CN103893447B - One kind treats prostatitic medicine and preparation method thereof - Google Patents
One kind treats prostatitic medicine and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, is related to a kind of Chinese medicine composition, and in particular to one kind treats prostatitic Chinese medicine composition and preparation method and application.The Chinese medicine composition is made of the raw material of following parts by weight：The parts by weight of Jehol Ligusticum Rhizome 1~8, the parts by weight of the flower bud of lily magnolia 1~8, the parts by weight of cynomorium songaricum 1~8, the parts by weight of Semen Cuscutae 1~8, the parts by weight of semen astragali complanati 1~8, the parts by weight of raspberry 1~8, the parts by weight of the fruit of Cherokee rose 1~8, the parts by weight of the Bi roots of grass 1~8, the parts by weight of cloves 1~8, the parts by weight of polygala 1~8, the parts by weight of rhizoma homalonemae 1~8, the parts by weight of rush 1~8.The Chinese medicine composition can treat prostatitis, hyperplasia of prostate, diabetic nephropathy and renal insufficiency.
Description
Technical field
The invention belongs to the field of Chinese medicines, is related to a kind of Chinese medicine composition, and in particular to one kind treats prostatitic Chinese medicine
Composition and preparation method and application.
Background technology
Prostatitis is the common disease of male reproductive system, and the right side of fifty group accounts for first place in Urology Surgery male patient,
Group occupies the 2nd within more than 51 years old.Its incidence of disease is up to 6%.There is prostatitis person to account for 8% in crowd.Its cause of disease and pathogenesis not by
Throw a flood of light on.Pathogen person is found with conventional method only to occupy the minority, and is not easy to determine which patient is to suffer from non-bacterial prostate
It is scorching.Some patients can find the evidence relevant with autoimmunity, but be difficult to accurate clinical classification.This sick clinical manifestation
For the syndrome of complexity, the diagnostic method that the past is commonly used is not detailed enough, and treatment has certain blindness, often lays particular stress on antibiotic
The treatment of medicine.
Only small number of patients has acute medical history, shows as chronic, recurrent more and passes through.Pathogen is mostly pathogenic entero becteria,
Conventional bacteriological inspection only about 20% patient find bacterium.Recent research indicate that prostatitis patient urodynamics test
It was found that Posterior urethral pressure increases, symptom mitigation or disappearance after α adrenomimetic drug energy receptor antagonists are taken orally, urinated after prompting prostate
Road smooth muscle ability increases, and makes urine turbulent flow, and urine reflux enters prostate, and the uric acid in urine produces chemical stimulation, causes pain
Bitterly.Pathogen invades prostate with urine, causes to infect.Pathological anatomy confirms that prostatitis lesion is typically limited to peripheral zone,
Glandular tube and uroflow vertical line are inversely opened on Posterior urethral herein, easily cause urine reflux, and central zone and transitional zone glandular tube trend with
Uroflow direction is consistent, is not susceptible to infect.Research recently is it has also been found that the lithate of urine not only has stimulation to prostate, also
It is precipitable into calculus, block glandular tube, the protection place as bacterium.These discoveries, which can illustrate prostatitis syndrome, is in fact
The coexpress of a variety of diseases, and complicated clinical manifestation is changeable, can produce various complication, also can voluntarily alleviate.
Though which kind when chronic prostatitis all can behave as similar clinical symptom, be referred to as prostatitis disease
Group, including basin sacrum pain, urination is upset and sex dysfunction.Basin sacrum pain present is extremely complex, pain is normally on pubis,
Lumbosacral region and perineum, Rediating Pain can behave as urethra, spermatic cord, testis, groin, abdomen inside portion pain, and ventrad radiation is cruel
Like acute abdomen, exactly like renal colic along urinary tract radiation, often lead to mistaken diagnosis.Urination upset shows as frequent micturition, urgent urination, odynuria, urination
Drip drop, enuresis nocturna number increase after not smooth, splitting of urinary stream, urine, and urethra flows out milky secretion etc. after urine or when defecating.Once in a while simultaneously
Send out sex dysfunction, including sexual hypoesthesia, premature ejaculation, painful ejaculation, erect decrease and impotence.Above-mentioned symptom can be because of prostatitis institute
Cause, also can be caused by urogenital tract other diseases.
