CN103816225B - A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction - Google Patents

A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction Download PDF

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CN103816225B
CN103816225B CN201410114053.6A CN201410114053A CN103816225B CN 103816225 B CN103816225 B CN 103816225B CN 201410114053 A CN201410114053 A CN 201410114053A CN 103816225 B CN103816225 B CN 103816225B
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toad
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semen
roripa
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刘灿坤
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Abstract

The invention belongs to Chinese medicinal formulae field, be specifically related to a kind of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction, in terms of parts by weight, raw material composition is as follows: Radix Scutellariae (processed with wine) 18 90 parts, Semen Lepidii (Semen Descurainiae) 6 24 parts, Semen Sinapis Albae 3 18 parts, Gekko Swinhonis 9 30 parts, wine Agkistrodon 9 30 parts, Scorpio 9 18 parts, toad-cortex 3 12 parts, Scolopendra 3 12 parts, the Radix Astragali 30 120 parts, Cordyceps powder 3 18 parts, Gecko 3 18 parts.Good effect of the present invention, without side reaction, effective percentage is high.

Description

A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction
Technical field
The invention belongs to Chinese medicinal formulae field, be specifically related to a kind of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction.
Background technology
Lung bronchogenic carcinoma, is called for short pulmonary carcinoma, is one of common malignant tumor in various places, the world today, and its M & M is year by year Rise.At present treatment pulmonary carcinoma mainly uses doctor trained in Western medicine getting up early operation, mid-term Radiotherapy chemotherapy scheme, Chinese medicine, but put, changed late period The unsatisfactory curative effect treated, erious adverse reaction, and early stage, mid-term are coordinated doctor trained in Western medicine effect ideal by Chinese medicine, the patients with terminal traditional Chinese medical science Drug effect fruit is the most ideal.
Summary of the invention
It is an object of the invention to provide a kind of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction, good effect, without side reaction, effective percentage is high.
A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction of the present invention, in terms of parts by weight, raw material composition is as follows:
Radix Scutellariae (processed with wine) 18-90 part, Semen Lepidii (Semen Descurainiae) 6-24 part, Semen Sinapis Albae 3-18 part, Gekko Swinhonis 9-30 part, wine Agkistrodon 9-30 part, Scorpio 9-18 part, toad-cortex 3-12 part, Scolopendra 3-12 part, Radix Astragali 30-120 part, Cordyceps powder 3-18 part, Gecko 3-18 part.
A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor soup, in terms of parts by weight, raw material composition is preferably as follows:
The raw material of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: Radix Scutellariae (processed with wine) 60 parts, Semen Lepidii (Semen Descurainiae) 12 parts, Semen Sinapis Albae 9 parts, Gekko Swinhonis 12 parts, wine Agkistrodon 12 parts, Scorpio 12 parts, toad-cortex 3 parts, Scolopendra 6 parts, the Radix Astragali 30 parts, Cordyceps powder 6 parts, Gecko 6 parts.
The preparation method of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: by Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad Clothing, Scolopendra, the Radix Astragali, Cordyceps powder and Gecko are poured in medicine pot, soak 40-50 minute, then add water to liquid level high Going out medicine 2-3cm, then intense fire is boiled, transfers intense fire to and decocts 30-40min, pours out medicinal liquid;Slag of getting it filled is put in medicine pot and is added water Exceeding medicine 2-3cm to liquid level, then intense fire is boiled, transfers intense fire to and decocts 30-40min, pours out secondary medicinal liquid;Remove medicinal residues, Take twice medicinal liquid to merge to put in medicine pot and be concentrated into 350-400ml.
The using method of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction for being decocted in water for oral dose, three times on the one, one after each meal.
