CN103830218B - A kind ofly be used for the treatment of release injectable Emulsion of cattle copper deficiency disease and preparation method thereof - Google Patents
A kind ofly be used for the treatment of release injectable Emulsion of cattle copper deficiency disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of release injectable Emulsion being used for the treatment of cattle copper deficiency disease, it is characterized in that, the raw material primarily of following components by weight percent is made: the former powder 5-10 of organic copper, glycerol 18-37, liquid paraffin 43-86, Tween 80 2-5, department class 805-10, co-emulsifier 1-3.And by first preparing aqueous phase and oil phase, the then required injectable emulsion of a step preparation.The injection that the present invention obtains is Emulsion, copper clad is got up, obtain uniform water in oil system, extend the action time of medicine, have slow releasing function by high-speed stirred; Copper clad got up, increase medical surfaces and amass, the chance of drug molecule generation crystallization reduces, and increases the stability of medicine; Meanwhile, production technology of the present invention is simple, and divided dose is accurate, and easy and simple to handle, a step can complete the production of Emulsion.
Description
Technical field
The present invention relates to a kind of veterinary medicine field, particularly relate to and a kind ofly treat release injectable Emulsion of cattle copper deficiency disease and preparation method thereof.
Background technology
Along with developing rapidly of China's animal husbandry, poultry production structure progressively frees change, and while chicken, pig intensive farm develop rapidly, cattle-raising is also flourish.But due to the impact by conventional husbandry mode, China's ruminant animal nutrition research lags behind World Developed Countries far away, basic research is few, the researches of mineral matter nutritional metabolic rule, the shortage of trace element or the unbalance key factor becoming restriction China beef cattle production level.Trace element is necessary in the basic vital movement of animal body, although requirement is very low, but serious or critical trace element deficiency, may cause breeding performonce fo animals to decline, and some trace element adds and excessively also may produce negative effect to animal and to environmental effects.
Wherein, copper be Niu Bixu a kind of trace element, the copper in feedstuff is by gastrointestinal absorption, and the copper of absorption combines in loosening with plasma protein, and is distributed to body tissue, plays important physiological function.Trace copper participate in hemopoietic, skeleton formation, by the matter of the calmness of hair color and brain cell and spinal cord, and be composition and the activator of multiple enzyme, also be synthesize necessary trace element as collagen protein and elastin, copper plays an important role in the reparation of fracture, invigorating blood circulation, blood stasis dispelling, also play a part in antiinflammatory positive.When copper lacks, spinal nerves fiber myelinoclasis can be made, and destructive enzyme system, each tissue fully can not be oxidized, then the various pathological changes of copper deficiency disease occur.Copper participates in the synthesis of hemoglobin with ferrum again as catalyst, when copper lacks, except making to deposit except a large amount of hemosiderin in disease cattle tissue, also can affect the formation of hemoglobin porphyrin core, thus anemia occurs.Damping off is the final performance of anemic anoxia.Copper can promote that tyrosine becomes melanin, maintains black hair color, and when lacking copper, hair fades; When daily ration undersupply or shortage, can cause deficiency disease, cause osteoblast activity to reduce, main manifestations is that skeleton development is abnormal.The copper deficiency of cattle is one of modal mineral deficiency disease in the world.The domestic research for copper supplementing preparation is only shown in there is peroral dosage form, and peroral dosage form palatability is poor, and absorb slowly, need life-time service, Financial cost is high.And the development of slow releasing injection yet there are no report.
Summary of the invention
The object of this invention is to provide a kind of release injectable medicine being used for the treatment of cattle copper deficiency disease, solve the problem that above-mentioned supplementation with copper source exists palatability difference, another object is to provide a kind of method preparing this release injectable medicine, simple to operation.
The bright release injectable Emulsion being used for the treatment of cattle copper deficiency disease provided of this law, the raw material primarily of following components by weight percent is made:
The former powder 5-10 of organic copper, glycerol 18-37, liquid paraffin 43-86, Tween 80 2-5, department class 805-10, co-emulsifier 1-3.