First have to carry out clinical assessment, determine disease type, treatment method, psychotherapy and modulability are selected for the cause of disease
Life will run through the overall process for the treatment of.Error understanding to disease, unnecessary anxiety and excessive continence can make exacerbation of symptoms.
Prostatitis is probably that a kind of symptom is slight or complete asymptomatic disease, it may be possible to a kind of self limiting disease that can voluntarily alleviate
Disease, it is also possible to a kind of complicated symptoms, cause urinary tract infections, sex dysfunction, infertility, the disease for substantially reducing quality of life,
Treatment to patient should avoid rendering this sick harmfulness to patient too, also to avoid taking the treatment of this disease it is simple, disappear
Pole, the attitude for blindly laying particular stress on antibiosis extract for treating, it should start with from the cause of disease, carry out complex treatment.
The invention provides a kind of Chinese medicine composition for treating hyperplasia of prostate, Chinese medicine composition row adenositis before the treatment
Aspect has extraordinary curative effect, and can also treat hyperplasia of prostate, diabetic nephropathy and renal insufficiency.The present invention is right
Pharmacodynamic study is carried out, it was demonstrated that its is curative for effect.
The content of the invention
It is an object of the invention to provide one kind to treat prostatitic Chinese medicine composition.
It is a further object of the present invention to provide the preparation method of the Chinese medicine composition.
Present invention also offers the Chinese medicine composition prepare treatment prostatitis, hyperplasia of prostate, diabetic nephropathy with
And the purposes in renal insufficiency medicine.
The purpose of the present invention is achieved in the following ways：
A kind of Chinese medicine composition for treating hyperplasia of prostate, the Chinese medicine composition are made up of the raw material of following parts by weight
's：The parts by weight of Jehol Ligusticum Rhizome 1~8, the parts by weight of the flower bud of lily magnolia 1~8, the parts by weight of cynomorium songaricum 1~8, the parts by weight of Semen Cuscutae 1~8, the weight of semen astragali complanati 1~8
Measure part, the parts by weight of raspberry 1~8, the parts by weight of the fruit of Cherokee rose 1~8, the parts by weight of the Bi roots of grass 1~8, the parts by weight of cloves 1~8, polygala 1~8
Parts by weight, the parts by weight of rhizoma homalonemae 1~8, the parts by weight of rush 1~8.
Described Chinese medicine composition, preferably made of the Chinese medicine material of following parts by weight：The parts by weight of Jehol Ligusticum Rhizome 8, the flower bud of lily magnolia 8
Parts by weight, the parts by weight of cynomorium songaricum 8, the parts by weight of Semen Cuscutae 8, the parts by weight of semen astragali complanati 4, the parts by weight of raspberry 4, the parts by weight of the fruit of Cherokee rose 4, Bi
The parts by weight of the roots of grass 4, the parts by weight of cloves 2, the parts by weight of polygala 2, the parts by weight of rhizoma homalonemae 2, the parts by weight of rush 2.
Described Chinese medicine composition, preferably made of the Chinese medicine material of following parts by weight：The parts by weight of Jehol Ligusticum Rhizome 4, the flower bud of lily magnolia 4
Parts by weight, the parts by weight of cynomorium songaricum 4, the parts by weight of Semen Cuscutae 4, the parts by weight of semen astragali complanati 8, the parts by weight of raspberry 8, the parts by weight of the fruit of Cherokee rose 8, Bi
The parts by weight of the roots of grass 8, the parts by weight of cloves 3, the parts by weight of polygala 3, the parts by weight of rhizoma homalonemae 1, the parts by weight of rush 1.
The Chinese medicine composition can use conventional preparation method in pharmacy of Chinese materia medica, be made tablet, pill, granule,
Grit agent, soft capsule, powder, lotion, liniment, ointment, mixture.
Described Chinese medicine composition, preferable method are prepared as：Prescription raw material is ground into fine powder, mixes, and with water pill, does
It is dry, produce.
Described Chinese medicine composition, preferable method are prepared as：Prescription raw material adds water to cook 1~3 time, and 1~3 is small every time
When, decocting liquid filtration, filtrate merges, and concentrates, and dries, and the conventional auxiliary material added in pharmacy of Chinese materia medica, mixes, particle is made, and dries,
Tabletting, produce.
Described Chinese medicine composition can also be used to prepare the prostatitic medicine for the treatment of.
Described Chinese medicine composition can be used for preparing the medicine for the treatment of hyperplasia of prostate.
