A kind of Chinese medicine composition for the treatment of cholinergic urticaria disease
Technical field
The present invention relates to a kind of smelting and treat the medicine of urticaria, the Chinese medicine composition of cholinergic urticaria disease is treated in especially a kind of smelting.
Background technology
Cholinergic urticaria is to be heated when human body, psychentonia, take in hot food or beverage, or body temperature slightly increases after motion, the blood flow of the gain of heat stimulates brain thermotaxic centre, and excited cholinergy is neural, and discharge acetylcholine, if irritated to this chemical substance of acetylcholine, can there is anaphylaxis, the symptom that people cause this allergy is referred to as the active urticaria of choline.This anaphylactoid reaction, except without erythra, only has outside the acute gargalesthesia of twinge, also can occur 2 red millimeter welts at trunk and limbs near-end skin, and this welt speed is carried out fast going, and leaves no trace.Whole process be several months to the several years not etc.Doctor trained in Western medicine there is no specific short to cholinergic urticaria at present, and for many Bian, antihistamine drug for oral administration, corticosteroids medicine suppress the symptom of cholinergic urticaria disease, separately by Xian's agent, Emulsion, mud cream, ointment etc., embrocate affected part, in order to alleviate disease.Above-mentioned treatment can only be to take stopgap measures, and does not effect a permanent cure, and patient often presents outbreak repeatedly.In recent years, someone studies and uses traditional Chinese medicine composition for treating cholinergic urticaria, as Chinese patent CN103393802 discloses the oral medicine of following traditional Chinese medicines component and weight portion; Herba Ephedrae 6-9, Radix Salviae Miltiorrhizae 6-9, Radix Sophorae Flavescentis 6-9, Fructus Cnidii 6-9, Radix Saposhnikoviae 6-9, Cortex Dictamni 3-5, Fructus Kochiae 3-5, Herba Lysimachiae 3-5, Herba Lysimachiae 3-5, Periostracum Cicadae 3-5, fry flying worm 3-5, Radix Gentianae Macrophyllae 3-5, Spina Gleditsiae 3-5, Flos Lonicerae 2-4, Fructus Forsythiae 2-4, Herba Portulacae 2-4, Fructus Atriplicis Sibiricae 2-4, leaf of Semen Juglandis 2-4, Radix Glycyrrhizae 2-4.Except above-mentioned oral medicine, still need and embrocate affected part with the Chinese medicine lotion for external use that following component and weight fraction form; Linum 6-9, Radix Rehmanniae 6-9, Fructus Gardeniae (parched to brown) 6-9 , Herba Siegesbeckiae 6-9, Radix Arnebiae (Radix Lithospermi) 2-4, Herba Menthae 2-4, Flos Chrysanthemi Indici 2-4, Herba Lycopi 2-4, comb Folium Cannabis 2-4, Folium Isatidis 2-4, Oleum sesami 5-10.The above-mentioned Chinese medicine composition complexity of not only filling a prescription, for oral administration and external of still needing starts at the same time, and therapeutic effect still can not be satisfactory.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind for the treatment of both the principal and secondary aspects of a disease is provided, the Chinese medicine composition of the treatment cholinergic urticaria disease that curative effect is high.Object of the present invention realizes by following technical proposals: a kind of Chinese medicine composition for the treatment of cholinergic urticaria disease, formulated by following component and weight portion: Herba Schizonepetae 5-12, Radix Saposhnikoviae 5-12, Periostracum Cicadae 3-10, Cortex Phellodendri 5-12, Fructus Forsythiae 5-15, Gypsum Fibrosum 10-40, Radix Sophorae Flavescentis 5-15, Cortex Dictamni 5-15, Rhizoma Cimicifugae 3-10, Radix Scutellariae 5-12, Radix Rehmanniae 5-20, Cortex Moutan 5-15, Radix Glycyrrhizae 3-8, above-mentioned each component by Chinese medicine preparation conventional method make decoction, electuary, pill or oral capsule any.
The present invention utilizes traditional Chinese medicine theoretical direction of science, through concentrating on studies for many years, obtains with clinical practice.The present invention mainly concentrates and optimizes heat-clearing and toxic substances removing in component, dispelling wind for relieving itching function, in order to the bad clinical symptoms of symptomatic treatment cholinergic urticaria, and by the coordinative role in each component medicine, accelerate measles and thoroughly send out, declare loose rash, endogenous wind stopping relieving convulsion, heat clearing and damp drying, YIN nourishing and the production of body fluid promoting, balance human internal environment, especially reduces nuisance in blood, thereby make the toxin in blood discharge body surface with antiperspirant, fundamentally treat this disease.The compatibility of each component of the present invention is rigorous proper, reasonable recipe, the effect of each component medicine is: if Herba Schizonepetae, windproof garment expelling pathogenic wind from the body surface function sends out not smooth for measles thoroughly, energy dispelling wind for relieving itching, the loose rash of a surname, Periostracum Cicadae is mainly dispelling wind heat, rash, endogenous wind stopping relieving convulsion function, above three medicines can be given full play to adjustment organismic internal environment function, coordinate the five internal organs, in the present invention as monarch drug.Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, Fructus Forsythiae heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, the clear part of the body cavity above the diaphragm housing the heart and lungs heat of two medicines, Cortex Phellodendri is mainly heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever, Rhizoma Cimicifugae is delivered rash, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang, above-mentioned four medicines all have the merit of removing toxic substances, as ministerial drug.Cortex Dictamni heat-clearing and toxic substances removing, removing damp to relieve itching, eliminating fire and detoxication, Gypsum Fibrosum clearing away heat-fire, relieving restlessness only exhausts, Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide, diuresis, upper three components are as adjuvant drug, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis (is controlled wind and is first controlled blood, blood wind is from going out) for making medicine, Radix Glycyrrhizae invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, relax the property of medicine, guide above-mentioned all medicines to enter blood and the five internal organs, thereby ensure medical effect of the present invention.
