CN103705732A - Tea oil for medical injection for treating hypertensive heart diseases and production technology thereof - Google Patents
Tea oil for medical injection for treating hypertensive heart diseases and production technology thereof Download PDFInfo
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- CN103705732A CN103705732A CN201410008122.5A CN201410008122A CN103705732A CN 103705732 A CN103705732 A CN 103705732A CN 201410008122 A CN201410008122 A CN 201410008122A CN 103705732 A CN103705732 A CN 103705732A
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Abstract
The invention provides an tea oil for medical injection for treating hypertensive heart diseases and a production technology thereof, relates to the technical field of biological medicines, in particular relates to the tea oil special for people with the hypertensive heart diseases and a processing technology thereof, and aims to provide the tea oil for medical injection, and the tea oil has a targeted medical effect and a high unsaturated fatty acid content and is suitable for the people with the hypertensive heart diseases, and the processing technology thereof. The processing technology comprises the following step: performing comprehensive extraction by taking the tea oil processed by a special method as a basic raw material matched with auxiliary raw materials comprising fleece-flower root, rhizoma polygonati, the root of kudzu vine, the root of red-rooted salvia and lignum dalbergiae odoriferae, thereby filtering a majority of useless and harmful ingredients and realizing the high content of beneficial ingredients in the raw materials such as the unsaturated fatty acid and the like. Thus, the tea oil provided by the invention has the strong pertinence, and is suitable for people with the hypertensive heart diseases.
Description
Technical field
The present invention relates to biological medicine technology field, special-purpose Oleum Camelliae and processing technique thereof that particularly a kind of hypertensive heart disease crowd uses.
Background technology
Oil tea is the distinctive woody oleiferous plants of China, the oil crop that Ye Shi China greatly develops.The comprehensive utilization value of oil tea is very high, contain the bioactive substances such as abundant unsaturated fatty acid, monounsaturated fatty acid, vitamin E, Squalene, tea polyphenols, polyunsaturated fatty acid particularly, medicinal or edible value is very high, there is the brain development of raising and cranial nerve function, strengthen brain cell informational function, promote human brain normal development; Unsaturated fatty acid in Oleum Camelliae (wherein containing essential fatty acid--linoleic acid) content height is its key property, and Oleum Camelliae is day by day extensive in health care and purposes pharmaceutically in recent years.Because Oleum Camelliae can prevent sclerosis of blood vessels after being absorbed by the body, therefore it is good oils and fats for health care, can be used to assisting in treating hypertension and obesity.At present, the Oleum Camelliae product of selling is on the market various, as Camellia oil, refine Oleum Camelliae, cold pressing Oleum Camelliae etc. and be added with mediation Oleum Camelliae of other various edible vegetable oils etc., these oils and fatss are in the course of processing, mostly adopt conventional method, do not remove the material that hypertension heart is harmful, thereby, can not be as hypertension heart patient's special-purpose medicinal tea oil.
Summary of the invention
The object of the present invention is to provide a kind of targeted medical effect, unsaturated fatty acid content is higher, be applicable to hypertensive heart disease crowd with medical injection Oleum Camelliae, and provides its production technology.