Described Chinese medicine composition can also be used to prepare the medicine for the treatment of diabetic nephropathy.
Described Chinese medicine composition can also be used to prepare the medicine for the treatment of renal insufficiency.
Embodiment：
For a better understanding of the present invention, inventor provides following research data, illustrates the technique effect of the present invention, but under
Experiment is stated to be used to further illustrate but be not limited to the present invention.
Embodiment 1：General antiinflammatory action experimental study
（One）Influence to swollen hyperplasia of rat granuloma
1st, test objective：Observe the inhibitory action to rat connective tissue proliferation caused by cotton balls implantation.
, test medicine
The present invention implements 5 Chinese medicine composition, faces the concentration that the used time is configured to 18% with distilled water.
Hydrogenate cortisone, specification 5mg/ml
3rd, experimental animal
From adult healthy SD male rats 50,190 ± 20g of body weight.
, test method
Healthy SD male rat 50 is taken, is randomly divided into 5 groups, every group 10.Respectively：Normal group, positive control
Group（With hydrogenation cortisone intramuscular injection 5mg/kg）, Chinese medicine composition heavy dose group of the present invention（4.0g crude drugs kg-1）；Chinese medicine of the present invention
Composition middle dose group（2.0g crude drugs kg-1）；Chinese medicine composition small dose group of the present invention（1.0g crude drugs kg-1）.
Rat is tested under 4% chloraldurate light anaesthesia, sterile working, by two sterile absorbent cotton balls（10 ± 1mg of weight,
6.5~8.5mm of diameter, autoclaving）It is implanted into rat both sides armpit subcutaneously and then sutures.Postoperative same day administration, once a day, hydrogen
Change cortisone intramuscular injection 0.1 ml/100g body weight, Chinese medicine composition gavage 1ml/100g body weight of the present invention, successive administration is after 7 days,
Animal is put to death in dislocation in 8th day, takes out cotton balls, is weighed after putting 60 DEG C of baking box drying.Subtract raw cotton ball weight, as granuloma weight
Amount.Compare each group granuloma weight and calculate inhibiting rate.The formula for calculating inhibiting rate is as follows：
Inhibiting rate（%）=
5th, result of the test：
After rat is administered 7 days, three dosage groups of Chinese medicine composition of the present invention have different degrees of to connective tissue proliferation
Inhibitory action.Chinese medicine composition inhibiting rate of the present invention is respectively 26.41%, 19.46%, 19.25%, especially with heavy dose of group of effect
It is most obvious（P ＜ 0.05）, the results are shown in Table 1-1.
Influences of the table 1-1 to swollen hyperplasia of rat granuloma（±SD）
The * P ＜ 0.05 compared with Normal group；* P ＜ 0.01
6th, conclusion
This experiment causes the hyperplasia of rat connective tissue with cotton balls implantation, causes inflammatory model.After modeling, in the present invention
To rat continuous use 7 days, result of the test was shown drug composition：The Chinese medicine composition of the present invention of three dosage groups is to rat cotton balls
Granuloma has different degrees of inhibitory action, and compared with control group, the inhibitory action of heavy dose group is the most obvious（P ＜
0.05）.Prompting, Chinese medicine composition of the present invention have certain suppression to make caused connective tissue proliferation in cotton balls implantation rat body
With, illustrate Chinese medicine composition of the present invention have the function that resist proliferative inflammation, this be its clinical practice in chronic prostate increase
Life provides pharmacology foundation.
（Two）Influence to mice auricle swelling
1st, test objective
Observe the inhibitory action of mouse ear swelling caused by paraxylene.
, test medicine
The present invention implements 6 Chinese medicine composition, faces the concentration that the used time is configured to 18% with distilled water.
Hydrogenate cortisone, specification 5mg/ml
3rd, experimental animal
From adult healthy Kunming mouse 50, male, 23.22 ± 2.31g.
