CN103816418A - Medicine for treating oral ulcer and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating oral ulcer and a preparation method thereof, which belongs to the technical field of traditional Chinese medicine. The medicine for treating oral ulcer comprises the following raw materials: radix astragali, Chinese yam, wrinkled giant hyssop, banksia rose, root of kudzu vine, Japanese honeysuckle stem, cortex of Chinese dittany root, barbat skullcap, tree peony bark, mint, bushy sophora, lophatherum stem and leaves, fritillaria cirrhosa, trichosanthes kirilowii maxim, jujube, licorice, borax, aureomycin, lidocaine, vitamin B, starch and membrane of hen egg. The medicine for treating oral ulcer employs pure natural Chinese herbal medicines, and is used by combining with borax, aureomycin, lidocaine and vitamin B, and the medicine for treating oral ulcer has no toxic or side effect, and has good treatment effect for oral ulcer.

Description

A kind of medicine for the treatment of oral ulcer and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of oral ulcer and preparation method thereof, belong to technical field of Chinese medicines.

Background technology

Oral ulcer, is called again " aphtha ", is the superficial ulcer occurring on oral mucosa, large I from the grain of rice to Semen Glycines size, circular or oval, ulcer surface is that oral ulcer is recessed, congested around, can cause pain because of irritable food, and generally one or two week can spontaneous recovery.Oral ulcer becomes generation periodically repeatedly, medically claims " recurrent oral ulceration ".Can betide any position of oral mucosa, common with lip, cheek, tongue, severe patient can involve pharyngeal mucosa, can within 1 year, fall ill for several times, also can within one month, fall ill several times, and even new and old pathological changes is appearance alternately.

Many patients are along with the prolongation of the course of disease, and ulcer area increases, and number increases, and pain increases the weight of, and healing stage extends, and shorten interval etc., affect diet and speak.Though a lot of to the Therapeutic Method of oral ulcer, be all symptomatic treatment substantially, object is mainly ease the pain or reduce recurrent number, Control in recurring is completely needed the medicine that a kind of fast treating oral ulcer is provided badly.

Summary of the invention

The object of the present invention is to provide a kind of medicine for the treatment of oral ulcer and preparation method thereof, this medicine adopts natural Chinese medicines, coordinates Borax, chlortetracycline, lignocaine, vitamin B group to use, and has no side effect, and treatment oral ulcer effect is better.

Technical scheme of the present invention is:

A medicine for the treatment of oral ulcer, is characterized in that, made by the raw material of following weight portion,

Radix Astragali 20g, Rhizoma Dioscoreae 20g, Herba Pogostemonis 20g, Radix Aucklandiae 20g, Radix Puerariae 20g, Caulis Lonicerae 20g, Cortex Dictamni 20g, Herba Scutellariae Barbatae 20g, Cortex Moutan 20g, 20 grams of Herba Menthaes, Radix Sophorae Tonkinensis 20g, Folium Bambusae 20g, Bulbus Fritillariae Cirrhosae 10g, Fructus Trichosanthis 10g, Fructus Jujubae 10g, Radix Glycyrrhizae 10g, Borax 2g, chlortetracycline 2g, lignocaine 1g, vitamin B group 1g, starch 8g.

The present invention also provides a kind of preparation method of medicine for the treatment of oral ulcer, it is characterized in that, comprises the following steps:

1. take raw material by above-mentioned weight portion;

2. the Radix Astragali, Rhizoma Dioscoreae, Herba Pogostemonis, the Radix Aucklandiae, Radix Puerariae, Caulis Lonicerae, Cortex Dictamni, Herba Scutellariae Barbatae, Cortex Moutan, Herba Menthae, Radix Sophorae Tonkinensis, Folium Bambusae, Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Fructus Jujubae, the Radix Glycyrrhizae that step are taken in are 1. put into marmite, add the water of 3 times of weight, soak half an hour, decoct after 1 hour, pour out filtrate, for filtrate one, filtering residue stays in marmite, then adds water not have filtering residue in adding, and decocts half an hour, pouring out filtrate, is filtrate two;

