CN103756282A - Medical composite membrane material and preparation method thereof - Google Patents
Medical composite membrane material and preparation method thereof Download PDFInfo
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- CN103756282A CN103756282A CN201310720909.XA CN201310720909A CN103756282A CN 103756282 A CN103756282 A CN 103756282A CN 201310720909 A CN201310720909 A CN 201310720909A CN 103756282 A CN103756282 A CN 103756282A
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- urethane
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Abstract
The invention discloses a medical composite membrane material which comprises polyurethane and starch acetate. By adopting the starch acetate, the air permeability of the polyurethane composite membrane is improved; on one hand, the starch acetate particles can absorb internal water molecules and are quickly dispersed in the composite membrane under the influence of external air pressure; on the other hand, by adding the starch acetate particles, an alkaline aqueous solution is adsorbed to the surface of the starch acetate particles, the tight and dense structure in the polyurethane matrix is damaged, and the channels of water molecules are increased, so that the air permeability and moisture permeability of a blend membrane are enhanced.
Description
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Technical field
The present invention relates to field of medical materials, especially, relate to a kind of medical compound film material and preparation method thereof.
Background technology
Skin is the organ of human body maximum; cover body surface; it is the important barrier that protection body is avoided the harm of machinery, chemical substance and pathogenic agent; and can prevent subcutis moisture loss; when burning, during the large area skin wounds such as scald, need with dressing, protect wound in time, ease the pain; and promote as far as possible the proliferation and differentiation of skin cells, healing acceleration process.
At present using clinically a more class dressing is cotton, gauze etc., although quality is soft, has stronger receptivity, and the surface of a wound is had to certain provide protection, does not have moisture-keeping function easily to form a scab, and dressing easily causes exogenous infection while permeating.And all there is defect at aspects such as intensity, elasticity, water vapour permeability, moisture absorption drainages as pigskin, sheepskin etc. in the bio-derived material of clinical use, can not meet medical and clinical demand, and easy and human body generation rejection, store, transportation inconvenience etc. all limited the large-scale application of this type of material.
The medical compound film of polyurethane material has been applied to medical field, although polyurethane medical compound film has certain Waterproof Breathable function, its breathable moisture permeability is very poor, attaches to body surface and easily causes skin surface to turn white, and it is uncomfortable that patient feels.
Summary of the invention
The present invention is directed to the defect of prior art, a kind of medical compound film material with fabulous breathable moisture permeability is provided, in addition, also provide the preparation method of this material.
A kind of medical compound film material comprises urethane and acetate starch.
Described urethane is selected from medical grade polyurethane,
The substitution value of described acetate starch is between 0.8-1.5.
A medical compound film material preparation method, comprises the following steps:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes the polyurethane solution that solid content is 20-50%;
A2, the acetate starch composition of urethane 10%-100% quality is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid.
A4, coated film forming liquid is placed in the alkaline aqueous solution of pH value between 9-12 together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
The present invention adopts acetate starch, has improved the venting capability of urethane composite membrane, is because acetate starch particle can absorb internal water molecule on the one hand, externally, under the impact of air pressure, in composite membrane, spreads rapidly; Due to the adding of acetate starch particle, alkaline aqueous solution is adsorbed in acetate starch particle surface on the other hand, has destroyed the structure of the inner consolidation densification of polyurethane matrix, and the passage of water molecules increases, and blend film breathable moisture permeability is increased.
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Embodiment
Below in conjunction with specific embodiment, further describe the present invention, advantage and disadvantage of the present invention will be more clear along with description.But these embodiment are only exemplary, scope of the present invention are not formed to any restriction.It will be understood by those skilled in the art that lower without departing from the spirit and scope of the present invention and can the details of technical solution of the present invention and form be modified or be replaced, but these modifications and replacement all fall within the scope of protection of the present invention.
DMF: analytical pure, Tianjin Yong great chemical reagent company limited;
Urethane A: pharmaceutical grade, by Shaoxing, Zhejiang Province, Zhen De medical dressing company limited provides, and raw material is the polyurethane solution of solid content 30%;
Urethane B: pharmaceutical grade, purchased from Bayer A.G, model 2790A DPS045, raw material is white polyurethane particle;
Acetate starch: substitution value 0.9, Wuhan Lai Te Chemical Co., Ltd.;
Alkaline aqueous solution: aqueous sodium hydroxide solution.
The present invention adopts method described in the pharmaceutical industries standard YY/T 0471.2-2004 of the People's Republic of China (PRC), the water vapor transmission rate (WVTR) when measuring film and contacting with water vapour.
Embodiment 1
Urethane A 100
Acetate starch 30
Aqueous sodium hydroxide solution: pH value 9
Preparation method:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes solid content and is 20% polyurethane solution;
A2, acetate starch composition is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid.
A4, coated film forming liquid is placed in alkaline aqueous solution together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
Comparative example 1:
Comparative example 1 is identical with embodiment 1, but does not use acetate starch.
Comparative example 2
Comparative example 1 is identical with embodiment 1, but uses pure water solution to substitute alkaline aqueous solution.
Embodiment 2
Urethane A 100
Acetate starch 50
Aqueous sodium hydroxide solution: pH value 9
Preparation method:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes solid content and is 20% polyurethane solution;
A2, acetate starch composition is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid.
A4, coated film forming liquid is placed in alkaline aqueous solution together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
Embodiment 3
Urethane B 100
Acetate starch 90
Aqueous sodium hydroxide solution: pH value 12
Preparation method:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes solid content and is 20% polyurethane solution;
A2, acetate starch composition is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid.
