CN103751323B - 一种治疗原发性甲状腺功能减退症的中药制剂 - Google Patents
一种治疗原发性甲状腺功能减退症的中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗原发性甲状腺功能减退症的中药制剂。原发性甲状腺功能减退症的主要病机是肾阳虚、脾肾阳虚。病因多由先天禀赋不足，后天失养，或者积劳内伤，久病失调引起的肾气、脾气不足，继之脾肾阳虚所致。本发明选择具有温补肾阳，活血化瘀，健脾益气，滋阴利湿中药多蕊蛇菰、金雀花、地血香果、苤蓝、青羊参、棱枝卫矛、龟版、粗叶悬钩子、木半夏根、观音苋根，水煎成汤剂，经80例患者临床试验，总有效率97.5％，而且服药治疗期间没有发现不良反应。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗原发性甲状腺功能减退症的中药制剂。
背景技术
原发性甲状腺功能减退症(简称甲减)是指甲状腺合成、分泌甲状腺激素减少或生理效应不足而引起的以基础代谢率降低为特征的内分泌疾病，临床表现常见畏寒、汗少、动作缓慢、精神萎靡、记忆力减退、肌肉无力、嗜睡、性功能减退、粘液性水肿等。甲减目前是一种难治之病，现代医学主要应用甲状腺激素替代性治疗，同时对症处理，需要较长时间才能达到体内激素水平的动态平衡，而且达平衡后部分患者需终身替代治疗。因此长时间服药所导致的多种副作用不可忽视，严重者可诱发心绞痛乃至心力衰竭等。中医治疗甲减可从根本上改善患者体质，调节体内的免疫功能，扶正祛邪，及时改善症状。部分甲减患者还可免于甲状腺素终身替代治疗，弥补了单纯甲状腺激素替代治疗的不足。
发明内容
本发明的目的是提供一种治疗原发性甲状腺功能减退症的中药制剂。原发性甲状腺功能减退症的主要病机是肾阳虚、脾肾阳虚。病因多由先天禀赋不足，后天失养，或者积劳内伤，久病失调引起的肾气、脾气不足，继之脾肾阳虚所致。本病属中医学“虚痨”、“水肿”等范畴。治以温补肾阳，活血化瘀，健脾益气，滋阴利湿。
本发明的目的是通过以下技术方案实现的，该治疗原发性甲状腺功能减退症的中药制剂由以下重量份的中药制成：多蕊蛇菰3-9份、金雀花3-9份、地血香果5-10份、苤蓝10-20份、青羊参10-15份、棱枝卫矛10-20份、龟版10-15份、粗叶悬钩子15-25份、木半夏根9-15份、观音苋根60-90份。
优选的，多蕊蛇菰6份、金雀花6份、地血香果7份、苤蓝15份、青羊参12份、棱枝卫矛15份、龟版12份、粗叶悬钩子20份、木半夏根12份、观音苋根75份。
制备方法将上述中药水煎制成汤剂。
方中：多蕊蛇菰滋阴补肾；金雀花滋阴、和血、健脾；地血香果强心补肾，止咳祛痰；苤蓝利水消肿，和脾；青羊参补肾镇痉，祛风湿；棱枝卫矛驱风除湿，舒筋活络；龟版滋肾潜阳，益肾健骨，养血补心；粗叶悬钩子活血化瘀、清热止血；木半夏根活血行气、补虚损；观音苋根活血行气。
临床资料
1、一般资料80例患者均符合原发性甲状腺功能减退症诊断标准，男34例，女46例，年龄28-70岁，病程1个月到5年。
2、诊断标准经2次甲状腺功能检查均显示血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)值降低，血清促甲状腺激素(TSH)水平显著升高。
3、治疗方法患者服用本发明所述的中药制剂，称取多蕊蛇菰6g、金雀花6g、地血香果7g、苤蓝15g、青羊参12g、棱枝卫矛15g、龟版12g、粗叶悬钩子20g、木半夏根12g、观音苋根75g，水煎成汤剂，每日一剂，分早晚2次服用，连续服用半年。
4、疗效标准临床治愈：症状消失，血清TSH、T3、T4、FT3、FT4恢复正常；显效：主要症状消失，血清TSH、T3、T4、FT3、FT4基本正常；有效：症状好转，血清TSH、T3、T4、FT3、FT4基本正常；无效：症状、体征及实验室检查均无明显改善。
5、治疗结果本组80例患者治疗半年后观察疗效，其中临床治愈34例(42.5％)，显效30例(37.5％)，有效14例(17.5％)，无效2例(2.5％)，总有效率97.5％。而且服药治疗期间没有发现不良反应。
具体实施方式
实施例一：称取多蕊蛇菰6g、金雀花6g、地血香果7g、苤蓝15g、青羊参12g、棱枝卫矛15g、龟版12g、粗叶悬钩子20g、木半夏根12g、观音苋根75g，将上述中药水煎成汤剂。
实施例二：称取多蕊蛇菰9g、金雀花3g、地血香果10g、苤蓝10g、青羊参15g、棱枝卫矛10g、龟版15g、粗叶悬钩子15g、木半夏根15g、观音苋根60g，将上述中药水煎成汤剂。
实施例三：称取多蕊蛇菰3g、金雀花9g、地血香果5g、苤蓝20g、青羊参10g、棱枝卫矛20g、龟版10g、粗叶悬钩子25g、木半夏根9g、观音苋根90g，将上述中药水煎成汤剂。
Claims (2)
1.一种治疗原发性甲状腺功能减退症的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：多蕊蛇菰3-9份、金雀花3-9份、地血香果5-10份、苤蓝10-20份、青羊参10-15份、棱枝卫矛10-20份、龟甲10-15份、粗叶悬钩子15-25份、木半夏根9-15份、观音苋根60-90份。
2.如权利要求1所述的一种治疗原发性甲状腺功能减退症的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：多蕊蛇菰6份、金雀花6份、地血香果7份、苤蓝15份、青羊参12份、棱枝卫矛15份、龟甲12份、粗叶悬钩子20份、木半夏根12份、观音苋根75份。
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| 加味柴胡疏肝散治疗桥本甲状腺炎伴甲减30例;傅能登;《中国中医药科技》;20130131;第20卷(第1期);第85页 * |
| 温肾方对亚临床甲状腺功能减退模型大鼠心肌组织结构的影响;杨瑞霞等;《辽宁中医药大学学报》;20130228;第15卷(第2期);第45-47页 * |
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