CN103800676A - Traditional Chinese medicine extractive for treating neurasthenia as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine extractive for treating neurasthenia as well as preparation method and application thereof Download PDFInfo
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- CN103800676A CN103800676A CN201410088718.0A CN201410088718A CN103800676A CN 103800676 A CN103800676 A CN 103800676A CN 201410088718 A CN201410088718 A CN 201410088718A CN 103800676 A CN103800676 A CN 103800676A
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Abstract
The invention discloses a traditional Chinese medicine extractive for treating neurasthenia. The traditional Chinese medicine extractive is prepared from angelica sinensis, radix rehmanniae preparata, phellodendron chinense schneid. var. glabriusculum schneid, coptis chinense franch, scutellaria linn., rhizoma polygonati, radix astragali, schisandra chinensls (turcz) baill., lycium barbarum L, divaricate saposhnikovia roots, rhizoma atractylodis macrocephalae and radix glycyrrhizae. The invention further discloses a preparation method of the traditional Chinese medicine extractive. The invention further discloses an application of the traditional Chinese medicine extractive to preparing a medicine for treating the neurasthenia.
Description
Technical field
The invention belongs to modern Chinese traditional medicine field, the present invention relates to a kind of from Radix Angelicae Sinensis (Angelica sinensis), Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), Cortex Phellodendri (Phellodendron chinense Schneid.var.glabriusculum Schneid), Rhizoma Coptidis (Coptis chinensis Franch), Radix Scutellariae (Scutellaria Linn.), Rhizoma Polygonati (Rhizoma Polygonati), the Radix Astragali (Radix Astragali), Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), Fructus Lycii (Lycium barbarum L), Radix Saposhnikoviae (DivaricateSaposhnikoviaRoot), the Rhizoma Atractylodis Macrocephalae (RhizomaAtractylodisMacrocephalae), the Chinese medicine extract that Radix Glycyrrhizae (Radix Glycyrrhizae) is extracted, be specifically related to a kind of preparation method of Chinese medicine extract and the application in preparation treatment neurasthenia medicine thereof.
Background technology
Neurasthenia refers to that brain is due to long-term nervous and stress, thereby produces weakening of ergasia ability, its principal character: 1. easy excited, irritability; 2. mental easily tired, as slightly of a specified duration in reading study, feel feeling of fullness in the head, giddy; Absent minded hypomnesis; 3. headache, position are unfixing.4. sleep disorder, mostly is difficulty falling asleep, early awakening, or after waking up, be difficult for falling asleep again, many nightmares; 5. autonomic nervous dysfunction, can tachycardia, perspiration, anorexia, constipation, diarrhoea, menoxenia, premature ejaculation; 6. Secondary cases hypochondriacal idea.Most of cases are fallen ill between 16-40 year, both sexes morbidity number no significant difference.The person of being engaged in mental work occupies the majority.Even primary disease can be delayed and reach several years many decades as dealt with improperly.As new Nervous and Mental Factors or the deficiency of having a rest, symptom can be reappeared or aggravate.
But now domestic medical level still falls behind, and all difference is little substantially for the medicine that various places hospital can open, and the more fruitful way of nothing, cures the symptoms, not the disease, and often eats more serious and more serious.Therefore be badly in need of now a kind of therapeutic effect good, few side effects, low-cost medicine occurs.From traditional medicine, find active strong, the low active drug of side effect and become the new way addressing this problem.
Radix Angelicae Sinensis, motherland's medical science thinks, Radix Angelicae Sinensis sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, is the key medicine in blood.Thereby it can be enriched blood, can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active.
Radix Rehmanniae Preparata is the tuber of Radix Rehmanniae, and Radix Rehmanniae is first appeared in Shennong's Herbal, has Radix Rehmanniae, Radix Rehmanniae and Radix Rehmanniae Preparata, but Radix Rehmanniae and Radix Rehmanniae are all the kinds of the Radix Rehmanniae, but no matter be the Radix Rehmanniae or Radix Rehmanniae Preparata, has effect of YIN nourishing and the production of body fluid promoting.Radix Rehmanniae Preparata is to be sweetly with sweetly, and tepor can be very not cold, returns liver, kidney channel.Generally can carry out nourishing YIN benefit essence with Radix Rehmanniae Preparata, as the medicine of enriching blood, and can treat blood deficiency, cardiopalmus, dizzy, insomnia, menoxenia, the hepatic and renal YIN deficiency, soreness of the waist and knees, night sweat seminal emission etc.In addition, Radix Rehmanniae Preparata also has the effect of the outer cell of heart tonifying, diuresis, blood sugar lowering and rising periphery, enhancing body immunity etc.