A4, coated film forming liquid is placed in alkaline aqueous solution together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
Embodiment 4
Urethane B 100
Acetate starch 50
Aqueous sodium hydroxide solution: pH value 12
Preparation method:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes solid content and is 20% polyurethane solution;
A2, acetate starch composition is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid.
A4, coated film forming liquid is placed in alkaline aqueous solution together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | |
| Water vapor transmission rate (WVTR) (g/m2/ days) | 4015 | 4512 | 8026 | 7541 | 3058 | 3561 |
Claims (4)
1. a medical compound film material, is characterized in that, comprises urethane and acetate starch.
2. a kind of medical compound film material according to claim 1, is characterized in that, described urethane is selected from medical grade polyurethane.
3. a kind of medical compound film material according to claim 1, is characterized in that, the substitution value of described acetate starch is between 0.8-1.5.
4. a medical compound film material preparation method, is characterized in that, comprises the following steps:
A1, urethane is dissolved in to N, N-dimethyl formyl, makes the polyurethane solution that solid content is 20-50%;
A2, the acetate starch composition of urethane 10%-100% quality is dissolved in to polyurethane solution, obtains film forming liquid;
A3, by a side of the preparation liquid paper substrate of falling a Ge Laxin body, with spreader, shift equably opposite side onto, thereby on matrix, be paved with evenly smooth film forming film liquid;
A4, coated film forming liquid is placed in the alkaline aqueous solution of pH value between 9-12 together with matrix, after film forming, takes out, washing, dry, from matrix stripping, obtain sample thin film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310720909.XA CN103756282B (en) | 2013-12-24 | 2013-12-24 | A kind of Medical composite membrane material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310720909.XA CN103756282B (en) | 2013-12-24 | 2013-12-24 | A kind of Medical composite membrane material and preparation method thereof |
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| CN103756282A true CN103756282A (en) | 2014-04-30 |
| CN103756282B CN103756282B (en) | 2016-02-24 |
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| CN201310720909.XA Active CN103756282B (en) | 2013-12-24 | 2013-12-24 | A kind of Medical composite membrane material and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119493A (en) * | 2014-08-05 | 2014-10-29 | 苏州巨联科技有限公司 | Soft dry-process waterproof air/moisture-permeable polyurethane resin and preparation method thereof |
| CN104151522A (en) * | 2014-08-05 | 2014-11-19 | 苏州巨联科技有限公司 | Soft wet-method waterproof air-permeable water-permeable polyurethane resin and preparation method thereof |
| CN104371230A (en) * | 2014-11-13 | 2015-02-25 | 无锡中洁能源技术有限公司 | Backing film material for solar cells and preparation method thereof |
| WO2017028528A1 (en) * | 2015-08-19 | 2017-02-23 | 欧阳晨曦 | Preparation method for polyurethane composite material and composite material obtained thereby |
| CN107513264A (en) * | 2017-08-12 | 2017-12-26 | 安徽巢湖南方膜业有限责任公司 | A kind of anticorrosive packaging film |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516815A (en) * | 1991-11-07 | 1996-05-14 | Ems-Inventa Ag | Starch-Containing fibers, process for their production and products made therefrom |
| CN1439506A (en) * | 2003-03-31 | 2003-09-03 | 四川大学 | Water polyurethane elastic thin-wall products preparation |
-
2013
- 2013-12-24 CN CN201310720909.XA patent/CN103756282B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516815A (en) * | 1991-11-07 | 1996-05-14 | Ems-Inventa Ag | Starch-Containing fibers, process for their production and products made therefrom |
| CN1439506A (en) * | 2003-03-31 | 2003-09-03 | 四川大学 | Water polyurethane elastic thin-wall products preparation |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119493A (en) * | 2014-08-05 | 2014-10-29 | 苏州巨联科技有限公司 | Soft dry-process waterproof air/moisture-permeable polyurethane resin and preparation method thereof |
| CN104151522A (en) * | 2014-08-05 | 2014-11-19 | 苏州巨联科技有限公司 | Soft wet-method waterproof air-permeable water-permeable polyurethane resin and preparation method thereof |
| CN104151522B (en) * | 2014-08-05 | 2016-06-22 | 苏州巨联科技有限公司 | A kind of soft wet method water-proof air-moisture-permeable polyurethane resin and preparation method thereof |
| CN104371230A (en) * | 2014-11-13 | 2015-02-25 | 无锡中洁能源技术有限公司 | Backing film material for solar cells and preparation method thereof |
| CN104371230B (en) * | 2014-11-13 | 2016-08-24 | 无锡中洁能源技术有限公司 | A kind of back membrane material used for solar batteries and preparation method thereof |
| WO2017028528A1 (en) * | 2015-08-19 | 2017-02-23 | 欧阳晨曦 | Preparation method for polyurethane composite material and composite material obtained thereby |
| CN107513264A (en) * | 2017-08-12 | 2017-12-26 | 安徽巢湖南方膜业有限责任公司 | A kind of anticorrosive packaging film |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103756282B (en) | 2016-02-24 |
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Address after: Room 1201, Building 518, Shenzhuan Highway, Songjiang District, Shanghai, 201508 Patentee after: Shanghai Bangzhong Polymer Materials Co., Ltd. Address before: Room 1201, Building 518, Shenzhuan Highway, Songjiang District, Shanghai, 201508 Patentee before: Shanghai Banzan Macromolecule Material Co., Ltd. |