Selecting 40 example lung bronchogenic carcinoma patients, utilize a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction to treat, therapeutic effect is notable.Situation is such as Under:
1 data and method
1.1 physical data
In November, 2009~, in December, 2010 accepted lung bronchogenic carcinoma patient 40 example altogether for medical treatment, made a definite diagnosis through cytology and pathology.Its In, male 25 examples, female 15 example, age 38~72 years old, average (64.2 scholar 5.8) year, scale cancer 16 example, adenocarcinoma 15 example, gland Cancer and compound 7 examples of scale cancer, other types 2 example.It is randomly divided into matched group and treatment group, often organizes 20 examples.Matched group, man 12 examples, female 8 example, year at age (62.6 scholar 5.1), the course of disease (1.1 scholar 0.3) year;Treatment group, male 13 examples, female 7 example, the age (65.0 Scholar 5.6) year, the course of disease (1.4 scholar 0.5) year.Sex, age, the course of disease and the cancer types comparing difference not statistically significant of two groups (P>0.05)。
1.2 Therapeutic Method
Two groups of patients all give to the ill and the conventional therapy such as nutritional support.
Matched group gives NP chemotherapy regimen, vinorelbine 30mg/m on basis of conventional therapy2Intravenous injection the 1st, 8 days;Suitable Platinum 100mg/m2Intravenous injection the 1st day;Aquation and diuresis.
Treatment group gives traditional Chinese medical science supplementing QI and nourishing YIN, fever, detoxicating and treating on basis of conventional therapy.Prescription drugs consists of: a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad disappear Tumor decoction.
1.3 criterion of therapeutical effect
With reference to WHO criterion, complete incidence graph (CR): focus fully absorbs;Part alleviates (PR): focus reduces > 50%; Minor responses (MC): focus reduces less than 50%;Invalid (PD): focus expands more than 25% before relatively treating.Objective effective percentage (RR)=(CR+PR)/case load × 100%, disease control rate (DC)=(CR+PR+MC)/case load × 100% can be evaluated can be evaluated.
1.4 statistical method
SPSS17.0 statistical software processes, and measurement data mean ± standard deviation (x ± s) represents, uses t inspection, and enumeration data is entered Row X2 checks, and P < 0.05 represents that difference is statistically significant.
2 results 2.1
Two groups of clinical efficacies of clinical efficacy are shown in Table l.
Two groups of clinical efficacies of table l clinical efficacy
Group number of cases CR PR MC PD RR (%) DC (%)
Matched group 20 5 4 3 8 45.0 60.0
Treatment group 20 6 5 2 7 55.0 65.0
Note: compare with matched group, P < 0.05.
After treatment, Karnofsky marks such as table 2.
Karnofsky scoring after table 2 treatment
Group number of cases (n) Before treatment After treatment
Matched group 20 45.82 scholar 11.31 56.78 scholar 14.72
Treatment group 20 46.02 scholar 11.45 66.44 scholar 15.09
It is significantly increased (P < 0.05) before Karnofsky scoring the most relatively treatment after two groups of treatments;Treatment group is after treatment Karnofsky marks apparently higher than matched group (P < 0.05), is shown in Table 2.Treatment group compares with matched group, P < 0.05;Before treatment Relatively, P < 0.05.
Table 3 compares for CEA and CA125 before and after matched group and treatment group two groups treatment.
Before and after table 3 matched group and the treatment for the treatment of group, CEA and CA125 compares
Table 3 show CEA and CA125 comparing difference not statistically significant (P > 0.05) before and after two groups of treatments.
In therapeutic process, matched group 20 example patient all has leukopenia in various degree, alopecia and hepatic and renal function injure etc. bad Reaction;Treatment group therapeutic process only has 1 example generation gastrointestinal upset.The adverse reaction rate for the treatment of group is significantly lower than matched group ((P<0.05)。
The traditional Chinese medical science thinks the lung qi deficiency of YIN, and evil poison accumulates strongly fragrant, is the Etiological pathogenesis of pulmonary carcinoma, therefore uses supplementing QI and nourishing YIN, method of dissipating heat and detoxifying Treatment.Cordyceps powder, Gecko supplementing QI and nourishing YIN, nourishing the lung to arrest cough in decoction;Radix Scutellariae (processed with wine) joins Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae heat clearing and damp drying, profit Water expectorant;Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra heat-clearing and toxic substances removing, removing obstruction for relieving pain;QI invigorating and do not love heresy, removing toxic substances and not Hindering healthy energy, the most all medicines share, and play strengthening vital QI to eliminate pathogenic factors altogether, and dampness removing toxic substances recovers the merit of healthy energy.