The technical solution used in the present invention is: a kind of medical injection Oleum Camelliae for hypertensive heart disease for the treatment of is provided, and is to be prepared from by following raw material by weight percentage:
Radix Polygoni Multiflori 3-7 Rhizoma Polygonati 4.5-10.5 Radix Puerariae 3-9 Radix Salviae Miltiorrhizae 2.5-5 Lignum Dalbergiae Odoriferae 1.5-3.5 Oleum Camelliae 65-85
The technical scheme one of its optimization is to be prepared from by following raw material by weight percentage:
The Radix Polygoni Multiflori 3 Rhizoma Polygonati 6.5 Radix Puerariae 7 Radix Salviae Miltiorrhizae 5 Lignum Dalbergiae Odoriferae 3.5 Oleum Camelliae 75
The technical scheme two of its optimization is to be prepared from by following raw material by weight percentage:
The Radix Polygoni Multiflori 7 Rhizoma Polygonati 10.5 Radix Puerariae 3 Radix Salviae Miltiorrhizae 4.5 Lignum Dalbergiae Odoriferae 1.5 Oleum Camelliae 72.5
The technical scheme three of its optimization is to be prepared from by following raw material by weight percentage:
The Radix Polygoni Multiflori 3 Rhizoma Polygonati 4.5 Radix Puerariae 3 Radix Salviae Miltiorrhizae 2.5 Lignum Dalbergiae Odoriferae 2 Oleum Camelliae 85
The technical scheme four of its optimization is to be prepared from by following raw material by weight percentage:
The Radix Polygoni Multiflori 7 Rhizoma Polygonati 10.5 Radix Puerariae 9 Radix Salviae Miltiorrhizae 5 Lignum Dalbergiae Odoriferae 3.5 Oleum Camelliae 65
the technical scheme five of its optimization is to be prepared from by following raw material by weight percentage:
The Radix Polygoni Multiflori 5 Rhizoma Polygonati 8 Radix Puerariae 6 Radix Salviae Miltiorrhizae 3.5 Lignum Dalbergiae Odoriferae 2.5 Oleum Camelliae 75
In above-mentioned each scheme, its Oleum Camelliae is to be prepared from as follows:
Fig. 1 is shown in technological process
1) crude oil pretreatment:the coarse tea oil of milling process being obtained in oil expression workshop, removes crumb wherein as filtration treatment, makes to be down to below 0.2% and can to enter next procedure through filtration rear impurity;
2) alkali refining:in coarse tea oil, gum level is lower, and acid value is not high yet, according to tea oil properties and purposes, adopts low temperature alkali refining method; Control 25 ℃ of crude oil initial temperature, with quantitative aqueous alkali tank gas force feed, alkali liquor atomizer is sprayed into alkali refining tank, alkali liquor added in 10 minutes; Mixing speed 70r/m left and right during beginning, should continue to stir, and sampling is observed after alkali liquor adds, when occur neat soap cohesion large and with the separated state of oil,, slowly to 30r/m, with indirect steam, heat up simultaneously, it is about 1.5 ℃/min that programming rate is controlled at, and resampling is observed, when neat soap large and solid, and, stop heating up when very fast with separating of oil, be to accelerate neat soap to form speed, on aqueous alkali tank limit, a brine tank is set, add saline, saline is equally with gas force feed, and atomization enters in pot; Then stop stirring, precipitate, the sedimentation time is more than 10 hours; Wherein alkali liquid tank, brine tank are all provided with reading plotter, to facilitate the amount of accurate control alkali liquor, saline;
3) washing:connect one procedure, upper strata oil is drawn onto to water washing pan, stir, oil is warming up to 80 ℃ of left and right, then with the hot water of 85 ℃ of temperature, wash left and right 3 times, controlling water consumption is 10% left and right that oil is heavy, carries out low rate mixing in washing process; Wash and whether qualifiedly adopt pre-configured volumetric solution to do experiment, not show that obvious alkalescence is as the criterion;
4) decolouring:by vacuum, oil is sucked to bleacher, be warming up to 95 ℃ of dehydrations, dewatering time is controlled at 20～30 minutes, reduces below moisture to 0.1%, disappears to steam in tank; Be cooled to 90 ℃ of left and right and add hargil, activated carbon: hargil, activated carbon thing adopt the disposable suction bleacher of vacuum atomizing nozzle; Concrete consumption is depending on product oil requirement; Decolouring, de-benzo (a) pyrene time are controlled at 20 minutes, and vacuum residual voltage is 97～99kPa, are cooled to 80 ℃ of following filtrations;
5) deodorize:bleached oil is sucked to bilayer withstand voltage, inside establish the odor removing pot of heat(ing) coil, first with indirect steam, be warming up to 110 ℃, while being warming up to 150 ℃ with conduction oil again, opening live (open) steam stirs, this live (open) steam is superheated steam, and live (open) steam should first be opened larger, but too severe for well not make oil splash; Continue to heat to 280 ℃ of timing, now arrive separator sampling and observe, sample retains; Timing after 2 hours resampling and original sample make comparisons, as color and luster is talked, when denseness is rare, turn down direct steam valve door, then heating system and live (open) steam are turned off in timing after 2 hours, then carrying out the additional pump power of high-temperature water forces cooling, when oil temperature is down to 70 ℃, in steam pipe, passes into cooling water and make oil continuation cooling, until pot is turned in 25 ℃ of left and right of oil temperature, the vacuum system of deodorize adopts three grades of steam jet pumps or four-stage pump, and vacuum absolute pressure is controlled at 300Pa left and right;
6) freezing (winterization) processed:deodorize Oleum Camelliae is entered to freezing and crystallizing tank with gas force feed, carry out freezing processing, when oil temperature is down to below 3 ℃, stop the circulation of cryogen in chuck, make oil temperature continue to be down to 0 ℃ of left and right, and keep 5.5 hours, then adopt medicinal filter paper to filter; Oleum Camelliae is filtered by polymeric membrane for separation under 0.15-0.3Mpa pressure, and membrane aperture is 10-20 μ m, collects filtrate, obtains Oleum Camelliae, unsaturated fatty acid>=90% that it is contained; Winterization process adopts thermostat, high-quality oil for injection not to allow to take external heat appearances of thawing, and therefore must not occur the too low knot pot phenomenon that causes of Yin Wendu in conventional freezing.
