CN103877099A - Nerve block medicinal composition - Google Patents
Nerve block medicinal composition Download PDFInfo
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- CN103877099A CN103877099A CN201410113878.6A CN201410113878A CN103877099A CN 103877099 A CN103877099 A CN 103877099A CN 201410113878 A CN201410113878 A CN 201410113878A CN 103877099 A CN103877099 A CN 103877099A
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- nerve block
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- medicinal composition
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Abstract
The invention relates to a nerve block medicinal composition. The nerve block medicinal composition consists of the following components in parts by volume: 10 parts of 0.75 percent ropivacaine, 2 parts of glucocorticoid and 13 parts of 0.9 percent normal saline. The nerve block medicinal composition has the advantages that dexamethasone is added into a formula, so that injuries to nerve roots and toxic reactions of local anesthetics in a puncturing process can be reduced; dexamethasone has the effects of resisting allergy, resisting angioedema and reducing the toxic reactions of local anesthetics, so that the nerve block success rate is increased, and toxic reactions are reduced.
Description
Technical field
The present invention relates to medical compositions, particularly a kind of nerve block pharmaceutical composition.
Background technology
At the surrounding injection local anaesthetics of nerve trunk, clump, joint, block its conduction of impulse, make arranged region produce anesthetic action, claim nerve block.Nerve block only need be injected a place, can obtain larger anesthesia region.But have the possibility that causes severe complication, therefore must be familiar with topography while operation, understand the tissue that puncture needle will pass through, and near blood vessel, internal organs and body cavity etc.Between conventional nerve block helps, under socket of the eye, ischium, refer to (toe) nerve trunk retardance, cervical plexus, brachial plexus block, and diagnosis and treatment stellate ganglion and the lumbar sympathetic ganglion block etc. used.
Nerve block anesthesia is the especially the most frequently used anesthesia method of basic hospital of clinical anesthesia, its pharmaceutical formulation uses simple local anaesthetics mostly, as lignocaine, bupivacaine, ropivacaine etc., clinical most popular formula is 0.75% ropivacaine 10ml, 0.9% normal saline 15ml, but nerve block needs Anesthetist according to clinical experience and anatomic landmark, use anesthetic puncture acupuncture to nerve root to find paresthesia, easily injured nerve; And simple high concentration local anaesthetics easily causes nerve root toxic reaction.
Summary of the invention
For the defect existing in prior art, the object of the present invention is to provide a kind of nerve block pharmaceutical composition.
Technical scheme of the present invention is as follows:
A kind of nerve block pharmaceutical composition, is made up of the component of following volume fraction:
0.75% 10 parts of ropivacaines, 2 parts of glucocorticoids, 0.9% 13 parts of normal saline.
On the basis of such scheme, described glucocorticoid is: dexamethasone, prednisolone or andrographolide.
On the basis of such scheme.Described glucocorticoid is: dexamethasone.
Advantage of the present invention is: in formula, add dexamethasone, can reduce piercing process nerve root is caused to damage and local anaesthetics toxic reaction, utilize the effect of dexamethasone antiallergic, anti-neural edema, minimizing local anaesthesia drug toxicity reaction, improve nerve block success rate, reduce toxic reaction.
The specific embodiment
Embodiment 1
A kind of nerve block pharmaceutical composition, is made up of the component of following volume fraction:
0.75% ropivacaine 10ml, dexamethasone 2ml, 0.9% normal saline 13ml.
Embodiment 2
A kind of nerve block pharmaceutical composition, is made up of the component of following volume fraction:
0.75% ropivacaine 10ml, prednisolone 2ml, 0.9% normal saline 13ml.
Embodiment 3
A kind of nerve block pharmaceutical composition, is made up of the component of following volume fraction:
0.75% ropivacaine 10ml, andrographolide 2ml, 0.9% normal saline 13ml.
Experimental example 1
Old women 69 years old, body weight 60kg, previously diabetes medical history 3 years, takes metformin, glycemic control can, physical examination: BP134/85mmhg, P60 beat/min, SPO
297%, R18 beat/min, every auxiliary examination is all within normal range.Because of left ulnar fracture, intend at the descending left ulnar fracture internal fixation of brachial plexus block anesthesia.Adopt 0.75% ropivacaine 10ml, dexamethasone 2ml, 0.9% normal saline 13ml, the left brachial plexus nerve block of row, anesthesia blockage effect is excellent, can meet requirements of operation.Patient is without local anaesthesia drug toxicity reaction.