, experimental method
Experiment is divided into 5 groups, every group 10, respectively Normal group, positive controls（Hydrogenate cortisone intramuscular injection 10mg/
kg）And Chinese medicine composition heavy dose group of the present invention（4.0g crude drugs kg-1）；Chinese medicine composition middle dose group of the present invention（2.0g
Crude drug kg-1）；Chinese medicine composition small dose group of the present invention（1.0g crude drugs kg-1）.Mouse gavages tested decoction respectively
0.2ml/10g body weight, cortisone intramuscular injection 0.02ml/10g body weight being hydrogenated, Normal group gives isometric distilled water gavage,
After administration 30 minutes, to proinflammatory agent, dimethylbenzene 0.03ml is applied to mouse right ear, left ear is as control.By mouse after 2.5 hours
Cervical dislocation is lethal, and left and right ear is cut along auricle baseline, and same position auricle, electronics day are removed respectively with diameter 9mm card punch
It is flat to weigh, left auricle weight, as ear swelling degree are subtracted per mouse auris dextra sheet weight, carries out statistical disposition.
, result of the test
The Chinese medicine composition of the present invention of three dosage has different degrees of inhibitory action to the ear swelling of mouse.With dosage
Increase, inhibitory action progressively strengthens, and big, middle dose group the inhibitory action of Chinese medicine composition especially of the present invention is the most obvious
（P ＜ 0.05；P ＜ 0.01）, and the effect of heavy dose of group is better than positive drug group, the results are shown in Table 1-2.As a result show, the present invention
Swelling caused by Chinese medicine composition paraxylene has obvious inhibitory action.
Influences of the table 1-2 to mice ear（±SD）
The * P ＜ 0.05 compared with Normal group；* P ＜ 0.01,
6th, conclusion
Experimental result is prompted, and after mouse gavaging Chinese medicine composition of the present invention, swelling caused by dimethylbenzene is applied to mouse ear
There is obvious inhibitory action, it is especially heavy dose of the most obvious with middle dose group, it is statistically significant（P ＜ 0.05；P ＜ 0.01）.
As a result show：Mouse ear caused by Chinese medicine composition paraxylene of the present invention is congested, and the acute inflammatory reaction such as oedema has bright
Aobvious inhibitory action, and as the increase of dosage, inhibitory action also strengthen.This be its clinical practice in chronic hyperplasia of prostate with
Prostatitis provides pharmacology foundation.
Embodiment 2：Influence to hemorheology of rat
1st, experiment purpose：The influence to hemorheology of rat is mainly inquired into this experiment.
, test medicine
The present invention implements 7 Chinese medicine composition, faces the concentration that the used time is configured to 18% with distilled water.
Positive drug：QIANLIEXIN JIAONANG, face the concentration that the used time is configured to 18% with distilled water.
Testosterone propionate, specification：25mg/ml, face the used time is diluted to 10mg/ml concentration with olive oil.
, experimental animal and test material
Male SD rat, 60,237.9 ± 30.1 grams of body weight.Blood rheological instrument：Beijing Puli gives birth to centre；Model：
LBY-N6
4th, experimental method
From the male SD big white mouse 60 of health, random taking-up 10 is only used as normal group.Another 50 use 4% chloraldurate fiber crops
It is liquor-saturated, bilateral testes are aseptically extractd, then skin suture.After one week, castrated rats are randomly divided into 5 groups, every group 10
Only, respectively model group；Chinese medicine composition heavy dose group of the present invention（2.0 g crude drugs kg-1）；Agent in Chinese medicine composition of the present invention
Amount group（1.0g crude drugs kg-1）；Chinese medicine composition small dose group of the present invention（0.5g crude drugs kg-1）；Positive drug control group（Before
Arrange the glad g crude drugs kg of capsule 2.0-1）；
Experimental animal sub-cage rearing, in addition to normal group, the daily sc testosterone propionates of remaining rat（1mg/300g body weight）One
Secondary, medication group is gavaged decoction 1ml/100g body weight simultaneously, and normal group gives isometric water gavage.Rat weighs weekly one
It is secondary, and adjust dosage.Successive administration 30 days from postoperative 7 days.4% chloraldurate after last dose（400mg/kg）Anesthesia, greatly
Mouse abdominal aortic blood 4.0ml, the anticoagulant tube of injection heparin processing, by LBY-N6 type rotary blood rheometer measurement rats
Hemorheology index.
, experimental result
For administration group compared with model group, WBV, blood reduced viscosity have more significant sex differernce.Chinese medicine group of the present invention
Compound is big, middle dose group can significantly reduce rat blood viscosity compared with model group（P ＜ 0.05；P ＜ 0.01）, and positive effect
Better than positive drug group, 3-1,3-2 the results are shown in Table.