Preferably, described raw material also comprises vitamin B group 1-2, vitamin D1-2, vitamin e1-2, vitamin C 1-2, diphenoxylate 0.1-2 and tranquilizer 0.2-1.Wherein vitamin D is relevant with the calcification of animal skeleton, helps skeleton calcification in skeleton, can promote that again calcium is free out by old bone marrow matter, thus sclerotin is constantly updated, also can maintain the balance of blood calcium simultaneously, effectively supplement the content of calcium in sick cattle body, reduction trouble is osteoporotic may; Vitamin E is required to animal breeding, and is easy to oxidation, and copper can be protected not oxidized, and being supplemented with of vitamin E helps reduce the risk that amyotrophy, anemia, cerebral malacia and other neurodegenerative pathological changes occur; Vitamin C can catch free radical, is conducive to improving immune system, builds up resistance; Add diphenoxylate simultaneously, improve gastrointestinal tension force, suppress enterokinesia, prevention pushability absorbs, thus slow down the fltting speed of food, make moisture have the sufficient time to absorb and antidiarrheal, thus reach and prevent disease cattle from suffering from diarrhoea and the effect of the nutritional deficiency that causes or dehydration, ataracticly to add, effectively prevent disease cattle because of manic go hither and thither to cause fall, increase the weight of the danger of the state of an illness, in treatment cattle copper deficiency disease, supplement other nutritional labelings from multiple channel simultaneously, reach the effect for the treatment of both the principal and secondary aspects of a disease.
Preferably, described raw material also comprises NaAc_HAc buffer solution.Adopt buffer solution to regulate the Ph value of injectable emulsion, effectively can ensure that the Ph of injectable emulsion is stable and remain on 7.The acetic acid that sodium acetate hydrolysis is simultaneously formed, contributes to the dissolving of copper, increases the bioavailability of copper, improve the absorption of cattle to copper to a certain extent.
Preferably, the former powder of described organic copper is one or more in the former powder of cupric glycinate, the former powder of phenylalanine copper, the former powder of valine copper, copper citrate, Fructus Vitis viniferae acid copper.The benefit copper method of current employing adds copper agent in daily ration, in oral copper agent, Inorganic Copper source mostly is copper sulfate, copper sulfate palatability is poor, and with 5 joining property differences of other compositions in feedstuff, reduce the nutritive value of feedstuff, copper sulfate has zest to gastrointestinal tract mucous simultaneously, and long-term interpolation eats easy copper poisoning.Oral organic copper production cost is higher, is difficult to widely apply aborning, and organic copper is transported to body desired area generation effect in blood with some protein bound, biological value is high.
Preferably, described co-emulsifier is aluminium stearate and/or glycerol monostearate.Be conducive to improving injectable emulsion stability.
Preferably, described vitamin B group B comprises one or more in vitamin B1, B2, B3, B12.Vitamin B group has facilitating digestion, increases appetite, promotes effect of the absorption of copper.Wherein B1 energy appetite stimulator, maintains neural normal activity; Vitamin B2 and energy produce directly relevant, the regeneration of enhancing development and cell; It is healthy that vitamin B3 maintains digestive system, is also that the indispensable material of synthesis is covered in property Hull; The nervous system that vitamin B12 can be kept fit, for erythrocytic formation, promotes cell development maturation and organism metabolism.Supplement vitamin B group to sick cattle to treat sick cattle targetedly, alleviate the symptom of disease cattle inappetence, anemia, promote the neural myelin normal development of phospholipid formation and brain and spinal cord, prevent the appearance of damping off.
Be used for the treatment of a preparation method for the release injectable Emulsion of cattle copper deficiency disease, it is characterized in that, described method mainly comprises the following steps:
1) preparation of aqueous phase: milled by former for organic copper powder, crosses 100 mesh sieves, takes 5-10 weight portion, be dissolved in the glycerol of 50-100mL30%, obtained B liquid, adds the Tween 80 that components by weight percent is 2-5, mixing, carries out sterilizing 20-60min, obtains aqueous phase under 80-121 DEG C of 1-5Mpa;
2) preparation of oil phase: liquid paraffin 43-86 is mixed with department class 805-10, and carries out high-speed stirred 5-10 minute, then add co-emulsifier, dissolve evenly, then carry out sterilizing 20-60min at 80-121 DEG C of 1-5Mpa, obtain oil phase;
3) preparation of Emulsion: by step 1) and step 2) aqueous phase that obtains and oil phase according to 1: 1 ratio mixing, then diphenoxylate 0.1-2 and tranquilizer 0.2-1 is added, pH to 7 is regulated while stirring with NaAc_HAc buffer solution, then putting into rotating speed is that the blender of 5000-9000rpm stirs 6-15min, namely makes required Emulsion.
Preferably, described step 1) first Tween 80 2-5 part, vitamin B group 1-2 part and vitamin C 1-2 part are carried out high-speed stirred 5-10 minute, obtained A liquid, and then by A liquid and the mixing of B liquid.
