CN103830557A - Traditional Chinese medicine health product having function of relieving fatigue - Google Patents
Traditional Chinese medicine health product having function of relieving fatigue Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine health product having the function of relieving fatigue, and is used for solving the problem of being low in effect in the original traditional Chinese medicine health product having the function of relieving fatigue. The traditional Chinese medicine health product disclosed by the invention is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 14-23% of ginseng, 20-30% of radix ophiopogonis, 8-16% of schisandra chinensis, 20-30% of lucid ganoderma, and 14-23% of worm grass. The traditional Chinese medicine health product having the function of relieving fatigue disclosed by the invention is capable of effectively relieving physical fatigue and has the advantages of being free from toxic and side effect, safe and reliable.
Description
technical field:
The present invention is relevant with the Chinese medicinal composition preparation of function of alleviating fatigue.
background technology:
Along with arrival information-based, globalization, fatigue syndrome has caused the concern of international the world of medicine.Fatigue is to prevent that body from a kind of protective response that life-threatening excessive failure function produces occurring.Along with social life rhythm is accelerated, sub-health population grows with each passing day at present, and these crowds wish to take a kind of convenient, have no side effect, permanently effective food or health product are alleviated various subhealth states, and natural plant food health product just have these advantages, therefore have very large potentiality.
At present, conventional anti-fatigue Chinese medicine has Cordyceps, Radix Panacis Quinquefolii, Radix Ginseng, Radix Rhodiolae and Radix Notoginseng etc. clinically, by independent or different compatibilities, makes Chinese patent medicine or the health care of food product of various dosage forms, and easy to carry, drug effect fully absorbs.But also to exist part medical material comparatively famous and precious simultaneously, cause asking a price high, audient's face is narrow, the high-grade nourishing health product with effect of resisting fatigue as there being brand ginseng Ganoderma the sixth of the twelve Earthly Branches, brand ginseng Ganoderma formula is mainly Radix Panacis Quinquefolii, Ganoderma, Cordyceps, in its mice burden swimming test, and the swimming time 9.53 ± 0.89min of dose,optimum group, the serum urea content of joining Ganoderma dose,optimum in its biochemical indicator is 10.88 ± 2.46mmol/L, and its function of alleviating fatigue has much room for improvement.
summary of the invention:
The object of this invention is to provide a kind of function of alleviating fatigue effect remarkable, formula is simple, and cost of material is cheap, the Chinese medicine health care product with function of alleviating fatigue having no side effect.
The present invention is achieved in that
There is the Chinese medicine health care product of function of alleviating fatigue, be prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 14-23, Radix Ophiopogonis 20-30, Fructus Schisandrae Chinensis 8-16, Ganoderma 20-30, Cordyceps 14-23.
There is the Chinese medicine health care product of function of alleviating fatigue, be prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 16-20, Radix Ophiopogonis 23-28, Fructus Schisandrae Chinensis 10-14, Ganoderma 23-28, Cordyceps 16-20.
There is the Chinese medicine health care product of function of alleviating fatigue, be prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 18.75, Radix Ophiopogonis 25, Fructus Schisandrae Chinensis 12.5, Ganoderma 25, Cordyceps 18.75.
Panax herbaceos perennial, contains ginsenoside and ginseng polysaccharide.Studies have shown that it has the effects such as the central nervous system of adjusting, resisting fatigue, antioxidation, enhancing human body immunity power.
Be the liliaceous plant dried root of Radix Ophiopogonis Radix Ophiopogonis, mainly containing multiple steroid saponin, flavone compound.There is calmness, arrhythmia, reinforcement myocardial contraction, anoxia enduring, fatigue-resisting function.
Fructus Schisandrae Chinensis, property acid temperature is nontoxic, is fallen leaves woody climbers, contains schisandrin (schizandrin), deoxyschizandrin, schisandrin B, volatile oil, organic acid, vitamin and polysaccharide etc.Modern study demonstration, in the time of suitable dosage, Fructus Schisandrae Chinensis can be increased work efficiency, and improving neurasthenia's insomnia has good effect.Schizandrin can improve people's intellectual activity, increases work efficiency, and improves work quality, strengthens the motility of brain excitement and process of inhibition, and impels two processes to tend to balance.
