CN103893413A - Pharmaceutical composition for treating eczema or cutaneous pruritus and preparation method thereof - Google Patents
Pharmaceutical composition for treating eczema or cutaneous pruritus and preparation method thereof Download PDFInfo
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- CN103893413A CN103893413A CN201410078334.0A CN201410078334A CN103893413A CN 103893413 A CN103893413 A CN 103893413A CN 201410078334 A CN201410078334 A CN 201410078334A CN 103893413 A CN103893413 A CN 103893413A
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Abstract
The invention discloses a pharmaceutical composition for treating eczema or cutaneous pruritus and a preparation method thereof, and belongs to the field of veterinary medicines. The method is characterized by comprising the following steps: proportioning harlequin glorybower leaf, folium eucalypti, bunge pricklyash leaf, mallotus apelta, leaf of chinese ilex and borneol at a certain ratio; extracting and refining; adding auxiliary materials of the preparation to prepare corresponding preparation according to the conventional method. The pharmaceutical composition disclosed by the invention has a good effect when being applied to treatment of eczema or cutaneous pruritus of a pet.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition that is used for the treatment of eczema or skin pruritus, particularly a kind of pharmaceutical composition that is used for the treatment of house pet eczema, and the preparation method of said composition and purposes, belong to field of traditional Chinese veterinary.
Background technology
Eczema is the common dermatoses on the upper strata (papillary layer) of a kind of major lesions position epidermal area and skin corium of occurring in pet skin.The pathogenesis etiology of eczema is the result under many factors combined influence in fact, and be not that the monistic cause of disease causes, the generation of each eczema case, can analyze haply for be endogenous cause of ill (house pet itself has an easy anaphylactogenic congenital body constitution) and exopathogenic factor (in environment or in food cause the irritated factor and all kinds of can anaphylactic anaphylactogen), the two result after simultaneously interacting in pet body of endexoteric.Why can there is this dermatosis of eczema in house pet, real most important leading factor is that first it must have a kind of special body constitution of easy allergy to house pet, have only after a house pet itself first has the easy hypersensitive body constitution of such one, next when this house pet has touched after special sensitizing factor, also can cause the generation of anaphylactic disease.But this irritated factor that causes that can cause some pet body generation allergic phenomenas, but not all can cause equally so-called " anaphylaxis " for any pet body, that is to say that not every sensitizing factor can both cause same anaphylaxis with it all house pets.The special body constitution of this easy allergy can be divided into again geneogenous allergic constitution and allergic constitution posteriority.Congenital allergic constitution refers to that pet body is congenital and just certain sensitizing factor is had to special sensitivity; Posteriority allergic constitution refers to that pet body is due to after the disorder of hormonal system or metabolic system has occurred, thereby causes animal body in a kind of responsive especially state.
Sum up the endexoteric why eczema occurs, first a pet body possesses and has allergic constitution, then touched again and can cause it anaphylactoid anaphylaxis factor occurs, so anaphylactogenic inflammatory reaction in the epidermal area of house pet and very peridermal tissue.Often aspect clinical symptoms, usually can see the unclear erythra of spottiness shape, pleomorphism boundary, be attended by titillation and fester, vesicle, pustule,, scurf coarse by hair, incrustation, depilation, pachyderma, lichen sample pathological changes.
The current doctor trained in Western medicine for the treatment of of eczema there is no specific short, and treatment is taking Chinese medicine as main.The present invention is pure Chinese medicinal preparation, selects conventional medical herbs among the people, and medicine source is extensive, cheap, is that treatment house pet eczema effect is preferably special product, and dehumidifying, antipruritic, anti-infection, promote skin to recover, and can rapid healing eczema not recur.
Summary of the invention
It is a kind of more effective that the first object of the present invention is to provide, and side effect is little, free of contamination, has synergistic herbal medicine; The second object of the present invention is to provide the preparation method of this herbal medicine and the application in treatment house pet eczema thereof.
The object of the invention the first object is achieved in that
The invention provides a kind of medicine, the crude drug of this medicine is made up of Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, Borneolum Syntheticum, and its consumption has good curative effect in following ranges: 400～600 parts of Folium Clerodendri Trichotomis, 200～300 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 200～300 parts of Folium Zanthoxyli Bungeanis, 80～120 parts of Folium Malloti Apeltaes, 80～120 parts of Folium Ilicis Purpureae, 3～8 parts of Borneolum Syntheticums.It is more than weight portion.
Preferred crude drug weight proportion is: 500 parts of Folium Clerodendri Trichotomis, 250 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 250 parts of Folium Zanthoxyli Bungeanis, 100 parts of Folium Malloti Apeltaes, 100 parts of Folium Ilicis Purpureae, 5 parts of Borneolum Syntheticums.
