CN103735319A - Method and device applicable to physical strength limit tolerance experiments on animals in high-pressure environments - Google Patents

Method and device applicable to physical strength limit tolerance experiments on animals in high-pressure environments Download PDF

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Publication number
CN103735319A
CN103735319A CN201410022465.7A CN201410022465A CN103735319A CN 103735319 A CN103735319 A CN 103735319A CN 201410022465 A CN201410022465 A CN 201410022465A CN 103735319 A CN103735319 A CN 103735319A
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China
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bearing platform
sensor
table top
touching
receiving
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CN201410022465.7A
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CN103735319B (en
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刘晓波
陈杰
陈海庭
许骥
何佳
陈锐勇
陈新
向导
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Navy Medicine Research Institute of PLA
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Navy Medicine Research Institute of PLA
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Abstract

The invention discloses a method and a device applicable to physical strength limit tolerance experiments on animals in high-pressure environments. The device applicable to the physical strength limit tolerance experiments on the animals in the high-pressure environments comprises a water tank and a control system. The water tank comprises a tank bottom and a tank wall, a lifting device is arranged at the tank bottom and comprises a bearing table and a hoisting support, the hoisting support is connected with the bearing table and is positioned above the bearing table, and sensors are arranged on a tabletop of the bearing table and are used for sensing touch, recording touch durations of the sensors and transmitting touch signals when the touch durations meet requirements of preset duration values; the control system is used for hoisting the hoisting support so as to drive the bearing table to rise after receiving the touch signals transmitted by the sensors, and is also used for recording durations from the moments when the experimental animals enter the water tank to the moments when the tabletop of the bearing table rises and exceeds a water surface. The method and the device have the advantages that the device conforms to operation and safety standards in the high-pressure field, and the experimental efficiency and the experimental accuracy can be improved by the aid of the device.

Description

Be applicable to animal muscle power limit tolerance experimental technique and device under environment under high pressure
Technical field
The present invention relates to a kind of animal movement experimental technique and modeling device, relate in particular to the animal muscle power limit resistance test method and the device that are applicable under environment under high pressure.
Background technology
Overtraining refers to training and recovery, motion and motor capacity, stress be unbalance with the state of stress tolerance, mainly by unreasonable, excusing from death reason weight training, caused, and comprise unify a kind of motion sickness of important support organ lesion of central nervous system.
With reference to figure 1, animal muscle power limit tolerance experimental provision of the prior art is only applicable to atmospheric pressure environment, is specially the tank 1 that rustless steel or fiberglass are made, and the length of this tank is that 1m, width are 1m, and height is 80cm.The water in tank 1 with certain depth, this water is for laboratory animal swimming.When laboratory animal is placed in the process sinking under water to being short of physical strength in water, give manual time-keeping and obtain laboratory animal from putting into water to the time sinking under water, so that the laboratory animal of carrying out after overtraining is carried out to physical ability screening experiment, physical ability is crossed or laboratory animal that physical ability is excessively poor is got rid of, thereby reduced the impact on integral experiment result of individual data items that dispersion is larger.Because at least two above laboratory animals are at same tank went swimming, can take and hold up mutually, make laboratory animal elongated to the time sinking under water in water, thereby the accuracy of impact experiment, so animal muscle power limit tolerance experimental provision of the prior art can only be tested a laboratory animal.When many laboratory animals of needs are tested, also can only carry out in turn, spended time is longer, and therefore, the conventional efficient of animal muscle power limit tolerance experimental provision of the prior art is low.In addition, adopt hand-timed method can make experimental result have subjective deviation, therefore, the experimental data precision of animal muscle power limit tolerance experimental provision of the prior art is not high.Adopt hand-timed method, testing whole process is all manual operation, and error is larger, not necessarily can guarantee each experiment all successfully, and therefore, the speed that obtains practical data is slower, therefore, from this respect, incites somebody to action, and also can affect conventional efficient.
Summary of the invention
The problem that the present invention solves is that animal muscle power limit tolerance experimental provision of the prior art is only applicable to atmospheric pressure environment, and conventional efficient is low, experimental data precision is not high.
For addressing the above problem, the invention provides a kind of animal muscle power limit tolerance experimental provision that is applicable to environment under high pressure, comprising:
Tank, comprise bottom land and cell wall, described bottom land is provided with lowering or hoisting gear, described lowering or hoisting gear comprises bearing platform, is connected with described bearing platform and is positioned at the lifting bracket of bearing platform top, described bearing platform table top is provided with sensor, the touched time of sensor is touched and recorded to described sensor for perception, and in the touching time, meet the time and send touching signals during predetermined value;
Control system, after receiving the touching signals that described sensor sends, for promoting described lifting bracket, drives described bearing platform to rise, and, for recording laboratory animal, enter tank and raise and exceed the time of the water surface to described bearing platform table top.
