CN103860513A - Piroxicam tablets and preparation process thereof - Google Patents
Piroxicam tablets and preparation process thereof Download PDFInfo
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- CN103860513A CN103860513A CN201410095250.8A CN201410095250A CN103860513A CN 103860513 A CN103860513 A CN 103860513A CN 201410095250 A CN201410095250 A CN 201410095250A CN 103860513 A CN103860513 A CN 103860513A
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- piroxicam
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Abstract
The invention discloses piroxicam tablets and a preparation process and purposes thereof. The product consists of piroxicam, lactose, pregelatinized starch, hydroxypropyl methyl cellulose, carboxymethyl starch sodium, polysorbate-80, 15% pregelatinized starch for slushing, superfine silica powder, magnesium stearate and a gastric soluble film coating premix. The production method comprises the steps: preparing tablet cores, coating and the like. The piroxicam tablets are used for treating 30 cases of rheumatoid arthritis, have good curative effects of diminishing inflammation and relieving pain and have slight influence on erythrocyte sedimentation rate, the total effective rate is 88 percent, and the piroxicam tablets have the characteristics of low administration frequency, stable blood concentration, long duration and the like.
Description
Invention field
The present invention relates to chemical pharmacy field, be specifically related to a kind of piroxicam tablet and preparation technology thereof.
Background of invention
Arthritis is a kind of commonly encountered diseases, chronic disease, wherein take osteoarthritis and rheumatoid arthritis as principal mode.It is reported, China approximately has 18% people to suffer from the arthritis of certain form, and number of the infected exceedes 200,000,000.The mankind's health in arthritis serious threat, has influence on patient's live and work, some patient be can't take care of oneself, disability.Some patient's activity is restricted, arthroncus, stiff and pain, and severe patient joint permanent deformation, is the major reason that old people is disabled, and therefore needs timely treatment.
Piroxicam (Piroxicam), have another name called piroxicam, piroxicam, An Erke, Xi Pukang, expense pyridine, chemistry 2-methyl-4-hydroxy-n-(2-pyridine radicals)-2H-1 by name, 2-benzothiazine-3-carboxamide-1,1-dioxide, for non-steroidal anti-inflammatory analgesics, there are antiinflammatory, analgesia and refrigeration function, its effect is slightly better than indometacin.Piroxicam makes the synthetic minimizing of tissue local prostaglandin by suppressing cyclooxygenase, suppresses the release of leukocytic chemotaxis and lysosomal enzyme and brings into play pharmacological action.For alleviating the pain of various arthritis and soft tissue lesions and the symptomatic treatment of swelling.For acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and acute gouty arthritis, be specially adapted to acute inflammation pain therapy clinically.Also can be used for acute and chronic periodontitis, periodontal turgescene, exodontia postoperative pain.
, there is undesirable part at aspects such as curative effects in the medicine of existing treatment rheumatoid arthritis, painful osteoarthritis (arthrosis, osteoarthritis).The object of the present invention is to provide a kind of rheumatoid arthritis, effective piroxicam tablet and preparation technology thereof of painful osteoarthritis for the treatment of, simple to operate, pollute less, with low cost, be applicable to suitability for industrialized production.
Summary of the invention
The object of the present invention is to provide a kind of rheumatoid arthritis, effective piroxicam tablet and preparation technology thereof of painful osteoarthritis for the treatment of, and through repetition test, each component screening is arrived to weight ratio of the present invention, be surprised to find that the tablet quality obtaining is stable, stripping is fast, in body, distribute rapidly, bioavailability is high.
On the one hand, the invention provides a kind of piroxicam tablet, wherein every 1000 are made up of following weight item:
Some embodiments therein, piroxicam tablet of the present invention, wherein every 1000 are made up of following weight item:
On the other hand, the invention provides a kind of preparation technology of piroxicam tablet, it comprises the following steps:
(1) make label: piroxicam, lactose, pregelatinized Starch, low-substituted hydroxypropyl cellulose are crossed to 100 mesh sieves, join mix homogeneously in wet mixing pelletizer by equivalent incremental method, obtain mixed powder; Tween-80 is dissolved in 30～50 times of ethanol, joins in above-mentioned mixed powder, mix, 15% concentration punching slurry is joined in mixed powder with pregelatinized Starch again, make 18～40 order granules, 60～70 ℃ dry, 24 mesh sieve granulate, rewinding when moisture is 1.0～3.0%, makes label for subsequent use;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with to 11% outstanding mixed liquid with 80% ethanol, be uniformly mixed 60 minutes for subsequent use; Label is poured in coating pan, coating pan adjustment of rotational speed is 2～3 revs/min, spray gun distance is adjusted to from sheet bed 30～40cm, start preheating label, ℃ left and right, label temperature to 40～50, atomisation pressure, at 0.5～0.6MPa, starts coating to 3.0%, 30～40 ℃ of sheet weightening finishes and within dry 12 hours, obtains product;
The consumption of above-mentioned each component, every 1000 are made up of following ingredients:
Piroxicam tablet of the present invention is applied to preparation treatment and is used for the treatment of clinically rheumatic and rheumatoid arthritis, has obvious analgesia, antiinflammatory and certain detumescence effect, and effective percentage can reach more than 85% in the recent period.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
(1) make label: piroxicam, lactose, pregelatinized Starch, hydroxypropyl methylcellulose, carboxymethylstach sodium are crossed to 100 mesh sieves, join in wet mixing pelletizer and mix equal Uniform by equivalent incremental method, obtain mixed powder; Tween-80 is dissolved in 30～50 times of ethanol, joins in above-mentioned mixed powder, mix, 15% concentration punching slurry is joined in mixed powder with pregelatinized Starch again, make 18～40 order granules, 60～70 ℃ dry, 24 mesh sieve granulate, rewinding when moisture is 1.0～3.0%, makes label for subsequent use;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with to 11% outstanding mixed liquid with 80% ethanol, be uniformly mixed 60 minutes for subsequent use; Label is poured in coating pan, coating pan adjustment of rotational speed is 2～3 revs/min, spray gun distance is adjusted to from sheet bed 30～40cm, start preheating label, ℃ left and right, label temperature to 40～50, atomisation pressure, at 0.5～0.6MPa, starts coating to 3.0%, 30～40 ℃ of sheet weightening finishes and within dry 12 hours, obtains product;
The consumption of above-mentioned each component, every 1000 are made up of following ingredients:
Piroxicam tablet of the present invention is applied to preparation treatment rheumatic and rheumatoid arthritis, has obvious analgesia, antiinflammatory and certain detumescence effect, and effective percentage can reach more than 85% in the recent period.