Preferably, described step 2) described in oil phase also add vitamin D1-2 parts, vitamin e1-2 parts and liquid paraffin 43-86 part, take charge of class's 805-10 part and mix.
The injection that the present invention obtains is Emulsion, by high-speed stirred copper clad got up, obtain uniform water in oil system, injectable emulsion transports in vivo from lymph circulation, then blood system is entered, accumulate in reticuloendothelium, therefore extend the action time of medicine, reach slow releasing function; Injectable emulsion can also control medicine directional profile in vivo simultaneously, can also control the rate of release of medicine.Copper is water soluble drug, there is certain dissolubility in water, make the restriction that aqueous solution preparation is easily subject to dissolubility, emulsion-type made by the medicine for the treatment of cattle copper deficiency disease, copper clad is got up, increase medical surfaces to amass, the chance of drug molecule generation crystallization reduces, and increases the stability of medicine; Accordingly, by copper clad in Emulsion, the rate of release of medicine reduces greatly, also reduces the concentration of free drug in body simultaneously, reduces the zest that medicine contacts with body tissue.Meanwhile, production technology of the present invention is simple, and divided dose is accurate, and easy and simple to handle, a step can complete the production of Emulsion.
Detailed description of the invention
Embodiment 1
Be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease, mainly comprise the raw material of following components by weight percent:
The former powder 5g of cupric glycinate, glycerol 18g, liquid paraffin 43g, Tween 80 2g, department class 805g, aluminium stearate 1g, vitamin B group 1g, vitamin D1 g, vitamin e1 g, vitamin C 1g, diphenoxylate 0.1g and tranquilizer 0.2g.
Prepare by the following method:
1) preparation of aqueous phase: first Tween 80, vitamin B group and vitamin C are carried out high-speed stirred 5 minutes, obtained A liquid; Then former for organic copper powder is milled, cross 100 mesh sieves, take 5g, be dissolved in the glycerol of 50mL30%, obtained B liquid; By A liquid and the mixing of B liquid, under 80 DEG C of 1Mpa, carry out sterilizing 60min, obtain aqueous phase;
2) preparation of oil phase: by liquid paraffin, class 80 of department, vitamin D and vitamin E mixing, and carry out high-speed stirred 5 minutes, then add co-emulsifier, dissolve evenly, then 80 DEG C of 1Mpa carry out sterilizing 60min, obtain oil phase;
3) preparation of Emulsion: by step 1) and step 2) aqueous phase that obtains and oil phase according to 1: 1 ratio mixing, then diphenoxylate and tranquilizer is added, pH to 7 is regulated while stirring with NaAc_HAc buffer solution, then putting into rotating speed is that the blender of 5000rpm stirs, and namely makes required Emulsion.
Embodiment 2
Be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease, mainly comprise the raw material of following components by weight percent:
The former powder 8g of copper citrate, glycerol 30g, liquid paraffin 50g, Tween 80 3g, department class 808g, aluminium stearate 2g, vitamin B group 1.5g, vitamin D1 .5g, vitamin e1 .5g, vitamin C 1.5g, diphenoxylate 1g and tranquilizer 0.8g.
Prepare by the following method:
1) preparation of aqueous phase: first Tween 80, vitamin B group and vitamin C are carried out high-speed stirred 8 minutes, obtained A liquid; Then former for organic copper powder is milled, cross 100 mesh sieves, take 8g, be dissolved in the glycerol of 80mL30%, obtained B liquid; By A liquid and the mixing of B liquid, under 100 DEG C of 3Mpa, carry out sterilizing 40min, obtain aqueous phase;
2) preparation of oil phase: by liquid paraffin, class 80 of department, vitamin D and vitamin E mixing, and carry out high-speed stirred 8 minutes, then add co-emulsifier, dissolve evenly, then 100 DEG C of 3Mpa carry out sterilizing 40min, obtain oil phase;
3) preparation of Emulsion: by step 1) and step 2) aqueous phase that obtains and oil phase according to 1: 1 ratio mixing, then diphenoxylate and tranquilizer is added, pH to 7 is regulated while stirring with NaAc_HAc buffer solution, then putting into rotating speed is that the blender of 8000rpm stirs, and namely makes required Emulsion.
Embodiment 3
Be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease, mainly comprise the raw material of following components by weight percent:
The former powder 10g of phenylalanine copper, glycerol 37g, liquid paraffin 86g, Tween 80 5g, department class 8010g, glycerol monostearate 3g, vitamin B group 2g, vitamin D2 g, vitamin E2 g, Catergen g, diphenoxylate 2g and tranquilizer 1g.
