CN103751714A - 一种治疗气滞血瘀型高脂血症的中药制备方法 - Google Patents
一种治疗气滞血瘀型高脂血症的中药制备方法 Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
一种治疗气滞血瘀型高脂血症的中药制备方法,属于中药制备方法技术领域。目前治疗气滞血瘀型高脂血症,一般采用调血脂药,存在的缺点是副作用大。该发明的技术方案为:取八月札、郁金、柚、枳壳、枳实、八角茴香、九里香、九香虫、刀豆、云实、杉木、佛手、玫瑰花、青皮、茅膏菜、枸橘、柿蒂、荔枝、荔枝核、厚朴、香附、香橼、娑罗子、丹参、水红花子、茺蔚子、鬼箭羽、凌霄花、川芎、川牛膝、王不留行、月季花、凤仙花、红花、杜鹃花、芸薹子、苏木、桃仁和甘草等,将以上中药放入水中浸泡,然后文火煎制,过滤去渣,煎出的药液即为治疗气滞血瘀型高脂血症的中药。它的优点是:制成的中药毒副作用小,疗程短,治愈率高。
Description
技术领域
本发明涉及中药制备方法技术领域,更具体的讲是一种治疗气滞血瘀型高脂血症的中药制备方法。
背景技术
目前治疗气滞血瘀型高脂血症,一般采用调血脂药:
1、苯扎贝特:①最常见不良反应为胃肠道不适,如消化不良、厌食、恶心、呕吐、饱胀感。②对本品过敏者、患胆囊疾病、胆石症者、肝功能不全或原发性胆汁性肝硬化的患者、严重肾功能不全患者、肾病综合征引起血白蛋白减少的患者禁用。③孕妇及哺乳期妇女慎用。
2、阿昔莫司:①治疗初期可引起皮肤血管扩张,提高对热的敏感性,如面部潮热或肢体瘙痒,这些症状通常在治疗后几日内消失,不需要停药。②对本品过敏及消化道溃疡者、孕妇、哺乳期妇女、儿童禁用。③在使用本品治疗之前,应先采取低胆固醇饮食、低脂肪饮食和停止酗酒的治疗措施。④肾功能不全者用量酌减。
3、藻酸双脂钠:①不良反应的发生率为5%-23%,主要表现为心悸、心绞痛、低血压及心电图异常;口干、恶心、呕吐、腹泻、腹痛、便秘及食欲减退等;有时出现肝脏异常,表现为TTT增高或ALT增高。皮肤发红、瘙痒、皮疹、环形红斑剥脱性皮炎、肢端静脉扩张、四肢末梢神经性水肿、急性喉头水肿和过敏性休克等。②有出血性疾病或出血倾向者、严重肝、肾功能不全者禁用。③低血压、血容量不足、血小板减少症、非高黏滞血症、非血小板聚集亢进、过敏性体质慎用。
4、非诺贝特:①不良反应发生率约有2%-15%。胃肠道反应、失眠较常见。②禁忌症:对本品过敏者、有胆囊疾病史、患胆石症的患者、严重肾功能不全、肝功能不全、原发性胆汁性肝硬化或不明原因的肝功能持续异常的患者。③胆囊结石症、肝功能不全、肾功能不全患者慎用。④使用本品过程中,如有血清淀粉酶增高,或血胆固醇、低密度脂蛋白增高,需停用本品。⑤本品不能作为饮食控制的替代疗法,继续饮食控制仍很必要。⑥与HMG-CoA还原酶抑制药非联用不可时,应密切监测患者的血清肌酸激酶(CK)水平,如CK值明显升高或怀疑出现肌病或横纹肌溶解,应立即停用。应告知患者,如果感到肌肉疼痛、疼痛肌肉敏感、肌肉无力,须立即就医,因为有时后果很严重。
5、氟伐他汀:①不良反应为轻微而短暂的消化不良。②禁忌症:活动性肝炎或不明原因的血清转氨酶持续升高者、孕妇及哺乳期妇女、18岁以下患者。③慎用:酗酒者、有肝病既往史者、对其他HMG-CoA还原酶抑制剂过敏者。④在应用本品治疗时须同时进行饮食治疗。⑤如果血清转氨酶持续升高,且超过正常上限3倍以上,或肌酸磷酸激酶显著增高或有肌炎,应立即停药。
