CN103691064B - The positioner of dynamic tumor target area and method thereof in radiotherapy - Google Patents
The positioner of dynamic tumor target area and method thereof in radiotherapy Download PDFInfo
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Abstract
The invention belongs to the device in radiotherapy, particularly relate to positioner and the method for thorax abdomen motion tumor target with patient respiratory.The positioner of dynamic tumor target area in a kind of radiotherapy, it is mainly characterized by: be provided with biside plate parallel to each other on base plate, left and right side plate is respectively equipped with a limit parallel with base plate, another limit and base plate are the groove of 45 degree of angles, in left plate groove, it is inlaid with left plate copper wire, in right plate groove, is inlaid with right plate copper wire.It is an advantage of the invention that positioner of the present invention, at the external additional a set of three-dimensional system of coordinate of patient, makes the scanning of CT simulator locating, treatment plan design and treatment pendulum position all carry out in the same coordinate system, therefore can ensure that the enforcement being accurately positioned with precise radiotherapy.
Description
Technical field
The invention belongs to the device in radiotherapy, particularly relate to determining of thorax abdomen motion tumor target with patient respiratory
Position device and method.
Background technology
On the impact of thorax abdomen internal organs CT scan and thorax abdomen internal organs are reflected at any time for eliminating or reducing respiratory movement artifact
Between change rule, reach the purpose of Accurate Diagnosis and treatment, it is necessary to time factor is included in the Three-dimensional Gravity of CT scan image
In building, form dynamic four-dimensional CT image.All CT images are grouped and three-dimensional reconstruction respectively by four-dimensional CT by breathing phases,
The 3-D view of each phase place constitutes a time dependent three-dimensional image sequence.Four-dimensional treatment planning systems (TPS) according to
The information that the three-dimensional CT image sequence of time change provides carries out four-dimensional Target delineations, adjusts irradiation field and arranges and implement four-dimensional agent
Amount optimizes and Rapid Dose Calculation, thus designs the treatment plan of optimization and generate that enforcement is radiocurable has related parameter, including target
The space coordinates of district center, the incident angle of launched field, shapes and sizes etc..That this treatment plan is accurately implemented it is crucial that can
Center, target area is accurately positioned in the grade of therapy apparatus in the heart.Owing to lacking the most corresponding closing between CT image and patient body-surface
System, center, target area tends not to directly obtain, thus patient's position fixing process contains the composition of a lot of experience and conjecture, thing
In the middle of implementing, being accurately positioned and treating required by four-dimensional TPS it is unable to reach in reality.Thus the four-dimensional each sequence of CT hits position
The measurement putting relativeness is key one ring in Four dimensional radiotherapy, the most accurately determines the position of different breathing phases downrange
It is set to the key for problem.
As the basic demand of CT simulator locating is simulated with two-direction X-ray, first by patient by the body of requirement during radiotherapy
Position carries out putting position and Postural immobilization, by swashing above the laser lamp cross hairs of CT simulated positioner both sides and CT simulated positioner
Light modulation cross hairs is arranged on reference fixation mark point (usually lead point) readily identified on CT image at patient body-surface, according to controlling
Patient's corresponding site is scanned by the requirement for the treatment of plan, then by CT faultage image drawing target outline profile and target area peripheral organs
Profile.The tumor target that thorax abdomen is moved with patient respiratory, the mode put outside general employing launched field, it is ensured that tumor target
It is included in launched field.Utilize the position that CT center, simulated positioner computed in software target area and three labelling points of patient body-surface determine
Side-play amount between putting (Δ x, Δ y, Δ z), reset on CT bed by patient by original body position, according to this side-play amount (Δ x, Δ y,
Δ z) parameter request moves laser lamp, and then about patient body-surface and top does three labellings again, level marks point line with
The target area central point that the intersection point of body surface overlay mark point vertical line just determines that.Can be seen that and implementing accurate Four dimensional radiotherapy
When, owing to target area is kept in motion, and body surface motion and internal target area are moved asynchronous, therefore cannot pass through side-play amount
(Δ x, Δ y, Δ z) accurately find the center of target area.So, traditional CT simulator locating method is when being applied to motion tumor
There is serious deviation during Target localization, reduce treatment precision.
Summary of the invention
It is an object of the invention to, for avoiding the deficiencies in the prior art, it is provided that dynamic tumor target area in a kind of radiotherapy
Positioner.