3. merging filtrate one and filtrate two, the filtrate that the Membrana Follicularis ovi that step is taken in is 1. placed in after merging is soaked 3h, takes out vacuum packaging; Then filtrate decompression is distilled to into thick liquid, by infrared drying, removes moisture, and clay into power, obtain powder one;

4. Borax step being taken in 1., chlortetracycline, lignocaine, vitamin B group and starch mix homogeneously, then add powder one, and mix homogeneously is packed and be get final product.

Using method: according to taking out vacuum-packed Membrana Follicularis ovi, get powder one and be evenly sprinkling upon on Membrana Follicularis ovi, be then affixed on affected part (powder one is pressed close to affected part), every day three times.

The pharmacological action of each medicine:

The Radix Astragali: warm in nature, sweet in the mouth.Tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent.Cure mainly weakness of the spleen and stomach, lack of appetite asthenia, deficiency of vital energy blood prostration, exterior deficiency spontaneous perspiration, night sweat.

Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.

Herba Pogostemonis :pungent, tepor.Enter lung, spleen, stomach warp.Fast gas, and in, ward off dirty, damp eliminating.The heat-damp in summer that cures cold, cold and heat, headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.

The Radix Aucklandiae: gas fragrance, taste is sweet, bitter, slightly stings tongue.Warm in nature, acrid in the mouth, hardship.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.

Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, and rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.

Caulis Lonicerae: sweet, cold.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, redness and swelling of joints burning pain.

Cortex Dictamni: hardship, cold.Return spleen, stomach, urinary bladder channel.Function cures mainly: heat clearing and damp drying, the removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.

Herba Scutellariae Barbatae: pungent, bitter, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.

Cortex Moutan: bitter, pungent, be slightly cold.Gui Jing: GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Herba Menthae: pungent, cool.Return lung, Liver Channel.Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.

Radix Sophorae Tonkinensis: hardship, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.Pent up laryngopharynx swelling and pain, gingivitis for fire-toxin.

Folium Bambusae: sweet; Light; Cold, return through the heart; Lung; Stomach warp, function cures mainly: clearing heat and relieving fidgetness; The diuresis of promoting the production of body fluid.Main calentura excessive thirst; little Jing Epilepsy; Cough with dyspnea is told nosebleed; Oliguria with reddish urine; Erosion of the oral mucosa tongue boil.

Bulbus Fritillariae Cirrhosae: lung moistening eliminating stagnation, antitussive reduces phlegm.Control cough due to consumptive disease, the spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat.

Fructus Trichosanthis: sweet, micro-hardship, cold.Return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.

Fructus Jujubae: sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.

Radix Glycyrrhizae: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Borax: colourless translucent crystal or white crystalline powder.Odorless, salty in the mouth.Proportion 1.73.380 ℃ time, lose whole water of crystallization.In soluble in water and glycerol, be slightly soluble in ethanol.Aqueous solution is alkalescence.Borax is in slowly air slaking of air.When melting, become flint glass shape material.Borax has bactericidal action, oral being pernicious to people.CAS:1303-96-4, molecular formula: Na ₂b ₄o ₇10H ₂o, molecular mass: 381.37.

Chlortetracycline: Chinese chlortetracycline, Chinese another name duomycin; English name: chlortetracycline; No. CAS: 57-62-5; No. EINECS: 200-341-7; Molecular formula: C ₂₂h ₂₃c _ln ₂o ₈; Molecular weight: 478.8796.

Lignocaine: English name: Lidocaine; Another name: lignocaine, lidocaine, xylocaine, Lidocaine base, Lidocainum, Lighocaine, Lignocaine; Molecular formula: C ₁₄h ₂₂n ₂o; No. CAS: 137-58-6.