The result of study of the present invention shows, the objective effective percentage of Chinese traditional treatment lung bronchogenic carcinoma is higher than chemotherapy, and life quality scores is the brightest Aobvious higher than chemotherapy group, and adverse reaction rate is significantly lower than chemotherapy group.Absolutely prove the clinical treatment of Chinese traditional treatment lung bronchogenic carcinoma Effect is definite, and untoward reaction is little, is worthy to be popularized.
Case 1: high mountain, female, 56 years old, it is engaged in agriculture, people from Zibo;Doctor trained in Western medicine is diagnosed as advanced lung cancer (adenocarcinoma), radial pattern pneumonia fibre Dimensionizations etc., radiotherapy, western medicine June, seriously ill go home;In November, 2005 please go family to hold a consultation before author, sees that patient is uncomfortable in chest Breathe hard, pant, dry cough, spiritlessness and weakness, movable asthma increases the weight of, time have spontaneous perspiration, night sweat to go out, inappetence, about one week is big The most once, body of the tongue is light red, white and thin fur, and thready pulse is micro-.Dialectical for type of deficiency of both QI and YIN, control suitable supplementing QI and nourishing YIN.
Therapeutic Method: take a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction three times a day, adds and subtracts with disease, takes continuously 5 years, never intermittent use, Interim medication in nearly 3 years, when increasing the weight of except cold cough, adds outside erythromycin, prednisone, useless any Western medicine;The most 8 Year, and physical efficiency recovery is fine, can look after the child and do housework, and self-induction health is fine.
Case 2: Cui, female, 86 years old, teacher, doctor trained in Western medicine CT was diagnosed as advanced lung cancer, and hydrothorax, between in May, 2008 Require to award treatment in person.Card is shown in cough with copious phlegm, asthma uncomfortable in chest, and loose stool is indigestion and loss of appetite, edema under limb, spiritlessness and weakness, shallow complexion, There is indentation on the fat limit of pale tongue, and tongue is the most greasy, and rolling pulse carefully delays.Dialectical for spleen emptiness and wet sputum type, control suitable replenishing QI to invigorate the spleen, diuretic dampness.
Therapeutic Method: take a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction three times a day, adds and subtracts with disease, after treating 45 days, and CT sheet display focus Reducing, after continued treatment half a year, CT sheet display focus is contracted to original 1/3, and during treatment, unused any Western medicine, is still living and in good health so far.
Case 3: Chen, female, 46 years old, it is engaged in agriculture, Zibo stone horse people;Imaging diagnosis is advanced lung cancer (alveolar cell carcinoma), The double Lung neoplasm 60% of CT is covered with pulmonary carcinoma focus, is transferred to ten finger tops, owing to the pain increased, performs the operation and is amputated by right hand forefinger. Outside treatment March more than, unsatisfactory curative effect, come to go to a doctor in January, 2010, symptom see chronic cough thin sputum, asthma of speaking, pant dehisce, Breathe hard uncomfortable in chest, tired, limb adynamia, two lower limbs are aching and limp, become thin, two finger tops are thick, deep-thready pulse or moisten, pale tongue thin fur. Dialectical for deficiency type of QI of the lung and kidney, control suitable nourishing lung and kidney.
Therapeutic Method: take a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction three times a day, adds and subtracts with disease, additionally uses herbal medicine immersion both hands, treatment half Nian Yu, both hands refer to that top reduces, pant and alleviate, and health self-induction is light, and in February, 2012, CT again, showed double Lung neoplasm 95% Being covered with pulmonary carcinoma focus, two lungs are circular nodules joint entirely, and during in January, 2010 in March, 2012, patient resolutely refuses to use doctor trained in Western medicine Treatment, until dying of illness.
Case 4: fourth, female, 51 years old, cadre, Zibo Boshan people;Pulmonary carcinoma, post-surgical chemotherapy, occur vomitting after the 3rd course for the treatment of Telling, alopecia, leukocyte declines rapidly about 2300 and waits untoward reaction, goes to a doctor over 2007, and disease sees chest pain, cough, xerostomia, Anorexia, retches, hoarseness, constipation.Dimly red tongue, the few Tianjin of tongue fur BOHUANG, thready and rapid pulse without strength.Dialectical for deficiency of YIN heat Junction type;Control suitable supplementing QI and nourishing YIN, heat clearing away eliminating stagnation.