Optionally, described sensor is multi-disc, described in multi-disc, sensor is matrix arrangement, distance between adjacent two sensors is less than or equal to the first preset distance value, and the distance between nearest string sensor, a line sensor and bearing platform table top border, described bearing platform table top border is less than or equal to second distance predetermined value;
Every described sensor comprises: sensing unit, the first timing unit and signal transmitting and receiving unit;
Described sensing unit is touched for perception, and sends touching signal;
Described the first timing unit, for receiving described touching signal and recording the touched time of sensing unit;
Signal transmitting and receiving unit, receiving the touching during time that meets time predetermined value, sends touching signals.
Optionally, described sensor is a slice, and the border of described sensor and described bearing platform table top border are less than or equal to second distance predetermined value;
Described sensor comprises: sensing unit, computing unit, the first timing unit and signal transmitting and receiving unit;
Described sensing unit is touched for perception, and sends touching signal;
Described computing unit is used for calculating the touched area of described sensor, and when the touched area of sensor meets area predetermined value, sends touching area of signal;
Described the first timing unit, for receiving described touching area of signal and recording the touched time of sensing unit;
Signal transmitting and receiving unit, meets touching time of time predetermined value and touching during area of signal receiving, and sends touching signals.
Optionally, described the first preset distance value is for being more than or equal to 3mm and being less than or equal to 6mm, and described second distance predetermined value is 3mm.
Optionally, described control system comprises:
Driver, is connected with described lifting bracket;
Processing unit, is connected with described actuator electrical, when receiving described touching signals, controls unlatching and the output power value of described driver;
The second timing unit, when receiving experiment enabling signal, starts timing; When receiving experiment end signal, finish timing.
Optionally, the horizontal range between described bearing platform table top border and described bottom land border is more than or equal to 1cm and is less than or equal to 2cm.
Optionally, described experimental provision is also applicable to atmospheric pressure environment.
Optionally, described bearing platform comprises table top, the lower surface relative with described table top, the sidewall that table top is connected with lower surface, the sidewall of described bearing platform is parallel with described cell wall, and the distance between the sidewall of bearing platform and described cell wall is for being more than or equal to 1mm and being less than or equal to 2mm.
Optionally, the sidewall of described bearing platform is higher than described table top 20~40mm.
The present invention also provides animal muscle power limit tolerance experimental technique under a kind of environment under high pressure, comprising:
Above-mentioned animal muscle power limit tolerance experimental provision is provided;
Animal is put into the tank of described device, start the clocking capability of described device simultaneously, start timing;
Described animal is sink to after the bearing platform of described device, and when bearing platform is raised to higher than the water surface, described timing finishes.
Compared with prior art, technical scheme of the present invention has the following advantages:
Adopt animal muscle power limit tolerance experimental provision of the present invention, when laboratory animal muscle power is not propped up while sinking down into the lowering or hoisting gear that is positioned at bottom land, health can contact with the sensor of bearing platform table top, sensor senses is after the touching of laboratory animal, record the touched time of sensor, and in the touching time, meet the time and send touching signals during predetermined value, that is to say, when time of laboratory animal touch sensor is to the scheduled time, illustrative experiment animal power exhausts, and sensor can send touching signals to control system.Control system, after receiving the touching signals that sensor sends, is controlled and is promoted described lifting bracket, drives bearing platform to be raised up to the position that table top exceeds the water surface, and experiment finishes.Control system has recorded laboratory animal and has entered tank and raise and exceed the time of the water surface to bearing platform table top.Avoided hand-timed subjective deviation, therefore, the experimental data precision of the animal of the technical program muscle power limit tolerance experimental provision is high.In addition, just because of the experimental data precision of the experimental provision of the technical program is high, can reduce personal error, thereby can guarantee that the chance of success of each experiment is large, from this respect, improve conventional efficient; Meanwhile, the experimental data precision of the experimental provision of the technical program is high, can reduce unnecessary people for the experiment loss that maloperation brings, and from this respect, can reduce experimental cost.
Moreover experimental provision of the present invention can be realized the physical ability limit to laboratory animal under hyperbaric environment and study.This hyperbaric environment is for being greater than an atmospheric environment.While carrying out overtraining experiment under above-mentioned hyperbaric environment, experimental system is required far away higher than the requirement under normal pressure, operation and the safety criterion that need to meet relevant hyperbar field, for example < < diver electricity consumption rules under water > > (GB16636-2008).Wherein, rated voltage, the electric current of whole each electric component of experimental system of needs will be in critical fields, that is to say, the rated voltage of whole each electric component of experimental system under hyperbaric environment, electric current need to be less than rated voltage, the electric current of whole each electric component of experimental system under atmospheric pressure environment, otherwise very easily cause security incident.The driving device of this experimental system is by controlling rise and the landing of lifting bracket, drive rise and the landing of bearing platform, mechanical realization is simple, accordingly, can be applied to driving device with simple circuit connecting mode, therefore, experimental system of the present invention can be tested with less rated voltage, electric current, not only meets operation and the safety criterion in relevant hyperbar field.And the automatization that also can realize whole experimentation under hyperbaric environment, has reached the object of saving manpower and improving experimental precision simultaneously.