Vitamin B group comprises vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxol), vitamin B12 (cobalamin), FA (folic acid), vitamin B7 (biotin).

Starch is the high polymer of glucose, claims again starch in catering trade, and general formula is (C ₆h ₁₀o ₅) n, in the present invention, be used as filler.

Membrana Follicularis ovi: sweet in the mouth; Light; Property is put down; Return spleen; Stomach; Lung meridian; Function cures mainly: nourishing YIN and clearing away lung-heat; Sore; Removing nebula; Synthetism.The main outer asthma of coughing; Pharyngalgia aphonia; Lymphoid tuberculosis; Ulcer being unable to heal; The raw cataracta of order; The vertigo; Trauma fracture.

Beneficial effect of the present invention: the present invention is by after said medicine combination, and its drug effect has synergism, has heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, removing the necrotic tissue and promoting granulation, effect of phencyclidine pathogenic fire purging, treatment oral ulcer is evident in efficacy.The present invention adopts Chinese medicine formula to coordinate Borax, chlortetracycline, lignocaine, vitamin B group to use, and better effects if treat sooner, has no side effect, and simply, medicine source is wide, cost is low, easy to use in preparation.This medicament is carried out to clinical practice, evident in efficacy, there is not toxic and side effects, total effective rate can reach 100%.

By concrete clinical practice, beneficial effect of the present invention is described below.

One, clinical observation

1. clinical data: use 100 people of medicament of the present invention, age bracket 18 years old～52 years old, 32 years old mean age.

2 diagnostic criterias:

There is the roun ulcer of 1-4mm in the positions such as lip, cheek, lingual margin, pain, has burning sensation, dryness of the mouth and throat.

3. Therapeutic Method:

Using method: according to taking out vacuum-packed Membrana Follicularis ovi, get powder one and be evenly sprinkling upon on Membrana Follicularis ovi, be then affixed on affected part (powder one is pressed close to affected part), every day three times.

4. efficacy assessment standard: 1. cure: in three days, above-mentioned symptom disappears substantially; 2. effective: in three days, above-mentioned symptom alleviates; 3. invalid: in three days, above-mentioned symptom slightly recovers, not recovery from illness.

5. therapeutic outcome:

Effective 100 people, effective percentage 100%, invalid 0 people, inefficiency 0%, effective number is 2, obvious effective rate is 2%, total effective rate 100%.

Two, model case:

Case 1: Wang, man, 23 years old, on October 12nd, 2013 was to our hospital.Upper and lower lip mucosa has 2 of ulcer, and scorching hot severe pain, dare not take food, and uses medicine of the present invention after three days, and aphtha pain disappears.

Medical record 2: Liu so-and-so, man, 35 years old.First visit on March 12 in 2012.While examining, respectively there is 1 ulcer on visible gums and tongue limit, and as Semen phaseoli radiati size, intermediate recess, covers tunica albuginea, surrounding protuberance, and color is light red, and conscious aphtha mild pain, has burning sensation.Use medicine of the present invention after three days, aphtha healing, transference cure.

Case 3: Wu, female, 28 years old.First visit on May 10 in 2013.Mucous membrane of lower lip has 1 ulcer, and as Semen Sesami size, intermediate recess, covers tunica albuginea, surrounding protuberance, and color is light red, conscious aphtha mild pain.Use medicine of the present invention 1 day, pain disappears, and after 2 days, aphtha heals substantially.

The specific embodiment

embodiment 1

Treat a medicine for oral ulcer, made by the raw material of following weight portion,

Radix Astragali 20g, Rhizoma Dioscoreae 20g, Herba Pogostemonis 20g, Radix Aucklandiae 20g, Radix Puerariae 20g, Caulis Lonicerae 20g, Cortex Dictamni 20g, Herba Scutellariae Barbatae 20g, Cortex Moutan 20g, Herba Menthae 20g, Radix Sophorae Tonkinensis 20g, Folium Bambusae 20g, Bulbus Fritillariae Cirrhosae 10g, Fructus Trichosanthis 10g, Fructus Jujubae 10g, Radix Glycyrrhizae 10g, Borax 2g, chlortetracycline 2g, lignocaine 1g, vitamin B group 1g, starch 8g.