Therapeutic Method: take a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction three times a day, adds and subtracts with disease, hence it is evident that mitigation symptoms, completes chemotherapy, continue And take 3 years continuously, follow-up discontinuity is taken medicine, and health is without exception so far.
Case 5: Zhang blood brother two people, man, 61 years old, 62 years old, it is pulverizing workman, Zibo Boshan people, imaging diagnosis For advanced lung cancer (scale cancer), pneumoconiosis, hemoptysis, once more than two hospital western medical treatment February, more than March, it is showed no Turning, within 2003, come to go to a doctor, card is shown in fullness and distention in the chest and hypochondrium, breast aching as needle stabbing, sputum mixed with blood or spitting of blood, irritability.Emotion changes whenever Time symptom aggravation.Dimly red tongue, has ecchymosis, tongue fur BOHUANG, thready and stringy pulse.Dialectical for qi stagnation blood stasis type.
Therapeutic Method: take a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction three times a day, adds and subtracts with disease, and one week hemoptysis of medication stops, other symptoms All alleviating, continue and use treatment by Chinese herbs more than 1 year, succeeding state is good.
Compared with prior art, the method have the advantages that
It is an object of the invention to provide a kind of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction, good effect, without side reaction, effective percentage is high.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
The raw material of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: Radix Scutellariae (processed with wine) 60g, Semen Lepidii (Semen Descurainiae) 12g, Semen Sinapis Albae 9g, Gekko Swinhonis 12g, wine Agkistrodon 12g, Scorpio 12g, toad-cortex 3g, Scolopendra 6g, Radix Astragali 30g, Cordyceps powder 6g, Gecko 6g.
Preparation method: by Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra, the Radix Astragali, worm Grass volvatus powder and Gecko are poured in medicine pot, soak 40 minutes, then add water and exceed medicine 2cm to liquid level, and then intense fire burns Open, transfer intense fire to and decoct 30min, pour out medicinal liquid;Slag of getting it filled is put into and is added water to liquid level in medicine pot and exceed medicine 3cm, then military Baked wheaten cake is opened, and transfers intense fire to and decocts 30min, pours out secondary medicinal liquid;Remove medicinal residues, take twice medicinal liquid merging and put into concentration in medicine pot To 350ml.
Embodiment 2
The raw material of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: Radix Scutellariae (processed with wine) 45g, Semen Lepidii (Semen Descurainiae) 18g, Semen Sinapis Albae 15g, Gekko Swinhonis 9g, wine Agkistrodon 9g, Scorpio 12g, toad-cortex 3g, Scolopendra 3g, Radix Astragali 90g, Cordyceps powder 6g, Gecko 6g.
Preparation method: by Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra, the Radix Astragali, worm Grass volvatus powder and Gecko are poured in medicine pot, soak 50 minutes, then add water and exceed medicine 3cm to liquid level, and then intense fire burns Open, transfer intense fire to and decoct 40min, pour out medicinal liquid;Slag of getting it filled is put into and is added water to liquid level in medicine pot and exceed medicine 2cm, then military Baked wheaten cake is opened, and transfers intense fire to and decocts 35min, pours out secondary medicinal liquid;Remove medicinal residues, take twice medicinal liquid merging and put into concentration in medicine pot To 400ml.
Embodiment 3
The raw material of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: Radix Scutellariae (processed with wine) 45g, Semen Lepidii (Semen Descurainiae) 24 parts, Semen Sinapis Albae 10 parts, Gekko Swinhonis 9g, wine Agkistrodon 9g, Scorpio 12g, toad-cortex 3g, Scolopendra 3g, Radix Astragali 120g, Cordyceps powder 6g, Gecko 6g.