Accompanying drawing explanation
Fig. 1 is the perspective view of animal muscle power limit tolerance experimental provision of the prior art;
Fig. 2 is the schematic top plan view of the animal muscle power limit tolerance experimental provision that is applicable to environment under high pressure in the specific embodiment of the invention;
Fig. 3 is the perspective view of the part experimental provision in Fig. 2.
The specific embodiment
For above-mentioned purpose of the present invention, feature and advantage can more be become apparent, below in conjunction with accompanying drawing, specific embodiments of the invention are described in detail.
Referring to figs. 2 and 3, the animal muscle power limit tolerance experimental provision 2 of the present embodiment comprises:
Tank 21, comprise bottom land and cell wall 210, described bottom land is provided with lowering or hoisting gear, described lowering or hoisting gear comprises bearing platform 212, is connected with described bearing platform 212 and is positioned at the lifting bracket 216 of bearing platform top, described bearing platform 212 table tops are provided with sensor (not shown), the touched time of sensor is touched and recorded to described sensor for perception, and in the touching time, meet the time and send touching signals during predetermined value;
Control system 41, after receiving the touching signals that described sensor sends, for promoting described lifting bracket 216, drive described bearing platform 212 to rise, and, for recording laboratory animal, enter tank and raise and exceed the time of the water surface to described bearing platform 212 table tops.
Adopt animal muscle power limit tolerance experimental provision of the present invention, when laboratory animal muscle power is not propped up while sinking down into the lowering or hoisting gear that is positioned at bottom land, health can contact with the sensor of bearing platform table top, sensor senses is after the touching of laboratory animal, record the touched time of sensor, and in the touching time, meet the time and send touching signals during predetermined value, that is to say, when time of laboratory animal touch sensor is to the scheduled time, illustrative experiment animal power exhausts, and sensor can send touching signals to control system.Control system, after receiving the touching signals that sensor sends, is controlled and is promoted described lifting bracket, drives bearing platform to be raised up to the position that table top exceeds the water surface, and experiment finishes.Control system has recorded laboratory animal and has entered tank and raise and exceed the time of the water surface to bearing platform table top.Avoided hand-timed subjective deviation, therefore, the experimental data precision of the animal of the technical program muscle power limit tolerance experimental provision is high.In addition, just because of the experimental data precision of the animal of the technical program muscle power limit tolerance experimental provision is high, can reduces personal error, thereby can guarantee that the chance of success of each experiment is large, from this respect, improve conventional efficient; Meanwhile, the experimental data precision of the animal of the technical program muscle power limit tolerance experimental provision is high, can reduce unnecessary people for the experiment loss that maloperation brings, and from this respect, can reduce experimental cost.
Moreover the animal muscle power limit tolerance experimental provision of application the technical program is tested and can tentatively be understood animal and feel bad ability in the limit of above-mentioned hyperbar underwater environment.Be specially, while carrying out overtraining experiment under being greater than an atmospheric hyperbaric environment, experimental system is required far away higher than the requirement under normal pressure, operation and the safety criterion that need to meet relevant hyperbar field, for example < < diver electricity consumption rules under water > > (GB16636-2008).Wherein, rated voltage, the electric current of whole each electric component of experimental system of needs will be in critical fields, that is to say, the rated voltage of whole each electric component of experimental system under hyperbaric environment, electric current need to be less than rated voltage, the electric current of whole each electric component of experimental system under atmospheric pressure environment, otherwise very easily cause security incident.The driving device of this experimental system is by controlling rise and the landing of lifting bracket, drive rise and the landing of bearing platform, mechanical realization is simple, accordingly, can be applied to driving device with simple circuit connecting mode, therefore, experimental system of the present utility model can be tested with less rated voltage, electric current, the automatization that not only meets the operation in relevant hyperbar field and safety criterion but also also can realize whole experimentation under hyperbaric environment has reached the object of saving manpower and improving experimental precision simultaneously.
The present embodiment utilizes compression chamber to realize hyperbaric environment.Experimental provision in the present embodiment need to be placed in compression chamber and test, and laboratory animal is experiment mouse.Please continue to refer to Fig. 2 and Fig. 3, the animal muscle power limit tolerance experimental provision 2 being applicable under hyperbaric environment specifically comprises:
Tank 21, the present embodiment is cuboid, can be also square, cylinder or Elliptic Cylinder or other shapes well-known to those skilled in the art in other embodiment.In the present embodiment, the long limit of tank 21 is that 45~55cm, broadside are that 25~35cm, height are 55~65cm.Therefore, the tank of the present embodiment is little with respect to tank volume of the prior art, can realize the stacking of tank, thereby can in limited space, place more animal muscle power limit tolerance experimental provision 2, the volume of tank 21 should be in above-mentioned scope, if the volume of tank 21 is too little, during laboratory animal swimming, stretch not open, do not reach the object that laboratory animal is swum under free state, thereby affect the behavior of laboratory animal, make experimental result inaccurate; If the volume of tank 21 is too large, can not realize the stacking of tank.
