CN101618026A - Meloxicam tablet, production technology and purposes thereof - Google Patents
Meloxicam tablet, production technology and purposes thereof Download PDFInfo
- Publication number
- CN101618026A CN101618026A CN200910182261A CN200910182261A CN101618026A CN 101618026 A CN101618026 A CN 101618026A CN 200910182261 A CN200910182261 A CN 200910182261A CN 200910182261 A CN200910182261 A CN 200910182261A CN 101618026 A CN101618026 A CN 101618026A
- Authority
- CN
- China
- Prior art keywords
- grams
- meloxicam
- pregelatinized starch
- gram
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a Meloxicam tablet, a production technology and purposes thereof. The Meloxicam tablet consists of Meloxicam, lactose, pregelatinized starch, low-substitute hyprolose, polysorbate 80, 12% of pregelatinized starch for flushing syrup, superfine silica gel powder, magnesium stearate, alcohol and gastric-solubility film coating premixer. The production method of the Meloxicam tablet comprises the following steps: manufacturing tablet cores and coatings, and the like. The Meloxicam tablet treats 125 cases of rheumatoid arthritis, and the anti-inflammatory and pain-relieving curative effects are good, while the curative effect on blood sedimentation is little, and the total effective rate achieves 84%. The invention has the characteristics of few medical taking times, stable blood and medicine concentration, long duration period, and the like.
Description
Technical field:
The present invention relates to a kind of medicine.
Background technology:
There is undesirable part in the medicine of existing treatment rheumatoid arthritis, painful osteoarthritis (arthrosis, osteoarthritis) at aspects such as curative effects.
Summary of the invention:
The object of the present invention is to provide a kind of rheumatoid arthritis, effective meloxicam tablet and production technology and purposes of painful osteoarthritis for the treatment of.
Technical solution of the present invention is:
A kind of meloxicam tablet is characterized in that: be made up of following weight item for per 1000:
Meloxicam 7.5 grams
Lactose 16.3~130 grams
Pregelatinized Starch 8.0~48 grams
Low-substituted hydroxypropyl cellulose 2.5~20 grams
Tween-80 0.1~0.8 gram
12% concentration is dashed slurry and is restrained with pregelatinized Starch 4.5~30
Micropowder silica gel 0.3~2.4 gram
Magnesium stearate 0.2~1.2 gram
Ethanol 6.5~65 grams
Stomach dissolved film coating pre-mix dose 4.5~8.5 grams.
A kind of production technology of meloxicam tablet is characterized in that: comprise the following steps:
(1) makes label: meloxicam, lactose, pregelatinized Starch, low-substituted hydroxypropyl cellulose are crossed 100 mesh sieves, join mix homogeneously in the wet mixing pelletizer, get mixed powder by the equivalent incremental method; Tween-80 is dissolved in 30~50 times of ethanol, join in the above-mentioned mixed powder, mix minute, again 12% concentration being dashed slurry joins in the mixed powder with pregelatinized Starch, make 18~40 order granules, 60~70 ℃ of dryings, 24 mesh sieve granulate, moisture is rewinding in 1.0~3.0% o'clock, and it is standby to make label;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with 11% the outstanding liquid that mixes with 80% ethanol, mix 60 minutes standby; Label is poured in the coating pan, the coating pan rotating speed is adjusted into 2~3 rev/mins, the spray gun distance is transferred to from sheet bed 30~40cm, beginning preheating label, about label temperature to 40~50 ℃, atomisation pressure is at 0.5~0.6MPa, and beginning coating to sheet weightening finish 3.0% gets final product, and 30~40 ℃ of dryings got product in 12 hours;
The consumption of above-mentioned each component, form by following ingredients for per 1000:
Meloxicam 7.5 grams
Lactose 16.3~130 grams
Pregelatinized Starch 8.0~48 grams
Low-substituted hydroxypropyl cellulose 2.5~20 grams
Tween-80 0.1~0.8 gram
12% concentration is dashed slurry and is restrained with pregelatinized Starch 4.5~30
Micropowder silica gel 0.3~2.4 gram
Magnesium stearate 0.2~1.2 gram
Ethanol 6.5~65 grams
Stomach dissolved film coating pre-mix dose 4.5~8.5 grams.