Biological test
The present invention treats piroxicam tablet and treats 30 routine rheumatoid arthritiss, its anti-inflammatory analgesic good effect, but the feature such as on the impact of erythrocyte sedimentation rate little, total effective rate is 88%, and it is few that medicine of the present invention has medicining times, and blood drug level is steady, and the persistent period is long.
Model case:
In certain, man, 55 years old, main disease: rheumatoid arthritis more than 10 year, walking disorder, start to take product of the present invention in August, 2010, and curative effect is obvious, and after one month, symptom has clear improvement, and can walk.
Chen, female, 50 years old, main disease: rheumatoid arthritis more than 8 year, walking disorder, start to take product of the present invention in August, 2010, and curative effect is obvious, freedom of movement after month.
Tang, man, 45 years old, main disease: rheumatoid arthritis more than 6 year, joint can not freely be stretched, and starts to take product of the present invention in March, 2010, joint can activity freely.
Claims (3)
1. a piroxicam tablet, wherein every 1000 are made up of following weight item:
2. piroxicam tablet according to claim 1, wherein every 1000 are made up of following weight item:
3. a preparation technology for piroxicam tablet, it comprises the following steps:
(1) make label: piroxicam, lactose, pregelatinized Starch, low-substituted hydroxypropyl cellulose are crossed to 100 mesh sieves, join mix homogeneously in wet mixing pelletizer by equivalent incremental method, obtain mixed powder; Tween-80 is dissolved in 30～50 times of ethanol, joins in above-mentioned mixed powder, mix, 15% concentration punching slurry is joined in mixed powder with pregelatinized Starch again, make 18～40 order granules, 60～70 ℃ dry, 24 mesh sieve granulate, rewinding when moisture is 1.0～3.0%, makes label for subsequent use;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with to 11% outstanding mixed liquid with 80% ethanol, be uniformly mixed 60 minutes for subsequent use; Label is poured in coating pan, coating pan adjustment of rotational speed is 2～3 revs/min, spray gun distance is adjusted to from sheet bed 30～40cm, start preheating label, ℃ left and right, label temperature to 40～50, atomisation pressure, at 0.5～0.6MPa, starts coating to 3.0%, 30～40 ℃ of sheet weightening finishes and within dry 12 hours, obtains product;
The consumption of above-mentioned each component, every 1000 are made up of following ingredients:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410095250.8A CN103860513A (en) | 2014-03-14 | 2014-03-14 | Piroxicam tablets and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410095250.8A CN103860513A (en) | 2014-03-14 | 2014-03-14 | Piroxicam tablets and preparation process thereof |
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| CN103860513A true CN103860513A (en) | 2014-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410095250.8A Pending CN103860513A (en) | 2014-03-14 | 2014-03-14 | Piroxicam tablets and preparation process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420672A (en) * | 2016-11-06 | 2017-02-22 | 成都先先先生物科技有限公司 | Piroxicam film coating agent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618026A (en) * | 2009-07-06 | 2010-01-06 | 江苏飞马药业有限公司 | Meloxicam tablet, production technology and purposes thereof |
| CN101766822A (en) * | 2009-01-06 | 2010-07-07 | 广州欧化药业有限公司 | Piroxicam beta-cyclodextrin inclusion compounds and preparation method of tablets thereof |
-
2014
- 2014-03-14 CN CN201410095250.8A patent/CN103860513A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766822A (en) * | 2009-01-06 | 2010-07-07 | 广州欧化药业有限公司 | Piroxicam beta-cyclodextrin inclusion compounds and preparation method of tablets thereof |
| CN101618026A (en) * | 2009-07-06 | 2010-01-06 | 江苏飞马药业有限公司 | Meloxicam tablet, production technology and purposes thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420672A (en) * | 2016-11-06 | 2017-02-22 | 成都先先先生物科技有限公司 | Piroxicam film coating agent and preparation method thereof |
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Application publication date: 20140618 |