CN103877280A - Traditional Chinese medicine for treating ankylosing spondylitis - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating ankylosing spondylitis. The traditional Chinese medicine is prepared from the following medical materials in parts by weight: 15 parts of cottonseed, 10 parts of pellionia radicans, 10 parts of blumea lanceolaria, 15 parts of cannabis indicae herba, 10 parts of philippine violet herb, 15 parts of rubia yunnanensis, 9 parts of elsholtzia blanda benth, 30 parts of the root of callicarpa longissima, 15 parts of abroma angusta, 9 parts of pistachio, 15 parts of diploclisia glaucescens and 10 parts of veronicastrum sibiricum. The clinical test proves that the ankylosing spondylitis is safely and effectively treated by the traditional Chinese medicine.

Description

A kind of Chinese medicine for the treatment of ankylosing spondylitis

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of ankylosing spondylitis.

Background technology

Ankylosing spondylitis (Ankylosing Spondylitis, AS) be to be more common in the between twenty and fifty agnogenic seronegative spondyloanthropathy taking axis joint chronic inflammatory disease as master, mainly involve sacroiliac joint, hip joint, articuli intervertebrales, intercostal joint, the most common with sacroiliac joint, can there is rigid spine, deformity late period so that serious function is impaired.Its main pathological change is tendon and ligament attachment point inflammation, and common sympton is the stiff and pain in back, after activity, can alleviate, and except joint, also can invade eye, lung, kidney and heart.Though the Therapeutic Method of ankylosing spondylitis is many, uncertain therapeutic efficacy is fixed, still lacks the specific drug that can control the state of an illness.

The present Research of the related medical material of Chinese medicine of the present invention is as follows:

Semen Gossypii [source] is the seed of Malvaceae cotton cotton Gossypium herbaceum L., tree cotton (Chinese cotton) G.arboreum L. and Gossypium hirsutum L. (highland cotton) G.hirsutum L..Xia Qiu gathers, and dries.[function cures mainly] invigorating the liver and kidney, strong waist knee joint, warming the stomach pain relieving, hemostasis, lactogenic.For menorrhagia, dysfunctional uterine hemorrhage, agalactosis, stomachache, weakness of the waist and knees.

Herba Pellioniae [source] Urticaceae Herba Pellioniae platymiscium Herba Pellioniae Pellionia radicans (Sieb.etZucc.) Wedd., with root or all herbal medicine.The spring and summer autumn gathers, using fresh herb or dry.[function cures mainly] blood stasis dispelling, detumescence, removing toxic substances, pain relieving.Swell and ache for dampening, toothache, furuncle, venom.

Herba Blumeae lanceolariae [source] Compositae Herba Blumeae Balsamiferae thousand Herba Blumeae Balsamiferae Blumea lanceolaria of platymiscium (Roxb.) Druce, is used as medicine with leaf.Can adopt the whole year, mostly is using fresh herb.[function cures mainly] wind-damp dispelling, reducing swelling and alleviating pain.For headache; Outward for rheumatic ostalgia, puerperal arthralgia, treating swelling and pain by traumatic injury.

Herba saussureae romuleifoliae [source] Compositae Genus Saussurea plant line leaf hieracioides Saussurea romuleifolia Franch., is used as medicine with herb or root.Autumn Mo gathers, and cleans using fresh herb or dries.[function cures mainly] dispelling, collateral-activating, removing toxic substances, removing food stagnancy.For rheumatic arthritis, traumatic injury, infantile malnutrition; Venom is controlled in external.

The little Radix Polygalae Polygala sibirica of little Lan flower Herba Violae [source] Polygalaceae polygala L. var.megalopha Franch., is used as medicine with Herb.Can adopt the whole year, and chopping is dried.[function cures mainly] antiinflammatory, pain relieving, draws out pus by applying a plaster to the affected part, granulation promoting.For parotitis, infantile pneumonia, gastroenteritis, stomachache, furuncle, toothache, bones and muscles pain due to rheumatism; Skin ulcer, furuncle are controlled in external, stremma, traumatic injury impairment caused by overstrain.

Radix Rubiae Yunnanensis [source] Labiatae salvia SANYE Mus tail Salvia trijuga Diels, is used as medicine with root.Adopt root spring and autumn, dry summer.[function cures mainly] regulating menstruation and activating blood, promoting tissue regeneration by removing blood stasis.For menoxenia, dysmenorrhea, blood deficiency amenorrhea, lumbago due to renal deficiency.