6、吉非罗齐:①不良反应胃肠道不适最常见,如消化不良、厌食、恶心、呕吐、饱胀感、胃部不适等。②禁忌症:对本品过敏者、患胆囊疾病、胆石症者、肝功能不全或原发性胆汁性肝硬化的患者、严重肾功能不全患者、肾病综合征引起血清蛋白减少的患者。③本品对诊断有干扰:a.血红蛋白、血细胞压积、白细胞计数可能减低。b.血肌酸磷酸酶、碱性磷酸酶、氨基转移酶、乳酸脱氢酶可能增高。④本品停用后血胆固醇和甘油三酯可能反跳超原来水平,故宜给低脂饮食并监测血脂至正常。
7、洛伐他丁:①胃肠道不适最常见如:腹泻、胀气,其他还有头痛、皮疹、头晕、视觉模糊和味觉障碍。偶可引起血氨基转移酶可逆性升高。因此需监测肝功能。②禁忌症:对本品过敏、有活动性肝病或不明原因血氨基转移酶持续升高的患者。③慎用:对其他HMG-CoA还原酶抑制剂过敏者。④在本品治疗过程中发生血氨基转移酶增高达正常高限的3倍,或血肌酸磷酸激酶显著增高或有肌炎、胰腺炎表现时,应停用本品。⑤应用本品时如有低血压、严重急性感染、创伤、代谢紊乱等情况,须注意可能出现的继发于肌溶解后的肾功能衰竭。
8、普伐他丁:①不良反应:可见轻度氨基转氨酶升高,皮疹,肌痛,头痛,胸痛,恶心,呕吐,腹泻,疲乏等。②禁忌症:对本品过敏、活动性肝炎或肝功能试验持续升高者、以及妊娠及哺乳期的妇女。③慎用:有肝脏病史或饮酒史的患者、对其他HMG-CoA还原酶抑制剂过敏者。④对纯合子家族性高胆固醇血症疗效差。⑤治疗期间,应定期检查肝功能,如ALT或AST增高等于或超过正常上限三倍且为持续性的,应停止治疗。⑥使用HMG-CoA还原酶抑制剂类降血脂药偶可引起CPK升高,如升高值为正常上限三倍的10倍应停止使用。使用过程中,患者如出现不明原因的肌痛、触痛、无力,特别是伴有不适和发热者,应引起注意。⑦应用本品时如有低血压、严重急性感染、创伤、代谢紊乱等情况,须注意可能出现的继发于肌溶解后的肾功能衰竭。
9、辛伐他汀:①一般耐受性良好,大部分不良反应轻微且为一过性。②禁忌症:对任何成分过敏者、妊娠期妇女、活动性肝炎或无法解释的持续血清氨基转移酶升高者慎用,慎与四氢萘酚类钙通道阻滞剂米贝地尔合用。③对酒精引用量过大或有既往肝脏病史的患者慎用。④对于有弥漫性的肌痛、肌软弱或/和显著的肌酸激酶(CK)升高(大于正常值十倍以上)的情况应考虑为肌病,应立即停止辛伐他汀的治疗。对于有急性或严重的条件暗示的肌病及有因横纹肌溶解而导致二次急性肾衰竭倾向的患者应停止甲基羟戊二酰辅酶A(HMG-CoA)还原酶抑制剂的治疗。⑤纯合子型家庭性高胆固醇血症。由于纯合子型家族性高胆固醇血症的患者低密度脂蛋白(LDL)受体的完全缺乏的缘故,辛伐他汀对此类患者的治疗效果不大理想。
10、维生素E烟酸酯:①不良反应可有颈、面部感觉温热、皮肤发红、头皮等反应,亦可出现严重皮肤潮红、瘙痒、胃肠道不适。②慎用:动脉出血、糖尿病、青光眼、痛风、高尿酸血症、肝病、溃疡病、低血压者。
发明内容
为克服上述缺点,本发明的目的是发明一种治疗气滞血瘀型高脂血症的中药制备方法。高脂血症是指血脂代谢发生紊乱;脂肪代谢或转运异常,血浆中一种或几种脂质浓度包括血浆总胆固醇及甘油三酯水平过高,高于同龄正常值者均称高脂血症。
中医学无“高脂血症”这一名称,但对其早有认识,其内容散见于“痰浊”、“肥人”、“中风”、“眩晕”等病的记载中,属中医的“污血病”范畴。污血者不洁之血,乃是因水谷中之浊气、水谷不化之痰湿,瘀滞不通之血液凝结于脉中而成。《儒门事亲》所曰:“夫膏梁之人……酒食所伤,胀闷痞满,酢心。”
