CN103768723A - Mouse lower-limb radioactivity osteoradionecrosis model construction device - Google Patents
Mouse lower-limb radioactivity osteoradionecrosis model construction device Download PDFInfo
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- CN103768723A CN103768723A CN201210401985.XA CN201210401985A CN103768723A CN 103768723 A CN103768723 A CN 103768723A CN 201210401985 A CN201210401985 A CN 201210401985A CN 103768723 A CN103768723 A CN 103768723A
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Abstract
The invention provides a mouse lower-limb radioactivity osteoradionecrosis (ORN) model construction device which includes a cuboid with an open upper bottom face, and two lead plates. A lower bottom face of the cuboid is divided into three areas, wherein the first area is a mouse body placing area; the second areas is a radiotherapy area; the third are is a claw-part pulling area; the three areas are separated by two baffles; a plurality of semi-circular-arc holes are arranged in an area of each baffle, close to the lower bottom face; and projections are arranged at positions of the third area, corresponding to the semi-circular-arc holes so that the projections and the semi-circular-arc are distributed at the same line. The size of the mouse lower-limb radioactivity ORN model construction device undergoes a plurality of tests and division of the three areas is precise and accurate so that healthy tissue of mouse non-radiotherapy areas can be protected effectively and thus mouse ORN model construction is helped. The device is capable of performing construction of a plurality of mouse lower-limb ORN models at the same time so that model construction time is saved and radiotherapy cost is also saved.
Description
Technical field
The present invention relates to medical domain, relate in particular to a kind of construction device of rat lower limb osteoradionecrosis model.
Background technology
In the treatment of tumor of head and neck, radiotherapy is a kind of assisted surgery Therapeutic Method of commonly using, and it often carries out with chemotherapy simultaneously, also can be late period or tumor that cannot excision simultaneously a kind of palliative treatment is provided.But when lonizing radiation act on tumor cell, also can kill and wound by normal tissue cell.The most serious complication is osteoradionecrosis (osteoradionecrosis, ORN) clinically.And for the treatment of ORN, lack at present effective means.Therefore build ORN animal model and there is certain clinical meaning and scientific value for effective therapeutic scheme of studying ORN.
Because lonizing radiation normal tissue has damaging action, therefore in rat lower limb ORN model construction process, the protection at other position is had to important function.Along with the progress of radiotherapy technology, radiotheraphy device has become linear accelerator by Co 60, and domestic and foreign literature is not all reported for work with the radiotheraphy device of linear accelerator structure rat lower limb ORN model.The present invention is directed to this problem and invented this device, it can effectively protect the health tissues outside lower limb in successfully building rat lower limb ORN model, especially the testis position of male rat is effectively protected.
Summary of the invention
Technical problem to be solved by this invention is, provides one can effectively protect the non-radiotherapy of rat region health tissues, can help the construction device of the rat lower limb osteoradionecrosis model of the structure of rat ORN model.
In order to address the above problem, the invention provides a kind of rat lower limb osteoradionecrosis model construction device, described device comprises cuboid and the two blocks of stereotypes that a upper bottom surface is open, described cuboid bottom surface is divided into three regions, first area is rat health put area, second area is radiotherapy region, the 3rd region is claw draw area, above-mentioned three regions separate with two dividing plates respectively, each dividing plate is near the some semicircular arcs of the region division hole of bottom surface, the place at corresponding semicircular arc hole, the 3rd region arranges outthrust, described outthrust and semicircular arc hole are distributed in a straight line, one of described two blocks of stereotype just in time cover first area, and another piece just in time covers the 3rd region.
As a preferred version, the length of described cuboid is 35-40cm, width is 27-30cm, be highly 4-5cm, wherein, first area width is 15-16cm, second area width is 5-6cm, the 3rd peak width is 7-8cm, and the height of described dividing plate is less than or equal to the height of cuboid, but is greater than the height at semicircular arc hole.
As another preferred version, described semicircular arc hole radius is 3-4cm, and the spacing between each hole is for being not less than 4cm.
As another preferred version, the size that described stereotype is is long 35-40cm, wide 15-16cm, and the size of another piece is long 35-40cm, wide 7-8cm.
