CN103750322A - 调节血脂的保健食品 - Google Patents
调节血脂的保健食品 Download PDFInfo
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- CN103750322A CN103750322A CN201410035596.9A CN201410035596A CN103750322A CN 103750322 A CN103750322 A CN 103750322A CN 201410035596 A CN201410035596 A CN 201410035596A CN 103750322 A CN103750322 A CN 103750322A
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- blood fat
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- care food
- food
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
本发明属于生物医药领域，涉及调节血脂的保健食品。它以山楂、枸杞、黄芪、菟丝子为主要原料。本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成。本发明具有疗效确切、安全可靠、服用方便、价格低廉等特点，适宜长期服用。
Description
技术领域
本发明属于生物医药领域，涉及一种调节血脂的保健食品。
背景技术
心血管病已成为我国城市和乡村人群的第一位死亡原因，我国心血管病的特点是脑卒中高发而冠心病发病率较低，但近20余年冠心病发病率和死亡率逐步上升；在经济发展较快的大城市如北京，监测结果显示，从1984年到1999年出血性脑卒中发病率呈明显下降趋势，而缺血性脑卒中发病率却明显上升，预示以动脉粥样硬化为基础的缺血性心血管病（包括冠心病和缺血性脑卒中）发病率正在升高。研究表明，血清总胆固醇(total cholesterol，TC)或低密度脂蛋白胆固醇(low density lipoproten-cholesterol，LDL-C)升高是冠心病和缺血性脑卒中发生的独立危险因素之一。为此，对血脂异常的防治必须及早给予重视。
血脂是指血浆中的胆固醇、甘油三酯(triglyceide，TG)和类脂如磷脂等的总称。与临床密切相关的血脂主要是胆固醇和甘油三酯，其他还有游离脂肪酸(FFA)和磷脂等。在人体内胆固醇主要以游离胆固醇及胆固醇酯形式存在。甘油三酯是甘油分子中的三个羟基被脂肪酸酯化而形成。循环血液中的胆固醇和甘油三酯必须与特殊的蛋白质即载脂蛋白(apolipoprotein，ap)结合形成脂蛋白，才能被运输至组织进行代谢。
由于血脂异常与饮食和生活方式有密切关系，所以饮食治疗和改善生活方式是血脂异常治疗的基础措施。无论是否进行药物调脂治疗都必须坚持控制饮食和改善生活方式。根据血脂异常的类型及治疗需要达到的目的，选择合适的调脂药物。需要定期进行调脂疗效和药物不良反应的监测。在决定采用药物进行调脂治疗时，需要全面了解患者患冠心病及伴随的危险因素情况。在进行调脂治疗时，应将降低LDL-C作为首要目标。临床上在决定开始药物调脂治疗以及拟定达到的目标值时，需要考虑患者是否同时并存其他冠心病的主要危险因素（即除LDL-C以外的危险因素）。分析这些冠心病的主要危险因素将有助判断罹患冠心病的危险程度，由此决定降低LDL-C的目标值。
目前临床上供选用的调脂药物主要分为五类：(1)他汀类；(2)贝特类；(3)烟酸类；(4)树脂类；(5)胆固醇吸收抑制剂。但个体对药物疗效与副作用有很大个体差异，副作用不少，且一般需要长期服用。所以仅在饮食和运动疗法治疗后，仍不能有效地降低血脂时才试用。
发明内容
本发明的目的是针对上述血脂控制中的不足而提供一种效果显著的调节血脂的保健食品。
本发明的技术解决方案是该调节血脂的保健食品由下列重量配比的组分组成：山楂10-30份、枸杞6-12份、黄芪9-30份、菟丝子9-15份。
下面对本发明所使用的主要原料进行逐一阐述。
山楂：本品为蔷薇科植物山里红Crataegus pinnatifida Bge.var.major N.E.Br.或山楂C.pinnatifida Bge.的成熟果实。主产于河南、山东、河北等地，以山东产量大质佳。多为栽培品。秋季果实成熟时采收。切片，干燥。生用或炒用。味酸、甘，性微温。归脾、胃、肝经。具有消食化积，行气散瘀的功效。山楂含黄酮类、三萜皂苷类（熊果酸、齐墩果酸、山楂酸等），皂苷鞣质、游离酸、脂肪酸、维生素C、无机盐、红色素等。所含脂肪酸能促进脂肪消化，并增加胃消化酶的分泌而促进消化，且对胃肠功能有一定调整作用。其提取物能扩张冠状动脉，增加冠脉流量，保护心肌缺血缺氧；并可强心、降血压及抗心律失常；又降血脂，抗动脉粥样硬化，其降低血清胆固醇及甘油三酯，可能是通过提高血清中高密度胆固醇及其亚组分浓度，增加胆固醇的排泄而实现的。