Ganoderma is that polypor can parasitical fungi Ganoderma lucidum (Leyss. Ex Fr.) Karst. (Ganodermalucidum, common name Ganoderma lucidum (Leyss. Ex Fr.) Karst.) and dry sporophore and the spore powder of Ganoderma (G.sinese), and main component has ganoderan class, Ganodenic acid esters, ucleosides, sterols, alkaloid etc.Modern pharmacology confirms that it has immunoregulation capability and the mutation of enhancing, antifatigue effect.
Cordyceps (Cordyceps powder) colonizes in Stroma on Hepialidae insect larvae and the dry composite body of larva corpse for section ergot fungus cordyceps sinensis bacterium.Cordyceps contains cordycepic acid approximately 7%, saccharide 28.9%, fat approximately 8.4%, protein approximately 25%.In Cordyceps, 82.2% is unsaturated fatty acid, in addition, still contains vitamin B
12, Ergota lipidol, hexose alcohol, multiple alkaloid etc.Also have and resist myocardial ischemia, the protection of the adjusting of resisting fatigue, antitumor, kidney, digestive system, strengthen the effects such as immunity, maincenter inhibition.
Through experiment, strictly contrast, scientific statistics, selects Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Ganoderma, Cordyceps (Cordyceps powder).Science compatibility, achieves good results.
Preparation of the present invention is Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Ganoderma, Cordyceps (Cordyceps powder) is according to its function scientific formula separately, effectively alleviating physical fatigue, and have no side effect, safe and reliable, so taste medical material is the article list that can be used for health food, aboundresources is with low cost, be applicable to life-time service, can be used as health food and promoted.Chinese medicine preparation of the present invention can need to be made into any dosage form use according to clinical.
There is the sixth of the twelve Earthly Branches brand ginseng Ganoderma formula to be mainly Radix Panacis Quinquefolii, Ganoderma, Cordyceps, in its mice burden swimming test, swimming time 9.53 ± the 0.89min of dose,optimum group, swimming time 799.8 ± 904.8s of the present invention, be significantly higher than the swimming with a load attached to the body time of brand ginseng Ganoderma, the serum urea content of joining Ganoderma dose,optimum in its biochemical indicator is 10.88 ± 2.46mmol/L, and the serum urea content of high, normal, basic three the dosage groups of the present invention is respectively 9.48 ± 1.32mmol/L, 8.92 ± 1.64mmol/L, 9.63 ± 1.34 mmol/L, all join the serum urea content of Ganoderma dose,optimum lower than brand, illustrate that the present invention can significantly reduce the urea content in serum, alleviate organism fatigue.The composition that Ganoderma and Cordyceps are rich in all has resisting fatigue, increases the effect of immunity, and formula of the present invention is except Ganoderma and Cordyceps, also add Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, these three kinds of medical materials contain respectively ginsenoside, polysaccharide, flavone compound, schizandrin etc., all there is the unify effect of resisting fatigue of the central nervous system of adjusting, in compatibility of the present invention, add this several Chinese crude drugs simultaneously, can increase significantly the time of mice burden swimming, reduce serum urea content, improve the effect of resisting fatigue.Prescription of the present invention is genuine medicinal materials, and the medical material place of production is pollution-free, guarantees quality of medicinal material, and its function of alleviating fatigue test significantly.
the specific embodiment:
Embodiment 1:
Take Radix Ginseng 18g; Radix Ophiopogonis 24g; Fructus Schisandrae Chinensis 16g; Ganoderma 24g; Cordyceps (Cordyceps powder) 18g, makes extractum and takes.
Embodiment 2:
Take Radix Ginseng 14g; Radix Ophiopogonis 30g; Fructus Schisandrae Chinensis 8g; Ganoderma 30g; Cordyceps (Cordyceps powder) 18g, makes tablets.
Embodiment 3:
Take Radix Ginseng 30g; Radix Ophiopogonis 20g; Fructus Schisandrae Chinensis 16g; Ganoderma 20g; Cordyceps (Cordyceps powder) 14g, makes tablets.
Embodiment 4:
Take Radix Ginseng 16g; Radix Ophiopogonis 28g; Fructus Schisandrae Chinensis 10g; Ganoderma 28g; Cordyceps (Cordyceps powder) 18g, makes tablets.
Embodiment 5:
Take Radix Ginseng 20g; Radix Ophiopogonis 23g; Fructus Schisandrae Chinensis 14g; Ganoderma 23g; Cordyceps (Cordyceps powder) 20g, makes tablets.