The prescription of pharmaceutical composition of the present invention, is according to the guidance of Chinese veterinarian's theory, and the prescription in conjunction with the feature of house pet morbidity, specifically: Folium Clerodendri Trichotomi expelling wind and removing dampness power is strong, is considered as monarch drug; Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani heat-clearing and toxic substances removing, Anti-Puritic and insecticidal are ministerial drug; Folium Malloti Apeltae, Folium Ilicis Purpureae, Borneolum Syntheticum have heat clearing away, dampness removing, loose fire removing toxic substances, are adjuvant drug altogether.In side, all medicines share, and gather altogether effect of expelling wind and removing dampness, detoxifying and relieving itching.We all medicines by traditional Chinese medical science monarch, minister, help, make theoretical reasonable formula, synergism is clear and definite, curative effect is ensured.
The second object of the present invention is to provide preparation method and the application thereof of above-mentioned herbal medicine.Those skilled in the art can coordinate ingredient of the present invention with suitable adjuvant easily, are prepared into various external preparation.The preparation technology of medicine of the present invention carries out in the steps below:
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 10～14 times of medical material weight, ebuillition of heated extracts 1～3 time, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 50～70% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with appropriate dissolve with ethanol, add sodium benzoate appropriate, mix, filter, to obtain final product.3～8 parts of sodium benzoate.
Further preferred preparation technology is:
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 12 times of medical material weight, ebuillition of heated extracts 2 times, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with appropriate dissolve with ethanol, add sodium benzoate appropriate, mix, filter, to obtain final product.5 parts of sodium benzoate.
In above preparation technology, can be prepared into spray or external-use lotion, to facilitate clinical practice.
More than form according to weight portion as proportioning, in the time producing, can increase or reduce according to corresponding ratio, as large-scale production can with kilogram or taking ton as unit, small-scale production also can be in grams, weight can increase or reduce, but raw medicinal herbs weight proportion constant rate between each composition.
Chinese veterinary medicinal composition of the present invention can be applied in the medicine for the preparation for the treatment of house pet eczema and skin pruritus disease.
Beneficial effect
For further verifying the therapeutical effect of Chinese veterinary medicinal composition of the present invention, inventor has carried out the clinical trial of pet dog and has investigated:
1, material
1.1 animal
Animal: 80 of pet dog.
1.2 test sample
Supply reagent thing: medicine of the present invention in embodiment 1.
Positive control drug: youngster's skin health liniment, Chengdu gloomy medicine pharmacy company limited.
2, method and result
2.1 suffer from eczema pet dog symptom skins there is erythema, is attended by titillation, and festering seriously appears in part, vesicle, pustule,, scurf coarse by hair, incrustation, depilation.
2.2 treatments are got and are suffered from eczema pet dog, are divided at random 2 groups, liniment group of the present invention, positive controls.Every day 3 times, administration 14 days, the healing state at observation eczema position.
2.3 curative effect determinate standard
Recovery from illness: eczema skin heals completely, without dermatosiss such as erythema, vesicle, crusts, without heat, bitterly, the symptom of itching.
Effective: eczema skin heals substantially, without vesicle, slightly have erythema, a crust, without heat, bitterly, the symptom of itching.
Effective: eczema skin take a favorable turn, erythema, crust, vesicle obviously reduce, tool heat, bitterly, the symptom of itching.
Invalid: eczema skin is unchanged or more serious, produce the dermatosiss such as erythema, vesicle, crust more, tool heat, bitterly, the symptom of itching.
2.4 result of the tests the results are shown in following table 1.
Table 1 pet dog eczema treatment result table
| Group | Number of animals | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| The present invention | 40 | 25 | 10 | 5 | 3 | 92.5% |
| Positive drug | 40 | 21 | 7 | 3 | 6 | 85% |
Above result of the test shows, medicine group of the present invention can obviously be treated pet dog eczema, more effective than positive drug group.
Ensureing that, under the prerequisite of curative effect, the crude drug in pharmaceutical composition of the present invention adopts the common medical herbs of field, medicine source is extensive, cheap.Through in the cost price comparison of above-mentioned positive drug, the results are shown in Table 2.
The comparison of table divalent lattice
| Group | Cost price (pressing 100ml calculates) |
| Medicine of the present invention (lotion) | 3.6 first |
| Medicine of the present invention (spray) | 3.8 first |
| Positive drug-youngster skin health liniment | 6.5 first |
Note: calculate by JIUYUE, 2013 Hui nationality medical material market gradeless and uniformly-priced goods price of medicinal material.
Visible, medicine of the present invention has higher price advantage, has good competitiveness in veterinary drug industry.Medicinal application of the present invention has a extensive future.