The invention has the advantages that, (1) device size dimension is through test of many times, and three regions are divided precisely, can effectively protect the non-radiotherapy of rat region health tissues, can help like this structure of rat ORN model; (2) can carry out the structure of many rat lower limb ORN models simultaneously, so not only saved build model time segmentum intercalaris but also approximately radiotherapy cost; (3) install easy to usely, after rat general anesthesia, be placed in device, with the fixing radiotherapy lower limb pawl palm of rubber band portion; (4) this device is made simply, with low cost, is convenient to promote the use of.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of this device.
Fig. 2 is the design sketch that device is placed rat, the picture after rat general anesthesia rear right-leg tractive is fixing.
Fig. 3 is the design sketch that device is placed radiotherapy after rat, after rat general anesthesia, is placed in device, covers stereotype protect in first area and the 3rd region, builds ORN model in the capable radiotherapy of second area.
Wherein, number in the figure is depicted as:
1---cuboid; 11---first area; 12---second area; 13---the 3rd region; 14---dividing plate; 141---semicircular arc hole; 15---outthrust.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.
1.5 type rat lower limb osteoradionecrosis model construction devices of embodiment
As shown in Figure 1, this device comprises cuboid 1 and the two blocks of stereotypes (diagram does not draw) that a upper bottom surface is open, described cuboid 1 bottom surface is divided into three regions, first area 11 is rat health put area, for protection zone, second area 12 is radiotherapy region, the 3rd region 13 is claw draw area, also be protection zone, above-mentioned three regions separate with two dividing plates 14 respectively, each dividing plate 14 is near 5 semicircular arc holes 141 of region division of bottom surface, the place in the 3rd corresponding semicircular arc hole, region 13 141 arranges outthrust 15, described outthrust 15 is distributed in a straight line with semicircular arc hole 141, one of described two blocks of stereotype just in time cover first area 11, and another piece just in time covers the 3rd region 13.
The length of cuboid is 35cm, and width is 27cm, is highly 5cm, and wherein, first area width is 15cm, and second area width is 5cm, and the 3rd peak width is 7cm, and the height of dividing plate is 5cm.
Semicircular arc hole radius is 3cm, and the spacing between each hole is 4cm.5 semicircular arc holes 141 are set on dividing plate 14, and the outthrust 15 on corresponding the 3rd region 13 is also 5.
The size that stereotype just in time covers 13, one, first area 11 and the 3rd region is long 35cm, wide 15cm, and the size of another piece is long 35cm, wide 7cm.
This device adopts organic resin glass to make, and in manufacturing process, the edge at each half arc hole, garden 141 will polish smooth, and causes wound to affect the structure of ORN model with exempt from customs examination lower limb.In addition, the semicircular arc hole 141 of first area 11 and second area 12 and the outthrust 15 in the 3rd region 13 will be point-blank, are convenient to like this tractive and protection lower limb.The effect of outthrust 15 is tractive lower limb fixing, can be that screw is screwed on, also can with cuboid one.
For easy and simple to handle, can not add dividing plate, like this convenient operation in 13 outthrust 15 regions below, the 3rd region.
Middle two dividing plates 14 can be to be fixed on cuboid body, can be also movable, treat to be loaded on after rat is placed.
This device is easy to use, is placed in device, with the fixing radiotherapy lower limb pawl palm of rubber band portion after rat general anesthesia.Can carry out the structure of 5 rat lower limb ORN models simultaneously, so not only saved build model time segmentum intercalaris but also approximately radiotherapy cost.Fig. 2 is the design sketch that device is placed rat, the picture after rat general anesthesia rear right-leg tractive is fixing.Fig. 3 is the design sketch that device is placed radiotherapy after rat, after rat general anesthesia, is placed in device, covers stereotype protect in first area and the 3rd region, builds ORN model in the capable radiotherapy of second area.
2. 6 type rat lower limb osteoradionecrosis model construction devices of embodiment
Apparatus structure is with embodiment 1, and the length of cuboid is 40cm, and width is 30cm, is highly 5cm, and wherein, first area width is 16cm, and second area width is 6cm, and the 3rd peak width is 8cm, and the height of dividing plate is 5cm.