The present invention is through clinical application for many years, and effect is very good, and cure rate reaches 89%, and effective percentage reaches 99%, refers to table 1.
Note: above-mentioned treatment is to be used as curative with embodiments of the invention 1 electuary.
The present invention treats case and all according to cholinergic urticaria diagnosis index, determines.
Described recovery from illness refers to that cholinergic urticaria symptom all disappears, nothing recurrence in month.
The described cholinergic urticaria symptom that effectively refers to obviously alleviates or disappears, but has recurrence in one month.
Described invalid finger cholinergic urticaria symptom is without obviously alleviating, or in one month, has twice recurrence.
Using method of the present invention: electuary every day three times, each 1 bag, decoction every day three times, each 30 milliliters, pill every day three times, each 20 grams.
The specific embodiment
Embodiment 1, and a kind of Chinese medicine composition electuary for the treatment of cholinergic urticaria disease is got the raw materials ready by following component and weight portion:
Herba Schizonepetae 5Kg, Radix Saposhnikoviae 12 Kg, Periostracum Cicadae 8 Kg, Cortex Phellodendri 5 Kg, Fructus Forsythiae 15 Kg, Gypsum Fibrosum 10 Kg, Radix Sophorae Flavescentis 10 Kg, Cortex Dictamni 15 Kg, Rhizoma Cimicifugae 3 Kg, Radix Scutellariae 10 Kg, the Radix Rehmanniae 20 Kg, Cortex Moutan 5 Kg, Radix Glycyrrhizae 8 Kg, production method, follows these steps to carry out:
1, accurately take each component standby;
2, by the 1-2 of each component total amount of Chinese medicine, doubly measure and add clean clean water, be placed in after decoction pot mixes with Chinese medicinal components and decoct into decoction;
3, concentrated; After filtering residue, decoction is concentrated into the thick paste of 1/4 weight of former dose;
4, sugaring powder was pulverized in time 40-60 mesh sieve by clean white sugar after 60 ℃ of left and right are dry, made dry Icing Sugar;
5, granule processed, gets thick paste 2 weight portions and adds Icing Sugar 2 weight portions to be placed in container, and stir into moisture state and cross 10-12 order granulation sieve, granulation, certain Icing Sugar is available dextrin or starch in replace also;
6, dry, the above-mentioned granule of making is packed after 40-70 ℃ of oven dry, every bag is 16 grams.
Embodiment 2, and a kind of Chinese medicine composition decoction for the treatment of cholinergic urticaria disease is got the raw materials ready by following component and weight portion:
Herba Schizonepetae 12Kg, Radix Saposhnikoviae 5 Kg, Periostracum Cicadae 3 Kg, Cortex Phellodendri 10 Kg, Fructus Forsythiae 5 Kg, Gypsum Fibrosum 40 Kg, Radix Sophorae Flavescentis 15 Kg, Cortex Dictamni 5 Kg, Rhizoma Cimicifugae 10 Kg, Radix Scutellariae 12 Kg, the Radix Rehmanniae 5 Kg, Cortex Moutan 15 Kg, Radix Glycyrrhizae 3 Kg, production method, follows these steps to carry out:
1, accurately take each component standby;
2, by the 1-2 of each component total amount of Chinese medicine, doubly measure and add clean clean water, be placed in after decoction pot mixes with Chinese medicinal components and decoct into decoction;
3, concentrated; After filtering residue, decoction is concentrated into the thick soup of 1/3 weight of former dose, subpackage, is advisable with every bottle or a bag 30ml.
Embodiment 3, and a kind of Chinese medicine composition pill for the treatment of cholinergic urticaria disease is got the raw materials ready by following component and weight portion:
Herba Schizonepetae 8Kg, Radix Saposhnikoviae 8 Kg, Periostracum Cicadae 10 Kg, Cortex Phellodendri 12Kg, Fructus Forsythiae 10 Kg, Gypsum Fibrosum 15 Kg, Radix Sophorae Flavescentis 5 Kg, Cortex Dictamni 10Kg, Rhizoma Cimicifugae 8 Kg, Radix Scutellariae 5Kg, the Radix Rehmanniae 15 Kg, Cortex Moutan 10 Kg, Radix Glycyrrhizae 5 Kg, production method, medicine pill producer legal system or pill routinely.