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.
Rhizoma Coptidis, has another name called Wang Lian, Zhi Lian etc., and herbaceos perennial belongs to Ranunculaceae Coptis.A kind of conventional Chinese medicine, can heat clearing and damp drying, eliminating fire and detoxication, vomiting acid regurgitation, dysentery, jaundice,, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tell nosebleed, conjunctival congestion, have a toothache, quench one's thirst,, carbuncle furuncle, eczema, eczema, auditory meatus suppurate, order, aphtha, clearing stomach, soothing liver-QI, incoordination between the liver and stomach, vomiting acid regurgitation, blood pressure lowering, removing toxic substances, arrhythmia, antibacterial, blood sugar lowering, antitumor, protection gastric mucosa etc.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root, it has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Rhizoma Polygonati, has another name called Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticus ginseng, cures mainly deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body, muscles and bones weakness, rheumatalgia, wind favus disease after being ill.
The Radix Astragali, has another name called continuous stilbene.The medicinal history of existing more than 2000 year so far of the Radix Astragali, it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis acid temperature is nontoxic." herbal classic " proposes these product the effects such as QI invigorating tonify deficiency reinforcing YIN-essence.Successive dynasties document is described Fructus Schisandrae Chinensis tonify deficiency labor, strengthening bone and muscle, special tonifying the lung kidney, hold concurrently tonifying five ZANG-organs, supplementing QI for promoting the production of body fluid.The suffer from a deficiency of the kidney cough with asthma of damage, the frequent micturition of quenching one's thirst, spontaneous sweating due to deficiency of QI, night sweat due to yin deficiency of common senile disease lung all had to therapeutical effect.The insomnia cardiopalmus of improving old deficiency of heart-blood, insufficiency of heart-QI, disarmony between the heart and kidney is all had to good action.
The flat sweet in the mouth of Fructus Lycii, enter liver, kidney channel, there is effect of replenishing YIN and blood, nourishing the liver and kidney, replenishing vital essence to improve eyesight, be usually used in treating that Liver and kidney is deficient, the disease such as soreness of the waist and knees due to asthenia of essence and blood, dizziness, tinnitus, seminal emission, to deficiency of the liver and kindey, essence and blood can not on the disease curative effect such as dim-sighted, the visual deterioration of the eyes that helps due to the order especially good.
Radix Saposhnikoviae, for cold, fever with chills, headache, general pain.And the disease such as cold anemopyretic, fever with chills, conjunctival congestion, pharyngalgia.
The Rhizoma Atractylodis Macrocephalae, perennial herb, the nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention have loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Radix Glycyrrhizae is a kind of tonification Chinese herbal medicine, and function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
We find by Pharmacodynamics screening, can obviously treat the symptom of insomnia and the perspiration of neurastheniac by extracting the extract obtaining after above-mentioned each medicine is mixed according to certain proportioning.
Summary of the invention
The object of the present invention is to provide a kind of therapeutic effect good, few side effects, the neurasthenic medicine of low-cost treatment, the drug extract that medicine of the present invention is plurality of Chinese.
Another object of the present invention is to provide the method for this drug extract of preparation.
Another object of the present invention is to propose this Chinese medicine extract and has the application in the medicine for the treatment of neurasthenia's effect in preparation.
In order to achieve the above object, the present invention has taked following technical scheme:
(1) take 12 parts of described medical material Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schnid.var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (Radix Astragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarumL), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Glycyrrhizae),
(2) medical material step (1) Suo Shu is soaked with clear water;
(3) medical material of immersion step (2) Suo Shu is mixed and put into the decoction of drug-decocting appliance marmite;
(4) by the extracting liquid filtering of step (3) gained;
(5) by the extracting solution bottling of step (4) gained, be placed in disinfecting container and carry out disinfection
(6) solution of step (5) gained is Chinese medicine extract of the present invention.
As the improvement to technique scheme and supplement:
(7) immersion process can be 6-10 hour.
(8) decoction process can carry out at twice, and doubled amount decocting boils 10 hours for the first time, adds for the second time 5 times of water gagings and decocts 2 hours.