Semicircular arc hole radius is 3cm, and the spacing between each hole is 4cm.6 semicircular arc holes 141 are set on dividing plate 14, and the outthrust 15 on corresponding the 3rd region 13 is also 6.
The size that stereotype just in time covers 13, one, first area 11 and the 3rd region is long 40cm, wide 16cm, and the size of another piece is long 40cm, wide 8cm.
This device can carry out the structure of 6 rat lower limb ORN models simultaneously.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (4)
1. a rat lower limb osteoradionecrosis model construction device, it is characterized in that, described device comprises cuboid and the two blocks of stereotypes that a upper bottom surface is open, described cuboid bottom surface is divided into three regions, first area is rat health put area, second area is radiotherapy region, the 3rd region is claw draw area, above-mentioned three regions separate with two dividing plates respectively, each dividing plate is near the some semicircular arcs of the region division hole of bottom surface, the place at corresponding semicircular arc hole, the 3rd region arranges outthrust, described outthrust and semicircular arc hole are distributed in a straight line, one of described two blocks of stereotype just in time cover first area, and another piece just in time covers the 3rd region.
2. a kind of rat lower limb osteoradionecrosis model construction device according to claim 1, it is characterized in that, the length of described cuboid is 35-40cm, and width is 27-30cm, is highly 4-5cm, wherein, first area width is 15-16cm, and second area width is 5-6cm, and the 3rd peak width is 7-8cm, the height of described dividing plate is less than or equal to the height of cuboid, but is greater than the height at semicircular arc hole.
3. a kind of rat lower limb osteoradionecrosis model construction device according to claim 1, is characterized in that, described semicircular arc hole radius is 3-4cm, and the spacing between each hole is for being not less than 4cm.
4. a kind of rat lower limb osteoradionecrosis model construction device according to claim 1, is characterized in that, the size that described stereotype is is long 35-40cm, wide 15-16cm, and the size of another piece is long 35-40cm, wide 7-8cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210401985.XA CN103768723B (en) | 2012-10-22 | 2012-10-22 | Rat lower limb osteoradionecrosis model construction device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210401985.XA CN103768723B (en) | 2012-10-22 | 2012-10-22 | Rat lower limb osteoradionecrosis model construction device |
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| Publication Number | Publication Date |
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| CN103768723A true CN103768723A (en) | 2014-05-07 |
| CN103768723B CN103768723B (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201453289U (en) * | 2009-03-18 | 2010-05-12 | 中国医学科学院放射医学研究所 | Fixed protecting device for locally irradiating experiment animal abdomen |
| DE102009058294A1 (en) * | 2009-12-05 | 2011-06-09 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Irradiation method and apparatus for carrying out the method |
| CN202020800U (en) * | 2011-03-31 | 2011-11-02 | 苏州大学 | Drawer-type local irradiation device for tumor bearing mouse |
| CN202283289U (en) * | 2011-10-28 | 2012-06-27 | 复旦大学附属肿瘤医院 | Fixing tube and fixing device for neoplasms illumination of medical small mice |
| CN202892670U (en) * | 2012-10-22 | 2013-04-24 | 上海交通大学医学院附属第九人民医院 | Device of constructing rat lower limb osteoradionecrosis model |
-
2012
- 2012-10-22 CN CN201210401985.XA patent/CN103768723B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201453289U (en) * | 2009-03-18 | 2010-05-12 | 中国医学科学院放射医学研究所 | Fixed protecting device for locally irradiating experiment animal abdomen |
| DE102009058294A1 (en) * | 2009-12-05 | 2011-06-09 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Irradiation method and apparatus for carrying out the method |
| CN202020800U (en) * | 2011-03-31 | 2011-11-02 | 苏州大学 | Drawer-type local irradiation device for tumor bearing mouse |
| CN202283289U (en) * | 2011-10-28 | 2012-06-27 | 复旦大学附属肿瘤医院 | Fixing tube and fixing device for neoplasms illumination of medical small mice |
| CN202892670U (en) * | 2012-10-22 | 2013-04-24 | 上海交通大学医学院附属第九人民医院 | Device of constructing rat lower limb osteoradionecrosis model |
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| CN103768723B (en) | 2016-03-30 |
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Granted publication date: 20160330 Termination date: 20161022 |