CN103816437A - Lotion for treating condyloma acuminate and preparation method of lotion - Google Patents
Lotion for treating condyloma acuminate and preparation method of lotion Download PDFInfo
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- CN103816437A CN103816437A CN201410104308.0A CN201410104308A CN103816437A CN 103816437 A CN103816437 A CN 103816437A CN 201410104308 A CN201410104308 A CN 201410104308A CN 103816437 A CN103816437 A CN 103816437A
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Abstract
The invention provides a lotion for treating condyloma acuminate and a preparation method of the lotion. The lotion for treating condyloma acuminate is characterized by being prepared from the following components in parts by weight: 30 parts of isatis roots, 30 parts of folium isatidis, 20 parts of houttuynia cordata, 30 parts of honeysuckle, 30 parts of radix sophorae flavescentis, 30 parts of golden cypress, 30 parts of purslane, 20 parts of pearl barley, 20 parts of dried alum, 30 parts of brucea javanica, 10 parts of borax, 20 parts of mint, 0.75 part of fluorouracil and 1500 parts of water. By proportioning cold and cool medicines, the lotion can restrain sarcoma caused by damp and hot, mainly aims to condyloma acuminate, and is matched with fluorouracil. By combination of traditional Chinese and western medicines, the lotion is extremely excellent in effect, high in cure rate, extremely low in recurrence rate, free from oral administration, free from any general side effects, safe and non-toxic, convenient to use and worth clinically applying.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of lotion for the treatment of condyloma acuminatum and preparation method thereof.
Background technology
Condyloma acuminatum is by the sexually transmitted disease (STD) take the infringement of anus genital area hypertrophy as main manifestations due to human papillomavirus (HPV) infection.Mostly betide the young people of 18～50 years old, men and women all can infect.This disease is comparatively common, main trafficability characteristic contact transmission.Its Therapeutic Method comprises chemotherapy, cryotherapy, laser therapy, the treatment of fulgerizing, operative treatment and immunotherapy etc., especially in the majority with cryotherapy, laser therapy.Because above-mentioned treatment majority only can be removed wart body, can not eliminate pathogenic human papillomavirus at all, so very easily recurrence, the relapse rate of common 3 months is up to more than 25%.
Summary of the invention
The object of the invention is to overcome the weak point of above-mentioned conventional art, a kind of lotion of easy to use, therapeutic effect good, relapse rate is low treatment condyloma acuminatum is provided.
The object of the invention is to reach by following technical measures:
The lotion for the treatment of condyloma acuminatum, is characterized in that: the component by following weight portion is made: 30 parts of Radix Isatidis, 30 parts of Folium Isatidiss, 20 parts of Herba Houttuyniae, 30 parts of Flos Loniceraes, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Cortex Phellodendris, 30 parts of Herba Portulacaes, 20 parts of Semen Coiciss, 20 parts of dried Alumens, 30 parts of Fructus Bruceaes, 10 parts of Boraxs, 20 parts of Herba Menthaes, 0.75 part of fluorouracil, 1500 parts, water.
The preparation method of the lotion for the treatment of condyloma acuminatum, is characterized in that: comprise the following steps:
Get 20 parts of 10 parts of 30 parts of 20 parts of 20 parts of 30 parts of 30 parts of 30 parts of 30 parts of 20 parts of 30 parts of 30 parts of Radix Isatidis, Folium Isatidiss, Herba Houttuyniae, Flos Loniceraes, Radix Sophorae Flavescentiss, Cortex Phellodendris, Herba Portulacaes, Semen Coiciss, dried Alumens, Fructus Bruceaes, Boraxs, Herba Menthaes, 1500 parts, water by weight, above-mentioned raw materials medicine is added to the water to soak after half an hour and boils, 20 minutes at a simmer, leach medicinal liquid, put after cool and add 0.75 part of fluorouracil by weight and get final product.Take every part as 1 gram, finally can obtain approximately 500 milliliters of medicinal liquids, can meet the use amount of about a week.
Usage of the present invention: according to pathological changes size and position, get appropriate medicinal liquid washout, soak, smear or soak, make medicinal liquid fully contact pathological changes at every turn and be no less than 1 hour, every day 2 times.With the present invention sufferer place washout, soak, smear or soak all can, as long as medicinal liquid can fully contact that pathological changes is no less than 1 hour, just can reach splendid therapeutic effect 2 every day.
The clinical comparison evidence that the present invention is done, cure rate of the present invention is high, and relapse rate is very low, substantially has no side effect.