A kind of meloxicam tablet was treated application in rheumatoid arthritis, the painful osteoarthritis medicine in preparation.
The present invention treats meloxicam tablet and treats 125 routine rheumatoid arthritiss, its anti-inflammatory analgesic good effect, but to the influence of erythrocyte sedimentation rate and little, total effective rate is 84%, and medicine of the present invention has that medicining times is few, and blood drug level is steady, characteristics such as longer duration.
Model case:
The Qin, the man, 66 years old, main disease: rheumatoid arthritis more than 10 year, walking disorder, begin to take product of the present invention in March, 2009, and curative effect is obvious, freedom of movement after month.
Product instructions about how to take medicine of the present invention: 1 of every day.
The invention will be further described below in conjunction with embodiment.
The specific embodiment:
(1) makes label: meloxicam, lactose, pregelatinized Starch, low-substituted hydroxypropyl cellulose are crossed 100 mesh sieves, join mix homogeneously in the wet mixing pelletizer, get mixed powder by the equivalent incremental method; Tween-80 is dissolved in 30~50 times of ethanol, join in the above-mentioned mixed powder, mix minute, again 12% concentration being dashed slurry joins in the mixed powder with pregelatinized Starch, make 18~40 order granules, 60~70 ℃ of dryings, 24 mesh sieve granulate, moisture is rewinding in 1.0~3.0% o'clock, and it is standby to make label;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with 11% the outstanding liquid that mixes with 80% ethanol, mix 60 minutes standby; Label is poured in the coating pan, the coating pan rotating speed is adjusted into 2~3 rev/mins, the spray gun distance is transferred to from sheet bed 30~40cm, beginning preheating label, about label temperature to 40~50 ℃, atomisation pressure is at 0.5~0.6MPa, and beginning coating to sheet weightening finish 3.0% gets final product, and 30~40 ℃ of dryings got product in 12 hours;
The consumption of above-mentioned each component, form by following ingredients for per 1000:
Meloxicam 7.5 grams
Lactose 16.3~130 grams
Pregelatinized Starch 8.0~48 grams
Low-substituted hydroxypropyl cellulose 2.5~20 grams
Tween-80 0.1~0.8 gram
12% concentration is dashed slurry and is restrained with pregelatinized Starch 4.5~30
Micropowder silica gel 0.3~2.4 gram
Magnesium stearate 0.2~1.2 gram
Ethanol 6.5~65 grams
Stomach dissolved film coating pre-mix dose 4.5~8.5 grams.
Meloxicam tablet of the present invention is applied to preparation and treated rheumatoid arthritis, painful osteoarthritis medicine.
Claims (3)
1, a kind of meloxicam tablet is characterized in that: be made up of following weight item for per 1000:
Meloxicam 7.5 grams
Lactose 16.3~130 grams
Pregelatinized Starch 8.0~48 grams
Low-substituted hydroxypropyl cellulose 2.5~20 grams
Tween-80 0.1~0.8 gram
12% concentration is dashed slurry and is restrained with pregelatinized Starch 4.5~30
Micropowder silica gel 0.3~2.4 gram
Magnesium stearate 0.2~1.2 gram
Ethanol 6.5~65 grams
Stomach dissolved film coating pre-mix dose 4.5~8.5 grams.