Herba Elsholtziae Blandae [source] is labiate Elsholtzia blanda Elsholtzia blanda (Benth.) Benth.[Aphanochilus blandus Benth; Mentha blanda Wall.ex Hook.] herb.Summer, autumn gather, magnesium with or dry in the shade.[function cures mainly] heat clearing away; Dampness removing; Removing toxic substances.Main cold, fever; Sensible heat dysentery; Jaundice; Dysuria; Foot a word used for translation is rotten itches; Burn.

Radix Callicarpae longissimae [source] is the root of dicotyledon medicine Verbenaceae Caulis te Folium Callicarpae Longissimae Callicarpa longissima (Hemsl.) Merr..Evenly can adopt the whole year, cleans, and section, dries or using fresh herb.[function cures mainly] wind-expelling pain-stopping; Invigorate blood circulation.Main air pain of dampness syndrome; Traumatic injury congestive edema; Caries pain.

High-spirited [source] is high large lotus Ambroma augusta (L.) the L. f.[Theobroma augusta L. of Sterculiaceae plant; Abroma fastuosa Jacq.] root.Autumn, winter take root, wash away silt, section, using fresh herb or dry.[function cures mainly] restores menstrual flow and invigorates blood circulation; Reducing swelling and alleviating pain.Main menoxenia; Skin infection furuncle and phyma; Traumatic injury.

Pistachio [source] is the fruit of Anacardiaceae plant pistachio Pistacia vera L..The mellow fruit of gathering the 7-8 month, dries for subsequent use.[function cures mainly] the kidney warming; Warm spleen.The main waist of suffering from a deficiency of the kidney is cold; Sexual impotence; Insufficiency of the spleen cold-dysentery.

Caulis Diploclisiae Glaucescentis [source] is the rattan of menispermaceous plants Caulis Diploclisiae Glaucescentis Diploclisia glaucescens (Bl.) Diels.All can adopt the whole year, extracts rattan fragrant plant, dries, or adopt fresh stem and use.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main rheumatic ostalgia; Laryngopharynx swelling and pain; Cholecystitis; Dysentery; Urinary tract infection; Venom.

Grass Radix Clematidis [source] is Scrophulariaceae Leptandra sibirica platymiscium Veronica sibirica Veronicastrum sibiricum (L.) Pennell[Veronica sibirica L.], be used as medicine with herb or root.Uproot autumn; Adopt herb summer, clean using fresh herb or dry.[function cures mainly] expelling wind and removing dampness, removing toxic substances, hemostasis.For flu, rheumatic lumbago and scelalgia, myalgia, cystitis; Wound hemorrhage is controlled in external, venom, insect-bite.

Summary of the invention

The present invention aims to provide a kind of Chinese medicine for the treatment of ankylosing spondylitis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective treatment ankylosing spondylitis.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of Chinese medicine for the treatment of ankylosing spondylitis, it is characterized in that, be prepared from by the medical material of following weight proportion: 15 parts of Semen Gossypiis, 10 parts of Herba Pellioniae, 10 parts of Herba Blumeae lanceolariaes, 15 parts of Herba saussureae romuleifoliaes, 10 parts of little Lan flower Herba Violaes, 15 parts of Radix Rubiae Yunnanensis, 9 parts of Herba Elsholtziae Blandae, 30 parts of Radix Callicarpae longissimaes, 15 parts of high-spiriteds, 9 parts of pistachios, 15 parts of Caulis Diploclisiae Glaucescentiss, 10 parts of careless Radix Clematidis.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, physical data

With reference to the New York standard of Americanism damp disease association 1984 revision and " new Chinese medicine guideline of clinical investigations. the guideline of clinical investigations of new Chinese medicine treatment ankylosing spondylitis " the active stage standard that adopts, the ankylosing spondylitis out-patient that 90 examples meet diagnostic criteria is collected between year June altogether in inventor in March, 2009-2010, age 18-45 year, course of disease 1-10.Be divided at random: treatment group 45 examples, matched group 45 examples.The data there was no significant differences such as two groups of ages, the state of an illness, have comparability.

2, test method

2.1 liang of groups all adopt identical Primary Care measure, comprise meals, Function Exercise Guiding After.Treatment group: the capsule that oral the present invention makes according to specific embodiment 1, sooner or later respectively once.Matched group: oral YISHEN JUANBI WAN 8g, every day 3 times.Be 3 months the course for the treatment of.