Influences of the table 2-1 to hyperplasia of prostate hemorheology of rat（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
Influences of the table 2-2 to hyperplasia of prostate hemorheology of rat（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
6th, conclusion
Prostatic hyperplasia model rat Chinese medicine composition gastric infusion of the present invention 30 days, then to associated blood rheology
Index is observed.As a result to prompt, Chinese medicine composition administration group of the present invention can reduce rat whole blood, whole blood reduction undercut, in
Viscosity is cut, compared with model group, difference highly significant（P ＜ 0.05；P ＜ 0.01）, and effect is better than the glad glue in positive drug forefront
Capsule.Illustrate that Chinese medicine composition of the present invention can reduce blood viscosity, play function of promoting blood circulation to disperse blood clots, increase for treatment chronic prostate
Life provides pharmacology foundation.
Embodiment 3：Influence to Rat Experimental hyperplasia of prostate pathology model
1st, experiment purpose：The effect for the treatment of hyperplasia of prostate, is mainly inquired into this experiment.
, test medicine
Test medicine：
The present invention implements 8 Chinese medicine composition, faces the concentration that the used time is configured to 18% with distilled water.
Positive drug：QIANLIEXIN JIAONANG, face the concentration that the used time is configured to 18% with distilled water.
Testosterone propionate：Specification：25mg/ml.
3rd, experimental animal
SD rats, male, 60, body weight 238.1 ± 30.3.
, experimental method
From the male SD big white mouse 60 of health, random taking-up 10 is only used as normal group.Another 50 use 4% chloraldurate fiber crops
It is liquor-saturated, bilateral testes are aseptically extractd, then skin suture.After one week, castrated rats are randomly divided into 5 groups, every group 10
Only, respectively：Model group, Chinese medicine composition heavy dose group of the present invention（2.0 g crude drugs kg-1）, agent in Chinese medicine composition of the present invention
Amount group（1.0g crude drugs kg-1）, Chinese medicine composition small dose group of the present invention（0.5g crude drugs kg-1）, positive drug control group（Before
Arrange the glad g crude drugs kg of capsule 2.0-1）.
Experimental animal sub-cage rearing, in addition to normal group, the daily sc testosterone propionates of remaining rat（1mg/300g body weight）One
Secondary, medication group is gavaged decoction 1ml/100g body weight simultaneously, and normal group gives isometric water gavage.Rat weighs weekly one
It is secondary, and adjust dosage.Successive administration 30 days from postoperative 7 days.1h puts to death animal after last dose, takes each leaf of prostate, electricity
Sub- balance claims weight in wet base, and volumetric method surveys prostate volume, takes left and right head lobe to claim weight in wet base and claims dry weight, calculated weight after 37 DEG C of drying
Coefficient（I.e. per the weight of prostate or volume of 100g rat body weights）.Take Ventral Prostates to be fixed in 10% formalin solution to make
Routine paraffin wax is cut into slices, HE microscopies.
, experimental result
（1）To rat prostate weight, the influence of volume
Each dosage group of Chinese medicine composition of the present invention can substantially mitigate rat prostate head lobe dry and wet weight compared with model group,
Mitigate siphonal lobe weight in wet base, reduce prostate volume.Especially it is the most obvious with the big of Chinese medicine composition of the present invention, middle dose group effect, together
Model group is compared, difference highly significant（P ＜ 0.01）, and effect is better than positive drug group, the results are shown in Table 3-1,3-2.
Influences of the table 3-1 to Rat Experimental prostate head lobe hyperplasia（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
Influences of the table 3-2 to rat prostate siphonal lobe and volume（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
（2）Pathology microscopy result：Normal group prostate gland marshalling, for lumen of gland without expansion, galandular epithelium is in simple columnar,
Visible interstitial between body of gland.Model group shows that body of gland arrangement is close, the increase of epithelial cell number, more in high column, galandular epithelium height
Increase, form mamillary and charge into lumen of gland, lumen of gland is substantially expanded, interior visible secretion.Chinese medicine composition heavy dose group of the present invention,
Middle dose group pathological examination shows that lumen of gland expansion unobvious, hyperplasia glandular epithelium number is considerably less than model group, and low column
Epithelium is common, partly tends to recover normal, lumen of gland diameter with galandular epithelium height compared with model group, difference highly significant（P ＜
0.05；P ＜ 0.01）And effect is better than positive drug group, the results are shown in Table 3-3.