病因病机:情志不畅,气郁日久,瘀血内停,脉络不通,膏酯转输、利用、排泄障碍,气滞血瘀,而生本病。
临床表现:情志抑郁,易怒,胸闷而喜太息,胸胁或乳房胀满,走窜疼痛,小腹疼痛,性情急躁,或月经不调,痛经,或咽中如梗,吞之不下,吐之不出,舌质紫暗,或有瘀斑,脉涩。
它的技术方案为:取八月札5重量份、郁金6重量份、柚6重量份、枳壳6重量份、枳实6重量份、八角茴香6重量份、九里香6重量份、九香虫6重量份、刀豆6重量份、云实6重量份、杉木6重量份、佛手6重量份、玫瑰花5重量份、青皮6重量份、茅膏菜5重量份、枸橘5重量份、柿蒂6重量份、荔枝6重量份、荔枝核6重量份、厚朴6重量份、香附6重量份、香橼2重量份、娑罗子6重量份、丹参2重量份、水红花子6重量份、茺蔚子3重量份、鬼箭羽2重量份、凌霄花6重量份、川芎6重量份、川牛膝6重量份、王不留行6重量份、月季花6重量份、凤仙花5重量份、红花6重量份、杜鹃花5重量份、芸薹子1重量份、苏木6重量份、皂角刺5重量份、没药6重量份、鸡血藤5重量份、乳香6重量份、泽兰6重量份、卷柏6重量份、降真香5重量份、桃仁6重量份和甘草9重量份,将以上46味中药放入1800毫升水中,浸泡30分钟,然后文火煎制30分钟,过滤去渣共煎药液390毫升,煎出的药液即为治疗气滞血瘀型高脂血症的中药。
该发明的优点是:本方46味中药,在药店均能买到,制作简单,制成的中药液毒副作用小,疗程短,治愈率高。君臣佐使,恰到好处。应用中药的同时,避免了西药抗菌素引起的不良反应、过敏反应和毒性反应。八月札、郁金、柚、枳壳、枳实、八角茴香、九里香、九香虫、刀豆、云实、杉木、佛手、玫瑰花、青皮、茅膏菜、枸橘、柿蒂、荔枝、荔枝核、厚朴、香附、香橼、娑罗子,以上23味药具有利水消肿,清热解毒,利湿退黄,利尿通淋,清热除烦,利水渗湿,消肿止痛之功效。在治疗气滞血瘀型高脂血症的过程中,起主要治疗作用,故为君药。丹参、水红花子、茺蔚子、鬼箭羽、凌霄花、川芎、川牛膝、王不留行、月季花、凤仙花、红花、杜鹃花、芸薹子、苏木、皂角刺、没药、鸡血藤、乳香、泽兰、卷柏、降真香,以上21味药具有补中益气,益肾补髓,和胃止痛,固表止汗,化湿解暑,健脾和中,生津止渴,消积化癥,养血柔肝,敛阴止汗,缓中止痛之功效。在治疗气滞血瘀型高脂血症的过程中,能辅助主药发挥治疗作用,故为臣药。桃仁:苦、甘,平。入肺、心、肝、大肠四经。活血祛瘀,润燥滑肠,行血祛风。能率诸药直达病灶,故为佐药。甘草:甘,平。入十二经。补脾润肺,益气复脉,缓急止痛,清热解毒,调和药性。既能纠诸药之偏性,又能缓解诸药之毒性,故为使药。八月札、郁金、柚、枳壳、枳实、八角茴香、九里香、九香虫、刀豆、云实、杉木、佛手、玫瑰花、青皮、茅膏菜、枸橘、柿蒂、荔枝、荔枝核、厚朴、香附、香橼、娑罗子、丹参、水红花子、茺蔚子、鬼箭羽、凌霄花、川芎、川牛膝、王不留行、月季花、凤仙花、红花、杜鹃花、芸薹子、苏木、皂角刺、没药、鸡血藤、乳香、泽兰、卷柏、降真香、桃仁、甘草,这46味药配伍应用,共同起到利水消肿,清热解毒,利湿退黄,利尿通淋,清热除烦,清热利尿,利水渗湿,强精益髓,和脾益胃,凉肝明目,分清化浊,养血安神,缓和药性,排脓消肿,健脾和中,缓中止痛之功效。君臣佐使,配伍得当,是治疗气滞血瘀型高脂血症的最佳配方。八月札:甘,寒。入肝、胃二经。舒肝和胃,活血止痛,利尿通淋,解烦止渴。郁金:辛、苦,寒。入心、肺、肝三经。