Tank 21 comprises bottom land and perpendicular to the cell wall 210 of bottom land.Bottom land is provided with lowering or hoisting gear, and lowering or hoisting gear comprises bearing platform 212, is connected with bearing platform 212 and is positioned at the lifting bracket 216 of bearing platform top.
Lifting bracket 216 comprises the lifting arm 216a that is separately fixed at bearing platform 212 both sides and the connecting rod 216b that connects described lifting arm 216a.Connecting rod 216b is higher than bearing platform 212.
Surrounding at tank 21 arranges driver mounting bracket 31, and driver mounting bracket 31 comprises support bar 311 and the crossbeam 312 that is connected described support bar 311.The length of support bar 311 is longer than the length of lifting arm 216a, and is less than pressurized cabin floor to the height of ceiling.Support bar 311 is parallel to lifting arm 216a.Crossbeam 312 is higher than connecting rod 216b and parallel with connecting rod 216b.
Driver 411 in control system is arranged on crossbeam 312.Described driver 411 comprises coil 411a and the motor (not shown) that drives described coil 411a to rotate.Coil 411a comprises spool and is wrapped in the cotton rope on spool.One end of cotton rope is wrapped on spool, and the other end is connected with connecting rod 216b.When motor driving spool clockwise direction or while counterclockwise rotating, the cotton rope being wrapped on spool increases, and the other end of cotton rope is mentioned connecting rod 216b, thereby drives bearing platform 212 to do ascending motion.It should be noted that, bearing platform 212 is to rise along the direction of cell wall 210, along in cell wall 210 uphill process, bearing platform 212 table tops keep vertical with cell wall 210, that is to say, bearing platform 212 table tops, always in level, prevent that the laboratory animal on it from dropping.When bearing platform table top surpasses the water surface, the laboratory animal on table top can be taken out.When motor driving spool counter-rotation, be wrapped in the minimizing of the cotton rope on spool, connecting rod 216b, bearing platform 212 can rely on the action of gravity landing of self.When driver is closed, connecting rod 216b and bearing platform 212 can rely on the action of gravity landing of self.
In the present embodiment, bearing platform 212 is also cuboid, matches with the shape of described tank 21.In other embodiment, be square, cylinder or Elliptic Cylinder or other shapes well-known to those skilled in the art.Bearing platform 212 comprises table top, the lower surface relative with table top, the sidewall 215 that table top is connected with lower surface.The sidewall 215 of bearing platform 212 is parallel with cell wall 210, and the distance between the sidewall of bearing platform and cell wall 210 is that 1~2mm(comprises end points).If the distance between the sidewall of bearing platform 215 and cell wall 210 is too large, the process shaking amplitude that bearing platform rises or lands is too large, and laboratory animal is easily stuck between sidewall 215 and cell wall 210.If the distance between the sidewall of bearing platform 215 and cell wall 210 is too little, in the process that bearing platform 212 rises or lands on the one hand, frictional force is too large, increases equipment loss; On the other hand, laboratory animal comprises Mus and experiment mice in experimental rat, experiment.Even experiment mice, height also can be greater than 6cm.Once laboratory animal sandwiches too little place, gap, this gap is very large to the injury of laboratory animal, has improved experimental cost.In the present embodiment, the sidewall 215 of bearing platform 212 is higher than table top 20~40mm.Reason is as follows: (1) prevents that laboratory animal from dropping from bearing platform 212.(2) if the sidewall 215 of bearing platform 212 is too many higher than table top, the lifting bracket 216 being arranged on bearing platform also needs to increase height, and most of pressurized cabin floor to the effective depth of ceiling is generally no more than 1.8 meters on the market, thereby so the height of lifting bracket 216 are conditional increases that can limit lifting bracket 216 height.(3) if the sidewall 215 of bearing platform 212 is too high, this sidewall 215 from the distance of lifting bracket 216 too close to, after experiment finishes, the difficulty of taking out laboratory animal strengthens.If the sidewall 215 of bearing platform 212 is less higher than table top, laboratory animal easily rides over health on sidewall 215, thereby the power of prolongation laboratory animal exhausts the time, impact experiment degree of accuracy, when serious, the foot of laboratory animal rides on sidewall, head above water, thus experiment cannot be proceeded.
The table top of bearing platform 212 is provided with sensor.Sensor is for the touching of perception laboratory animal, and records the touched time of sensor, meets the time send touching signals during predetermined value in the touching time, and now illustrative experiment animal exhausts state in power.
The type of described sensor is pressure transducer or infrared ray sensor, for example, is pressure transducer.
It should be noted that, described time predetermined value can artificially be set according to the size of laboratory animal.Through research and performing creative labour, in the present embodiment, time predetermined value is 5s~40s.If the time that time predetermined value arranges is oversize, the dead probability of laboratory animal is very large, increases experimental cost.If the time that time predetermined value arranges is too short, laboratory animal does not exhaust state in power.It should be noted that, consider the adaptive capacity of laboratory animal, laboratory animal tolerance time may increasing and progressively extend with Experiment Training number of times.