Pharmacology to each component in the present invention and drug effect brief introduction are as follows:
Radix Isatidis: bitter in the mouth, cold in nature, nontoxic.Energy heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash, can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Folium Isatidis: bitter in the mouth is property Great Cold, nontoxic.Energy heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Cure mainly epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Folium Isatidis is mainly used in pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.Radix Isatidis and Folium Isatidis are the Different plant parts of same plant, and both are collaborative, strengthening heat clearing away, removing toxic substances, removing heat from blood effect.
Herba Houttuyniae: acrid in the mouth, cold, can heat-clearing and toxic substances removing, detumescence treats skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion, be the lung abscess suffered from, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. with controlling excess-heat, pyretic toxicity, damp, disease heat.Modern pharmacology experiment shows, the effects such as that this product has is antibacterial, antiviral, raising immunity of organisms, diuresis.
Flos Lonicerae: have another name called Radix Ophiopogonis.Be described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold fragrance of its property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, and for various febrile diseases, as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.
Radix Sophorae Flavescentis: bitter in the mouth; Cold in nature.Energy heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Radix Sophorae Flavescentis has the effect of anti-inflammation, and Propiobacterium, staphylococcus aureus, escherichia coli are all had to inhibitory action.In the present invention, make effect of dampness removing to stop itchin with Radix Sophorae Flavescentis.
Cortex Phellodendri: bitter in the mouth, cold in nature.Energy heat clearing away, dampness, pathogenic fire purging, removing toxic substances.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Pharmacological research confirms, Cortex Phellodendri has antibacterial, antiinflammatory action, staphylococcus aureus, diphtheria corynebacterium, streptococcus pneumoniae, dysentery bacterium, Hemolytic streptococcus, clostridium tetani, Streptococcus viridans are all had to good inhibitory action, especially streptococcus pneumoniae, bacillus pyocyaneus are had to obvious fungistatic effect, best to the fungistatic effect of staphylococcus aureus.Be used for the treatment of infectious disease as diarrhoea, jaundice, arthritis have certain curative effect, especially the in the situation that of tcm treatment according to syndrome differentiation, there is good curative effect.
Herba Portulacae: energy heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula.Often smash juice external application, control carbuncle.
Semen Coicis: slightly sweet flavor, cold nature, nontoxic.Energy eliminating damp-heat, except rheumatism, diuresis, lung benefiting evacuation of pus, strengthening the spleen and stomach, bone and muscle strengthening.Cure mainly rheumatism general pain, hygropyretic beriberi, damp and hot muscular contracture contracture, arthralgia chiefly caused by damp pathogen, edema, the lung lung abscess of withering, coughs vomiting bloody pus, sore throat carbuncle, acute appendicitis pyretic stranguria.Now Chinese and western medicine with Semen Coicis treat that pulmonary tuberculosis, cough due to lung-heat, nephritis, struma, enteritis are just rushed down, cardiac edema, pleuritis, chronic arthritis, muscle arteries and veins spasm etc.In the present invention, Semen Coicis and Herba Menthae compatibility are in order to the damp eliminating of subsiding a swelling, refrigerant antipruritic.
Dried Alumen: have another name called calcined Alumen.Sour in the mouth, cold.Cure mainly expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing.
Fructus Bruceae: bitter in the mouth, cold in nature, there is the effect such as heat-clearing and toxic substances removing, dysentery relieving disease.Fructus Bruceae is containing alkaloid, glucoside, phenolic constituent and bruceolic acid etc.Clinically be usually used in treating anything superfluous or useless, for papilloma of external auditory meatus, laryngeal papillomatosis, and verruca vulgaris, verruca plana etc. all have therapeutic effect.
Borax: sweet-salty, cool in nature.External heat-clearing and toxic substances removing, detumescence, anticorrosion; Removing heat from the lung and dissipating phlegm for oral administration.For acute tonsillitis, pharyngolaryngitis, laryngopharynx swelling and pain, aphtha of the mouth and tongue, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain, tinea versicolor, is the common medicine of department of eye illness! Detumescence
Herba Menthae: Herba Menthae is one of Chinese conventional Chinese medicine, and nature and flavor are pungent, cool.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.In the present invention, Herba Menthae and Semen Coicis compatibility are in order to the damp eliminating of subsiding a swelling, refrigerant antipruritic.
Fluorouracil: fluorouracil is the most frequently used uracil antimetabolite, is one of main antineoplastic agent, mainly by affecting, DNA is synthetic to play a role, and still can disturb protein synthesis.Copy in order to suppress viral growth in the present invention.