Prepare by the following method:
4) preparation of aqueous phase: first Tween 80, vitamin B group and vitamin C are carried out high-speed stirred 10 minutes, obtained A liquid; Then former for organic copper powder is milled, cross 100 mesh sieves, take 10g, be dissolved in the glycerol of 100mL30%, obtained B liquid; By A liquid and the mixing of B liquid, under 121 DEG C of 5Mpa, carry out sterilizing 20min, obtain aqueous phase;
5) preparation of oil phase: by liquid paraffin, class 80 of department, vitamin D and vitamin E mixing, and carry out high-speed stirred 10 minutes, then add co-emulsifier, dissolve evenly, then 121 DEG C of 5Mpa carry out sterilizing 20min, obtain oil phase;
6) preparation of Emulsion: by step 1) and step 2) aqueous phase that obtains and oil phase according to 1: 1 ratio mixing, then diphenoxylate 0.1-2 and tranquilizer 0.5-2 is added, pH to 7 is regulated while stirring with NaAc_HAc buffer solution, then putting into rotating speed is that the blender of 9000rpm stirs, and namely makes required Emulsion.
Embodiment 4
Test Niu Suiji is divided into 3 groups, and often organize 4, often group is 2 bulls, 2 cows, is numbered 1,2,3 respectively.Wherein numbering 1 is matched group, cervical region subcutaneous injection G/NS injection, injection measurement every 10ml; Numbering 2 is not containing the organic copper release injectable Emulsion of vitamin, and injection measurement is 100mgCu/10ml, cervical region subcutaneous injection; The release injectable Emulsion that numbering 3 obtains for the present invention, the organic copper release injectable Emulsion containing vitamin, injection measurement is 100mgCu/10ml, cervical region subcutaneous injection.The loss of appetite of cattle before injection, becomes thin, and matt by hair, black hair becomes rust brown, near the eyes by hair owing to fading or lose hair or feathers, in without hair or white like glasses outward appearance, and symptoms such as adjoint diarrhoea, dehydration, anemia, sexual cycle delay or non-estrus.Test Niu Pingjun blood copper content is low to moderate 0.58 μ g/ml, and liver copper drops to 30 μ g/ml.Therapeutic outcome is as shown in the table:
Contrast finds, the blood copper content of numbering 3 during injection detection content higher than the blood copper content of numbering 2, find in observation, test cattle the 19th day appetite after injection of numbering 3 is obviously recovered, and depilation, diarrhoea, dehydrating phenomena and the glossiness etc. by hair have had obvious improvement, the test Niu of numbering 2 just had obvious appetite after 31 days, and adjoint other the symptom of cattle copper deficiency disease has just had and is clearly better.The recovery time that numbering 3 tests cattle during injection detection is faster than the test cattle of numbering 2; the absorption of the favourable promotion copper of vitamin is described; although single injection organic copper also can treat cattle copper deficiency disease; but the time is comparatively of a specified duration, and the disease of cattle is dragged more of a specified duration, also larger to the loss of raiser; inject together with organic copper by adding vitamin; sick cattle convalescent period is short, and curative effect is remarkable, reduces the loss of raiser to greatest extent.
The release injectable Emulsion of cattle copper deficiency disease that what the present invention obtained be used for the treatment of, simple to operate, be easy to realize, and can the synergism of Appropriate application medicine, play the functional effect of various medicine to greatest extent, multi-pronged, supplement various nutrient elements sanatory simultaneously, shorten treatment time, reach the effect for the treatment of both the principal and secondary aspects of a disease.Vitamin B group has facilitating digestion, increases appetite, promotes effect of the absorption of copper; Vitamin D can promote that calcium is dissociated out by old bone marrow matter, thus sclerotin is constantly updated, and also can maintain the balance of blood calcium simultaneously, effectively supplements the content of calcium in sick cattle body, and reduction trouble is osteoporotic may; Vitamin C is conducive to improving immune system, builds up resistance; Being supplemented with of vitamin E helps reduce the risk that amyotrophy, anemia, cerebral malacia and other neurodegenerative pathological changes occur.