2, a kind of production technology of meloxicam tablet is characterized in that: comprise the following steps:
(1) makes label: meloxicam, lactose, pregelatinized Starch, low-substituted hydroxypropyl cellulose are crossed 100 mesh sieves, join mix homogeneously in the wet mixing pelletizer, get mixed powder by the equivalent incremental method; Tween-80 is dissolved in 30~50 times of ethanol, join in the above-mentioned mixed powder, mix minute, again 12% concentration being dashed slurry joins in the mixed powder with pregelatinized Starch, make 18~40 order granules, 60~70 ℃ of dryings, 24 mesh sieve granulate, moisture is rewinding in 1.0~3.0% o'clock, and it is standby to make label;
(2) coating: stomach dissolved film coating pre-mix dose is mixed with 11% the outstanding liquid that mixes with 80% ethanol, mix 60 minutes standby; Label is poured in the coating pan, the coating pan rotating speed is adjusted into 2~3 rev/mins, the spray gun distance is transferred to from sheet bed 30~40cm, beginning preheating label, about label temperature to 40~50 ℃, atomisation pressure is at 0.5~0.6MPa, and beginning coating to sheet weightening finish 3.0% gets final product, and 30~40 ℃ of dryings got product in 12 hours;
The consumption of above-mentioned each component, form by following ingredients for per 1000:
Meloxicam 7.5 grams
Lactose 16.3~130 grams
Pregelatinized Starch 8.0~48 grams
Low-substituted hydroxypropyl cellulose 2.5~20 grams
Tween-80 0.1~0.8 gram
12% concentration is dashed slurry and is restrained with pregelatinized Starch 4.5~30
Micropowder silica gel 0.3~2.4 gram
Magnesium stearate 0.2~1.2 gram
Ethanol 6.5~65 grams
Stomach dissolved film coating pre-mix dose 4.5~8.5 grams.
3, the described meloxicam tablet of a kind of claim 1 was treated application in rheumatoid arthritis, the painful osteoarthritis medicine in preparation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101822619A CN101618026B (en) | 2009-07-06 | 2009-07-06 | Meloxicam tablet, production technology and purposes thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101822619A CN101618026B (en) | 2009-07-06 | 2009-07-06 | Meloxicam tablet, production technology and purposes thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101618026A true CN101618026A (en) | 2010-01-06 |
CN101618026B CN101618026B (en) | 2011-03-16 |
Family
ID=41511556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101822619A Active CN101618026B (en) | 2009-07-06 | 2009-07-06 | Meloxicam tablet, production technology and purposes thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101618026B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103054872A (en) * | 2013-01-24 | 2013-04-24 | 宁夏康亚药业有限公司 | Meloxicam pharmaceutical composition and preparation method thereof |
CN103099791A (en) * | 2011-11-15 | 2013-05-15 | 海南澳美华制药有限公司 | Oral composition of meloxicam capable of increasing dissolution rate |
CN103784416A (en) * | 2014-02-25 | 2014-05-14 | 翟宏华 | Dienogest tablets and preparation process thereof |
CN103860513A (en) * | 2014-03-14 | 2014-06-18 | 崔书豪 | Piroxicam tablets and preparation process thereof |
CN103877058A (en) * | 2014-03-26 | 2014-06-25 | 邵娜 | Levonorgestrel tablet and preparation process thereof |
CN103877059A (en) * | 2014-03-26 | 2014-06-25 | 邵娜 | Nomegestrol acetate tablet and preparation process thereof |
CN103989654A (en) * | 2014-05-30 | 2014-08-20 | 青岛市市立医院 | Lornoxicam tablet and preparation process thereof |
CN103989653A (en) * | 2014-05-30 | 2014-08-20 | 青岛市市立医院 | Tenoxicam tablet and preparation process thereof |
CN105412257A (en) * | 2015-12-15 | 2016-03-23 | 大连大学 | Rhizoma corydalis pain-relieving particle and preparation method thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1233323C (en) * | 2003-12-09 | 2005-12-28 | 成都圣诺科技发展有限公司 | Orally disintegrating tablet of meloxicam and its preparation |
JP2009510007A (en) * | 2005-09-30 | 2009-03-12 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pharmaceutical preparation containing meloxicam |