The sensor of bearing platform 212 table tops can be whole piece or multi-disc.In the present embodiment, sensor is multi-disc (the label 213 representative sensor regions in Fig. 2 and Fig. 3).Sensor embeds table top in the mode of matrix.Distance between adjacent two sensors is less than or equal to the first preset distance value, and the distance between nearest string sensor, a line sensor and bearing platform table top border, described bearing platform table top border is less than or equal to second distance predetermined value.Every described sensor comprises: sensing unit, the first timing unit and signal transmitting and receiving unit.Described sensing unit is touched for perception, and sends touching signal; Described the first timing unit, for receiving described touching signal and recording the touched time of sensing unit; Signal transmitting and receiving unit, receiving the touching during time that meets time predetermined value, sends touching signals.
In the present embodiment, be specially: every sensor is square, the size of every sensor is that 1cm * 1cm~2cm * 2cm(comprises end points), spacing between two adjacent sensors, that is, the first preset distance value is that 3mm~6mm(comprises end points), and the distance between nearest string sensor, a line sensor and bearing platform table top border, bearing platform table top border is less than or equal to 3cm, therefore, second distance predetermined value is 3cm.Why distance between distance, sensor and table top border between two adjacent sensors is set like this, and reason is as follows: when laboratory animal power exhausts, be that the mode of lying sinks to bearing platform.Laboratory animal, even mice, height also can be greater than 6cm, therefore, laboratory animal contacts two sensors to I haven't seen you for ages after sinking to bearing platform.Therefore, in the present embodiment, set at least two described sensors when touched, just can start to record the touched time of sensor, and when the touching time meets the scheduled time, send touching signals.When laboratory animal only contacts described in a slice sensor, only have described in a slice when sensor is touched, cannot start to record the touched time of sensor, in case the time that the experimental period of follow-up acquisition is not laboratory animal to sink under water in water.Reason is as follows: when laboratory animal only contacts a slice sensor, illustrative experiment animal is not the mode of the lying table top that sinks to bearing platform, but in the mode of standing, sinking to the table top of bearing platform, the laboratory animal that sinks to the table top of bearing platform in the mode of standing does not exhaust effectively.
In other embodiment; the shape of described every sensor also can rectangle, circle, regular polygon; the first preset distance value, second distance predetermined value can be adjusted according to the shape of every sensor, size, within also belonging to the scope of protection of the invention.
In other embodiment, sensor can be also a slice, is rectangle.The table top of this sheet sensor embed wholly bearing platform and the border of this sheet sensor and described bearing platform border are less than or equal to 3cm.At this moment sensor also comprises computing unit, the area of being touched by laboratory animal for calculating sensor, and when the touched area of sensor meets area predetermined value, send touching area of signal.Area predetermined value is 4cm * 4cm.When the area of laboratory animal touch sensor is greater than 4cm * 4cm, illustrative experiment animal is that the mode of lying contacts with sensor, computing unit sends touching area of signal to the first timing unit, the first timing unit receives described touching area of signal and records the touched time of sensing unit, when receiving, signal transmitting and receiving unit reaches touching time of time predetermined value and touching during area of signal, illustrate that laboratory animal now exhausts state in power, signal transmitting and receiving unit can send touching signals.When the area of laboratory animal touch sensor is less than 4cm * 4cm, now laboratory animal is not the mode touch sensor of lying, therefore, this laboratory animal is not to exhaust state in power, computing unit can not send touching area of signal to the first timing unit, thereby makes sensor cannot send touching signals.It should be noted that, more than why area predetermined value being arranged on to 4cm * 4cm, be because, even laboratory animal experiment mice now also can contact with sensor with the state of lying.
In the present embodiment, cell wall 210 is divided into external groove sidevall and internal groove side wall (not shown).Internal groove side wall and external groove sidevall are all transparent.The baffle plate of different colours can be placed in position between internal groove side wall and external groove sidevall, and the baffle plate of different colours can be realized the stimulation to laboratory animal in experimentation, and laboratory animal can be made different reactions according to different baffle plate colors.Therefore, experimental provision of the present invention can carry out adequate stimulus to laboratory animal, thereby has enriched experiment content.In other embodiment, cell wall also can not be divided into external groove sidevall and internal groove side wall, between external groove sidevall and internal groove side wall, also baffle plate can be set, and also belongs to protection scope of the present invention.
In the present embodiment, the cell wall that tank width is relative is respectively equipped with water inlet 217 and outlet 218.The position of water inlet 217 and outlet 218 can exchange.Water outside tank (water in running water pipe or the water in tank) flows into tank by water inlet 217; Water in tank flows out to outside tank by outlet 218 again.In the present embodiment, with reference to figure 3, be specially: water inlet 217 is divided into internal groove side wall water inlet, external groove sidevall water inlet; Outlet 218 is divided into the outlet of internal groove side wall outlet and external groove sidevall.
With reference to figure 1, the animal muscle power limit tolerance experimental provision 2 in the present embodiment also comprises control system 41.Control system 41, after receiving the touching signals that described sensor sends, for lifting bracket 216, drives bearing platform 212 to rise, and, for recording laboratory animal, enter tank to the table top of bearing platform 212 and raise and exceed the time of the water surface.Control system 51 is arranged on cell wall 210 outsides.
