CN103751364A - Traditional Chinese medicine composition for treatment of mare persistant corpus luteum - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treatment of mare persistant corpus luteum, and the traditional Chinese medicine composition comprises the following raw materials: toosendan fruit, bupleurum, semen litchi, fennel, frankincense, notopterygium and radix angelicae pubescentis. The traditional Chinese medicine composition uses the therapeutic principle of warming spleen and stomach for dispelling cold and benefiting qi for lifting yang, and is reasonable in prescription, simple in preparation process and wide in scope of application. The traditional Chinese medicine composition is prepared from pure Chinese herbal medicines, and is wide in source, low in cost, high in cure rate, free of medicine residue, and free of toxic and side effects. In particularly, after super fine crushing, maximum destruction of plant cell walls can be realized by the traditional Chinese medicine composition, and the traditional Chinese medicine composition solves the deficiency that traditional medicine powder is high in crude fiber content, and effective components are not easy to dissolving out, and is easy for absorption of horses. The traditional Chinese medicine composition has the substantial effects of relieving, easing pains, and regulating body functions, can effectively treat the mare persistant corpus luteum, can shorten the recovery period, compared with western medicine treatment, and is free of recurrence.

Description

A kind of Chinese medicine composition for the treatment of mare retained corpus luteum

Technical field

The present invention relates to technology of pharmaceutical engineering field, relate in particular to a kind of Chinese medicine composition for the treatment of mare retained corpus luteum.

Background technology

Retained corpus luteum refers to the corpus luteum or point puerperium that after sexual cycle ovulation, form, in sexual cycle corpus luteum or corpus luteum of pregnancy sustainable existence ovary, makes the ovary can not normal development and the pathological state of non-estrus.The treatment of retained corpus luteum adopts western medicine more, particularly hormone therapy.The hormone therapy such as multiplex prostaglandin clinically.But hormone therapy has also brought certain drawback, easily make to suffer from endocrine regulation disorder in horse body.

Summary of the invention

Technical problem to be solved by this invention is, overcomes the Chinese medicine composition that prior art provides a kind of effective reduction toxic and side effects, elimination operation risk, effectively treats the treatment mare retained corpus luteum of the stress that rear convalescent period of mare retained corpus luteum and treatment is short, minimizing mare brings because of pain.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of mare retained corpus luteum, described Chinese medicine composition comprises following raw medicinal material: Fructus Toosendan, Radix Bupleuri, Semen Litchi, Fructus Foeniculi, Olibanum, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Fructus Toosendans, 15～25 parts of Radix Bupleuri, 15～25 parts of Semen Litchis, 15～25 parts, Fructus Foeniculi, 7～15 parts of Olibanums, 7～15 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Fructus Toosendans, 19～21 parts of Radix Bupleuri, 19～21 parts of Semen Litchis, 19～21 parts, Fructus Foeniculi, 9～11 parts of Olibanums, 9～11 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Fructus Toosendans, 20 parts of Radix Bupleuri, 20 parts of Semen Litchis, 20 parts, Fructus Foeniculi, 10 parts of Olibanums, 10 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

Described Chinese medicine composition can further include Fructus Evodiae, and the ratio of weight and number of described Fructus Evodiae is 15～20 parts.Be preferably 18 parts.

Described Chinese medicine composition can further include the Radix Astragali, Rhizoma Cimicifugae, Radix Ginseng and the Rhizoma Atractylodis Macrocephalae, and ratio of weight and number is respectively Radix Astragali 15-20 part, 15～20 parts of Rhizoma Cimicifugaes, Radix Ginseng 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of the Radixs Astragali, 16 parts of Rhizoma Cimicifugaes, 10 parts of Radix Ginsengs and the Rhizoma Atractylodis Macrocephalaes.

The present invention also provides the preparation method of the Chinese medicine composition of above-mentioned any one treatment mare retained corpus luteum, and the preparation method of described Chinese medicine composition is,

Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;

Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.