(9) sterilisation temp of disinfecting container is for being not less than 100 ℃.
The extract preparing by technique scheme is the plant extract of medicine food pure natural, and effect experiment subsequently will prove, Chinese medicine extract of the present invention has effect of significant neurasthenia.
The specific embodiment
Below in conjunction with specific embodiment; further set forth the present invention; these embodiment are interpreted as being only not used in and limiting the scope of the invention for the present invention is described; after having read the content of the present invention's record; those skilled in the art can make various changes or modifications the present invention, and these equivalences change and modification falls into the claims in the present invention book limited range equally.
The preparation of embodiment 1 Chinese medicine extract
(1) take 12 parts of described medical material Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schneid.var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (Radix Astragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Thrcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarumL), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Glycyrrhizae),
(2) medical material step (1) Suo Shu is soaked 6 hours with clear water;
(3) medical material of immersion step (2) Suo Shu is mixed and put into the decoction of drug-decocting appliance marmite; Decoction process can carry out at twice, and doubled amount decocting boils 10 hours for the first time, adds for the second time 5 times of water gagings and decocts 2 hours;
(4) by the extracting liquid filtering of step (3) gained;
(5) by the extracting solution bottling of step (4) gained, be placed in disinfecting container and carry out disinfection, the sterilisation temp of disinfecting container is 100 ℃.
(6) solution of step (5) gained is Chinese medicine extract of the present invention.
The preparation of embodiment 2 Chinese medicine extract
(1) take 12 parts of described medical material Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schneid.var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (Radix Astragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarumL), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Gltcyrrhizae),
(2) medical material step (1) Suo Shu is soaked 8 hours with clear water;
(3) medical material of immersion step (2) Suo Shu is mixed and put into the decoction of drug-decocting appliance marmite; Decoction process can carry out at twice, and doubled amount decocting boils 10 hours for the first time, adds for the second time 5 times of water gagings and decocts 2 hours;
(4) by the extracting liquid filtering of step (3) gained;
(5) by the extracting solution bottling of step (4) gained, be placed in disinfecting container and carry out disinfection, the sterilisation temp of disinfecting container is for being not less than 120 ℃.
(6) solution of step (5) gained is Chinese medicine extract of the present invention.
The preparation of embodiment 3 Chinese medicine extract
(1) take 12 parts of described medical material Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schneid.var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (Radix Astragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarumL), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Glycyrrhizae),
(2) medical material step (1) Suo Shu is soaked 10 hours with clear water;
(3) medical material of immersion step (2) Suo Shu is mixed and put into the decoction of drug-decocting appliance marmite; Decoction process can carry out at twice, and doubled amount decocting boils 10 hours for the first time, adds for the second time 5 times of water gagings and decocts 2 hours;
(4) by the extracting liquid filtering of step (3) gained;
(5) by the extracting solution bottling of step (4) gained, be placed in disinfecting container and carry out disinfection, the sterilisation temp of disinfecting container is 150 ℃.
(6) solution of step (5) gained is Chinese medicine extract of the present invention.
Embodiment 4 Chinese medicine extract are treated neurasthenic functional study
Suffer from neurasthenic patient in various degree by 300 and be divided at random 3 groups, every patient sleeps and within first 3 hours, all takes drug extract of the present invention (each whole amounts of extracting), every morning is investigated every patient, situation the record of sleep and perspiration after inquiry drug administration.After 1 month, add up effective percentage, result is as shown in table 1, and to have a sleepless night and to perspire as the whether effective parameter for the treatment of, the effective percentage that drug extract of the present invention is treated neurasthenic patient reaches more than 90%, and the lighter one week, severe one are obviously alleviated for one month.
Table 1 Chinese medicine extract is treated neurasthenic effective percentage
| Group | 1 | 2 | 3 |
| Total case load | 100 | 100 | 100 |
| Remission number | 90 | 96 | 97 |
| Effective percentage | 90％ | 96％ | 97％ |
Claims (8)
1. a Chinese medicine extract, it is characterized in that, described Chinese medicine extract is by Radix Angelicae Sinensis (Angelicasinensis), Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), Cortex Phellodendri (Phellodendron chinense Schneid.var.glabriusculum Schneid), Rhizoma Coptidis (Coptis chinensis Franch), Radix Scutellariae (Scutellaria Linn.), Rhizoma Polygonati (Rhizoma Polygonati), the Radix Astragali (Radix Astragali), Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), Fructus Lycii (Lycium barbarumL), Radix Saposhnikoviae (DivaricateSaposhnikoviaRoot), the Rhizoma Atractylodis Macrocephalae (Rhizoma Atractylodis Macrocephalae), Radix Glycyrrhizae (Radix Glycyrrhizae) makes.