Control system 41 comprises driver 411, processing unit 412 and the second timing unit 413.
Driver 411, is connected with the connecting rod 216b of lifting bracket 216 with described bearing platform 212.
Processing unit 412, is electrically connected to driver 411, when receiving the touching signals that sensor sends, controls driver 411 and opens output power values, and at this moment bearing platform can rise.
In the present embodiment, control system can also comprise the second timing unit 413, when receiving experiment enabling signal, starts timing; When receiving experiment end signal, finish timing.
In the present embodiment, when laboratory animal enters tank, directly experiment enabling signal is sent in artificial manually control.In other embodiment, control system can also comprise start unit, and when laboratory animal enters tank, start unit sends experiment enabling signal.
In the present embodiment, when being increased to, the table top of bearing platform sends experiment end signal when exceeding the water surface and stopping.In other embodiment, can directly artificially manually control and send experiment end signal.
In the present embodiment, the second timing unit can directly accept to test enabling signal and experiment end signal carries out timing.
In other embodiment, processing unit can also accept to test one or both in enabling signal and experiment end signal.When receiving experiment enabling signal, send timing commencing signal; When receiving experiment end signal, send timing end signal.When the second timing unit receives the timing commencing signal sending from processing unit, start timing; When receiving the timing end signal sending from processing unit, finish timing.
Therefore, the second timing unit 413 can carry out timing by four kinds of modes:
(1) when receiving experiment enabling signal, start timing; When receiving experiment end signal, finish timing.(2) when receiving experiment enabling signal, start timing; When receiving timing end signal, finish timing.(3), when receiving timing commencing signal, start timing; When receiving experiment end signal, finish timing.(4), when receiving timing commencing signal, start timing; When receiving timing end signal, finish timing.
It should be noted that, in animal muscle power limit tolerance experimental provision 2, the temperature of water should be roughly the same with the body temperature of laboratory animal, it is 39 ℃~43 ℃, so that laboratory animal is in the swimming instruction that there is no to carry out under the condition of additional interference free state, for example can not be burned or scald dead, can frost bitten or freeze to death etc.Or the temperature of the water in animal muscle power limit tolerance experimental provision 2 also can surpass body temperature, carries out swimming test under the heat-resistant limit of laboratory animal.The temperature of described heat-resistant limit is 45 ℃.And animal in the present embodiment muscle power limit tolerance experimental provision 2 is applicable to hyperbaric environment, so can be by regulating the temperature of compression chamber realize the adjusting to the temperature of water in animal muscle power limit tolerance experimental provision 2.
It should be noted that, by the means of artificial cooling, utilize animal muscle power limit tolerance experimental provision of the present invention to carry out swimming test under the cold-resistant limit to laboratory animal.The temperature of the described cold-resistant limit is 4 ℃.Wherein, the means of artificial cooling can be: by freezing in advance, to the water of 4 ℃, flow directly in tank or between internal groove side wall and external groove sidevall ice cube etc. is set.But animal muscle power limit tolerance experimental provision of the present invention does not adopt the mode of compressor to freeze, because the volume of compressor is too large, is unfavorable for the downsizing of apparatus of the present invention.
In other embodiment, animal muscle power limit tolerance experimental provision is not carried out within artificial cooling also belongs to protection scope of the present invention.
In the present embodiment, control system also comprises and showing and guidance panel 414, is connected with processing unit 412.Be divided into display floater and guidance panel.On guidance panel, be also provided with action button group, timing action button group of driver 411 etc.Display floater can show experimental animal enter water under sink to time of bearing platform, the parameters such as water temperature.Demonstration and guidance panel 414, driver 411 have respectively unified data-interface, processing unit 412 also has data-interface, respectively with corresponding connection of data-interface of demonstration and guidance panel 414, driver 411, and realize show and guidance panel 414, driver 411 and processing unit 412 between signal, transfer of data.
The control system of the present embodiment specifically can be controlled following operation: when laboratory animal enters tank 21, control system 41 starts timing.When laboratory animal sinks down into bearing platform 212 touch sensor, when the time of the described sensor of contact, reach the time during predetermined value, sensor is triggered and sends touching signals to processing unit 412, processing unit 412 receives after the touching signals that sensor sends, control unlatching and the output power value of described driver 411, so that bearing platform 212 is increased to and exceeds the water surface.When the table top of bearing platform 212 is increased to and exceeds the water surface and stop, control system timing finishes.When laboratory animal is from the table top of bearing platform is removed, can people the action button group that is manual operation driver, control closing or making spool reversion of driver, so that bearing platform landing.
In the present embodiment, when a laboratory animal is tested, adopt an above-mentioned animal muscle power limit tolerance experimental provision 2 to test separately.