A further object of the present invention provides the using method of the positioner of dynamic tumor target area in a kind of radiotherapy.
With solve traditional CT simulator locating method determine exist on motion tumor target position bigger uncertainty and
Systematic error.This device, at the external additional a set of three-dimensional system of coordinate of patient, makes the scanning of CT simulator locating, treatment plan design and controls
Treat pendulum position all to carry out in the same coordinate system, therefore can ensure that the enforcement being accurately positioned with precise radiotherapy.
For achieving the above object, the technical scheme that the present invention takes is: in a kind of radiotherapy, dynamic tumor target area determines
Position device, it is mainly characterized by: be provided with biside plate parallel to each other on base plate, is respectively equipped with one on left and right side plate
Limit is parallel with base plate, and another limit and base plate are the groove of 45 degree of angles, are inlaid with left plate copper wire in left plate groove,
Right plate copper wire it is inlaid with in right plate groove.
The positioner of dynamic tumor target area in described radiotherapy, described brass wire diameter is 0.2～0.5mm.
The positioner of dynamic tumor target area in described radiotherapy, is respectively equipped with identical quarter on base plate and biside plate
The scale of degree.
The positioner of dynamic tumor target area in described radiotherapy, is provided with screw rod, biside plate and nut on base plate
It is connected, screw rod and nut screw connection, it is provided with screw rod turning handle in one end of screw rod.
The positioner of dynamic tumor target area in described radiotherapy, the material of base plate, biside plate, nut and screw rod is
Lucite
The using method of the positioner of dynamic tumor target area in described radiotherapy, it is mainly characterized by step
For:
(1) positioner being located at CT scan bed, adjustment positioner is in horizontal position, and its longitudinal axis hangs down with CT scan tomography
Directly, patient lies supine or prostrate, both hands upwards intersect, and lie or crouch on stereoscopic localized base plate；
(2) CT scan: patient lie (or sleeping) on stereoscopic localized base plate, and fix with body mould, between regulation biside plate
Distance, is fixed on patient's abdominal part by pressure transducer fixing band, utilizes a pressure transducer detection patient when image acquisition
Breath signal, this signal amplified CT simulated positioner of passing to, synchronous acquisition CT image and breath signal, allow collecting
Every layer of CT image all " irons " temporal information (i.e. phase place) residing in the breathing cycle, then schemes all CT respectively by phase place
As re-starting packet and three-dimensional reconstruction, the 3-D view of each phase place constitutes a time dependent three-dimensional image sequence, will
This image sequence is input to TPS work station；
(3) four-dimensional location: sketch out tumor target profile on each three-dimensional image sequence respectively, form a position at any time
Between change dynamic target area, then determine that the center, each phase place target area coordinate figure relative to external three-dimensional system of coordinate；
(4) treatment pendulum position: Postural reduction when patient press CT simulator locating in therapeutic room, lie (or crouching) is in stereoscopic localized
On base plate, fix body mould, the position at biside plate place during reset CT scan, move under therapeutic room's location laser lamp instruction and control
Treat bed, make both sides laser lamp accurately indicate the target area centre coordinate value that required breathing phases is corresponding with top lasers lamp,
I.e. the center, target area of this breathing phases coordinate figure in external three-dimensional system of coordinate, is thus accurately placed in treatment by center, target area
The center positions such as machine, treatment pendulum position completes, and next can implement irradiation treatment by the requirement of breathing phases.
Beneficial effects of the present invention has following 4 points: (1) positioner of the present invention is at the external additional a set of three-dimensional seat of patient
Mark system, makes the scanning of CT simulator locating, treatment plan design and treatment pendulum position all carry out in the same coordinate system, therefore can ensure that accurately
Location and the enforcement of precise radiotherapy；(2) the present invention overcomes with body surface marking location motion tumor bring serious
Deviation, can be accurately positioned the three-dimensional coordinate of tumor target under different breathing phases, makes laser lamp accurately to refer to when treatment pendulum position
Show on the pinwheel coordinate that required breathing phases is corresponding；(3) need not place with reference to fixation mark point at patient body-surface,
Also without calculating the reference marker point position offset to center, target area, (Δ x, Δ y, Δ z), because for motion tumor target
District cannot pass through side-play amount, and (Δ x, Δ y, Δ z) find center, target area accurately；(4) present invention can conceivably be used to put
Position checking, if the three-dimensional locating frame longitudinal axis is not orthogonal to CT scan cross section, then on biside plate, the distance between coordinate labelling is just
Can be inconsistent, can be calculated by distance L between difference Δ l and the biside plate of labelling point distance on biside plate on CT image
To the angle, θ=arctg (Δ l/L) of set-up deviation, therefore ensure that positioning precision.
Accompanying drawing illustrates:
Fig. 1 is the perspective view of the present invention；
1. left plate in figure, 2. base plate, 3. right plate, the 4. groove of left plate, the 5. groove of right plate, 6. left plate copper
Silk, 7. right plate copper wire, 8. front screw, 9. after screw rod, 10. front hand grip, 11. back handles, 12. left plate scales, 13. right plates
Scale, the 14. left scales of base plate, scale before 15. base plates, the 16. right scales of base plate, front nut on the left of in the of 17., front nut on the right side of in the of 18., 19
Left side back nut, back nut on the right side of in the of 20.
Fig. 2 (a) is the schematic front view of Fig. 1；
Fig. 2 (b) is the left view schematic diagram of Fig. 1；
Wherein 1: along CT scan direction, CT faultage image there will be copper wire labelling point, by tolerance center, target area institute
On tomography, distance | PjSj | between two labelling points can be obtained by the center, target area z coordinate in external coordinate system, and 2:
Center, target area is can be obtained by by distance | CX |, | the CY | at tolerance center, target area to labelling point (Pj, Sj), (Sj, Sj) line
X and y coordinates in external coordinate system.
Fig. 3 motion target body is the coordinate position in external 3 D positioning equipment three-dimensional system of coordinate when 0% air-breathing phase place；
Fig. 4 motion target body is the coordinate position in external 3 D positioning equipment three-dimensional system of coordinate when 20% air-breathing phase place；
Fig. 5 motion target body is the coordinate position in external 3 D positioning equipment three-dimensional system of coordinate when 50% air-breathing phase place；
Fig. 6 motion target body is the coordinate position in external 3 D positioning equipment three-dimensional system of coordinate when 80% air-breathing phase place；
Fig. 7 motion target body is the coordinate position in external 3 D positioning equipment three-dimensional system of coordinate when 100% air-breathing phase place.
Detailed description of the invention
It is described in further detail below in conjunction with the preferred example shown in accompanying drawing:
Embodiment 1: see Fig. 1, the positioner of dynamic tumor target area in a kind of radiotherapy, it is provided with on a base plate 2 mutually
Parallel biside plate 1,3, is respectively equipped with a limit parallel with base plate 2 on left plate 1, right plate 3, another limit and base plate 2
Groove 4,5 in 45 degree of angles, is inlaid with left plate copper wire 6 in left plate groove 4, is inlaid with the right side in right plate groove 5
Side plate copper wire 7.In an experiment angle must 45 °, such guarantee location z coordinate, simultaneously experiment prove use copper wire ratio
Galvanized wire to be got well, and artifact is little.
Described brass wire diameter is 0.2～0.5mm.
Described base plate 2 and left plate 1, right plate 3 are respectively equipped with the scale of identical scale, left plate 1 sets
There is left plate scale 12, right plate 3 is provided with right plate scale 13, mark before being provided with base plate left scale 14. base plate on a base plate 2
The right scale of chi 15. base plate 16.
The positioner of dynamic tumor target area in described radiotherapy, is provided with front screw 8, rear screw rod 9 on a base plate 2,
Left plate 1 is connected with left side front nut 17, left side back nut 19, and right plate 3 is with right side front nut 18, right side back nut 20 admittedly
Even, front screw 8 coordinates with left side front nut 17, right side front nut 18, rear screw rod 9 and left side back nut 19, right side back nut 20
Coordinate, be provided with screw rod in one end of front screw 8, rear screw rod 9 and rotate front hand grip 10, back handle 11.
Described base plate 2, left plate 1, right plate 3, left side front nut 17, right side front nut 18, left side back nut 19, right
The material of rear flank nut 20 and front screw 8, rear screw rod 9 is lucite.
3 D positioning equipment of the present invention is to be attached to the lucite frame with three-dimensional coordinate mark that patient is external
Shelf structure, is made up of base plate, side plate and lead screw, two lucites being positioned on base plate according to the different rotary that patient's body is wide
Lead screw regulates the distance between biside plate, keeps biside plate parallel, its biside plate is all carved with width be 1mm be 45 degree of angles
Two grooves of distribution, and it is embedded on CT the two copper wire marks in 45 degree of angles that can image in a groove, wherein
Copper wire is parallel with base plate, the summit alignment that on biside plate, copper wire determines.For reducing copper wire produced artifact in scanning process,
Its diameter should be in the range of 0.2～0.5mm.This construction features makes copper wire labelling point have coordinate direct-reading on CT faultage image
Property, thus in can determine that sweep limits, any point is relative to the space coordinates of external coordinate system.X is had on this positioning framework,
The scale of y, z three-dimensional, for treatment pendulum position, is shown in Fig. 1.
Embodiment 2: the using method of the positioner of dynamic tumor target area in described radiotherapy, its main feature exists
In step it is:
(1) positioner being located at CT scan bed, adjustment positioner is in horizontal position, and its longitudinal axis hangs down with CT scan tomography
Directly, patient lies supine or prostrate, both hands upwards intersect, and lie or crouch on stereoscopic localized base plate；
(2) CT scan: patient lie (or sleeping) on stereoscopic localized base plate, and fix with body mould, between regulation biside plate
Distance, is fixed on patient's abdominal part by pressure transducer fixing band, utilizes a pressure transducer detection patient when image acquisition
Breath signal, this signal amplified CT simulated positioner of passing to, synchronous acquisition CT image and breath signal, allow collecting
Every layer of CT image all " irons " temporal information (i.e. phase place) residing in the breathing cycle, then schemes all CT respectively by phase place
As re-starting packet and three-dimensional reconstruction, the 3-D view of each phase place constitutes a time dependent three-dimensional image sequence, will
This image sequence is input to TPS work station；
(3) four-dimensional location: sketch out tumor target profile on each three-dimensional image sequence respectively, form a position at any time
Between change dynamic target area, then determine that the center, each phase place target area coordinate figure relative to external three-dimensional system of coordinate；
(4) treatment pendulum position: Postural reduction when patient press CT simulator locating in therapeutic room, lie (or crouching) is in stereoscopic localized
On base plate, fix body mould, the position at biside plate place during reset CT scan, move under therapeutic room's location laser lamp instruction and control
Treat bed, make both sides laser lamp accurately indicate the target area centre coordinate value that required breathing phases is corresponding with top lasers lamp,
I.e. the center, target area of this breathing phases coordinate figure in external three-dimensional system of coordinate, is thus accurately placed in treatment by center, target area
The center positions such as machine, treatment pendulum position completes, and next can implement irradiation treatment by the requirement of breathing phases.
During use:
1 Postural immobilization: patient lies supine's (or prostrate), both hands upwards intersect, lie (or sleeping) on three-dimensional locating frame base plate,
Making body mould (each patient makes an individual mould) with thermoplastic, the support of these body mould both sides can be square by plastic bolt
Just it is fixed on positioning framework base plate, reaches good fixed effect.
2CT scans: patient lie (or sleeping) fix on three-dimensional locating frame base plate and with body mould, adjust three-dimensional locating frame
In horizontal position, its longitudinal axis is vertical with CT scan tomography, the distance between regulation biside plate, is fixed on by pressure transducer fixing band
Patient's abdominal part, utilizes the breath signal of a pressure transducer detection patient when image acquisition, and this signal is amplified to be passed to
CT simulated positioner, synchronous acquisition CT image and breath signal, allow the every layer of CT image collected all " iron " in the breathing cycle
Then all CT images are re-started packet and three-dimensional reconstruction respectively, respectively by the temporal information (i.e. phase place) residing in by phase place
The 3-D view of phase place constitutes a time dependent three-dimensional image sequence, and this image sequence is input to TPS work station.
3 four-dimensional location: sketch out tumor target profile on each three-dimensional image sequence respectively, be formed for a position at any time
Between change dynamic target area, then determine that the center, each phase place target area coordinate figure relative to external three-dimensional system of coordinate.
Specific practice is: can clearly show this center, target area and external coordinate system mark on CT image on the tomography of center, target area
Position, be can be obtained by target by copper wire distance between two labelling points of imaging in this aspect on tolerance side plate
Heart z coordinate in external coordinate system, center, target area is exactly x coordinate to the distance of the two labelling point line, pinwheel to two
The distance of the line being parallel to base plate copper wire imaging labelling point on side plate is exactly y-coordinate.See that Fig. 2 (b), CT are along stereoscopic localized frame
Frame y direction scans, and target area is centrally located at jth CT scan tomography, can present two copper wire labellings on this tomography CT image
Point (Pj, Sj), due to ∠ PjOSj=45 °, therefore | PjSj |=| OSj |, say, that by two labellings point (Pj, Sj) of tolerance
Between distance can be obtained by the center, target area z coordinate in external coordinate system.See Fig. 2 (a), by center, target area (C point) to
CT image epipleural copper wire labelling point (Pj, Sj), (Sj, Sj) does vertical line, and intersection point is respectively X, Y, by tolerance C point to X, Y point
Distance | CX |, | CY | can be obtained by the center, target area x and y coordinates in external coordinate system.So can obtain each phase place
The spatial value at center, target area, this coordinate figure accurately puts position by be used for patient.
4 treatment pendulum positions: Postural reduction when patient press CT simulator locating in therapeutic room, lie (or crouching) is in stereoscopic localized frame
On frame base plate, fix body mould, the position at biside plate place during reset CT scan, move under therapeutic room's location laser lamp instruction
Therapeutic bed, makes both sides laser lamp accurately indicate the target area centre coordinate that required breathing phases is corresponding with top lasers lamp
Value, i.e. the center, target area of this breathing phases coordinate figure in external three-dimensional system of coordinate, is thus accurately placed in center, target area
The center positions such as therapy apparatus, treatment pendulum position completes, and next can implement irradiation treatment by the requirement of breathing phases.
Experimental example:
Motion target body is the special respiratory movement mould for verifying its breath gate controlling system that ANZAI MEDICAL company produces
Intend target body.This target body comprises the spheroid of three a diameter of 50mm, and material is respectively timber, acryl, rubber.Motor pattern is
The one-dimensional sinusoidal motion of vertical CT scan tomography, motion amplitude is 20mm, and the period of motion is 4s.
Experimental procedure is: the first step, and three-dimensional locating frame axis oriented normal is placed on scanning bed in CT scan cross section, by this
Motion target body is placed on three-dimensional locating frame base plate by inventive method, the distance between regulation biside plate, makes motion target body firm
It is clipped in the middle well, respiration pickup (Japan ANZAI MEDICAL, for the pressure transducer of detection patient respiratory motion) is installed
At [LOADCELL IN] port of motion target body, the other end is connected to CT simulated positioner (Siemens Sensation Open)；
Second step, carries out CT scan, and presses 0% air-breathing, 20% air-breathing, 50% air-breathing, 80% air-breathing, 100% air-breathing to all CT images again
Carrying out being grouped and three-dimensional reconstruction, result is as shown in Figure 3, Figure 4, Figure 5, Figure 6, Figure 7；3rd step, measures center, each phase target area and exists
Coordinate figure in external coordinate system, can draw from Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, and CT image can clearly demonstrate external seat
The mark of mark system, by tolerance coordinate system mark and the position relationship with center, target area thereof, obtains the sky at center, each phase place target area
Between coordinate figure.Here the center, target area corresponding to 0% air-breathing, 20% air-breathing, 50% air-breathing, 80% air-breathing, 100% air-breathing phase place
Three-dimensional coordinate is respectively as follows: (125.2,27.8,49.0), (125.2,27.8,56.6), (125.2,27.8,64.4), (125.2,
27.8,68.9),(125.2,27.8,69.4).Due to the motion in one dimension that the motor pattern of this target body is vertical CT scan tomography,
Therefore x, y-coordinate value are the most equal, but center, target area z coordinate has significant change with the difference of breathing phases, and the inventive method is described
It is feasible.These coordinate figures make laser lamp can accurately indicate the target area that required breathing phases is corresponding when treatment pendulum position
On centre coordinate.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (3)
1. the positioner of dynamic tumor target area in a radiotherapy, it is characterised in that: it is provided with parallel to each other on base plate
Biside plate, is respectively equipped with a limit parallel with base plate on left and right side plate, and another limit and base plate are the groove of 45 degree of angles,
In left plate groove, it is inlaid with left plate copper wire, in right plate groove, is inlaid with right plate copper wire；Described brass wire diameter
It is 0.2～0.5mm；Base plate and biside plate are respectively equipped with the scale of identical scale；Base plate is provided with screw rod, biside plate with
Nut is connected, and screw rod and nut screw connection are provided with screw rod turning handle in one end of screw rod.
2. the positioner of dynamic tumor target area in radiotherapy as claimed in claim 1, it is characterised in that: base plate, both sides
The material of plate, nut and screw rod is lucite.
3. the using method of the positioner of dynamic tumor target area in radiotherapy as claimed in claim 1, it is characterised in that
Step is:
(1) positioner being located at CT scan bed, adjustment positioner is in horizontal position, and its longitudinal axis is vertical with CT scan tomography, suffers from
Person lies on the back or prostrate, and both hands upwards intersect, and lies or crouches on stereoscopic localized base plate；
(2) CT scan: patient lies or crouches on stereoscopic localized base plate, and fix with body mould, the distance between regulation biside plate, will
Pressure transducer fixing band is fixed on patient's abdominal part, utilizes the breathing letter of a pressure transducer detection patient when image acquisition
Number, the amplified CT simulated positioner of passing to of this signal, synchronous acquisition CT image and breath signal, allow the every layer of CT collected scheme
As all " ironing " temporal information residing in the breathing cycle, then respectively all CT images are re-started by phase place packet and
Three-dimensional reconstruction, the 3-D view of each phase place constitutes a time dependent three-dimensional image sequence, is input to by this image sequence
TPS work station；
(3) four-dimensional location: sketch out tumor target profile on each three-dimensional image sequence respectively, form a position in time
The dynamic target area of change, then determines that the center, each phase place target area coordinate figure relative to external three-dimensional system of coordinate；
(4) treatment pendulum position: Postural reduction when patient presses CT simulator locating in therapeutic room, lies or crouches in stereoscopic localized base plate
On, fix body mould, the position at biside plate place during reset CT scan, moving treatment under therapeutic room's location laser lamp instruction
Bed, makes both sides laser lamp accurately indicate the target area centre coordinate value that required breathing phases is corresponding with top lasers lamp, i.e.
The center, target area of this breathing phases coordinate figure in external three-dimensional system of coordinate, is thus accurately placed in therapy apparatus by center, target area
Deng center position, treatment pendulum position completes, and next can implement irradiation treatment by the requirement of breathing phases.
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| CN104849123B (en) * | 2015-06-10 | 2017-10-31 | 孟雪 | Ex vivo Tumor fixing device and the method that pathological section is made using the device |
| CN107158582A (en) * | 2017-05-25 | 2017-09-15 | 成都博唯康医药科技有限公司 | The method of precise positioning radiotherapy focus target area |
| WO2018227449A1 (en) * | 2017-06-15 | 2018-12-20 | Shanghai United Imaging Healthcare Co., Ltd. | Imaging systems and methods thereof |
| CN107261341A (en) * | 2017-07-12 | 2017-10-20 | 江西省肿瘤医院 | Patient body displacement detector in a kind of thorax and abdomen malignant radiation therapy process |
| CN108663989B (en) * | 2018-04-25 | 2021-04-06 | 中国科学院合肥物质科学研究院 | Inverse solution engineering and trajectory planning algorithm of five-axis treatment bed |
| CN109675209A (en) * | 2019-02-28 | 2019-04-26 | 姜春富 | A kind of accurate radiation therapy head locating rack |
| CN111127550B (en) * | 2019-12-26 | 2023-08-29 | 上海联影医疗科技股份有限公司 | Image slice positioning method, device and system based on bed board and storage medium |
| CN113018707B (en) * | 2021-03-24 | 2022-09-13 | 中国科学院近代物理研究所 | Range-based intratumoral target area generation system |
| CN118485669B (en) * | 2024-07-16 | 2024-10-01 | 四川省肿瘤医院 | Real-time positioning method and device for lung tumor target area |
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Effective date of registration: 20180917 Address after: 100190 Haidian District, Beijing, North Fourth Ring Road 9, 7, 710 room. Patentee after: Guo Ke ion Medical Technology Co., Ltd. Address before: 730000 science and technology office, 363 Nanchang Road, Lanzhou, Gansu Patentee before: Modern Physics Inst., Chinese Academy of Sciences |