2. Chinese medicine extract according to claim 1, it is characterized in that, described medical material takes in weight portion, 12 parts of Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schneid var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (Radix Astragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarum L), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Glycyrrhizae).
3. a method of preparing the Chinese medicine extract as described in any one in claim 1-2, is characterized in that, described preparation method comprises the following steps:
(1) take 12 parts of described medical material Radix Angelicae Sinensis (Angelica sinensis), 30 parts, Radix Rehmanniae Preparata (Radix Rehmanniae Preparata), 9 parts of Cortex Phellodendris (Phellodendron chinense Schneid.var.glabriusculum Schneid), 3 parts of Rhizoma Coptidis (Coptis chinensis Franch), 9 parts of Radix Scutellariaes (Scutellaria Linn.), 18 parts of Rhizoma Polygonatis (Rhizoma Polygonati), 15 parts of the Radixs Astragali (RadixAstragali), 9 parts of Fructus Schisandrae Chinensis (Schisandra chinensls (Turcz) Baill.), 18 parts of Fructus Lycii (Lycium barbarum L), 15 parts of Radix Saposhnikoviaes (DivaricateSaposhnikoviaRoot), 15 parts of the Rhizoma Atractylodis Macrocephalaes (Rhizoma Atractylodis Macrocephalae), 9 parts, Radix Glycyrrhizae (Radix Glycyrrhizae),
(2) medical material step (1) Suo Shu is soaked with clear water;
(3) medical material of immersion step (2) Suo Shu is mixed and put into the decoction of drug-decocting appliance marmite;
(4) by the extracting liquid filtering of step (3) gained;
(5) by the extracting solution bottling of step (4) gained, be placed in disinfecting container and carry out disinfection;
(6) solution of step (5) gained is Chinese medicine extract of the present invention.
4. preparation method according to claim 3, is characterized in that, described immersion process is 6-10 hour.
5. preparation method according to claim 3, is characterized in that, described decoction process carries out at twice, and doubled amount decocting boils 10 hours for the first time, adds for the second time 5 times of water gagings and decocts 2 hours.
6. preparation method according to claim 3, is characterized in that, the sterilisation temp of described disinfecting container is for being not less than 100 ℃.
One kind prepare as any one in claim 1-2 or according to the method as described in any one in claim 3-6 as described in the application of Chinese medicine extract in preparation treatment neurasthenia medicine.
8. according to the application described in claim 7, it is characterized in that, described neurasthenic symptom comprises insomnia and perspires.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410088718.0A CN103800676B (en) | 2014-03-12 | One treats neurasthenic Chinese medicine extract, preparation method and applications |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410088718.0A CN103800676B (en) | 2014-03-12 | One treats neurasthenic Chinese medicine extract, preparation method and applications |
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| CN103800676A true CN103800676A (en) | 2014-05-21 |
| CN103800676B CN103800676B (en) | 2016-11-30 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169301A (en) * | 1996-06-24 | 1998-01-07 | 王春儒 | Compounded |
| CN102526474A (en) * | 2012-03-22 | 2012-07-04 | 王寿江 | Chinese medicine composition for treating neurasthenia |
| CN102526329A (en) * | 2012-02-21 | 2012-07-04 | 简福川 | Traditional Chinese medicine for treating night sweat symptom |
| CN102846822A (en) * | 2012-08-19 | 2013-01-02 | 李承平 | Capsule for soothing nerves and relieving inner heat |
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169301A (en) * | 1996-06-24 | 1998-01-07 | 王春儒 | Compounded |
| CN102526329A (en) * | 2012-02-21 | 2012-07-04 | 简福川 | Traditional Chinese medicine for treating night sweat symptom |
| CN102526474A (en) * | 2012-03-22 | 2012-07-04 | 王寿江 | Chinese medicine composition for treating neurasthenia |
| CN102846822A (en) * | 2012-08-19 | 2013-01-02 | 李承平 | Capsule for soothing nerves and relieving inner heat |
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