Wherein, the granularity in described step 1 is preferably 150-200 order.

The present invention provides again the preparation method of the Chinese medicine composition of above-mentioned any one treatment mare retained corpus luteum, and the preparation method of described Chinese medicine composition comprises the following steps,

The first step, is mixed in proportion described component, is ground into powder;

Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;

The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;

The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;

The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.

Wherein, the granularity in described the 5th step is preferably 150-200 order.

Wherein, the unit of above-mentioned various raw medicinal materials " part " is preferably " g ", and the unit " part " of yellow wine is preferably " ml ".

Beneficial effect of the present invention: the present invention is take warming spleen and stomach for dispelling cold, benefiting qi and raising yang as the rule for the treatment of, reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, wide material sources, cost are low, cure rate is high, medicine noresidue, have no side effect, particularly after micronizing, destroy to greatest extent plant cell wall, solved the deficiency that traditional drugs powder crude fiber content is high, effective ingredient is difficult to stripping, be easier to horses and absorb.There is the effect of the analgesia of releiving significantly and adjusting body function, effectively treat mare retained corpus luteum, shorten the period of convalescence with western medicine phase specific energy, and do not recur.

The specific embodiment

The invention provides a kind of Chinese medicine composition for the treatment of mare retained corpus luteum, described Chinese medicine composition comprises following raw medicinal material: Fructus Toosendan, Radix Bupleuri, Semen Litchi, Fructus Foeniculi, Olibanum, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Fructus Toosendans, 15～25 parts of Radix Bupleuri, 15～25 parts of Semen Litchis, 15～25 parts, Fructus Foeniculi, 7～15 parts of Olibanums, 7～15 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Fructus Toosendans, 19～21 parts of Radix Bupleuri, 19～21 parts of Semen Litchis, 19～21 parts, Fructus Foeniculi, 9～11 parts of Olibanums, 9～11 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Fructus Toosendans, 20 parts of Radix Bupleuri, 20 parts of Semen Litchis, 20 parts, Fructus Foeniculi, 10 parts of Olibanums, 10 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

Described Chinese medicine composition can further include Fructus Evodiae, and the ratio of weight and number of described Fructus Evodiae is 15～20 parts.Be preferably 18 parts.

Described Chinese medicine composition can further include the Radix Astragali, Rhizoma Cimicifugae, Radix Ginseng and the Rhizoma Atractylodis Macrocephalae, and ratio of weight and number is respectively Radix Astragali 15-20 part, 15～20 parts of Rhizoma Cimicifugaes, Radix Ginseng 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of the Radixs Astragali, 16 parts of Rhizoma Cimicifugaes, 10 parts of Radix Ginsengs and the Rhizoma Atractylodis Macrocephalaes.

The present invention also provides the preparation method of the Chinese medicine composition of above-mentioned any one treatment mare retained corpus luteum, and the preparation method of described Chinese medicine composition is,

Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;

Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.

Granularity in described step 1 is preferably 150-200 order.

The present invention provides again the preparation method of the Chinese medicine composition of above-mentioned any one treatment mare retained corpus luteum, and the preparation method of described Chinese medicine composition comprises the following steps,

The first step, is mixed in proportion described component, is ground into powder;

Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;

The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;

The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;

The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.

Granularity in described the 5th step is preferably 150-200 order.

The pharmacology of described each component is as follows:

Fructus Toosendan: claim again chinaberry reality, Fructus Toosendan, core Fructus Jujubae, Fructus Toosendan, chinaberry, the stone Fructus Evodiae, Fructus Toosendan tree, Fructus Toosendan reality etc.Cold in nature, bitter in the mouth; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Energy soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Radix Bupleuri: another name: Asia puecon recklessly, smoke < < Sheng Nong's herbal classic > >, mountain dish, eat careless < < WU Pu Bencao > >, faggot < < product converge essence and want > >.Cold nature, bitter in the mouth, pungent; GUIXIN bag, liver, gallbladder, tri-jiao channel.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For fever caused by exogenous pathogens, the diseases such as the internal organs prolapsus of collapse of QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.