Owing to having adopted technique scheme, compared with prior art, advantage of the present invention is:
The present invention, with cold and cool medicine compatibility, can restrain the damp and hot anything superfluous or useless causing, and is mainly for condyloma acuminatum, coordinate fluorouracil, Chinese and western medicine coordinates, and effect is splendid, and cure rate is high, relapse rate is extremely low, do not need to take orally, there will not be any systemic side effects, safety non-toxic, easy to use, clinic is promoted.
Below in conjunction with the specific embodiment, the invention will be further described.
The specific embodiment
Embodiment: the lotion for the treatment of condyloma acuminatum, made by following component: 30 grams of Radix Isatidis, 30 grams of Folium Isatidiss, 20 grams of Herba Houttuyniae, 30 grams of Flos Loniceraes, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Cortex Phellodendris, 30 grams of Herba Portulacaes, 20 grams of Semen Coiciss, 20 grams of dried Alumens, 30 grams of Fructus Bruceaes, 10 grams of Boraxs, 20 grams of Herba Menthaes, 0.75 gram of fluorouracil, 1500 grams, water.
The preparation method of the lotion for the treatment of condyloma acuminatum, comprises the following steps:
Get 30 grams of Radix Isatidis, 30 grams of Folium Isatidiss, 20 grams of Herba Houttuyniae, 30 grams of Flos Loniceraes, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Cortex Phellodendris, 30 grams of Herba Portulacaes, 20 grams of Semen Coiciss, 20 grams of dried Alumens, 30 grams of Fructus Bruceaes, 10 grams of Boraxs, 20 grams of Herba Menthaes, 1500 grams, water, above-mentioned raw materials medicine is added to the water to soak after half an hour and boils, 20 minutes at a simmer, leach medicinal liquid, put and add 0.75 gram of the fluorouracil of gram meter by weight after cool and get final product.Take every gram as 1 gram, finally can obtain approximately 500 milliliters of medicinal liquids, can meet the use amount of about a week.
Usage of the present invention: according to pathological changes size and position, get appropriate medicinal liquid washout, soak, smear or soak, make medicinal liquid fully contact pathological changes at every turn and be no less than 1 hour, every day 2 times, using one week is a course for the treatment of.With the present invention sufferer place washout, soak, smear or soak all can, as long as medicinal liquid can fully contact that pathological changes is no less than 1 hour, just can reach splendid therapeutic effect 2 every day.
Clinical comparison test: totally 47 patients, be divided at random two groups, one group of 24 people, as treatment group, adopts the present invention's treatment, and with liquid medicine painting of the present invention, immersion or soak diseased region, each 1 hour, every day 2 times, continuing 1 week was a course for the treatment of; Another organizes 23 people as a control group, and with podophyllotoxin Ointment in Treatment, according to medication every day 2 times, for three days on end, it 4 days is a course for the treatment of that drug withdrawal is observed.Residually repeat a course for the treatment of as focus still has, but be no more than at most three courses for the treatment of.Disappear completely as healing take wart body, dwindle more than 50% for effectively, wart body unchanged or be increased to invalid.After medication, there is burn feeling in various degree or sensation of pricking, and the stimulation such as erythema, edema, after wart body comes off can there is erythema or shallow table erosion in part, is mild adverse effects; Local response is serious, occurs serious ulcer, edema, and the person of having an intense pain is severe untoward reaction, occurs that severe untoward reaction stops test at once, changes other therapeutic scheme.Healing person is respectively at following up a case by regular visits to after 3 months and after 6 months, statistics relapse rate.
Statistical result is as table one.As shown in Table 1, effective percentage of the present invention is high, and without serious untoward reaction, there is no patient because of untoward reaction drug withdrawal, and relapse rate is also significantly lower than matched group.The present invention treats the curative effect excellence of condyloma acuminatum, definite effect, and untoward reaction is few, and treatment compliance is high, is significantly better than conventional medicine at present.
Table one
Model case:
Case one: Lin, male, 43 years old, rural migrant worker, once had unclean sexual intercourse history, from the beginning of being tiny pale red pimple on glans penis, after increase gradually, the multiple distributions of trooping of the nipple sample that takes on a red color, surface irregularity, moistening softness, has slight gargalesthesia.Look into polymerase chain reaction (PCR) positive.Give liquid medicine painting diseased region of the present invention, each 1 hour, every day 2 times, continue wart body after a week and disappear, without any discomfort symptom.Follow up a case by regular visits to 6 months without recurrence.