Influences of the table 3-3 to rat prostate lumen of gland diameter and galandular epithelium height（±SD）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
6th, conclusion
This experiment is reported according to the country on chronic hyperplasia of prostate pathological model, causes benign prostatic hyperplasia in rats disease mould
Type.Rat gave traditional Chinese medicine composition for treating of the present invention after 30 days, compared with model group, can substantially mitigate weight of prostate, subtract
Small prostate volume.And pathological examination is prompted：Compared with model group, the lumen of gland tissue expander of Chinese medicine composition administration group of the present invention
Relatively light, hyperplasia glandular epithelium number is also less, and lumen of gland diameter reduces, and galandular epithelium height is obvious to be reduced, difference highly significant（P
＜ 0.05；P ＜ 0.01）.Experimental result is prompted：Chinese medicine composition of the present invention can effectively treat benign prostatic hyperplasia in rats, and effect
Better than positive drug QIANLIEXIN JIAONANG.
Embodiment 4：Influence to mouse urogenital sinus implantable prostatic hyperplasia model
1st, experiment purpose
The influence to mouse prostate hyperplasia pathological model is observed, observes it whether there is treatment hyperplasia of prostate effect.
, test medicine
The present invention implements 9 Chinese medicine composition, faces the concentration that the used time is configured to 18% with distilled water.
Positive drug：QIANLIEXIN JIAONANG, face the concentration that the used time is configured to 18% with distilled water.
, experimental animal
From adult healthy Kunming mouse 60, male, 25.41 ± 3.16g.
, experimental method
From male mice 60, intraperitoneal injection yellow Jackets anesthesia（3%, 60mg/kg）, under aseptic condition along abdomen just
In split stomach wall, prostate siphonal lobe is gently separated with tweezers, under anatomical lens be implanted into 3 16 day age tire mouse urogenital sinus group
Knit, suturing them muscle, skin, sterilize, put back to mouse cage.Then it is grouped, normal group 10 only gavages isometric physiological saline,
Model group 10, the heavy dose of group 10 of Chinese medicine composition of the present invention（4.0g crude drugs kg-1）, Chinese medicine composition middle dosage of the present invention
Group 10（2.0g crude drugs kg-1）, Chinese medicine composition small dose group 10 of the present invention（1.0g crude drugs kg-1）, positive drug forefront
Glad Capsules group 10（4.0g crude drugs kg-1）.
All free diet of mouse, in postoperative 3rd day start gastric infusion, administered volume 0.2ml/10g body weight, daily one
Secondary, for successive administration after 30 days, the marrow that breaks puts to death mouse, takes each leaf of prostate, testis and seminal vesicle respectively, is claimed with electronic balance wet
Weight.Take side head lobe to claim weight in wet base and claim dry weight, calculated weight coefficient after 37 DEG C of drying（The body of gland weight of i.e. every gram mouse weight
Amount）It is another to take prostate siphonal lobe tissue to be fixed on 10% formalin solution, send section microscopy.
, experimental result
（1）Influence to mouse prostate weight
Each dosage group of Chinese medicine composition of the present invention can substantially mitigate mouse prostate head lobe dry and wet weight compared with model group,
Mitigate siphonal lobe weight in wet base and weight of seminal vesicle, especially so that Chinese medicine composition of the present invention is big, middle dose group effect is the most obvious, same to model group
Compare, significant difference（P ＜ 0.05；P ＜ 0.01）, and effect is better than positive drug group, the results are shown in Table 4-1,4-2.
Influences of the table 4-1 to mouse experiment hyperplasia of prostate（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
Influences of the table 4-2 to mouse experiment hyperplasia of prostate（± SD, n=10）
Compared with model group, * P ＜ 0.05；* P ＜ 0.01
（2）Pathology microscopy is found：Normal group prostate gland marshalling, galandular epithelium are in simple columnar, lumen of gland without expansion,
Visible interstitial between body of gland.Model group shows glandular hyperplasia, and arrangement is close, with interstitial tissue hyperplasia, lumen of gland expansion, in high column
The increase of epithelial cell number, form mamillary and charge into lumen of gland.Chinese medicine composition heavy dose group of the present invention, middle dose group microscopy are cut
Piece result is shown：Lumen of gland expansion is lighter；Galandular epithelium height, lumen of gland diameter are significantly less than model group, significant difference（P ＜ 0.05）,
And effect is better than positive drug group, the results are shown in Table 4-3.