Experiment 2
Elderly men 70 years old, body weight 70kg, previously coronary heart disease medical history 2 years, takes Drug therapy certainly.Physical examination: BP138/80mmhg, P62 beat/min, SPO
298%, R18 beat/min, every auxiliary examination is all within normal range.Because of right ulnar fracture, intend at the descending right ulnar fracture internal fixation of brachial plexus block anesthesia.Adopt 0.75% ropivacaine 10ml, prednisolone 2ml, 0.9% normal saline 13ml, the right brachial plexus nerve block of row, anesthesia blockage effect is excellent, can meet requirements of operation.Patient is without local anaesthesia drug toxicity reaction.
Experiment 3
Middle-aged male 50 years old, body weight 69kg, previously body is strong.Physical examination: BP129/80mmhg, P75 beat/min, SPO2100%, R17 beat/min, every auxiliary examination is all within normal range.Because of right clavicular fracture, intend at the descending right clavicular fracture internal fixation of block anesthesia of cervical plexus.Adopt 0.75% ropivacaine 10ml, andrographolide 2ml, 0.9% normal saline 13ml, the right cervical plexus nerve block of row, anesthesia blockage effect is excellent, can meet requirements of operation.Patient is without local anaesthesia drug toxicity reaction.
Manufacturer and lot number:
Ropivacaine Cisen Pharmaceutical Co., Ltd. lot number 130224633
Dexamethasone Cisen Pharmaceutical Co., Ltd. lot number 1307116421
The lot number Z08941 of prednisolone pfizer inc
Andrographolide profit monarch pharmacy lot number 120710.
Claims (2)
1. a nerve block pharmaceutical composition, is characterized in that being made up of the component of following volume fraction:
0.75% 10 parts of ropivacaines, 2 parts of glucocorticoids, 0.9% 13 parts of normal saline.
2. nerve block pharmaceutical composition according to claim 1, is characterized in that described glucocorticoid is: dexamethasone, prednisolone or andrographolide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410113878.6A CN103877099A (en) | 2014-03-25 | 2014-03-25 | Nerve block medicinal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410113878.6A CN103877099A (en) | 2014-03-25 | 2014-03-25 | Nerve block medicinal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103877099A true CN103877099A (en) | 2014-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410113878.6A Pending CN103877099A (en) | 2014-03-25 | 2014-03-25 | Nerve block medicinal composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758933A (en) * | 2014-10-29 | 2015-07-08 | 吴鑫欣 | Drug and drug delivery system for treating |
| RU2672046C1 (en) * | 2017-12-12 | 2018-11-08 | Федеральное государственное бюджетное учреждение "Российский ордена Трудового Красного Знамени научно-исследовательский институт травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "РНИИТО им. Р.Р. Вредена" Минздрава России) | Method of one-stage local infiltration anesthesia for hip arthroplasty |
| CN115463084A (en) * | 2021-06-10 | 2022-12-13 | 北京泰德制药股份有限公司 | Compound oil solution preparation for long-acting analgesia and preparation method thereof |
| RU2798308C1 (en) * | 2022-07-21 | 2023-06-21 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации | Method of perioperative combined analgesia in decompressive and stabilizing operations on the thoracic or lumbar spine |
-
2014
- 2014-03-25 CN CN201410113878.6A patent/CN103877099A/en active Pending
Non-Patent Citations (3)
| Title |
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| 刘月江: "地塞米松对0.5%罗哌卡因腰丛-坐骨神经联合阻滞作用的影响", 《临床麻醉学杂志》 * |
| 苗鲁民等: "地塞米松对罗哌卡因臂丛神经阻滞效果的影响", 《天津医药》 * |
| 陈会: "地塞米松对麻醉手术后神经损伤的预防和控制效果", 《环球中医药》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758933A (en) * | 2014-10-29 | 2015-07-08 | 吴鑫欣 | Drug and drug delivery system for treating |
| RU2672046C1 (en) * | 2017-12-12 | 2018-11-08 | Федеральное государственное бюджетное учреждение "Российский ордена Трудового Красного Знамени научно-исследовательский институт травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "РНИИТО им. Р.Р. Вредена" Минздрава России) | Method of one-stage local infiltration anesthesia for hip arthroplasty |
| CN115463084A (en) * | 2021-06-10 | 2022-12-13 | 北京泰德制药股份有限公司 | Compound oil solution preparation for long-acting analgesia and preparation method thereof |
| CN115463084B (en) * | 2021-06-10 | 2024-05-28 | 北京泰德制药股份有限公司 | Compound oil solution preparation for long-acting analgesia and preparation method thereof |
| RU2798308C1 (en) * | 2022-07-21 | 2023-06-21 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации | Method of perioperative combined analgesia in decompressive and stabilizing operations on the thoracic or lumbar spine |
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Application publication date: 20140625 |
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