The aqueous alkali using in the 2nd step is the aqueous solution of sodium hydroxide or calcium hydroxide or sodium carbonate or sodium bicarbonate.
The polymeric membrane for separation using in the 6th step is flat diaphragm type segregation apparatus or periosteum formula segregation apparatus or volume membrane type segregation apparatus or hollow fiber film type segregation apparatus.
A kind of production technology of medical injection Oleum Camelliae for treatment hypertensive heart disease of making is also provided, and its technical process is as follows:
1) batching: take respectively according to the above ratio the Radix Polygoni Multiflori, Rhizoma Polygonati, Radix Puerariae, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Oleum Camelliae;
2) lixiviate: above-mentioned raw materials is inserted in resistant to elevated temperatures pot for solvent extraction, extract at 200-300 ℃, the time is 0.5-1.5h, filters, and collects filtrate, becomes extraction Oleum Camelliae;
3) remove impurity: standby extraction Oleum Camelliae is put into pot for solvent extraction, add and account for the neutral active carbon that extracts Oleum Camelliae gross weight 1-10%, fully stir, filter, 3 times repeatedly, collect filtrate, become remove impurity Oleum Camelliae;
4) coarse filtration: standby remove impurity Oleum Camelliae is carried out to coarse filtration, remove active carbon and other impurity particle, collect filtrate, become coarse filtration Oleum Camelliae;
5) membrane filtration: standby coarse filtration Oleum Camelliae is passed through under 0.15-0.20Mpa pressure to reverse osmosis membrane apparatus, membrane aperture is 5～15nm, collects filtrate, must treat the special-purpose Oleum Camelliae of medicine injection for hypertensive heart disease.
The 5th) reverse osmosis membrane using in step is cellulose acetate membrane or aromatic series polyhydrazide film or aromatic polyamide film.
Medical injection Oleum Camelliae for treatment hypertensive heart disease of the present invention, adopt the Oleum Camelliae of processing through specific process as base stock, be equipped with the Radix Polygoni Multiflori, Rhizoma Polygonati, Radix Puerariae, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae auxiliary material, comprehensively extract, elimination most useless composition and oxious component, make the content of the useful compositions such as unsaturated fatty acid wherein high, simultaneously, in the auxiliary material adopting, Radix Polygoni Multiflori chemical composition: containing lecithin, emodin (emodin), chrysophanol (chrysophanol), chrysophanic acid (rhein), physcione (physcion), 2, 3, 5, 4 '-tetrahydroxy is to styrene-2-0-β-D-Glucose glycoside (2'3'5'4 '-tetrahydrox-ystibene-2-0-β-D-glucoside) etc., the effective ingredient with blood fat reducing and anti-cholesterol effect comprises Anthraquinones, hexichol ene compound and lecithin, can expand the coronary artery of heart, blood fat reducing, promote erythrocytic generation, so to coronary heart disease, hyperlipidemia, old anemia, brain degeneration, senilism sign etc., there is preventive effect, Radix Polygoni Multiflori also has decreased heart rate, coronary artery dilating, resist myocardial ischemia.Rhizoma Polygonati chemical composition mainly contains polygonatum polysaccharide, steroidal saponin, anthraquinone analog compound, alkaloid, cardiac glycoside, lignanoid, vitamin and multiple to useful aminoacid of human body etc., there is blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial.Its main component of Radix Puerariae is starch, in addition containing having an appointment 12% flavone compound, comprises that Semen sojae atricolor (Semen Glycines) glycoside, daidzein, puerarin etc. more than 10 plant; And contain daucosterol, aminoacid, Coumarins etc., Radix Puerariae has α receptor and angiotensin-ii-receptor also has blocking effect, can reverse the myocardial hypertrophy of caused by hypertension, puerarin can make very fast the recovery normally of endothelin level (ET) level of obviously increasing, therefore one of mechanism of Treatment of Hypertension with Puerarine is to suppress the