CN103845271A - Whitening skin care product - Google Patents
Whitening skin care product Download PDFInfo
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- CN103845271A CN103845271A CN201410049241.5A CN201410049241A CN103845271A CN 103845271 A CN103845271 A CN 103845271A CN 201410049241 A CN201410049241 A CN 201410049241A CN 103845271 A CN103845271 A CN 103845271A
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- licochalcone
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- verbascoside
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Abstract
The invention discloses a whitening skin care product. The whitening skin care product is prepared from the following raw materials in percentage by weight by a conventional method: 3 to 5% of beewax, 4 to 6% of hexadecanol, 6 to 10% of hydrogenated lanolin, 30 to 40% of squalane, 3 to 5% of tetradecanol lactate, 1 to 3% of tween 80, 4 to 6% of propylene glycol, 0.05 to 0.15% of skin-lightening agent, and the balance of water. The whitening skin care product is able to effectively remove skin melanin and whiten the skin.
Description
Technical field:
The present invention relates to a kind of Skin whitening care cosmetics.
Background technology:
Along with there is chromogenesis imbalance on the aging of population, environmental pollution, the increasing people's skin of global warning, the brown patch of skin, freckle have become serious skin puzzlement in recent years.Particularly after brown patch, freckle and Exposure to Sunlight, the black pigment on skin is calm can increase and produce, increase with the age, was more and more difficult to eliminate, thereby became the unavoidable worry of people simultaneously.Black pigment calm on skin is almost melanin entirely, in the melanosome in its melanocyte between epidermis and corium, produces, and the melanocyte of generation spreads to flanking cell by osmosis.
As everyone knows, skin color is mainly determined by melanic content in skin, and melanin can protect body to avoid ultraviolet injury, and melanin is synthesized by melanocyte.The biochemical reaction process occurring in melanocyte: fatty acid tyrosine, under the effect of tryrosinase, generates DOPA quinone, and it changes melanin into through red pigment and colourless pigment under the Oxidation of enzyme or non-enzyme, and this process is melanic main reason.Therefore, hinder or suppress the effect of tryrosinase in this reaction first stage, can suppress melanogenesis, so, seek and can hinder or the medicine of restraint of tyrosinase effect, to stoping or to suppress the melanocyte that generates because of tryrosinase effect very important.
Expect to occur a kind of Skin whitening care cosmetics, can hinder tyrosinase activity, or act on each stage of melanin metabolic pathway, the generation of control, check melanin.
Summary of the invention:
For prior art above shortcomings, technical problem to be solved by this invention is to provide a kind of Skin whitening care cosmetics.
A kind of Skin whitening care cosmetics, adopts conventional method to be prepared from by following materials by weight percentage: Cera Flava 3-5%, palmityl alcohol 4-6%, hydrogenated lanolin 6-10%, squalane 30-40%, tetradecyl alchohol lactate 3-5%, Tween 80 1-3%, propylene glycol 4-6%, skin-whitening agents 0.05-0.15%, surplus are water.
Described skin-whitening agents is Licochalcone A and/or verbascoside.
Described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Licochalcone A, English name: Licochalcone A, CAS accession number: 58749-22-7, can restraint of tyrosinase, can suppress again the oxidasic activity of dopachrome interconvertible enzyme and DHICA, having obvious removing free radical and antioxidation, is one whitening cosmetics additive fast and efficiently.
Verbascoside, English name: Acteoside, No. CAS: 61276-17-3, extract the fleshy stem of source for the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma, there is antioxidation, whitening, antidotal effect.
Obviously can also add in the present invention other raw materials, as chelating agen, antibacterial, antiseptic, pigment and essence etc.
Skin whitening care cosmetics of the present invention can adopt industry universal method to be prepared from, for example, can adopt following method: (1) mixes Cera Flava, palmityl alcohol, hydrogenated lanolin, squalane, tetradecyl alchohol lactate and Tween 80, is heated to 70 DEG C, obtains A component; (2) propylene glycol is added to the water, is heated to 70 DEG C, obtain B component; (3) above-mentioned steps A, B component are mixed, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature.Obviously, preparation method adopts known technology, is not innovation of the present invention.
Skin whitening care cosmetics of the present invention can effectively be eliminated the melanin on skin, skin whitening.
Detailed description of the invention:
In the present invention, if no special instructions, each raw material is all taking working substance content as 100%.
Embodiment 1
Composition of raw materials (percentage by weight): Cera Flava 4%, palmityl alcohol 5%, hydrogenated lanolin 8%, squalane 35%, tetradecyl alchohol lactate 4%, Tween 80 2%, propylene glycol 5%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is Licochalcone A.
(1) Cera Flava, palmityl alcohol, hydrogenated lanolin, squalane, tetradecyl alchohol lactate and Tween 80 are mixed, be heated to 70 DEG C, obtain A component;
(2) propylene glycol is added to the water, is heated to 70 DEG C, obtain B component;
(3) above-mentioned steps A, B component are mixed, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature, can make this Skin whitening care cosmetics.
Embodiment 2
Composition of raw materials and preparation method are substantially the same manner as Example 1, and difference is only: skin-whitening agents described in composition of raw materials is verbascoside.
Embodiment 3
Composition of raw materials and preparation method are substantially the same manner as Example 1, and difference is only: skin-whitening agents described in composition of raw materials is made up of following compositions in weight percentage: 80% Licochalcone A and 20% verbascoside.