Semen Litchi: this product is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensisSonn..Pluck mature fruit summer, remove peel and meat aril, clean, dry.Have another name called that litchi props up, red litchi, beautiful branch.Warm in nature, sweet in the mouth, micro-hardship.Enter liver, kidney channel.Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.For colic of cold type stomachache, painful and swollen testis.

Fructus Foeniculi: claim again Fructus Foeniculi, bosom perfume, fragrant silk dish.Acrid in the mouth, warm in nature.Enter kidney, bladder, stomach warp.Energy warming the liver kidney, stimulating appetite, the cold expelling of regulating the flow of vital energy, has supporing yang road.Cure mainly: cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain etc.

Olibanum: smoked Lu Xiang, horse hair perfume (or spice), nipple perfume (or spice), the perfume (or spice) that collapses, it pool is fragrant, Moller is fragrant, many gals Luo Xiang etc.Acrid in the mouth, hardship, warm in nature.Enter the heart, liver, spleen channel.Invigorate blood circulation, circulation of qi promoting, pain relieving, detumescence and promoting granulation.For traumatic injury, skin infection carbuncle, congestion blocks all diseases etc.< < does not record > >: treat edema due to wind pathogen poison swollen, remove bad odor.Treat the urticaria poison of itching.< < Bencao Shiyi > >: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooledly, stop large intestine and let out Bleach, treat all skin ulcers and make internal diabetes.

Rhizoma Et Radix Notopterygii: claim again Qiang green grass or young crops, protect the envoy of Qiang, recklessly king envoy, Qiang sliding, move back wind envoy, black powder.Acrid in the mouth, hardship; Warm in nature.Enter bladder, kidney channel.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.

Radix Angelicae Pubescentis: have another name called recklessly king envoy, solely shake grass, solely cunning, Sempervivum tectorum, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, meat Radix Angelicae Pubescentis, qualifications and record of service Qiu's Radix Angelicae Pubescentis, the east of Sichuan Radix Angelicae Pubescentis, fragrant Radix Angelicae Pubescentis, achievement Radix Angelicae Pubescentis, Radix Angelicae Dahuricae (Radix Heraclei Scabridi), mountain Radix Angelicae Dahuricae (Radix Heraclei Scabridi), beautiful work.Acrid in the mouth, hardship, slightly warm in nature.Return liver, kidney, urinary bladder channel.Expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.

Yellow wine: be field of medicaments, particularly very important adjuvant or " extra conductant ingredient " in the field of Chinese medicines.Help blood circulation, enhance metabolism, there is blood-enriching face-nourishing, the effect of the cold relieving of invigorating blood circulation, dredge the meridian passage, effectively the cold resisting stimulation, preventing cold.

Fructus Evodiae: another name Koji, volt spicy, smelly lake, Fructus Evodiae, tea are peppery, paint spicy, smelly spicy tree, the deep and remote son of Zuo Lichun, rice spicy etc.Acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.

The Radix Astragali: latin name Astragali Radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effect of holder skin ulcer granulation promoting, cures mainly the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action, the Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.

Rhizoma Cimicifugae: have another name called big cattle card holder, Radix Longan, hole root of the tooth.Acrid in the mouth, micro-sweet, cold nature.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome is sent out speckle; Proctoptosis, uterine prolapse.

Radix Ginseng: SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO, Sphallerocarpus gracilis, Herba Wedeliae Wallichii, Herba Stellariae Saxatilis, hundred chi pestles, extra large fat, the beautiful door screen of golden well, Radix Ginseng etc.Sweet in the mouth, micro-hardship, slightly warm in nature.Return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourishes blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, palpitation with fear insomnia, sexual impotence official is cold.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement; The effects such as the Rhizoma Atractylodis Macrocephalae has the gastrointestinal motility function of adjustment, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1:

Fructus Toosendan 25g, Radix Bupleuri 20g, Semen Litchi 20g, Fructus Foeniculi 20g, Olibanum 10g, Rhizoma Et Radix Notopterygii 10g and Radix Angelicae Pubescentis 25g.Mix, be ground into powder, granularity is 200 orders; In powder, add 100ml yellow wine, mix homogeneously.During use, gavage.