When a plurality of laboratory animals are tested simultaneously, animal in the present embodiment muscle power limit tolerance experimental provision 2 volumes are smaller, can carry out stacking, to save placement space.Between stacking tank, need to arrange preset distance, this preset distance can be realized laboratory animal putting into and taking out in tank.When a plurality of animals muscle power limit tolerance experimental provisions are carried out to when stacking, adopts a total control system to control the equipment such as tank that each animal muscle power limit tolerates experimental provision simultaneously.Need to again illustrate, the animal of the present embodiment muscle power limit tolerance experimental provision 2 volumes are little, and the mode that can carry out independent assortment according to the size and shape in space to animal muscle power limit tolerance experimental provision 2 is carried out stacking.Both conventional efficient can be improved, placement space can be saved again, and the same control system of a plurality of animal muscle power limit tolerance experimental provision 2 employing, meet large batch of zooperal demand.But this experimental provision is tested in compression chamber, therefore, be subject to floor space and with the restriction of electric standard, the stacking quantity of experimental provision is less than the stacking quantity under atmospheric pressure state.
In sum, adopt animal muscle power limit tolerance experimental provision 2 of the present invention to have the following advantages:
(1) volume of the tank of the present embodiment reduces a lot, and it is also smaller that the control system outside tank cell wall takies volume.In the present embodiment, animal muscle power limit tolerance experimental provision 2 can carry out stacking, according to placement space, carry out independent assortment, more animal muscle power limit tolerance experimental provision 2 can be set in limited space, and, by same control system, stacking tank is controlled, can be met large batch of zoopery demand.
(2), when laboratory animal enters tank, control system timing starts.At bottom of gullet, arrange on bearing platform, table top at bearing platform sensor is set.Sensor and control system closely cooperate, and when laboratory animal sinks to the table top of bearing platform and reaches after time predetermined value, bearing platform can automatically be increased to table top and surface, and now, control system timing finishes.When laboratory animal is from the table top of the bearing platform that raises is removed, control system can realize the automatic landing of bearing platform or control bearing platform landing.With respect to prior art, experimental data (for example, laboratory animal is from entering water to the time sinking under water) precision that the device of employing the present embodiment obtains is high.
(3) setting of control system, makes experimentation automatization, has greatly improved conventional efficient, and has eliminated hand-timed deviation, and experimental result precision is also increased substantially.
(4) control system of this experimental provision is by controlling rise and the landing of lifting bracket, drive rise and the landing of bearing platform, mechanical realization is simple, accordingly, can be applied to control system with simple circuit connecting mode, therefore, experimental provision of the present invention can be tested with less rated voltage, electric current, not only meets operation and the safety criterion in relevant hyperbar field.And the automatization that also can realize whole experimentation under hyperbaric environment, reached the object of saving manpower and improving experimental precision simultaneously.
(5) experimental provision in the present embodiment also can be applied to atmospheric pressure environment.
It should be noted that, in other embodiment, when animal muscle power limit tolerance experimental provision is applied to normal pressure, animal muscle power limit tolerance experimental provision also comprises heater, and described heater is heater strip.Heater strip and cell wall laminating, and below the water surface.Why reason is set so as follows: (1) can make the temperature of tank keep constant temperature, thereby makes the temperature parameter in experimentation be converted into constant by variable, eliminates the impact of experimental situation temperature influence factor on experimental result.(2) heater is electrical heating wire, takes up room less, is beneficial to the downsizing of whole animal muscle power limit tolerance experimental provision.Wherein, the set point that the temperature of tank is passable is 12 ℃~48 ℃.For example, be specifically as follows the preference temperature (be more than or equal to 39 ℃ and be less than or equal to 43 ℃) of laboratory animal.For example, be specifically as follows the range of temperature (be more than or equal to 11 ℃ and be less than or equal to 29 ℃) on China coast sea.Again for example, can also be specifically 44 ℃~48 ℃ (comprising end points), now, laboratory animal is carried out swimming test under heat-resistant limit.
Experimenter is artificial to be set after a heating-up temperature, described control system also for automatically control described heater unlatching, close and output power value, thereby realize the automatic unlatching of heater, automatically close and input power value automatically.Experimenter can also realize manually opened, the manual-lock of heater and manual output power value.For example, experimenter can be directly by switch manual unlocking of heater etc.
When control system also comprises demonstration and guidance panel, on guidance panel, be provided with the action button group of heater.Heater is by carrying out the transmission of signal and data between unified data-interface and processing unit.Be specially:
Water temperature on display floater is during lower than design temperature, the action button group of the heater on experimenter's open operation panel, to processing unit, send intensification signal, processing unit sends intensification signal to heater, heater receives after intensification signal, automatically open heater, water in tank is heated, when water temperature arrives after design temperature, the action button group of the heater on experimenter's shutoff operation panel, to processing unit, send shutdown signal, processing unit sends shutdown signal to heater, realize automatically closing of heater.
In the present invention, carry out animal muscle power limit tolerance experimental technique as follows:.
Carry out first step: according to experiment batch needs, in compression chamber, experimental site size is assembled the animal muscle power limit tolerance experimental provision 2 of the present embodiment.
Carry out second step: water inlet pipeline is connected with water inlet, water outlet pipeline is connected with outlet.
Carry out third step: in tank, put into laboratory animal, timing button when putting into laboratory animal on start-up operation panel.