3, efficacy determination and therapeutic outcome

3.1 detect index: Schober test, erythrocyte sedimentation rate (ESR), c reactive protein (CRP)

3.2 criterion of therapeutical effect

Clinical remission: waist and sacrum pain disappearance, spinal function recovers normal with standing up to stand up, periphery arthralgia, tenderness, stiff disappearance in morning, ESR, CRP are down to normally.Effective: waist and sacrum pain obviously alleviates, spinal function and stand up dysstasia and obviously improve, periphery arthralgia, tenderness, morning, deadlock obviously alleviated, and ESR, CRP obviously decline.Effective: to swell and ache and alleviate to some extent in the position of getting involved, spinal column range of activity increases, and stands up dysstasia and periphery arthroncus takes a turn for the better to some extent, morning deadlock time < 20min, ESR, CRP decline to some extent.Invalid: the position symptom and sign of getting involved is without improving or increasing the weight of, and ESR, CRP are without declining or having rising.

3.2 treatment statistical results are in table 1, table 2.

Table 1 liang group curative effect comparison

Group

n

Clinical remission

Effective

Effectively

Invalid

Untoward reaction example

Total effective rate (%)

Treatment group

45

5(11.1％)

17(37.8％)

13(28.9％)

10(22.2％)

3(6.7％)

77.8％

Matched group

45

7(15.6％)

18(40.0％)

14(31.1％)

6(13.3％)

5(11.1％)

86.7％

Table 2 liang group treatment before and after test index comparison

Note: relatively have significant difference before and after two groups of treatments, * P < 0.05, shows to improve disease situation after Drug therapy visible, and the medicine that the present invention makes can safe and effective treatment ankylosing spondylitis.

Detailed description of the invention

In order to understand better and to implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Specific embodiment 1

Take: 15 grams of Semen Gossypiis, 10 grams of Herba Pellioniae, 10 grams of Herba Blumeae lanceolariaes, 15 grams of Herba saussureae romuleifoliaes, 10 grams of little Lan flower Herba Violaes, 15 grams of Radix Rubiae Yunnanensis, 9 grams of Herba Elsholtziae Blandae, 30 grams of Radix Callicarpae longissimaes, 15 grams of high-spiriteds, 9 grams of pistachios, 15 grams of Caulis Diploclisiae Glaucescentiss, 10 grams of careless Radix Clematidis, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.

Be used for the treatment of ankylosing spondylitis.Oral, every bu is taken for twice sooner or later.

Specific embodiment 2

Take: 15 grams of Semen Gossypiis, 10 grams of Herba Pellioniae, 10 grams of Herba Blumeae lanceolariaes, 15 grams of Herba saussureae romuleifoliaes, 10 grams of little Lan flower Herba Violaes, 15 grams of Radix Rubiae Yunnanensis, 9 grams of Herba Elsholtziae Blandae, 30 grams of Radix Callicarpae longissimaes, 15 grams of high-spiriteds, 9 grams of pistachios, 15 grams of Caulis Diploclisiae Glaucescentiss, 10 grams of careless Radix Clematidis, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, pulverize, must meet the powder of 1 day consumption of normal adult.

Be used for the treatment of ankylosing spondylitis.Oral, every bu is taken for twice sooner or later.

Specific embodiment 3

Take: 15 grams of Semen Gossypiis, 10 grams of Herba Pellioniae, 10 grams of Herba Blumeae lanceolariaes, 15 grams of Herba saussureae romuleifoliaes, 10 grams of little Lan flower Herba Violaes, 15 grams of Radix Rubiae Yunnanensis, 9 grams of Herba Elsholtziae Blandae, 30 grams of Radix Callicarpae longissimaes, 15 grams of high-spiriteds, 9 grams of pistachios, 15 grams of Caulis Diploclisiae Glaucescentiss, 10 grams of careless Radix Clematidis, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, then add appropriate dextrin and correctives, and to granulate according to this area common process, packaging, can make the granule that meets 1 day consumption of normal adult.

Be used for the treatment of ankylosing spondylitis.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. treat the Chinese medicine of ankylosing spondylitis for one kind, it is characterized in that, be prepared from by the medical material of following weight proportion: 15 parts of Semen Gossypiis, 10 parts of Herba Pellioniae, 10 parts of Herba Blumeae lanceolariaes, 15 parts of Herba saussureae romuleifoliaes, 10 parts of little Lan flower Herba Violaes, 15 parts of Radix Rubiae Yunnanensis, 9 parts of Herba Elsholtziae Blandae, 30 parts of Radix Callicarpae longissimaes, 15 parts of high-spiriteds, 9 parts of pistachios, 15 parts of Caulis Diploclisiae Glaucescentiss, 10 parts of careless Radix Clematidis.