Case two: Song, male, 54 years old, after unclean sexual intercourse history, within 2 months, there is the red pimple of foreskin and glans penis, and increase and be cauliflower-like projection gradually, without malaise symptoms, (PCR) is positive for polymerase chain reaction.Give medicinal liquid of the present invention and soak diseased region, each 1 hour, every day 2 times, continue wart body after a week and be contracted to 30% of original volume, continue to use a course for the treatment of, the disappearance of wart body, in therapeutic process without any untoward reaction.Follow up a case by regular visits to 6 months without recurrence.
Case history three: Zhang, male, 37 years old, there is repeatedly unclean sexual intercourse history, on glans penis, there is the dirty papilla grisea sample of cluster wart body around urethral orifice, surface irregularity, that touches is easily hemorrhage, has sexual anhedonia.(PCR) is positive for polymerase chain reaction.Give medicinal liquid soak glans penis of the present invention, each 1 hour, every day 2 times, continue wart body after a week and significantly dwindle, continue 2 courses for the treatment of of use, wart body disappears substantially, in therapeutic process without any untoward reaction.Follow up a case by regular visits to 6 months without recurrence.
Case four: Lee, women, 29 years old, there is unclean sexual intercourse history, labium majus inner face, nympha and vaginal orifice are dispersed in papillary vegetation, and that touches is easily hemorrhage, and surface has purulent secretion to adhere to, and has stench taste.(PCR) is positive for polymerase chain reaction.Once row cold therapy, reduced in the wart body short time, was increased to again subsequently the front state for the treatment of.Give liquid medicine applying of the present invention 12 days, vegetation all disappears, skin of vulva mucosa clean, smooth.Therapeutic process patient is without any discomfort.Follow up a case by regular visits to and have no recurrence half a year.
Claims (2)
1. the lotion for the treatment of condyloma acuminatum, is characterized in that: the component by following weight portion is made: 30 parts of Radix Isatidis, 30 parts of Folium Isatidiss, 20 parts of Herba Houttuyniae, 30 parts of Flos Loniceraes, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Cortex Phellodendris, 30 parts of Herba Portulacaes, 20 parts of Semen Coiciss, 20 parts of dried Alumens, 30 parts of Fructus Bruceaes, 10 parts of Boraxs, 20 parts of Herba Menthaes, 0.75 part of fluorouracil, 1500 parts, water.
2. the preparation method of the lotion for the treatment of condyloma acuminatum, is characterized in that: comprise the following steps:
Get 20 parts of 10 parts of 30 parts of 20 parts of 20 parts of 30 parts of 30 parts of 30 parts of 30 parts of 20 parts of 30 parts of 30 parts of Radix Isatidis, Folium Isatidiss, Herba Houttuyniae, Flos Loniceraes, Radix Sophorae Flavescentiss, Cortex Phellodendris, Herba Portulacaes, Semen Coiciss, dried Alumens, Fructus Bruceaes, Boraxs, Herba Menthaes, 1500 parts, water by weight, above-mentioned raw materials medicine is added to the water to soak after half an hour and boils, 20 minutes at a simmer, leach medicinal liquid, put after cool and add 0.75 part of fluorouracil by weight and get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410104308.0A CN103816437A (en) | 2014-03-15 | 2014-03-15 | Lotion for treating condyloma acuminate and preparation method of lotion |
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| CN201410104308.0A CN103816437A (en) | 2014-03-15 | 2014-03-15 | Lotion for treating condyloma acuminate and preparation method of lotion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523773A (en) * | 2014-12-11 | 2015-04-22 | 董介正 | Wart prevention and control composition |
| CN104547741A (en) * | 2014-12-30 | 2015-04-29 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine preparation with antiviral function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354009A (en) * | 2001-12-02 | 2002-06-19 | 王宗耀 | Prescription of medicine for curing pointed condyloma |
-
2014
- 2014-03-15 CN CN201410104308.0A patent/CN103816437A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354009A (en) * | 2001-12-02 | 2002-06-19 | 王宗耀 | Prescription of medicine for curing pointed condyloma |
Non-Patent Citations (1)
| Title |
|---|
| 刘建平等: "《当代妇科名方验方大全》", 30 April 2011, 广东科技出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523773A (en) * | 2014-12-11 | 2015-04-22 | 董介正 | Wart prevention and control composition |
| CN104547741A (en) * | 2014-12-30 | 2015-04-29 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine preparation with antiviral function |
| CN104547741B (en) * | 2014-12-30 | 2017-12-01 | 兰州古驰生物科技有限公司 | One kind has antiviral functions Chinese medicine preparation |
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