excessive release of ET, promote endothelium restore funcitons, and then excited PG12 synthase activity, significantly increase EC and generate PG anticoagulant, play and improve sanguimotor effect, blood glucose can be reduced, serum cholesterol can be obviously reduced; Radix Salviae Miltiorrhizae, containing tanshinone Ⅰ, II A, II B, Isotanshinone I., II A, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxyl TANSHINONES etc., enters the heart, Liver Channel, blood circulation promoting and blood stasis dispelling, and calming heart and tranquilizing mind, invigorates blood circulation, logical percardium; Volatile oil and the Aromatic water thereof of Lignum Dalbergiae Odoriferae have anti thrombotic action, and yellow wingceltis have faint anticoagulation, can significantly increase coronary flow, and decreased heart rate, slightly increases heart beating amplitude, does not cause arrhythmia, has convulsion, analgesic activity.Thereby Oleum Camelliae of the present invention is pointed strong, is applicable to hypertensive heart disease crowd and uses.
Beneficial effect of the present invention has been to provide a kind of oil for medical injection that is exclusively used in hypertensive heart disease crowd treatment.It can improve rapidly patient's resistance against diseases, improves immunocompetence, and patient can be got well as soon as possible;
Description of drawings 1 is process chart of the present invention.
Specific embodiment
Below in conjunction with embodiment, the present invention is described further.
One, prepare the process of special-purpose Oleum Camelliae of the present invention as follows:
Fig. 1 is shown in technological process
1) crude oil pretreatment:the coarse tea oil of milling process being obtained in oil expression workshop, removes crumb wherein as filtration treatment, makes to be down to below 0.2% and can to enter next procedure through filtration rear impurity;
2) alkali refining:in coarse tea oil, gum level is lower, and acid value is not high yet, according to tea oil properties and purposes, adopts low temperature alkali refining method; Control 25 ℃ of crude oil initial temperature, with quantitative aqueous alkali tank gas force feed, alkali liquor atomizer is sprayed into alkali refining tank, alkali liquor added in 10 minutes; Mixing speed 70r/m left and right during beginning, should continue to stir, and sampling is observed after alkali liquor adds, when occur neat soap cohesion large and with the separated state of oil,, slowly to 30r/m, with indirect steam, heat up simultaneously, it is about 1.5 ℃/min that programming rate is controlled at, and resampling is observed, when neat soap large and solid, and, stop heating up when very fast with separating of oil, be to accelerate neat soap to form speed, on aqueous alkali tank limit, a brine tank is set, add saline, saline is equally with gas force feed, and atomization enters in pot; Then stop stirring, precipitate, the sedimentation time is more than 10 hours; Wherein alkali liquid tank, brine tank are all provided with reading plotter, to facilitate the amount of accurate control alkali liquor, saline;
3) washing:connect one procedure, upper strata oil is drawn onto to water washing pan, stir, oil is warming up to 80 ℃ of left and right, then with the hot water of 85 ℃ of temperature, wash left and right 3 times, controlling water consumption is 10% left and right that oil is heavy, carries out low rate mixing in washing process; Wash and whether qualifiedly adopt pre-configured volumetric solution to do experiment, not show that obvious alkalescence is as the criterion;
4) decolouring:by vacuum, oil is sucked to bleacher, be warming up to 95 ℃ of dehydrations, dewatering time is controlled at 20～30 minutes, reduces below moisture to 0.1%, disappears to steam in tank; Be cooled to 90 ℃ of left and right and add hargil: hargil thing adopts the disposable suction bleacher of vacuum atomizing nozzle; Concrete consumption is depending on product oil requirement; Decolouring, de-benzo (a) pyrene time are controlled at 20 minutes, and vacuum residual voltage is 97～99kPa, are cooled to 80 ℃ of following filtrations;