Detailed description of the invention
Enumerate embodiment below, further illustrate the present invention, each embodiment only, for the present invention is described, does not limit the present invention:
Embodiment 1
Folium Clerodendri Trichotomi 500g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 250g, Folium Zanthoxyli Bungeani 250g, Folium Malloti Apeltae 100g, Folium Ilicis Purpureae 100g, Borneolum Syntheticum 5g
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 12 times of medical material weight, ebuillition of heated extracts 2 times, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with 20ml dissolve with ethanol, add sodium benzoate 5g, mix, filter, obtain lotion.
Embodiment 2
Folium Clerodendri Trichotomi 4kg, Folium eucalypti globueli (Eucalyptus globulus Labill.) 2kg, Folium Zanthoxyli Bungeani 3kg, Folium Malloti Apeltae 1.2kg, Folium Ilicis Purpureae 1.2kg, Borneolum Syntheticum 30g
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 10 times of medical material weight, ebuillition of heated extracts 3 times, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 70% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with 150ml dissolve with ethanol, add sodium benzoate 50g, mix, filter, obtain lotion.
Embodiment 3
Folium Clerodendri Trichotomi 1800g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 900g, Folium Zanthoxyli Bungeani 900g, Folium Malloti Apeltae 240g, Folium Ilicis Purpureae 240g, Borneolum Syntheticum 24g
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 14 times of medical material weight, ebuillition of heated extracts 1 time, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 50% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with 75ml dissolve with ethanol, add sodium benzoate 24g, mix, filter, obtain spray.
Embodiment 4
Folium Clerodendri Trichotomi 550g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 250g, Folium Zanthoxyli Bungeani 200g, Folium Malloti Apeltae 100g, Folium Ilicis Purpureae 80g, Borneolum Syntheticum 5g
Get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 12 times of medical material weight, ebuillition of heated extracts 2 times, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 70% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds the Borneolum Syntheticum with 25ml dissolve with ethanol, add sodium benzoate 6g, mix, filter, obtain spray.
Claims (7)
1. a pharmaceutical composition that is used for the treatment of eczema or skin pruritus, is characterized in that: include following crude drug: Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, Borneolum Syntheticum.
2. the pharmaceutical composition for the treatment of eczema as claimed in claim 1, is characterized in that the crude drug that contains following weight portion:
400～600 parts of Folium Clerodendri Trichotomis, 200～300 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 200～300 parts of Folium Zanthoxyli Bungeanis, 80～120 parts of Folium Malloti Apeltaes, 80～120 parts of Folium Ilicis Purpureae, 3～8 parts of Borneolum Syntheticums.
3. pharmaceutical composition as claimed in claim 2, is characterized in that the crude drug that contains following weight portion:
500 parts of Folium Clerodendri Trichotomis, 250 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 250 parts of Folium Zanthoxyli Bungeanis, 100 parts of Folium Malloti Apeltaes, 100 parts of Folium Ilicis Purpureae, 5 parts of Borneolum Syntheticums.
4. the preparation method of the pharmaceutical composition as described in claim 1 or 2 or 3, it is characterized in that: get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 10～14 times of medical material weight, ebuillition of heated extracts 1～3 time, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 50～70% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, add the Borneolum Syntheticum with dissolve with ethanol, add sodium benzoate appropriate, mix, filter, to obtain final product.
5. the preparation method of pharmaceutical composition as claimed in claim 4, it is characterized in that: get Folium Clerodendri Trichotomi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Zanthoxyli Bungeani, Folium Malloti Apeltae, Folium Ilicis Purpureae, add the water of 12 times of medical material weight, ebuillition of heated extracts 2 times, each 1.5 hours, filter, when filtrate decompression is concentrated into 60 DEG C, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, add the Borneolum Syntheticum with dissolve with ethanol, add sodium benzoate appropriate, mix, filter, to obtain final product.
6. the preparation method of the pharmaceutical composition as described in claim 4 or 5, is characterized in that: said composition can be made into external-use lotion or spray.
7. the pharmaceutical composition described in claim 1 or 2 or 3 is used for the treatment of eczema or skin pruritus.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375127A (en) * | 2017-07-06 | 2017-11-24 | 陈瑞琼 | A kind of refrigerant miliaria composition of dispelling of infant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1390591A (en) * | 2002-07-18 | 2003-01-15 | 代元丁 | Chinese-medicinal liniment fr treating dermatopathy |
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- 2014-03-05 CN CN201410078334.0A patent/CN103893413A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1390591A (en) * | 2002-07-18 | 2003-01-15 | 代元丁 | Chinese-medicinal liniment fr treating dermatopathy |
Non-Patent Citations (1)
| Title |
|---|
| 朱胤龙编: "《实用临床中药学》", 31 July 2013, 陕西科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375127A (en) * | 2017-07-06 | 2017-11-24 | 陈瑞琼 | A kind of refrigerant miliaria composition of dispelling of infant |
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