Compared with model group, * P ＜ 0.05
6th, conclusion
This experiment is reported according to the country on chronic hyperplasia of prostate pathological model, causes mouse urogenital sinus prostate to increase
Raw disease model.Mouse prostate was implanted into tire mouse urogenital sinus tissue after 3 days, then gave Chinese medicine composition of the present invention 30.Knot
Fruit shows that Chinese medicine composition of the present invention can substantially mitigate each leaf weight of mouse prostate and weight of seminal vesicle, with model group phase
Than significant difference（P ＜ 0.05；P ＜ 0.01）.Pathological section result is visible, and Chinese medicine composition of the present invention is big, middle dose group mouse
Gland tissue and interstitial tissue hyperplasia it is lighter, lumen of gland degrees of expansion is lighter, galandular epithelium height be also significantly lower than model group（P ＜
0.05）.Experimental result is prompted：Chinese medicine composition of the present invention can effectively treat mouse prostate hyperplasia, and effect is better than positive drug
Thing QIANLIEXIN JIAONANG.
Embodiment 5：
Prescription：Jehol Ligusticum Rhizome 80, the flower bud of lily magnolia 80, the g of cynomorium songaricum 80, the g of Semen Cuscutae 80, the g of semen astragali complanati 40, the g of raspberry 40, the fruit of Cherokee rose 40
G, the g of the Bi roots of grass 40, the g of cloves 20, the g of polygala 20, the g of rhizoma homalonemae 20, the g of rush 20.
Preparation method：The taste bulk drug of prescription 12, is ground into fine powder, mixes, and with water pill, dries, produces.
Embodiment 6：
Prescription：Jehol Ligusticum Rhizome 80, the flower bud of lily magnolia 80, the g of cynomorium songaricum 80, the g of Semen Cuscutae 80, the g of semen astragali complanati 40, the g of raspberry 40, the fruit of Cherokee rose 40
G, the g of the Bi roots of grass 40, the g of cloves 20, the g of polygala 20, the g of rhizoma homalonemae 20, the g of rush 20.
Preparation method：The taste bulk drug of prescription 12, add water to cook 1 time, 3 hours, decocting liquid filtration, concentrate, dry, add starch and fit
Amount, mix, particle is made, dry, tabletting, produce.
Embodiment 7：
Prescription：Jehol Ligusticum Rhizome 80, the flower bud of lily magnolia 80, the g of cynomorium songaricum 80, the g of Semen Cuscutae 80, the g of semen astragali complanati 40, the g of raspberry 40, the fruit of Cherokee rose 40
G, the g of the Bi roots of grass 40, the g of cloves 20, the g of polygala 20, the g of rhizoma homalonemae 20, the g of rush 20.
Preparation method：The taste bulk drug of prescription 12, add water to cook 2 times, 2 hours every time, decocting liquid filtration, filtrate merged, and concentrates, and does
Dry, addition dextrin is appropriate, mixes, particle is made, and dries, tabletting, produces.
Embodiment 8：
Prescription：Jehol Ligusticum Rhizome 80, the flower bud of lily magnolia 80, the g of cynomorium songaricum 80, the g of Semen Cuscutae 80, the g of semen astragali complanati 40, the g of raspberry 40, the fruit of Cherokee rose 40
G, the g of the Bi roots of grass 40, the g of cloves 20, the g of polygala 20, the g of rhizoma homalonemae 20, the g of rush 20.
Preparation method：The taste bulk drug of prescription 12, add water to cook 3 times, 1 hour every time, decocting liquid filtration, filtrate merged, and concentrates, and does
It is dry, Magnesium Stearate proper quantity is added, mixes, particle is made, dries, tabletting, produces.
Embodiment 9：
Prescription：The g of Jehol Ligusticum Rhizome 40, the g of the flower bud of lily magnolia 40, the g of cynomorium songaricum 40, the g of Semen Cuscutae 40, the g of semen astragali complanati 80, raspberry 80 g, Jin Ying
The sub g of 80 g, Bi roots of grass 80, the g of cloves 30, the g of polygala 30, the g of rhizoma homalonemae 10, the g of rush 10.
Preparation method：The taste bulk drug of prescription 12, is ground into fine powder, mixes, and with water pill, dries, produces.