The preparation method of said medicine, comprises the following steps:

1. take raw material by above-mentioned weight portion;

2. the Radix Astragali, Rhizoma Dioscoreae, Herba Pogostemonis, the Radix Aucklandiae, Radix Puerariae, Caulis Lonicerae, Cortex Dictamni, Herba Scutellariae Barbatae, Cortex Moutan, Herba Menthae, Radix Sophorae Tonkinensis, Folium Bambusae, Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Fructus Jujubae, the Radix Glycyrrhizae that step are taken in are 1. put into marmite, add the water of 3 times of weight, soak half an hour, decoct after 1 hour, pour out filtrate, for filtrate one, filtering residue stays in marmite, then adds water not have filtering residue in adding, and decocts half an hour, pouring out filtrate, is filtrate two;

3. merging filtrate one and filtrate two, the filtrate that the Membrana Follicularis ovi that step is taken in is 1. placed in after merging is soaked 3h, takes out vacuum packaging; Then filtrate decompression is distilled to into thick liquid, by infrared drying, removes moisture, and clay into power, obtain powder one;

4. Borax step being taken in 1., chlortetracycline, lignocaine, vitamin B group and starch mix homogeneously, then add powder one, and mix homogeneously is packed and be get final product.

Using method: according to taking out vacuum-packed Membrana Follicularis ovi, get powder one and be evenly sprinkling upon on Membrana Follicularis ovi, be then affixed on affected part (powder one is pressed close to affected part), every day three times.

Claims (2)

1. a medicine for the treatment of oral ulcer, is characterized in that, made by the raw material of following weight portion,

Radix Astragali 20g, Rhizoma Dioscoreae 20g, Herba Pogostemonis 20g, Radix Aucklandiae 20g, Radix Puerariae 20g, Caulis Lonicerae 20g, Cortex Dictamni 20g, Herba Scutellariae Barbatae 20g, Cortex Moutan 20g, Herba Menthae 20g, Radix Sophorae Tonkinensis 20g, Folium Bambusae 20g, Bulbus Fritillariae Cirrhosae 10g, Fructus Trichosanthis 10g, Fructus Jujubae 10g, Radix Glycyrrhizae 10g, Borax 2g, chlortetracycline 2g, lignocaine 1g, vitamin B group 1g, starch 8g, Membrana Follicularis ovi 3g.

2. a preparation method for the medicine for the treatment of oral ulcer claimed in claim 1, is characterized in that, comprises the following steps:

1. take raw material by weight portion claimed in claim 1;

2. the Radix Astragali, Rhizoma Dioscoreae, Herba Pogostemonis, the Radix Aucklandiae, Radix Puerariae, Caulis Lonicerae, Cortex Dictamni, Herba Scutellariae Barbatae, Cortex Moutan, Herba Menthae, Radix Sophorae Tonkinensis, Folium Bambusae, Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Fructus Jujubae, the Radix Glycyrrhizae that step are taken in are 1. put into marmite, add the water of 3 times of weight, soak half an hour, decoct after 1 hour, pour out filtrate, for filtrate one, filtering residue stays in marmite, then adds water not have filtering residue in adding, and decocts half an hour, pouring out filtrate, is filtrate two;

3. merging filtrate one and filtrate two, the filtrate that the Membrana Follicularis ovi that step is taken in is 1. placed in after merging is soaked 3h, takes out vacuum packaging; Then filtrate decompression is distilled to into thick liquid, by infrared drying, removes moisture, and clay into power, obtain powder one;

4. Borax step being taken in 1., chlortetracycline, lignocaine, vitamin B group and starch mix homogeneously, then add powder one, and mix homogeneously is packed and be get final product.