Preparation method: by Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra, the Radix Astragali, worm Grass volvatus powder and Gecko are poured in medicine pot, soak 45 minutes, then add water and exceed medicine 2cm to liquid level, and then intense fire burns Open, transfer intense fire to and decoct 35min, pour out medicinal liquid;Slag of getting it filled is put into and is added water to liquid level in medicine pot and exceed medicine 2cm, then military Baked wheaten cake is opened, and transfers intense fire to and decocts 30min, pours out secondary medicinal liquid;Remove medicinal residues, take twice medicinal liquid merging and put into concentration in medicine pot To 400ml.
Embodiment 4
The raw material of a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction: Radix Scutellariae (processed with wine) 60g, Gekko Swinhonis 18g, toad-cortex 8g, wine Agkistrodon 20g, Scorpio 9g, worm Grass volvatus powder 12g, Scolopendra 3g, Gecko 3g, Semen Sinapis Albae 6g, Semen Lepidii (Semen Descurainiae) 13g, Radix Astragali 100g.
Preparation method: by Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra, the Radix Astragali, worm Grass volvatus powder and Gecko are poured in medicine pot, soak 50 minutes, then add water and exceed medicine 3cm to liquid level, and then intense fire burns Open, transfer intense fire to and decoct 30min, pour out medicinal liquid;Slag of getting it filled is put into and is added water to liquid level in medicine pot and exceed medicine 3cm, then military Baked wheaten cake is opened, and transfers intense fire to and decocts 40min, pours out secondary medicinal liquid;Remove medicinal residues, take twice medicinal liquid merging and put into concentration in medicine pot To 380ml.

Claims (3)

1. a kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction, it is characterised in that in terms of parts by weight, raw material composition is as follows:
Radix Scutellariae (processed with wine) 18-90 part, Semen Lepidii (Semen Descurainiae) 6-24 part, Semen Sinapis Albae 3-18 part, Gekko Swinhonis 9-30 part, wine Agkistrodon 9-30 part, Scorpio 9-18 part, toad-cortex 3-12 part, Scolopendra 3-12 part, Radix Astragali 30-120 part, Cordyceps powder 3-18 part, Gecko 3-18 part.
A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction the most according to claim 1, it is characterised in that in terms of parts by weight, raw material forms It is preferably as follows:
Radix Scutellariae (processed with wine) 60 parts, Semen Lepidii (Semen Descurainiae) 12 parts, Semen Sinapis Albae 9 parts, Gekko Swinhonis 12 parts, wine Agkistrodon 12 parts, Scorpio 12 parts, toad-cortex 3 parts, Scolopendra 6 parts, the Radix Astragali 30 parts, Cordyceps powder 6 parts, Gecko 6 parts.
A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction the most according to claim 1 and 2, it is characterised in that preparation method is as follows:
By Radix Scutellariae (processed with wine), Semen Lepidii (Semen Descurainiae), Semen Sinapis Albae, Gekko Swinhonis, wine Agkistrodon, Scorpio, toad-cortex, Scolopendra, the Radix Astragali, Cordyceps powder and clam A red-spotted lizard is poured in medicine pot, soaks 40-50 minute, then adds water and exceeds medicine 2-3cm to liquid level, and then intense fire is boiled, turns For slow fire boiling 30-40min, pour out medicinal liquid;Slag of getting it filled is put into and is added water to liquid level in medicine pot and exceed medicine 2-3cm, then intense fire Boiled, transfer slow fire boiling 30-40min to, pour out secondary medicinal liquid;Remove medicinal residues, take twice medicinal liquid merging and put into concentration in medicine pot To 350-400ml.
CN201410114053.6A 2014-03-25 2014-03-25 A kind of reed mentioned in ancient books Roripa five poisonous creatures: scorpion, viper, centipede, house lizard, toad dispersing tumor decoction Expired - Fee Related CN103816225B (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067000B1 (en) * 1981-05-22 1986-04-23 Snow Brand Milk Products Co. Ltd. Production of a nitrogen-containing polysaccharide having antitumour activity
CN101966310A (en) * 2010-09-27 2011-02-09 陈树亮 Traditional Chinese medicine for treating lung cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
自拟"解毒消瘤汤"治疗肺癌验案两则;张秀萍;《上海中医药杂志》;19981115(第11期);第27页 *

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