water temperature, constant temperature impregnates 50 minutes, loose wire, and room temperature air-dries, with spare；
（2）It is prepared by silk fibroin porous biomaterial：By step（1）Obtained material is handled through thick shredding；Speed is
0.30Hz feeds transmission mode mixed cotton；Speed is 0.30Hz essence shreddings；By the vacuum diversion box transfer containing metering pump, control is true
The condition of empty diversion box is：Main cylinder speed is 25Hz, and doffer speed 25Hz, mixed and disorderly speed is 17Hz；Bilayer combs, and combs
It is 0.3Hz that condition, which is to cotton speed, and coaster speed is 9.0Hz；Through bilayer, cross lapping, the oblique curtain speed of lapping is 13.0Hz, thick
Degree is 4mm；Transfer conveying, bottom curtain output speed is 1.20Hz in transfer conveying；Spun lacing, spun lacing mesh version version thickness are 0.8mm, in advance
Wet pressing power is 25bar, and main thorn pressure is 30bar, and a counter-pressure is 40bar, and two counter-pressures are 45bar, and three counter-pressures are
50bar, traction condition are：It is 3Hz that drawing-off 1, which is closed, and it is 3Hz that drawing-off 2, which is closed, and it is 3Hz that drawing-off 3, which is closed,；Vacuum drying, pressure are 35 big
Air pressure；Thick trimming, is frittered at the conveying of rolled system tumbler；
（3）By step（2）It is 5cm long 60cm to obtain silk fibroin porous material crop width, spare to be made to make wound protection layer
Apply finished product.
Porous material obtained uses electron scanning（SEM）Microscope figure carries out structural characterization, such as the C in Fig. 2.
Embodiment 5 applies finished product and prepares
By step described in on-woven medical air-permeable adhesive plaster, embodiment 2-4（3）Obtain wound protection layer, two sections of peeling layers from it is lower to
On be sequentially placed on the material shelf of composite roll, wherein wound protection layer is placed in nonwoven, through air adhesive plaster center, and two sections of peeling layers have
Fraction is overlapped, and three carries out compound, finished product.Finished product is referring to Fig. 1
6 antibacterial experiment in vitro of embodiment
Made from the silk fibroin porous biomaterial made from specific method of the present invention and conventional process
Silk fibroin porous biomaterial compares its fungistatic effect.
The bacteriostatic test method of development is as follows：Choose Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, white
Color candida albicans, using silk fibroin porous biomaterial made from embodiment 2,3,4 and by the fibroin albumen routine work reported
([academic dissertation 11] Hu Aijun regeneration Static Spinning fibroin nanofibers act on skill-electrospinning process in Facial Nerve Repair
The Suzhou experimental study [D]：University Of Suzhou, 2012：23.) silk fibroin porous material made from compares, and observes 48 hours
Fungistatic effect.
Concrete operations：Culture dish is taken, Escherichia coli, staphylococcus aureus, verdigris are inoculated with tablet coating method respectively
Pseudomonas alba, Candida albicans, the silk fibroin porous biomaterial that then prepared by Example 2,3,4, and with reference to right
Silk fibroin porous material prepared by ratio method, is cut to the sample of diameter 5mm, is placed on culture dish, after cultivating 48 lab scales, sees
Examine antibacterial ring size.
Microscopy results are shown in body outer suppressioning experiment, compared with the control group, the specific preparation method system of the present invention
The silk fibroin porous biomaterial obtained is compared with fibroin albumen prepared by control methods, silk fibroin porous biology of the invention
Material has obviously more preferably fungistatic effect, dialogue to Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa
Color candida albicans inhibition no significant difference, as a result referring to Fig. 3, A is silk fibroin porous material prepared by conventional method in Fig. 3
It is antibacterial as a result, B, C, D be 2,3,4 method of the embodiment of the present invention prepare silk fibroin porous material it is antibacterial as a result, wherein 1 is big
Enterobacteria culture dish, 2 be staphylococcus aureus culture dish, and 3 be pseudomonas aeruginosa culture dish, and 4 be Candida albicans training
Support ware.
Above example is the specific implementation mode of the present invention, cannot be recognized the further detailed description of the present invention
Determine embodiments of the present invention and is only limitted to this.For those of ordinary skill in the art to which the present invention belongs, it is not departing from
Under the premise of present inventive concept, several improvement can also be made, these are all within the scope of protection of the present invention.Therefore, of the invention
The protection domain of patent should be determined by the appended claims.