Experimental example 1 clinical practice:
Method: the extractum of its mouse oral gavage embodiment 1 30 days, observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Mice is selected 18-22g, male, is divided at random 4 groups by body weight, every group 15, set up respectively matched group, matched group is refused gavage, the extractum of embodiment 1 divides high, medium and low 3 dosage groups (10.8,5.4,2.7g crude drug in whole/Kg), be administered once every day, and gavage volume is 0.1ml/10g, continuous 30 days, record respectively mice swimming time (swimming started to the dead time), the content of serum urea, the content of hepatic glycogen, the size of full blood lactic area under curve.
Matched group: 293.5 ± 152.5 seconds swimming with a load attached to the body time, serum urea content 10.80 ± 1.29mmol/L, hepatic glycogen content 0.27 ± 0.037mg/g in tissue, blood lactic acid area under curve size is 849.47 ± 173.21mmol/L.
High dose group: 799.8 ± 904.8 seconds swimming with a load attached to the body time, serum urea content 9.48 ± 1.32mmol/L, hepatic glycogen content 0.292 ± 0.034mg/g in tissue, blood lactic acid area under curve size is 826.71 ± 225.6mmol/L.
Middle dosage group: 429.4 ± 202.4 seconds swimming with a load attached to the body time, serum urea content 8.92 ± 1.64mmol/L, hepatic glycogen content 0.26 ± 0.06mg/g in tissue, blood lactic acid area under curve size is 800.65 ± 194.00mmol/L.
Low dose group: 289.7 ± 163.5 seconds swimming with a load attached to the body time, serum urea content 9.63 ± 1.34 mmol/L, hepatic glycogen content 0.300 ± 0.05mg/g in tissue, blood lactic acid area under curve size is 918.05 ± 227.67mmol/L.
From experimentation, can find out, the extractum of embodiment 1 can obviously extend the mice burden swimming time, reduces mice serum urea content, and Mouse Liver glycogen and blood lactic acid area under curve are had no significant effect.According to the middle health food anti-fatigue effect testing requirement of health food check and assessment technique enforcement of regulations handbook (2003 editions), the swimming with a load attached to the body experimental result positive, and wantonly two index positives in blood lactic acid, serum urea, three biochemical indicators of liver glycogen, can judge that this given the test agent has the effect of alleviating physical fatigue function.In this experiment, the result positive of swimming with a load attached to the body time, the serum urea result positive in biochemical indicator, therefore can judge that this prescription has the effect of alleviating physical fatigue function.
Experimental example 2:
Clinical practice:
Method: the tablet of its mouse oral gavage embodiment 2 30 days, observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Mice is selected 18-22g, male, be divided at random 4 groups by body weight, 15 every group, set up respectively matched group, matched group is refused administration, and the tablet of embodiment 2 divides high, medium and low 3 dosage groups (10.8,5.4,2.7g crude drug in whole/Kg), and be administered once every day, continuous 30 days, record respectively mice swimming time (swimming started to the dead time), the content of serum urea, the content of hepatic glycogen.
Matched group: 287.5 ± 96.7 seconds swimming with a load attached to the body time, serum urea content 12.35 ± 0.41mmol/L, hepatic glycogen content 0.68 ± 0.61mg/g in tissue.
High dose group: 768.5 ± 125.6 seconds swimming with a load attached to the body time, serum urea content 7.74 ± 1.45mmol/L, hepatic glycogen content 1.09 ± 0.43mg/g in tissue.
Middle dosage group: 463.1 ± 325.2 seconds swimming with a load attached to the body time, serum urea content 8.85 ± 1.32mmol/L, hepatic glycogen content 0.99 ± 0.56mg/g in tissue.
Low dose group: 294.5 ± 216.7 seconds swimming with a load attached to the body time, serum urea content 9.13 ± 1.65mmol/L, hepatic glycogen content 1.07 ± 0.34mg/g in tissue.
From experimentation, can find out, the tablet of embodiment 2 can obviously extend the mice burden swimming time, reduces mice serum urea content, and Mouse Liver glycogen is had no significant effect.According to the middle health food anti-fatigue effect testing requirement of health food check and assessment technique enforcement of regulations handbook (2003 editions), the swimming with a load attached to the body experimental result positive, and wantonly two index positives in blood lactic acid, serum urea, three biochemical indicators of liver glycogen, can judge that this given the test agent has the effect of alleviating physical fatigue function.In this experiment, the result positive of swimming with a load attached to the body time, the serum urea result positive in biochemical indicator, therefore can judge that this prescription has the effect of alleviating physical fatigue function.