Comparative example 1
Composition of raw materials and preparation method are substantially the same manner as Example 1, and difference is only: in composition of raw materials, do not add any skin-whitening agents.
Test case 1
Phosphate buffer (PBS) with 0.2mol/L pH=6.8 is prepared respectively:
Sample solution 1: the solution that Licochalcone A concentration is 0.2mg/ml;
Sample solution 2: the solution that verbascoside concentration is 0.2mg/ml;
Sample solution 3: Licochalcone A concentration is the mixed solution that 0.16mg/ml and verbascoside concentration are 0.04mg/ml;
In the sample solution of 0.9ml, add the phosphate buffer (PBS) of 1mlL-tyrosine (0.3mol) and 1ml pH=6.8, preheating 10 minutes in 37 DEG C of thermostatic water bath, add again 0.1ml tryrosinase aqueous solution (1.0mg/ml, mcllvains buffer), fully stir, after 15 minutes, measure 475nm absorbance (D1) 37 DEG C of reactions.In addition, replace style solution to carry out same reaction with above-mentioned phosphate buffer, record absorbance (D2).In order to contrast, do not adding under the condition of sample solution and tryrosinase, record absorbance (D3).Calculate tyrosinase activity suppression ratio with following formula.
Tyrosinase activity suppression ratio (%)=(D2-D1)/(D2-D3) × 100
Table 1: tyrosinase activity suppression ratio test chart
| ? | Tyrosinase activity suppression ratio, % |
| Sample solution 1 (Licochalcone A) | 60.2 |
| Sample solution 2 (verbascoside) | 32.5 |
| Sample solution 3 (80% Licochalcone A+20% verbascoside) | 64.8 |
As seen from the above table, all effective restraint of tyrosinase activity of Licochalcone A and verbascoside, play whitening effect.By composite to Licochalcone A and verbascoside, tyrosinase activity suppression ratio surprisingly improves, whitening effect Synergistic.
Test case 2:
Experimental selection female volunteers, measures melanin content in human body skin, and the white-skinned face function of cosmetic product is evaluated.
Adopt MEXAMETER MX18 skin pigment instrument before making to apply some make up 1 day and make continuously to apply some make up and within 14 days, measure afterwards the melanin content of its hand skin.Measure environment: test environment temperature (22 ± 1) DEG C, humidity (50 ± 5) %, averages.Study subject uses cosmetic product one time every day, and using method is: after clean hand skin, dry, with hands by cosmetic applying on hand skin.Study subject does not use other whitening products at test period.Measure numerical value higher, illustrate that in skin, melanin content is higher.
Melanin reduction rate=(make the melanin content that applies some make up first 1 day-make continuously to apply some make up 14 days after melanin content) ÷ makes melanin content × 100% applying some make up first 1 day.
Melanin reduction rate is higher, illustrates that whitening effect is more obvious.
Table 2: test data table
| ? | Melanin reduction rate, % |
| Embodiment 1 | 10.8 |
| Embodiment 2 | 5.6 |
| Embodiment 3 | 12.6 |
| Comparative example 1 | 1.8 |
As seen from the above table, in cosmetics, add Licochalcone A and verbascoside and all have good whitening effect.By Licochalcone A with verbascoside is composite is added in cosmetics, whitening effect Synergistic, its mechanism needs the further Exploration and Research of inventor.
Claims (3)
1. a Skin whitening care cosmetics, adopts conventional method to be prepared from by following materials by weight percentage: Cera Flava 3-5%, palmityl alcohol 4-6%, hydrogenated lanolin 6-10%, squalane 30-40%, tetradecyl alchohol lactate 3-5%, Tween 80 1-3%, propylene glycol 4-6%, skin-whitening agents 0.05-0.15%, surplus are water.
2. Skin whitening care cosmetics claimed in claim 1, is characterized in that, described skin-whitening agents is Licochalcone A and/or verbascoside.
3. Skin whitening care cosmetics as claimed in claim 2, is characterized in that, described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049241.5A CN103845271A (en) | 2014-02-13 | 2014-02-13 | Whitening skin care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049241.5A CN103845271A (en) | 2014-02-13 | 2014-02-13 | Whitening skin care product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103845271A true CN103845271A (en) | 2014-06-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410049241.5A Withdrawn CN103845271A (en) | 2014-02-13 | 2014-02-13 | Whitening skin care product |
Country Status (1)
| Country | Link |
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| CN (1) | CN103845271A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103142435A (en) * | 2013-03-13 | 2013-06-12 | 广州市天吻娇颜化妆品有限公司 | Whitening composition inhibiting tyrosinase activities with multiple mechanisms, and products of composition |
-
2014
- 2014-02-13 CN CN201410049241.5A patent/CN103845271A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103142435A (en) * | 2013-03-13 | 2013-06-12 | 广州市天吻娇颜化妆品有限公司 | Whitening composition inhibiting tyrosinase activities with multiple mechanisms, and products of composition |
Non-Patent Citations (1)
| Title |
|---|
| 傅博强等: "甘草黄酮类化合物对酪氨酸酶单酚酶的抑制", 《天然产物研究与开发》 * |
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| WW01 | Invention patent application withdrawn after publication | ||
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Application publication date: 20140611 |