Embodiment 2:

Fructus Toosendan 24g, Radix Bupleuri 19g, Semen Litchi 19g, Fructus Foeniculi 20g, Olibanum 9g, Rhizoma Et Radix Notopterygii 9g, Radix Angelicae Pubescentis 24g and Fructus Evodiae 18g.Mix, be ground into powder, granularity is 180 orders; In powder, add 90ml yellow wine, mix homogeneously.During use, gavage.

Embodiment 3:

Fructus Toosendan 26g, Radix Bupleuri 21g, Semen Litchi 21g, Fructus Foeniculi 19g, Olibanum 10g, Rhizoma Et Radix Notopterygii 11g, Radix Angelicae Pubescentis 26g, Radix Astragali 16g, Rhizoma Cimicifugae 16g, Radix Ginseng 10g and Rhizoma Atractylodis Macrocephalae 12g.Preparation method comprises the following steps:

The first step, is mixed in proportion various raw medicinal materials, is ground into powder;

Second step, obtains powder by the first step and adds in cold water and soak 10 hours, and with slow fire boiling, decocting time is 4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;

The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 3 hours, filters and obtains the second filtrate, and the quality of the water adding is 3 times of powder quality that second step obtains;

The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 150 orders;

The 5th step, to the yellow wine that adds 100ml in the powder of the 4th step, mix homogeneously.During use, gavage.

Embodiment 4:

Fructus Toosendan 26g, Radix Bupleuri 19g, Semen Litchi 20g, Fructus Foeniculi 21g, Olibanum 11g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Pubescentis 25g, Fructus Evodiae 20g, Radix Astragali 18g, Rhizoma Cimicifugae 20g, Radix Ginseng 12g and Rhizoma Atractylodis Macrocephalae 10g.Preparation method comprises the following steps:

The first step, is mixed in proportion various raw medicinal materials, is ground into powder;

Second step, obtains powder by the first step and adds in cold water and soak 8 hours, and with slow fire boiling, decocting time is 5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3 times of the powder quality that obtains of the first step;

The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 4 hours, filters and obtains the second filtrate, and the quality of the water adding is 4 times of powder quality that second step obtains;

The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 orders;

The 5th step, to the yellow wine that adds 110ml in the powder of the 4th step, mix homogeneously.During use, gavage.

Acute toxicity test:

120 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity testing.Mice is divided into three groups at random, be that (concentration is 6.28g crude drug/ml for the Chinese medicine composition of matched group, the administration embodiment of the present invention 1, maximum concentration) administration group 1 and the administration embodiment of the present invention 4 (concentration is 6.28g crude drug/ml, maximum concentration) the administration group 2 of Chinese medicine composition, fasting 12 hours before experiment.The Chinese medicinal powder that administration group 1 and administration group 2 are prepared embodiments of the invention 1 and embodiment 4 is respectively dissolved in water mouse stomach, gavage volume is 5ml/kg (being that single-dose dosage is 31.4g crude drug/kg), matched group gives equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Clinical trial:

Chinese medicine composition avirulence of the present invention, easy to use, can directly gavage or add in feedstuff and use.During application, Chinese medicine composition of the present invention directly can be gavaged by per kilogram of body weight 0.4g crude drug, or mix and in feedstuff, feed mare, and statistical data demonstration, generally can fully recover for the continuous 4-20 of taking days, and treatment time is short, clinical cure rate reaches 95%, and cure rate is high.