Experimental example 3:
Clinical practice:
Method: the tablet of its mouse oral gavage embodiment 3 30 days, observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Mice is selected 18-22g, male, be divided at random 4 groups by body weight, 15 every group, set up respectively matched group, matched group is refused administration, and the tablet of embodiment 3 divides high, medium and low 3 dosage groups (10.8,5.4,2.7g crude drug in whole/Kg), and be administered once every day, continuous 30 days, record respectively mice swimming time (swimming started to the dead time), the content of serum urea, the content of hepatic glycogen.
Matched group: 321.4 ± 161.8 seconds swimming with a load attached to the body time, serum urea content 9.87 ± 1.45mmol/L, hepatic glycogen content 0.45 ± 0.012mg/g in tissue.
High dose group: 678.4 ± 501.3 seconds swimming with a load attached to the body time, serum urea content 7.63 ± 0.98mmol/L, hepatic glycogen content 0.98 ± 0.075mg/g in tissue.
Middle dosage group: 542.3 ± 215.6 seconds swimming with a load attached to the body time, serum urea content 7.95 ± 1.56mmol/L, hepatic glycogen content 1.45 ± 0.03mg/g in tissue.
Low dose group: 301.8 ± 144.7 seconds swimming with a load attached to the body time, serum urea content 8.59 ± 0.14mmol/L, hepatic glycogen content 0.39 ± 0.015mg/g in tissue.
From experimentation, can find out, the tablet of embodiment 3 can obviously extend the mice burden swimming time, reduces mice serum urea content, and Mouse Liver glycogen is had no significant effect.According to the middle health food anti-fatigue effect testing requirement of health food check and assessment technique enforcement of regulations handbook (2003 editions), the swimming with a load attached to the body experimental result positive, and wantonly two index positives in blood lactic acid, serum urea, three biochemical indicators of liver glycogen, can judge that this given the test agent has the effect of alleviating physical fatigue function.In this experiment, the result positive of swimming with a load attached to the body time, the serum urea result positive in biochemical indicator, therefore can judge that this prescription has the effect of alleviating physical fatigue function.
Experimental example 4:
Clinical practice:
Method: the tablet of its mouse oral gavage embodiment 4 30 days, observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Mice is selected 18-22g, male, be divided at random 4 groups by body weight, 15 every group, set up respectively matched group, matched group is refused administration, and the tablet of embodiment 4 divides high, medium and low 3 dosage groups (10.8,5.4,2.7g crude drug in whole/Kg), and be administered once every day, continuous 30 days, record respectively mice swimming time (swimming started to the dead time), the content of serum urea, the content of hepatic glycogen.
Matched group: 278.6 ± 312.5 seconds swimming with a load attached to the body time, serum urea content 11.3 ± 2.51mmol/L, hepatic glycogen content 0.22 ± 0.041mg/g in tissue.
High dose group: 815.4 ± 615.3 seconds swimming with a load attached to the body time, serum urea content 10.84 ± 1.02mmol/L, hepatic glycogen content 0.34 ± 0.092mg/g in tissue.
Middle dosage group: 565.5 ± 123.4 seconds swimming with a load attached to the body time, serum urea content 9.43 ± 1.46mmol/L, hepatic glycogen content 0.25 ± 0.03mg/g in tissue.
Low dose group: 367.9 ± 115.1 seconds swimming with a load attached to the body time, serum urea content 8.31 ± 1.21mmol/L, hepatic glycogen content 0.31 ± 0.025mg/g in tissue.
From experimentation, can find out, the tablet of embodiment 4 can obviously extend the mice burden swimming time, reduces mice serum urea content, and Mouse Liver glycogen is had no significant effect.According to the middle health food anti-fatigue effect testing requirement of health food check and assessment technique enforcement of regulations handbook (2003 editions), the swimming with a load attached to the body experimental result positive, and wantonly two index positives in blood lactic acid, serum urea, three biochemical indicators of liver glycogen, can judge that this given the test agent has the effect of alleviating physical fatigue function.In this experiment, the result positive of swimming with a load attached to the body time, the serum urea result positive in biochemical indicator, therefore can judge that this prescription has the effect of alleviating physical fatigue function.