行气解郁,活血破瘀,凉血清心,凉血止血,利胆退黄。柚:辛、甘、酸,寒。入肝、脾、胃三经。理气宽中,化痰止咳,解酒毒。枳壳:苦、辛,凉。入肺、脾、大肠三经。破气消积,下气祛痰,行气止疼,利气消肿,皮肤风痒,肠风下血,脱肛阴挺。枳实:苦、辛、微酸,微寒。入脾、胃、肝、心四经。破气消积,化痰消痞,理气达郁,逐水消肿,风疹苦痒,脱肛阴挺。八角茴香:辛、甘,温。入肝、肾、脾、胃四经。温中散寒,行气止痛,温补肾阳,辟恶除秽。九里香:辛、苦,温。入心、肝、肺三经。行气止痛,活血散瘀,祛风除湿,软坚散结。九香虫:咸,甘,温,无毒。入肝、脾、肾三经。行气止痛,温肾壮阳,温中止泻。刀豆:甘,平,无毒。入脾、胃、大肠、肾四经。温中下气,益肾补元,祛痰平喘,行气止痛。云实:辛,温。入肺、大肠二经。行气止痛,截疟,止消渴。杉木:辛,微温。入脾、胃二经。下气降逆,消胀止痛,祛湿消肿。佛手:辛、苦、酸,温。入肝、胃二经。止咳化痰,理气开胃。玫瑰花:甘、微苦、气香、温。入肝、胃二经。行气解郁,和血散瘀。青皮:苦、辛、微酸,温。入肝、胆、胃、脾四经。疏肝破气,消积散结,化痰消瘿。茅膏菜:甘、辛,平。入肺、脾、胃三经。行气活血,消食化积,调气止痢。枸橘:辛、苦,温。入肝、胃二经。疏肝理气,行气止疼,祛风止痒,解酒毒。柿蒂:苦、涩,平。入肺、胃二经。降逆止呃,止咳下气,淋下尿血。荔枝:辛、酸、甘,温。入脾、肝二经。理气止痛,消肿散结,益气止血,生津止渴。荔枝核:辛、甘,温。入肝、肾二经。理气止痛,温中散寒。厚朴:苦、辛,温。入脾、肺、胃、大肠四经。燥湿散满,消食散痞,降气平喘,霍乱及腹痛。香附:辛、微苦、微甘,平。入肝、三焦二经。舒肝解郁,调经止痛,温化寒湿。香橼:辛、苦酸,温。入肝、肺、脾三经。疏肝理气,和中化痰,利膈止呕。娑罗子:甘、辛,温。入脾、胃、肺三经。疏肝理气,宽中和胃,杀虫。丹参:苦,微寒。入心、肝、肾、脾四经。活血调血,祛瘀止痛,凉血消肿,养血安神,补血益气。水红花子:咸,寒。入肝、胃、脾三经。散血破癥,利水消肿,消积止痛。茺蔚子:辛、苦,微寒。入心包、肝二经。活血祛瘀,凉肝明目,利水消肿,清热解毒消肿。鬼箭羽:苦,寒。入肝经。活血通经,化瘀止崩,产后腹疼,胸痹心疼,血瘀癃闭,皮肤风肿,虫积腹疼。凌霄花:辛、酸,寒。入肝经。行血祛瘀,凉血祛风,行血通经消肿。川芎:辛、苦,温。入肝、胆、膀胱、三焦经。行气开郁,祛风燥湿,活血止痛,消肿排脓。川牛膝:甘、微苦,平,无毒。入肝、肾二经。祛风利湿,利湿通淋,活血通络。王不留行:苦,平。入肝、胃二经。活血通经,通络下乳,消肿敛疮,利水通淋。月季花:甘,温。入肝经。活血调经,消肿解毒。凤仙花:甘、微苦,温。入肝经。活血通经,祛风止痛。红花:辛,温。入心、肝二经。活血祛瘀,通经止痛,调血和血。杜鹃花:辛、甘、酸,温。入肝、脾、肾三经。活血止血,祛风除湿。芸薹子:辛,温,无毒。入肝、肾二经。破气行血,消肿散结。苏木:甘、咸,平。入肝、胃、大肠三经。行血破瘀,消肿止痛。皂角刺:辛,温。入肝、肺二经。消肿排脓,搜风拔毒,行气理气。没药:苦、辛,平。入心、肝、脾、肾四经。散血祛瘀,活血止血,生肌治痿,坠胎,疗目祛翳。鸡血藤:苦、甘,温。入心、脾二经。活血化瘀,舒筋通络,补中暖胃。乳香:辛、苦,温。入心、肝、脾三经。活血止痛,解毒消肿,生肌止痒。泽兰:苦、辛,微温。入肝、脾二经。活血祛瘀,行水消肿,消散瘀滞,散痈消肿。卷柏:辛,平。入脾、肝二经。破血散瘀,活血止血,止咳化痰,通经活络。降真香:辛,温。入肝、脾二经。散瘀止血,散瘀止痛,散瘀消痈,活血祛风,辟秽化浊。桃仁:苦、甘,平。入肺、心、肝、大肠四经。活血祛瘀,润燥滑肠,行血祛风。甘草:甘,平。入十二经。补脾润肺,益气复脉,缓急止痛,清热解毒,调和药性。