Claims (1)
1. a kind of medical sanitary shield wound application, by base layer（1）, wound protection layer（2）With two peeling layers（3）Composition, wound protection layer（2）
It fits closely in base layer（1）The center of side, two peeling layers（3）One end partly overlap and be covered in wound protection layer（2）
On, two peeling layers（3）The respective other end and base layer（1）Two ends bond, and are removed when easy to use, base layer（1）With shield
Create layer（2）One side surface of fitting has the ripple type on-woven medical air-permeable adhesive plaster for carrying glue-line, peeling layer（3）For release paper,
It is characterized in that, wound protection layer（2）For silk fibroin porous biomaterial；The wound protection layer（2）It is prepared by following steps：
（1）Raw natural silk degumming：1% soap water lotion is configured, the NaHCO for being 0.5% containing mass concentration3, will raw Silk Soaking its
In, silk is with solution weight than 1：25, the temperature of immersion is 70 DEG C -90 DEG C, and soaking time is 40-60 minutes, and deionized water is clear
It washes, 70 DEG C -90 DEG C of water temperature, constant temperature impregnates 40-60 minutes, loose wire, and room temperature air-dries, with spare；
（2）It is prepared by biological stephanoporate biomaterial：By step（1）Obtained material is handled through thick shredding, speed 0.20-0.40Hz
Transmission mode mixed cotton is fed, speed is 0.20-0.40Hz essence shreddings, is shifted by the vacuum diversion box containing metering pump, control is true
The condition of empty diversion box is：Main cylinder speed is 20-30Hz, and doffer speed 20-30Hz, mixed and disorderly speed is 14-19Hz, double-deck
It combs, it is 0.2-0.4Hz that carding condition, which is to cotton speed, and coaster speed is 8-10Hz, through bilayer or multilayer, intersects or lay-up is spread
Net, the oblique curtain speed of lapping are 10.0-15.0Hz, thickness 3-5mm；Transfer conveying, bottom curtain output speed is in transfer conveying
0.80-1.50Hz；Spun lacing, spun lacing mesh plate plate thickness are 0.8mm, and pressure of prewetting is 20-30bar, and main thorn pressure is 25-
35bar, a counter-pressure are 35-45bar, and two counter-pressures are 40-50 bar, and three counter-pressures are 45-55 bar, and traction condition is：
It is 2-4 Hz that drawing-off 1, which is closed, and it is 2-4Hz that drawing-off 2, which is closed, and it is 2-4Hz that drawing-off 3, which is closed,；Vacuum drying, pressure are 25-50 atmospheric pressure；Slightly cut
Side, is frittered at the conveying of rolled system tumbler；
（3）By step（2）It obtains the specification of biological stephanoporate biomaterial as required to cut, as wound protection layer.
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105031714A (en) * | 2015-06-24 | 2015-11-11 | 南通纺织丝绸产业技术研究院 | Adhesive bandage and method for manufacturing same |
| CN107419430A (en) * | 2015-09-01 | 2017-12-01 | 苏州先蚕丝绸生物科技有限公司 | A kind of feature silk non-woven fabric and its production method |
| CN106178073A (en) * | 2016-08-24 | 2016-12-07 | 广东中科国丝生物科技有限公司 | A kind of bandage that can automatically point out wound inflammation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121836A (en) * | 1995-07-25 | 1996-05-08 | 苏州丝绸工学院 | Wound surface protection film and its preparation method |
| WO1998057676A1 (en) * | 1997-06-18 | 1998-12-23 | Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisheries | Wound covering material containing silk fibroin and silk sericin as the main components and process for producing the same |
| CN102038575A (en) * | 2010-12-06 | 2011-05-04 | 陈德华 | Wound filling dressing for closed negative pressure drainage of surgical wound as well as preparation method |
| CN103143050A (en) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | Carboxymethyl chitosan band-aid and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020150612A1 (en) * | 2000-12-22 | 2002-10-17 | Kimberly-Clark Worldwide, Inc. | Removal of targeted proteases with proteinaceous wound dressings |
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2014
- 2014-03-30 CN CN201410122254.0A patent/CN103893814B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121836A (en) * | 1995-07-25 | 1996-05-08 | 苏州丝绸工学院 | Wound surface protection film and its preparation method |
| WO1998057676A1 (en) * | 1997-06-18 | 1998-12-23 | Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisheries | Wound covering material containing silk fibroin and silk sericin as the main components and process for producing the same |
| CN102038575A (en) * | 2010-12-06 | 2011-05-04 | 陈德华 | Wound filling dressing for closed negative pressure drainage of surgical wound as well as preparation method |
| CN103143050A (en) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | Carboxymethyl chitosan band-aid and preparation method thereof |
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