Carry out the 4th step: etc. laboratory animal power exhaust and be sink to the table top of bearing platform and reach after time predetermined value, when the table top of bearing platform is raised to higher than the water surface, timing finishes automatically, the laboratory animal that the power of removing exhausts, bearing platform drop to previous status.
It should be noted that, experimental provision of the present invention comprises following two kinds of application: when (1) only puts a laboratory animal in each tank, the laboratory animal of carrying out after overtraining is carried out to physical ability screening experiment, physical ability is crossed or laboratory animal that physical ability is excessively poor is got rid of, thereby reduced the impact on integral experiment result of individual data items that dispersion is larger.
(2) experimental provision of the present invention is finished after described screening experiment, in each tank in experimental provision of the present invention, also can put the overtraining that many animals carry out many animals, and described screening experiment is verified.The result demonstration, the experimental precision of described screening experiment is very high.
Although the present invention discloses as above, the present invention is not defined in this.Any those skilled in the art, without departing from the spirit and scope of the present invention, all can make various changes or modifications, so protection scope of the present invention should be as the criterion with claim limited range.

Claims (10)

1. be applicable to the animal muscle power limit tolerance experimental provision under environment under high pressure, it is characterized in that, comprising:
Tank, comprise bottom land and cell wall, described bottom land is provided with lowering or hoisting gear, described lowering or hoisting gear comprises bearing platform, is connected with described bearing platform and is positioned at the lifting bracket of bearing platform top, described bearing platform table top is provided with sensor, the touched time of sensor is touched and recorded to described sensor for perception, and in the touching time, meet the time and send touching signals during predetermined value;
Control system, after receiving the touching signals that described sensor sends, for promoting described lifting bracket, drives described bearing platform to rise, and, for recording laboratory animal, enter tank and raise and exceed the time of the water surface to described bearing platform table top.
2. device as claimed in claim 1, it is characterized in that, described sensor is multi-disc, described in multi-disc, sensor is matrix arrangement, distance between adjacent two sensors is less than or equal to the first preset distance value, and the distance between nearest string sensor, a line sensor and bearing platform table top border, described bearing platform table top border is less than or equal to second distance predetermined value;
Every described sensor comprises: sensing unit, the first timing unit and signal transmitting and receiving unit;
Described sensing unit is touched for perception, and sends touching signal;
Described the first timing unit, for receiving described touching signal and recording the touched time of sensing unit;
Signal transmitting and receiving unit, receiving the touching during time that meets time predetermined value, sends touching signals.
3. device as claimed in claim 1, is characterized in that, described sensor is a slice, and the border of described sensor and described bearing platform table top border are less than or equal to second distance predetermined value;
Described sensor comprises: sensing unit, computing unit, the first timing unit and signal transmitting and receiving unit;
Described sensing unit is touched for perception, and sends touching signal;
Described computing unit is used for calculating the touched area of described sensor, and when the touched area of sensor meets area predetermined value, sends touching area of signal;
Described the first timing unit, for receiving described touching area of signal and recording the touched time of sensing unit;
Signal transmitting and receiving unit, meets touching time of time predetermined value and touching during area of signal receiving, and sends touching signals.
4. device as claimed in claim 2, is characterized in that, described the first preset distance value is for being more than or equal to 3mm and being less than or equal to 6mm, and described second distance predetermined value is 3mm.
5. device as claimed in claim 1, is characterized in that, described control system comprises:
Driver, is connected with described lifting bracket;
Processing unit, is connected with described actuator electrical, when receiving described touching signals, controls unlatching and the output power value of described driver;
The second timing unit, when receiving experiment enabling signal, starts timing; When receiving experiment end signal, finish timing.
6. device as claimed in claim 1, is characterized in that, the horizontal range between described bearing platform table top border and described bottom land border is more than or equal to 1cm and is less than or equal to 2cm.
7. experimental provision as claimed in claim 1, is characterized in that, described experimental provision is also applicable to atmospheric pressure environment.
8. experimental provision as claimed in claim 1, it is characterized in that, described bearing platform comprises table top, the lower surface relative with described table top, the sidewall that table top is connected with lower surface, the sidewall of described bearing platform is parallel with described cell wall, and the distance between the sidewall of bearing platform and described cell wall is for being more than or equal to 1mm and being less than or equal to 2mm.
9. experimental provision as claimed in claim 8, is characterized in that, the sidewall of described bearing platform is higher than described table top 20~40mm.
10. an animal muscle power limit tolerance experimental technique under environment under high pressure, is characterized in that, comprising:
Animal muscle power limit tolerance as described in claim 1~9 any one experimental provision is provided;
Animal is put into the tank of described device, start the clocking capability of described device simultaneously, start timing;
Described animal is sink to after the bearing platform of described device, and when bearing platform is raised to higher than the water surface, described timing finishes.
CN201410022465.7A 2014-01-17 2014-01-17 Be applicable to the animal muscle power limit tolerance test device under environment under high pressure Expired - Fee Related CN103735319B (en)

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