具体实施方式:取八月札5g、郁金6g、柚6g、枳壳6g、枳实6g、八角茴香6g、九里香6g、九香虫6g、刀豆6g、云实6g、杉木6g、佛手6g、玫瑰花5g、青皮6g、茅膏菜5g、枸橘5g、柿蒂6g、荔枝6g、荔枝核6g、厚朴6g、香附6g、香橼2g、娑罗子6g、丹参2g、水红花子6g、茺蔚子3g、鬼箭羽2g、凌霄花6g、川芎6g、川牛膝6g、王不留行6g、月季花6g、凤仙花5g、红花6g、杜鹃花5g、芸薹子1g、苏木6g、皂角刺5g、没药6g、鸡血藤5g、乳香6g、泽兰6g、卷柏6g、降真香5g、桃仁6g和甘草9g,将以上46味药一起放入1800毫升水中,浸泡30分钟,然后文火煎制30分钟,过滤去渣,煎出的药液即为治疗气滞血瘀型高脂血症的中药。共煎药液390毫升,当气滞血瘀型高脂血症的病人需要治疗时,使药液温度为35℃,每次130毫升,口服,每日三次, 二日为一疗程,若症状仍存,再服第二疗程,以至痊愈。
气滞血瘀型高脂血症患者共369例,男性226例,占61.3%,女性143例,占38.7%。
表一、369例气滞血瘀型高脂血症患者的年龄范围
年龄(岁) | 30~35 | 36~40 | 41~45 | 46~50 |
例数 | 193 | 49 | 121 | 6 |
百分比 | 52.3% | 13.3% | 32.8% | 1.6% |
表二、369例气滞血瘀型高脂血症患者疗效表
疗效 | 治愈 | 好转 | 无效 |
例数 | 366 | 3 | 无 |
百分比 | 99.2% | 0.8% | 无 |
表三、369例气滞血瘀型高脂血症患者疗程表
治疗天数 | 3~5 | 6~9 | 10~14 | 15~20 |
例数 | 213 | 29 | 122 | 5 |
百分比 | 57.7% | 7.9% | 33.1% | 1.3% |
表四、369例气滞血瘀型高脂血症患者治疗前后情况表
Claims (1)
1.一种治疗气滞血瘀型高脂血症的中药制备方法,其特征是:取八月札5克、郁金6克、柚6克、枳壳6克、枳实6克、八角茴香6克、九里香6克、九香虫6克、刀豆6克、云实6克、杉木6克、佛手6克、玫瑰花5克、青皮6克、茅膏菜5克、枸橘5克、柿蒂6克、荔枝6克、荔枝核6克、厚朴6克、香附6克、香橼2克、娑罗子6克、丹参2克、水红花子6克、茺蔚子3克、鬼箭羽2克、凌霄花6克、川芎6克、川牛膝6克、王不留行6克、月季花6克、凤仙花5克、红花6克、杜鹃花5克、芸薹子1克、苏木6克、皂角刺5克、没药6克、鸡血藤5克、乳香6克、泽兰6克、卷柏6克、降真香5克、桃仁6克和甘草9克,将以上46味中药放入1800毫升水中,浸泡30分钟,然后文火煎制30分钟,过滤去渣共煎药液390毫升,煎出的药液即为治疗气滞血瘀型高脂血症的中药。
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CN107998339A (zh) * | 2018-01-05 | 2018-05-08 | 顾文革 | 一种治疗冠心病的药物组合物及其制备方法 |
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