5) deodorize:bleached oil is sucked to the odor removing pot through particular design, first with indirect steam, be warming up to 110 ℃, then open live (open) steam while being warming up to 150 ℃ with conduction oil and stir, this live (open) steam is superheated steam, live (open) steam should first be opened larger, but too severe for well not make oil splash; Continue to heat to 280 ℃ of timing, now arrive separator sampling and observe, sample retains; Timing after 2 hours resampling and original sample make comparisons, as color and luster is talked, when denseness is rare, turn down direct steam valve door, then heating system and live (open) steam are turned off in timing after 2 hours, then carrying out the additional pump power of high-temperature water forces cooling, when oil temperature is down to 70 ℃, in steam pipe, passes into cooling water and make oil continuation cooling, until pot is turned in 25 ℃ of left and right of oil temperature, the vacuum system of deodorize adopts three grades of steam jet pumps or four-stage pump, and vacuum absolute pressure is controlled at 300Pa left and right;
6) freezing (winterization) processed:deodorize Oleum Camelliae is entered to freezing and crystallizing tank with gas force feed, carry out freezing processing, when oil temperature is down to below 3 ℃, stop the circulation of cryogen in chuck, make oil temperature continue to be down to 0 ℃ of left and right, and keep 5.5 hours, then adopt medicinal filter paper to filter; High-quality oil for injection does not allow to take the external heat appearance of thawing, and therefore must not occur the too low knot pot phenomenon that causes of Yin Wendu in conventional freezing.
Two, base stock proportioning and production craft step:
According to following percentage by weight:
The Radix Polygoni Multiflori 3 Rhizoma Polygonati 6.5 Radix Puerariae 7 Radix Salviae Miltiorrhizae 5 Lignum Dalbergiae Odoriferae 3.5 Oleum Camelliae 75
Take respectively: Radix Polygoni Multiflori 30kg Rhizoma Polygonati 65kg Radix Puerariae 70 kg Radix Salviae Miltiorrhizae 50kg Lignum Dalbergiae Odoriferae 35 kg Oleum Camelliae 750kg
(ii), preparation:
1), by above-mentioned, take that standby base stock is pulverized and auxiliary material drops in resistant to elevated temperatures pot for solvent extraction, at 220 ℃, extract, the time is 1h, filters, and collects filtrate, becomes extraction Oleum Camelliae, standby;
2), standby extraction Oleum Camelliae is put into pot for solvent extraction, add the neutral active carbons of 75 kg, fully stir, filter, 3 times repeatedly, collect filtrate, become remove impurity Oleum Camelliae, standby;
3), standby remove impurity Oleum Camelliae is carried out to coarse filtration, remove the impurity particles such as active carbon, collect the Oleum Camelliae after filtering, become coarse filtration Oleum Camelliae, standby;
4), by standby coarse filtration Oleum Camelliae under 0.15Mpa pressure by reverse osmosis membrane apparatus (this example adopt cellulose acetate membrane), membrane aperture is 10nm, collects filtrate, must treat the medical special-purpose Oleum Camelliae 720kg of injection for hypertensive heart disease.
Claims (9)
1. treating a medical injection Oleum Camelliae for hypertensive heart disease, is to be prepared from by following raw material by weight percentage: Radix Polygoni Multiflori 3-7 Rhizoma Polygonati 4.5-10.5 Radix Puerariae 3-9 Radix Salviae Miltiorrhizae 2.5-5 Lignum Dalbergiae Odoriferae 1.5-3.5 Oleum Camelliae 65-85.
2. medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 1, is characterized in that: be to be prepared from by following raw material by weight percentage: the Radix Polygoni Multiflori 3 Rhizoma Polygonati 6.5 Radix Puerariae 7 Radix Salviae Miltiorrhizae 5 Lignum Dalbergiae Odoriferae 3.5 Oleum Camelliae 75.
3. medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 1, is characterized in that: be to be prepared from by following raw material by weight percentage: the Radix Polygoni Multiflori 7 Rhizoma Polygonati 10.5 Radix Puerariae 3 Radix Salviae Miltiorrhizae 4.5 Lignum Dalbergiae Odoriferae 1.5 Oleum Camelliae 72.5.
4. medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 1, is characterized in that: be to be prepared from by following raw material by weight percentage: the Radix Polygoni Multiflori 3 Rhizoma Polygonati 4.5 Radix Puerariae 3 Radix Salviae Miltiorrhizae 2.5 Lignum Dalbergiae Odoriferae 2 Oleum Camelliae 85.
5. medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 1, is characterized in that: be to be prepared from by following raw material by weight percentage: the Radix Polygoni Multiflori 7 Rhizoma Polygonati 10.5 Radix Puerariae 9 Radix Salviae Miltiorrhizae 5 Lignum Dalbergiae Odoriferae 3.5 Oleum Camelliae 65.
6. medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 1, is characterized in that: be to be prepared from by following raw material by weight percentage: the Radix Polygoni Multiflori 5 Rhizoma Polygonati 8 Radix Puerariae 6 Radix Salviae Miltiorrhizae 3.5 Lignum Dalbergiae Odoriferae 2.5 Oleum Camelliae 75.
7. according to medical injection Oleum Camelliae for the treatment hypertensive heart disease one of claim 1-6 Suo Shu, it is characterized in that: wherein Oleum Camelliae is to be prepared from as follows, as shown in Figure of description 1:
1) crude oil pretreatment:the coarse tea oil of milling process being obtained in oil expression workshop, removes crumb wherein as filtration treatment, makes to be down to below 0.2% and can to enter next procedure through filtration rear impurity;
2) alkali refining:in coarse tea oil, gum level is lower, and acid value is not high yet, according to tea oil properties and purposes, adopts low temperature alkali refining method; Control 25 ℃ of crude oil initial temperature, with quantitative aqueous alkali tank gas force feed, alkali liquor atomizer is sprayed into alkali refining tank, alkali liquor added in 10 minutes; Mixing speed 70r/m left and right during beginning, should continue to stir, and sampling is observed after alkali liquor adds, when occur neat soap cohesion large and with the separated state of oil,, slowly to 30r/m, with indirect steam, heat up simultaneously, it is about 1.5 ℃/min that programming rate is controlled at, and resampling is observed, when neat soap large and solid, and, stop heating up when very fast with separating of oil, be to accelerate neat soap to form speed, on aqueous alkali tank limit, a brine tank is set, add saline, saline is equally with gas force feed, and atomization enters in pot; Then stop stirring, precipitate, the sedimentation time is more than 10 hours; Wherein alkali liquid tank, brine tank are all provided with reading plotter, to facilitate the amount of accurate control alkali liquor, saline;
3) washing:connect one procedure, upper strata oil is drawn onto to water washing pan, stir, oil is warming up to 80 ℃ of left and right, then with the hot water of 85 ℃ of temperature, wash left and right 3 times, controlling water consumption is 10% left and right that oil is heavy, carries out low rate mixing in washing process; Wash and whether qualifiedly adopt pre-configured volumetric solution to do experiment, not show that obvious alkalescence is as the criterion;
4) decolouring:by vacuum, oil is sucked to bleacher, be warming up to 95 ℃ of dehydrations, dewatering time is controlled at 20～30 minutes, reduces below moisture to 0.1%, disappears to steam in tank; Be cooled to 90 ℃ of left and right and add hargil, activated carbon: hargil, activated carbon thing adopt the disposable suction bleacher of vacuum atomizing nozzle; Concrete consumption is depending on product oil requirement; Decolouring, de-benzo (a) pyrene time are controlled at 20 minutes, and vacuum residual voltage is 97～99kPa, are cooled to 80 ℃ of following filtrations;
5) deodorize:bleached oil is sucked to bilayer withstand voltage, inside establish the odor removing pot of heat(ing) coil, first with indirect steam, be warming up to 110 ℃, while being warming up to 150 ℃ with conduction oil again, opening live (open) steam stirs, this live (open) steam is superheated steam, and live (open) steam should first be opened larger, but too severe for well not make oil splash; Continue to heat to 280 ℃ of timing, now arrive separator sampling and observe, sample retains; Timing after 2 hours resampling and original sample make comparisons, as color and luster is talked, when denseness is rare, turn down direct steam valve door, then heating system and live (open) steam are turned off in timing after 2 hours, then carrying out the additional pump power of high-temperature water forces cooling, when oil temperature is down to 70 ℃, in steam pipe, passes into cooling water and make oil continuation cooling, until pot is turned in 25 ℃ of left and right of oil temperature, the vacuum system of deodorize adopts three grades of steam jet pumps or four-stage pump, and vacuum absolute pressure is controlled at 300Pa left and right;