Embodiment 10：
Prescription：The g of Jehol Ligusticum Rhizome 40, the g of the flower bud of lily magnolia 40, the g of cynomorium songaricum 40, the g of Semen Cuscutae 40, the g of semen astragali complanati 80, raspberry 80 g, Jin Ying
The sub g of 80 g, Bi roots of grass 80, the g of cloves 30, the g of polygala 30, the g of rhizoma homalonemae 10, the g of rush 10.
Preparation method：The taste bulk drug of prescription 12, add water to cook 2 times, 2 hours every time, decocting liquid filtration, filtrate merged, and concentrates, and does
Dry, addition starch is appropriate, mixes, particle is made, and dries, tabletting, produces.
Claims (7)
1. a kind of Chinese medicine composition for treating hyperplasia of prostate, it is characterised in that the Chinese medicine composition is by following parts by weight
Made of raw material：The parts by weight of Jehol Ligusticum Rhizome 1~8, the parts by weight of the flower bud of lily magnolia 1~8, the parts by weight of cynomorium songaricum 1~8, the parts by weight of Semen Cuscutae 1~8, Sha Yuan
Sub 1~8 parts by weight, the parts by weight of raspberry 1~8, the parts by weight of the fruit of Cherokee rose 1~8, the parts by weight of the Bi roots of grass 1~8, the parts by weight of cloves 1~8,
The parts by weight of polygala 1~8, the parts by weight of rhizoma homalonemae 1~8, the parts by weight of rush 1~8.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the Chinese medicine composition is by the Chinese medicine of following parts by weight
Made of raw material：The parts by weight of Jehol Ligusticum Rhizome 8, the parts by weight of the flower bud of lily magnolia 8, the parts by weight of cynomorium songaricum 8, the parts by weight of Semen Cuscutae 8, the parts by weight of semen astragali complanati 4, cover
The parts by weight of basin 4, the parts by weight of the fruit of Cherokee rose 4, the parts by weight of the Bi roots of grass 4, the parts by weight of cloves 2, the parts by weight of polygala 2, the parts by weight of rhizoma homalonemae 2,
The parts by weight of rush 2.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that the Chinese medicine composition is by the Chinese medicine of following parts by weight
Made of raw material：The parts by weight of Jehol Ligusticum Rhizome 4, the parts by weight of the flower bud of lily magnolia 4, the parts by weight of cynomorium songaricum 4, the parts by weight of Semen Cuscutae 4, the parts by weight of semen astragali complanati 8, cover
The parts by weight of basin 8, the parts by weight of the fruit of Cherokee rose 8, the parts by weight of the Bi roots of grass 8, the parts by weight of cloves 3, the parts by weight of polygala 3, the parts by weight of rhizoma homalonemae 1,
The parts by weight of rush 1.
4. a kind of preparation method of the Chinese medicine composition for the treatment of hyperplasia of prostate as any one of claim 1-3,
It is characterized in that：Prescription raw material is ground into fine powder, mixed, with water pill, dries, produces.
5. a kind of preparation method of the Chinese medicine composition for the treatment of hyperplasia of prostate as any one of claim 1-3,
It is characterized in that：Prescription raw material is added water to cook 1~3 time, 1~3 hour every time, decocting liquid filtration, filtrate merged, and concentrates, and dries,
The conventional auxiliary material added in pharmacy of Chinese materia medica, mix, particle is made, dry, tabletting, produce.
6. the Chinese medicine composition as described in claims 1 to 3 any one is preparing the application in treating prostatitis medicine.
7. the Chinese medicine composition as described in claims 1 to 3 any one is preparing the application in treating prostatic hyperplasia agents.
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| CN201410166163.7A CN103893447B (en) | 2014-04-24 | 2014-04-24 | One kind treats prostatitic medicine and preparation method thereof |
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| CN201410166163.7A CN103893447B (en) | 2014-04-24 | 2014-04-24 | One kind treats prostatitic medicine and preparation method thereof |
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| CN103893447B true CN103893447B (en) | 2017-12-08 |
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| US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
| CN103028083A (en) * | 2012-12-05 | 2013-04-10 | 纪瑞 | Traditional Chinese medicine for treating benign prostatic hyperplasia |
| CN103830527B (en) * | 2014-03-20 | 2016-01-06 | 孙吉胜 | One treats prostatitic preparation |
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