KR101400064B1 (en) * | 2006-04-13 | 2014-05-27 | 니폰 조키 세야쿠 가부시키가이샤 | Dry direct compression fast disintegrating tablet |
-
2009
- 2009-07-06 CN CN2009101822619A patent/CN101618026B/en active Active
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103099791A (en) * | 2011-11-15 | 2013-05-15 | 海南澳美华制药有限公司 | Oral composition of meloxicam capable of increasing dissolution rate |
CN103054872A (en) * | 2013-01-24 | 2013-04-24 | 宁夏康亚药业有限公司 | Meloxicam pharmaceutical composition and preparation method thereof |
CN103054872B (en) * | 2013-01-24 | 2014-06-04 | 宁夏康亚药业有限公司 | Meloxicam pharmaceutical composition and preparation method thereof |
CN103784416A (en) * | 2014-02-25 | 2014-05-14 | 翟宏华 | Dienogest tablets and preparation process thereof |
CN103860513A (en) * | 2014-03-14 | 2014-06-18 | 崔书豪 | Piroxicam tablets and preparation process thereof |
CN103877058A (en) * | 2014-03-26 | 2014-06-25 | 邵娜 | Levonorgestrel tablet and preparation process thereof |
CN103877059A (en) * | 2014-03-26 | 2014-06-25 | 邵娜 | Nomegestrol acetate tablet and preparation process thereof |
CN103989654A (en) * | 2014-05-30 | 2014-08-20 | 青岛市市立医院 | Lornoxicam tablet and preparation process thereof |
CN103989653A (en) * | 2014-05-30 | 2014-08-20 | 青岛市市立医院 | Tenoxicam tablet and preparation process thereof |
CN105412257A (en) * | 2015-12-15 | 2016-03-23 | 大连大学 | Rhizoma corydalis pain-relieving particle and preparation method thereof |
CN105412257B (en) * | 2015-12-15 | 2020-06-30 | 大连大学 | Rhizoma corydalis pain-relieving granules and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN101618026B (en) | 2011-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101618026B (en) | Meloxicam tablet, production technology and purposes thereof | |
WO2012053785A3 (en) | Sustained-release pellets containing tacrolimus as an active ingredient | |
HRP20161470T1 (en) | Controlled release flurbiprofen and muscle relaxant combinations | |
CN102357096A (en) | Statins zinc salt-containing blood fat-reducing composite | |
CN102406626B (en) | Pramipexole hydrochloride slow release tablet and preparation method thereof | |
CN106698380A (en) | Hydroxyapatite prepared from shells and preparation method thereof | |
CN102755310B (en) | A kind of composition medicine preparation containing levodopa | |
CN100411621C (en) | Cefixime oral disintegration tablet and its preparation method | |
CN101822684A (en) | Compound combined preparation for preventing osteoarticular pain and preparation method thereof | |
CN101278935A (en) | Medical composition containing derivative of vitamin B group | |
CN101224210A (en) | Mizolastine sustained release capsule | |
CN104146977A (en) | Pantoprazole sodium enteric coated tablet and preparation method thereof | |
CN101502495A (en) | Pemirolast Potassium and technique for producing the same | |
CN103860513A (en) | Piroxicam tablets and preparation process thereof | |
CN101732271A (en) | Dextromethorphan orally disintegrating tablets and preparation method thereof | |
CN112603902A (en) | Dexketoprofen trometamol capsule and preparation process thereof | |
CN105412132A (en) | Compound invermectin slow-release granules and preparation method thereof | |
CN101040850A (en) | Colchicine sustained-release pellets and the preparing method | |
CN103989654A (en) | Lornoxicam tablet and preparation process thereof | |
CN102247369B (en) | Compound naproxen esomeprazole medicine composition and preparation method thereof | |
CN117338711A (en) | Preparation method of ibuprofen injection with high stability | |
CN102698274B (en) | Medicine composition for treating intractable escherichia coli of fowls | |
CN1437935A (en) | Method for preparing medicine for relieving cough and reducing sputum | |
CN106692086B (en) | A kind of compound tablet of glycyrrhizin agent and preparation method thereof | |
CN105250240B (en) | Oral sustained-release preparation containing hydrocodone and chlorpheniramine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |