CN103705467B - A kind of Toltrazuril alkali metal salt soluble powder and preparation method thereof - Google Patents
A kind of Toltrazuril alkali metal salt soluble powder and preparation method thereof Download PDFInfo
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- CN103705467B CN103705467B CN201310698502.1A CN201310698502A CN103705467B CN 103705467 B CN103705467 B CN 103705467B CN 201310698502 A CN201310698502 A CN 201310698502A CN 103705467 B CN103705467 B CN 103705467B
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Abstract
The invention discloses a kind of Toltrazuril alkali metal salt soluble powder and preparation method thereof, the component of this soluble powder comprises toltrazuril alkali metal salt, the anticaking agents of 0.1% ~ 3% and the water-soluble diluent of 47% ~ 97.4% that mass percent is 2.5% ~ 50%.The preparation method of this soluble powder is: take toltrazuril alkali metal salt, anticaking agents and water-soluble diluent according to the component proportion of Toltrazuril alkali metal salt soluble powder, by got each component mixing, mix homogeneously, namely obtains Toltrazuril alkali metal salt soluble powder.This soluble powder with toltrazuril alkali metal salt for main component, soluble in water, stability is strong, draw moist weak, be used for the treatment of and prevent the coccidiosis of chicken, evident in efficacy and convenient drug administration, and dosage can be controlled exactly according to the state of an illness weight of animal, can not only prevention and therapy animal's coccidiosis quickly and accurately, and the waste of administration process Chinese medicine can be avoided.The method preparing this soluble powder is simple, and cost is low.
Description
Technical field
The present invention relates to a kind of Toltrazuril alkali metal salt soluble powder and preparation method thereof, belong to veterinary drug field.
Background technology
Chicken coccidiosis is the chicken parasitic disease caused by Eimeria, mostly breaks out in growing animal, and mortality rate, up to 30%, is endanger maximum a kind of parasitic disease to poultry husbandry at present.There is no cross immunity between each worm kind of eimeria tenella, be easy to break out the coccidiosis caused by different worm kind.
The main infection carrying out prevention and therapy Eimeria species with toltrazuril crude drug at present.Toltrazuril is referred to as methyl triazon, and toltrazuril is very extensive to the site of action of coccidiosis, has good spectrum Anti-human globulin test.But toltrazuril is insoluble in water, usually with the administration of pre-mixing agent spice, due to the particularity of the custom of searching for food of chicken, spice administering mode is not only inconvenient, and more difficultly mixes with feedstuff, causes dosage inaccurate, also can cause medicine serious waste.Moreover, toltrazuril crude drug also existence and stability difference and draw moist strong problem, toltrazuril crude drug was easily lost efficacy in a short period of time, is unfavorable for the production of toltrazuril crude drug, transport and use.
Summary of the invention
The invention provides a kind of Toltrazuril alkali metal salt soluble powder and preparation method thereof, this soluble powder with toltrazuril alkali metal salt for main component, soluble in water, stability is strong, draws moist weak, is used for the treatment of and prevents the coccidiosis of chicken, evident in efficacy and convenient drug administration, and dosage can be controlled exactly according to the state of an illness weight of chicken, can not only prevention and therapy chicken coccidiosis quickly and accurately, and the waste of administration process Chinese medicine can be avoided.The method preparing this soluble powder is simple, and cost is low.
Realizing the technical scheme that the object of the invention takes is:
A kind of Toltrazuril alkali metal salt soluble powder, the component of this soluble powder comprises toltrazuril alkali metal salt, the anticaking agents of 0.1% ~ 3% and the water-soluble diluent of 47% ~ 97.4% that mass percent is 2.5% ~ 50%.
Described toltrazuril alkali metal salt is toltrazuril potassium salt or toltrazuril sodium salt.
Described anticaking agents is anhydrous calcium chloride, ammonium chloride, hydrogenated-tallow group primary amine and primary octadecylamine one wherein.
Described water-soluble diluent is lactose, sucrose, glucose, mannitol and sorbitol one wherein.
Present invention also offers the preparation method of this Toltrazuril alkali metal salt soluble powder, comprise the steps:
1) toltrazuril alkali metal salt, anticaking agents and water-soluble diluent is taken according to the component proportion of Toltrazuril alkali metal salt soluble powder;
2) by got each component mixing, mix homogeneously, namely obtains Toltrazuril alkali metal salt soluble powder.
Beneficial effect of the present invention and advantage are:
Toltrazuril alkali metal salt water solublity in Toltrazuril alkali metal salt soluble powder provided by the invention is fabulous, and stability is high, and has efficient anti-animal's coccidiosis curative effect.Therefore, soluble in water with the Toltrazuril alkali metal salt soluble powder that toltrazuril alkali metal salt is main component, stability is high, can be used for the treatment of and prevent the coccidiosis of chicken, evident in efficacy.And this soluble powder draws moist weak, untoward reaction is little.On the one hand, this soluble powder solves moist strong, the poor stability of toltrazuril raw material guiding drug and problem not soluble in water, this soluble powder is made in the processes such as production, transport, use, to keep stable curative effect and good dissolubility on the other hand, this soluble powder convenient drug administration, and dosage can be controlled exactly according to the state of an illness weight of chicken, can not only fast, prevention and therapy chicken coccidiosis easily and accurately, and the waste of administration process Chinese medicine can be avoided.
The invention provides the preparation method of Toltrazuril alkali metal salt soluble powder, the method technical process is very simple, only need, by toltrazuril alkali metal salt, anti-caking agent and water-soluble diluent mix homogeneously, can Toltrazuril alkali metal salt soluble powder be obtained.The method takes full advantage of toltrazuril alkali metal salt feature soluble in water, the amount of the water-soluble diluent added, and water-soluble diluent, in alkalescence, does not need to add pH adjusting agent separately, can improve the therapeutic effect of toltrazuril alkali metal salt soluble powder.Adopt common apparatus in the method preparation process, raw material is easy to get, and the raw material adopted is solid, produces in preparation process without waste water, waste gas and solid waste.Therefore, the method is simple, economic environmental protection, is applicable to industrialization large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
1) take according to the component proportion of toltrazuril potassium salt soluble powder toltrazuril potassium salt, the anhydrous calcium chloride of 0.1% and the lactose of 97.4% that mass percent is 2.5%;
2) got each component is joined in mixer, mix homogeneously, obtain toltrazuril potassium salt soluble powder.
Embodiment 2
1) take according to the component proportion of toltrazuril potassium salt soluble powder toltrazuril potassium salt, the ammonium chloride of 3% and the sucrose of 47% that mass percent is 50%;
2) got each component is joined in mixer, mix homogeneously, obtain toltrazuril potassium salt soluble powder.
Toltrazuril potassium salt soluble powder stability test
According to the requirement of " veterinary drug stability test technical specification ", under accelerated stability test condition, the stability of toltrazuril potassium salt soluble powder prepared by testing example 2.
Test method: toltrazuril potassium salt soluble powder embodiment 2 prepared is placed in SHH-250SD testing chamber for medicine stability (immortality experimental apparatus factory of Chongqing City), place 6 months under the condition of temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5%, respectively sampling in 0,1,2,3,6 month once, investigate by stability high spot reviews project, investigate appearance character, content, dissolubility and moisture, and record investigation situation.
Result of the test is as shown in the table:
| Time (moon) | Appearance character | Dissolubility | Moisture (%) | Labelled amount (%) |
| 0 | Off-white powder | Conform with the regulations | 2.36 | 99.93 |
| 1 | Off-white powder | Conform with the regulations | 2.35 | 100.22 |
| 2 | Off-white powder | Conform with the regulations | 2.33 | 98.96 |
| 3 | Off-white powder | Conform with the regulations | 2.29 | 99.45 |
| 6 | Off-white powder | Conform with the regulations | 2.40 | 101.03 |
As seen from the above table, toltrazuril potassium salt soluble powder prepared by embodiment 2 is within the accelerated stability test phase, and character does not all change, and dissolubility conforms with the regulations, and loss on drying, content do not have significant change, and indices meets the requirements.
Stability test result shows: toltrazuril potassium salt soluble powder provided by the invention has good stability.