Embodiment 5
2009-2011 years, by an Emulsion shot of making to the test suffering from copper deficiency disease cattle l0ml, before injection, cattle became thin, fluffy and disorderly and matt by hair, and obviously, lassitude, test cattle blood copper is lower than 0.600 μ g/ml in skeleton expression.In 30 days of just injection, plasma copper content raises rapidly, and about 60 days plasma copper concentration reaches maximum after injection.Illustrate that subcutaneous injection slow releasing injection of the present invention can play and significantly mend copper effect.In addition, in 150 days that detect, injection Ox blood plasma copper content is all at 1.0 more than μ g/ml, and maximum is not more than 1.6 μ g/ml; Show that the slow release effect of release injectable Emulsion of the present invention is obvious.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (8)
1. be used for the treatment of a release injectable Emulsion for cattle copper deficiency disease, it is characterized in that, the raw material primarily of following components by weight percent is made:
The former powder 5-10 of organic copper, glycerol 18-37, liquid paraffin 43-86, Tween 80 2-5, department class 805-10, co-emulsifier 1-3, vitamin B group 1-2, vitamin D1-2, vitamin e1-2, vitamin C 1-2, diphenoxylate 0.1-2 and tranquilizer 0.2-1.
2. be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 1, it is characterized in that, described raw material also comprises acetic acid one sodium acetate buffer.
3. be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 1, it is characterized in that, the former powder of described organic copper is one or more in the former powder of cupric glycinate, the former powder of phenylalanine copper, the former powder of valine copper, copper citrate, Fructus Vitis viniferae acid copper.
4. be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 1, it is characterized in that, described co-emulsifier is aluminium stearate and/or glycerol monostearate.
5. be used for the treatment of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 1, it is characterized in that, described vitamin B group B comprises one or more in vitamin B1, B2, B3, B12.
6. be used for the treatment of a preparation method for the release injectable Emulsion of cattle copper deficiency disease, it is characterized in that, described method mainly comprises the following steps:
1) preparation of aqueous phase: milled by former for organic copper powder, crosses 100 mesh sieves, takes 5-10 weight portion, be dissolved in the glycerol of 50-100mL30%, obtained B liquid, adds the Tween 80 that weight portion is 2-5, mixing, carries out sterilizing 20-60min, obtains aqueous phase under 80-121 DEG C of 1-5Mpa;
2) preparation of oil phase: liquid paraffin 43-86 weight portion is mixed with department class 805-10 weight portion, and carries out high-speed stirred 5-10 minute, then add co-emulsifier, dissolve evenly, then carry out sterilizing 20-60min at 80-121 DEG C of 1-5Mpa, obtain oil phase;
3) preparation of Emulsion: by step 1) and step 2) aqueous phase that obtains and oil phase according to 1: 1 ratio mixing, then diphenoxylate 0.1-2 weight portion and tranquilizer 0.2-1 weight portion is added, pH to 7 is regulated while stirring with acetic acid one sodium acetate buffer, then putting into rotating speed is that the blender of 5000-9000rpm stirs 6-15min, namely makes required Emulsion.
7. be used for the treatment of the preparation method of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 6, it is characterized in that, described step 1) first Tween 80 2-5 weight portion, vitamin B group 1-2 weight portion and vitamin C 1-2 weight portion are carried out high-speed stirred 5-10 minute, obtained A liquid, and then by A liquid and the mixing of B liquid.
8. be used for the treatment of the preparation method of the release injectable Emulsion of cattle copper deficiency disease as claimed in claim 6, it is characterized in that, described step 2) described in oil phase also add vitamin D1-2 weight portion and vitamin e1-2 weight portion.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3170836A (en) * | 1962-05-24 | 1965-02-23 | Glaxo Lab Ltd | Injectable compositions comprising a copper-containing chelate complex compound dispersed in a stabilized oil-in-water emulsion and method of using the same |
| CN1052428A (en) * | 1990-08-08 | 1991-06-26 | 叶玉辉 | Poultry are with trace mineral supplement and preparation method |
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2014
- 2014-02-26 CN CN201410066328.3A patent/CN103830218B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3170836A (en) * | 1962-05-24 | 1965-02-23 | Glaxo Lab Ltd | Injectable compositions comprising a copper-containing chelate complex compound dispersed in a stabilized oil-in-water emulsion and method of using the same |
| CN1052428A (en) * | 1990-08-08 | 1991-06-26 | 叶玉辉 | Poultry are with trace mineral supplement and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 家畜缺铜及甘氨酸铜防治试验;郑绍仪;《新疆八一农学院学报》;19811231(第4期);11-16 * |
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Application publication date: 20140604 Assignee: Guangxi Tianqi Ecological Agriculture Co.,Ltd. Assignor: NANNING University Contract record no.: X2022450000607 Denomination of invention: A slow-release injection emulsion for treatment of bovine copper deficiency and its preparation method Granted publication date: 20160330 License type: Common License Record date: 20221230 |
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