6) freezing (winterization) processed:deodorize Oleum Camelliae is entered to freezing and crystallizing tank with gas force feed, carry out freezing processing, when oil temperature is down to below 3 ℃, stop the circulation of cryogen in chuck, make oil temperature continue to be down to 0 ℃ of left and right, and keep 5.5 hours, then adopt medicinal filter paper to filter; Oleum Camelliae is filtered by polymeric membrane for separation under 0.15-0.3Mpa pressure, and membrane aperture is 10-20 μ m, collects filtrate, obtains Oleum Camelliae, unsaturated fatty acid>=90% that it is contained; Winterization process adopts thermostat, high-quality oil for injection not to allow to take external heat appearances of thawing, and therefore must not occur the too low knot pot phenomenon that causes of Yin Wendu in conventional freezing;
The aqueous alkali using in the 2nd step is the aqueous solution of sodium hydroxide or calcium hydroxide or sodium carbonate or sodium bicarbonate;
The polymeric membrane for separation using in the 6th step is flat diaphragm type segregation apparatus or periosteum formula segregation apparatus or volume membrane type segregation apparatus or hollow fiber film type segregation apparatus.
8. the processing technique with medical injection Oleum Camelliae according to the treatment hypertensive heart disease one of claim 1-6 Suo Shu, is characterized in that: its technical process is as follows:
1) batching: take respectively according to the above ratio the Radix Polygoni Multiflori, Rhizoma Polygonati, Radix Puerariae, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Oleum Camelliae;
2) lixiviate: above-mentioned raw materials is pulverized and inserted in resistant to elevated temperatures pot for solvent extraction except Oleum Camelliae, extract at 200-300 ℃, the time is 0.5-1.5h, filters, and collects filtrate, becomes extraction Oleum Camelliae;
3) remove impurity: standby extraction Oleum Camelliae is put into pot for solvent extraction, add and account for the neutral active carbon that extracts Oleum Camelliae gross weight 1-10%, fully stir, filter, 3 times repeatedly, collect filtrate, become remove impurity Oleum Camelliae;
4) coarse filtration: standby remove impurity Oleum Camelliae is carried out to coarse filtration, remove active carbon and other impurity particle, collect filtrate, become coarse filtration Oleum Camelliae;
5) membrane filtration: standby coarse filtration Oleum Camelliae is passed through under 0.15-0.20Mpa pressure to reverse osmosis membrane apparatus, membrane aperture is 5～15nm, collects filtrate, must treat the special-purpose Oleum Camelliae of medicine injection for hypertensive heart disease.
9. the processing technique of medical injection Oleum Camelliae for treatment hypertensive heart disease according to claim 8, is characterized in that: the reverse osmosis membrane the 5th) using in step is cellulose acetate membrane or aromatic series polyhydrazide film or aromatic polyamide film.
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| CN104312719A (en) * | 2014-09-30 | 2015-01-28 | 江西绿杉油脂有限公司 | Production technique of tea oil |
| CN105567420A (en) * | 2015-12-24 | 2016-05-11 | 福建优创油脂有限公司 | Preparation method of health care tea oil |
| CN107022412A (en) * | 2017-06-02 | 2017-08-08 | 安徽山美生物科技有限公司 | A kind of discoloration method of medical material level camellia seed oil |
| CN109233996A (en) * | 2017-07-11 | 2019-01-18 | 江西兴国嘉香乐食品有限公司 | A kind of production technology of herb mixtures tea oil |
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| CN104312719A (en) * | 2014-09-30 | 2015-01-28 | 江西绿杉油脂有限公司 | Production technique of tea oil |
| CN105567420A (en) * | 2015-12-24 | 2016-05-11 | 福建优创油脂有限公司 | Preparation method of health care tea oil |
| CN107022412A (en) * | 2017-06-02 | 2017-08-08 | 安徽山美生物科技有限公司 | A kind of discoloration method of medical material level camellia seed oil |
| CN109233996A (en) * | 2017-07-11 | 2019-01-18 | 江西兴国嘉香乐食品有限公司 | A kind of production technology of herb mixtures tea oil |
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