枸杞：为茄科植物宁夏枸杞Lycium barbarum L.的成熟果实。主产于宁夏、甘肃、新疆等地。夏秋二秋果实呈橙红色时采收，晾至皮皱后，再晒至外皮干硬，果肉柔软，生用。味甘，性平。归肝、肾经。滋补肝肾，益精明目。本品含甜菜碱、多糖、粗脂肪、粗蛋白、硫胺素、核黄素、烟酸、胡萝卜素、抗坏血酸、尼克酸、β-谷甾醇、亚油酸、微量元素及氨基酸等成分。枸杞子对免疫有促进作用，同时具有免疫调节作用；可提高血睾酮水平，起强壮作用；对造血功能有促进作用；对正常健康人也有显著升白细胞作用；还有抗衰老、抗突变、抗肿瘤、降血脂、保肝及抗脂肪肝、降血糖、降血压作用。
黄芪：为豆科植物蒙古黄芪Astragalus memeranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao或膜荚黄芪A.membranaceus(Fisch.)Bge.的根。主产于内蒙古、山西、黑龙江等地。春秋二季采挖，除去须根及根头，晒干，切片，生用或蜜炙用。味甘，性微温。归脾、肺经。健脾补中，升阳举陷，益卫固表，利尿，托毒生肌。本品主要含苷类、多糖、黄酮、氨基酸、微量元素等。黄芪能促进机体代谢、抗疲劳、促进血清和肝脏蛋白质的更新；有明显的利尿作用，能消除实验性肾炎尿蛋白；能改善贫血动物现象；能升高低血糖，降低高血糖；能兴奋呼吸；能增强和调节机体免疫功能，对干扰素系统有促进作用，可提高机体的抗病力；对流感病毒等多种病毒所致细胞病变有轻度抑制作用，对流感病毒感染小鼠有保护作用；有较广泛的抗菌作用；黄芪在细胞培养中，可使细胞数明显增多，细胞生长旺盛，寿命延长；能增强心肌收缩力，保护心血管系统，抗心率失常，扩张冠状动脉和外周血管，降低血压，能降低血小板粘附力，减少血栓形成；还有降血脂、抗衰老、抗缺氧、抗辐射、保肝等作用。
菟丝子：为旋花科植物菟丝子Cuscuta chinensis Lam.或大菟丝子C.japonica Choisy的成熟种子。我国大部分地区均有分布。秋季果实成熟时割取地上部分，晒干，打下种子。生用，或煮熟捣烂作饼用。味辛、甘，平。归肾、肝、脾经。补肾益精，养肝明目，止泻安胎。菟丝子水煎剂能明显增强黑腹果蝇交配次数；菟丝子灌胃对大鼠半乳糖性白内障有治疗作用；菟丝子水煎剂连续灌胃1个月，能明显增强小鼠心肌组织匀浆乳酸脱氢酶的活性，对心肌过氧化氢酶及脑组织的乳酸脱氢酶和过氧化氢酶活性有增强趋势。
上述发明的保健食品中，还可以含有适量的药剂学可接受的载体，包括赋形剂和辅料，所述的赋形剂和辅料有淀粉、微晶纤维素、无机盐类、羟丙基甲基纤维素、乙基纤维素、聚丙烯酸树脂类、聚羧乙烯类、海藻酸的可溶性/不溶性盐类、十八醇、十八酸、蔗糖、糊精、乳糖、糖粉、葡萄糖、氯化钠、半胱氨酸、柠檬酸和亚硫酸钠等的一种或几种物质的组合物，包衣材料包括虫胶、醋酸纤维素、醋酸纤维素酞酸酯、乙基纤维素、羟丙基甲基纤维素、羟丙基纤维素、丙烯酸树脂类、聚醋酸乙烯苯二甲酸酯、邻苯二甲酸羟丙甲纤维素酯、琥珀酸醋酸羟丙甲基纤维素、醋酸羟丙基甲基纤维素酞酸酯、单硬脂酸甘油酯、以及增塑剂与致孔剂等多种药剂学辅料。
本发明的调节血脂的保健食品的剂型是丸剂或片剂或颗粒剂或胶囊剂。
本发明提供的保健食品具有疗效确切、安全可靠、服用方便、价格低廉等特点，适宜长期服用。
具体实施方式
实施例1.主要原料配比
山楂10份、枸杞6份、黄芪30份、菟丝子15份。
提取方法如下：
将药材按重量配比粉碎，加10倍量75%乙醇，闪式连续提取3次，每次5分，合并提取液，抽滤，减压回收干燥，备用。
实施例2.主要原料配比
山楂30份、枸杞12份、黄芪9份、菟丝子9份。
提取方法如下同实施例1。
实施例3.调节血脂的功效性研究
试验方法：将大鼠适应性饲养5d后，根据甘油三酯含量将动物分为3组，每组12只。阴性对照组给予普通饲料，模型对照组及给药组给予高脂饮食，喂养28天后测量空腹12h后甘油三酯含量。
试验结果：喂养28天结束后模型对照组血脂显著增高；与模型对照组比较，预防给药组血脂均显著性降低（表1）。
表1喂养28天结束后动物血脂含量
与模型对照组比较△P＜0.05
试验结论：本发明保健食品能降低受试大鼠血清甘油三酯含量，提示具有调节血脂的功效。
Claims (2)
1.调节血脂的保健食品，其特征在于由下列重量配比的组分组成：
山楂10-30份 枸杞6-12份 黄芪9-30份 菟丝子9-15份。
2.根据权利要求1所述的调节血脂的保健食品，其特征在于所述的保健食品的剂型是丸剂或片剂或颗粒剂或胶囊剂。
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Application publication date: 20140430 |