Embodiment 3
1) according to the component proportion of toltrazuril sodium salt soluble powder take mass percent be the toltrazuril sodium salt of 30%, the hydrogenated-tallow group primary amine of 1% and 69% glucose;
2) got each component is joined in mixer, mix homogeneously, obtain toltrazuril sodium salt soluble powder.
Embodiment 4
1) take according to the component proportion of toltrazuril sodium salt soluble powder toltrazuril sodium salt, the primary octadecylamine of 2% and the mannitol of 58% that mass percent is 40%;
2) got each component is joined in mixer, mix homogeneously, obtain toltrazuril sodium salt soluble powder.
Embodiment 5
1) take according to the component proportion of toltrazuril sodium salt soluble powder toltrazuril sodium salt, the ammonium chloride of 2% and the sorbitol of 78% that mass percent is 20%;
2) got each component is joined in mixer, mix homogeneously, obtain toltrazuril sodium salt soluble powder.
Toltrazuril sodium salt soluble powder stability test
According to the requirement of " veterinary drug stability test technical specification ", under accelerated stability test condition, the stability of toltrazuril sodium salt soluble powder prepared by testing example 5.
Test method: toltrazuril sodium salt soluble powder embodiment 5 prepared is placed in SHH-250SD testing chamber for medicine stability (immortality experimental apparatus factory of Chongqing City), place 6 months under the condition of temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5%, respectively sampling in 0,1,2,3,6 month once, investigate by stability high spot reviews project, investigate appearance character, content, dissolubility and moisture, and record investigation situation.
Result of the test is as shown in the table:
| Time (moon) | Appearance character | Dissolubility | Moisture (%) | Labelled amount (%) |
| 0 | Off-white powder | Conform with the regulations | 2.15 | 99.28 |
| 1 | Off-white powder | Conform with the regulations | 2.24 | 100.01 |
| 2 | Off-white powder | Conform with the regulations | 2.37 | 98.86 |
| 3 | Off-white powder | Conform with the regulations | 2.35 | 99.76 |
| 6 | Off-white powder | Conform with the regulations | 2.44 | 101.10 |
As seen from the above table, toltrazuril sodium salt soluble powder prepared by embodiment 5 is within the accelerated stability test phase, and character does not all change, and dissolubility conforms with the regulations, and loss on drying, content do not have significant change, and indices meets the requirements.
Stability test result shows: toltrazuril sodium salt soluble powder provided by the invention has good stability.
Claims (2)
1. a Toltrazuril alkali metal salt soluble powder, is characterized in that: toltrazuril alkali metal salt, the anticaking agents of 0.1% ~ 3% and the water-soluble diluent of 47% ~ 97.4% that the component of this soluble powder is 2.5% ~ 50% by mass percent form;
Described toltrazuril alkali metal salt is toltrazuril potassium salt or toltrazuril sodium salt;
Described anticaking agents is ammonium chloride;
Described water-soluble diluent is sucrose or sorbitol.
2. a preparation method for Toltrazuril alkali metal salt soluble powder according to claim 1, is characterized in that comprising the steps:
1) toltrazuril alkali metal salt, anticaking agents and water-soluble diluent is taken according to the component proportion of claim 1;
2) by got each component mix homogeneously, namely Toltrazuril alkali metal salt soluble powder is obtained.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331561A (en) * | 1998-10-08 | 2002-01-16 | 高新研究公司 | Novel compsns. and methods for prevention and treatment of protozoal disease |
| CN103142487A (en) * | 2013-03-22 | 2013-06-12 | 黑龙江大学 | High-content toltrazuril soluble powder, as well as preparation method and application thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331561A (en) * | 1998-10-08 | 2002-01-16 | 高新研究公司 | Novel compsns. and methods for prevention and treatment of protozoal disease |
| CN103142487A (en) * | 2013-03-22 | 2013-06-12 | 黑龙江大学 | High-content toltrazuril soluble powder, as well as preparation method and application thereof |
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Address after: Five, 435402 Li Cun, Long Ping Town, Huanggang City, Hubei, Wuxue Patentee after: Hubei Longxiang Pharmaceutical Tech. Co., Ltd. Address before: 435402 Wuxue City, Hubei Province, Liuzhou City, Ping Li in the five Lane Patentee before: Hubei Longxiang Pharmaceutical Co., Ltd. |