Model case 1

Hebei province's veterinary station Mongolian horse

This veterinary station is accepted one of the mare that suffers from retained corpus luteum for medical treatment, suffers from horse B ultrasonic and detects corpus luteum and do not move back lastingly.The Chinese medicine composition of the application embodiment of the present invention 1, by the dosage in prescription, adds yellow wine 100ml after being ground into powder, gavages (dosage is 0.4g crude drug/kg), twice on the one; Wherein 4, to observe after serveing on respectively 4-6 days, mare is all fully recovered; Wherein 5, take continuously respectively after 7-10 days and observe, mare is all fully recovered; Wherein 2, take continuously respectively and observe afterwards for 12 days and 15 days, mare is all fully recovered; Every example all has no recurrence for 2 months with examining.

Model case 2

Hebei province county peasant household Mongolian horse

Suffer from horse B ultrasonic detection corpus luteum and do not move back lastingly, 2 months persistent period.Use the dosage in the Chinese medicine composition prescription of the embodiment of the present invention 4, add yellow wine 110ml after being prepared into powder, gavage (dosage is 0.4g crude drug/kg).One day twice, serve on after five days, be completely recovered, with examining not recurrence in 2 months.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. a Chinese medicine composition for the treatment of mare retained corpus luteum, is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Fructus Toosendan, Radix Bupleuri, Semen Litchi, Fructus Foeniculi, Olibanum, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis.

2. the Chinese medicine composition for the treatment of mare retained corpus luteum as claimed in claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 20～30 parts of 20～30 parts of Fructus Toosendans, 15～25 parts of Radix Bupleuri, 15～25 parts of Semen Litchis, 15～25 parts, Fructus Foeniculi, 7～15 parts of Olibanums, 7～15 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

3. the Chinese medicine composition for the treatment of mare retained corpus luteum as claimed in claim 1 or 2, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 24～26 parts of 24～26 parts of Fructus Toosendans, 19～21 parts of Radix Bupleuri, 19～21 parts of Semen Litchis, 19～21 parts, Fructus Foeniculi, 9～11 parts of Olibanums, 9～11 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

4. the Chinese medicine composition of the treatment mare retained corpus luteum as described in claims 1 to 3, it is characterized in that: the ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition is 25 parts of 25 parts of Fructus Toosendans, 20 parts of Radix Bupleuri, 20 parts of Semen Litchis, 20 parts, Fructus Foeniculi, 10 parts of Olibanums, 10 parts of Rhizoma Et Radix Notopterygiis and Radix Angelicae Pubescentiss.

5. the Chinese medicine composition of the treatment mare retained corpus luteum as described in claim 1 to 4, is characterized in that: described Chinese medicine composition also further comprises Fructus Evodiae, the ratio of weight and number of described Fructus Evodiae is 15～20 parts.

6. the Chinese medicine composition of the treatment mare retained corpus luteum as described in claim 1 to 5, it is characterized in that: described Chinese medicine composition also further comprises the Radix Astragali, Rhizoma Cimicifugae, Radix Ginseng and the Rhizoma Atractylodis Macrocephalae, ratio of weight and number is respectively Radix Astragali 15-20 part, 15～20 parts of Rhizoma Cimicifugaes, Radix Ginseng 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.

7. the Chinese medicine composition of the treatment mare retained corpus luteum as described in claim 1 to 6, is characterized in that: the preparation method of described Chinese medicine composition is,

Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;

Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.

8. the Chinese medicine composition for the treatment of mare retained corpus luteum as claimed in claim 7, is characterized in that: the granularity in described step 1 is 150-200 order.

9. the Chinese medicine composition of the treatment mare retained corpus luteum as described in claim 1 to 6, is characterized in that:

The preparation method of described Chinese medicine composition comprises the following steps,

The first step, is mixed in proportion described component, is ground into powder;

Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;

The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;

The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;

The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.

10. the Chinese medicine composition for the treatment of mare retained corpus luteum as claimed in claim 9, is characterized in that: the granularity in described the 5th step is 150-200 order.