Experimental example 5:
Clinical practice:
Method: the tablet of its mouse oral gavage embodiment 5 30 days, observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Observe mice burden swimming time, serum urea content, hepatic glycogen mensuration, full blood lactic mensuration.Mice is selected 18-22g, male, be divided at random 4 groups by body weight, 15 every group, set up respectively matched group, matched group is refused administration, and the tablet of embodiment 5 divides high, medium and low 3 dosage groups (10.8,5.4,2.7g crude drug in whole/Kg), and be administered once every day, continuous 30 days, record respectively mice swimming time (swimming started to the dead time), the content of serum urea, the content of hepatic glycogen.
Matched group: 357.6 ± 120.1 seconds swimming with a load attached to the body time, serum urea content 15.74 ± 2.18mmol/L, hepatic glycogen content 0.25 ± 0.018mg/g in tissue.
High dose group: 750.18 ± 240.12 seconds swimming with a load attached to the body time, serum urea content 13.45 ± 0.74mmol/L, hepatic glycogen content 0.28 ± 0.09mg/g in tissue.
Middle dosage group: 753.85 ± 241.04 seconds swimming with a load attached to the body time, serum urea content 10.88 ± 1.35mmol/L, hepatic glycogen content 0.31 ± 0.07mg/g in tissue.
Low dose group: 427.95 ± 141.1 seconds swimming with a load attached to the body time, serum urea content 9.51 ± 3.21mmol/L, hepatic glycogen content 0.25 ± 0.03mg/g in tissue.
From experimentation, can find out, the tablet of embodiment 5 can obviously extend the mice burden swimming time, reduces mice serum urea content, and Mouse Liver glycogen is had no significant effect.According to the middle health food anti-fatigue effect testing requirement of health food check and assessment technique enforcement of regulations handbook (2003 editions), the swimming with a load attached to the body experimental result positive, and wantonly two index positives in blood lactic acid, serum urea, three biochemical indicators of liver glycogen, can judge that this given the test agent has the effect of alleviating physical fatigue function.In this experiment, the result positive of swimming with a load attached to the body time, the serum urea result positive in biochemical indicator, therefore can judge that this prescription has the effect of alleviating physical fatigue function.
Claims (3)
1. there is the Chinese medicine health care product of function of alleviating fatigue, it is characterized in that being prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 14-23, Radix Ophiopogonis 20-30, Fructus Schisandrae Chinensis 8-16, Ganoderma 20-30, Cordyceps 14-23.
2. the Chinese medicine health care product with function of alleviating fatigue according to claim 1, is characterized in that being prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 16-20, Radix Ophiopogonis 23-28, Fructus Schisandrae Chinensis 10-14, Ganoderma 23-28, Cordyceps 16-20.
3. the Chinese medicine health care product with function of alleviating fatigue according to claim 1, is characterized in that being prepared from by the raw material of Chinese medicine of following weight percentage ratio: Radix Ginseng 18.75, Radix Ophiopogonis 25, Fructus Schisandrae Chinensis 12.5, Ganoderma 25, Cordyceps 18.75.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104688930A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Anti-fatigue ginseng and deer bone health care wine and preparation method thereof |
| CN106177061A (en) * | 2016-08-29 | 2016-12-07 | 黑龙江德能理疗技术开发有限责任公司 | A kind of fatigue alleviating oral liquid and preparation method thereof |
| CN106262843A (en) * | 2016-08-19 | 2017-01-04 | 福建拓天生物科技有限公司 | A kind of composite nutrition powder for resisting fatigue |
| CN110279737A (en) * | 2019-07-08 | 2019-09-27 | 湖北圣峰药业有限公司 | Careless preparation of a kind of selenium-rich ginseng spirit and preparation method thereof |
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| CN102406163A (en) * | 2010-09-17 | 2012-04-11 | 江中药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of health food or medicament for preventing and relieving physical fatigue |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688930A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Anti-fatigue ginseng and deer bone health care wine and preparation method thereof |
| CN106262843A (en) * | 2016-08-19 | 2017-01-04 | 福建拓天生物科技有限公司 | A kind of composite nutrition powder for resisting fatigue |
| CN106177061A (en) * | 2016-08-29 | 2016-12-07 | 黑龙江德能理疗技术开发有限责任公司 | A kind of fatigue alleviating oral liquid and preparation method thereof |
| CN110279737A (en) * | 2019-07-08 | 2019-09-27 | 湖北圣峰药业有限公司 | Careless preparation of a kind of selenium-rich ginseng spirit and preparation method thereof |
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Application publication date: 20140604 |