CN103689268B - Plant extract feed additive for runt pigs - Google Patents
Plant extract feed additive for runt pigs Download PDFInfo
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- CN103689268B CN103689268B CN201310668160.9A CN201310668160A CN103689268B CN 103689268 B CN103689268 B CN 103689268B CN 201310668160 A CN201310668160 A CN 201310668160A CN 103689268 B CN103689268 B CN 103689268B
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a plant extract feed additive. The plant extract feed additive comprises a hawthorn extract, a grape seed extract, a leonurus extract, a pueraria extract, a myrobalan extract, a sea-buckthorn extract, an acanthopanax extract, a clove extract and a cinnamon extract and is prepared by steps of performing micro grinding, extracting, and concentrating on the raw materials. The plant extract feed additive has the advantages of rich sources, high bioavailability, non-toxicity and no residue. The plant extracts are compounded into the compound feed additive for the runt pigs, the compound feed additive plays a role in protecting parenchymal organs of the runt pigs, regulating the gastrointestinal functions, improving the immunity and improving the palatability of feeds. Therefore, the plant extract feed additive can effectively cure the runt pigs and help the runt pigs to grow normally.
Description
Technical field
The present invention relates to disease cad pig and take off deadlock plant extract feed additive.Additive of the present invention effectively prevention and therapy infectious disease to the harm of pig growth performance and health status, can belong to the feed additive field ensureing growth of animal performance and meat food safety.
Background technology
Cad pig refers to certain one-phase at pig growth and development, and owing to suffering the impact of some unfavorable factor, pig long term development is stagnated, although feeding time is longer, physique is little, and by hair slightly disorderly, skeletonize, is formed pointed at both ends, middle thick " little Lai pig ".This boar eats like a bird, and looks slow, or only eats not long, brings very large loss to Swine Production.The reason forming cad pig mainly contains following several respects:
Tire is stiff: the offspring's variety deterioration caused due to inbreeding, stagnations of growing, and the age of boar is excessive, and physique reduces, motherhood under-reserve, or carries out mating prematurely, breeding stock self depauperation and cause the depauperation formation cad pig of offspring.
Milk is stiff: because the trophic level of sow is low, lack protein, mineral matter, trace element and vitamin in daily ration, or sow latent disease development, causes milk subalimentation or milk poor water mass, causes sucking pig congenital malformation, affects the growth day after tomorrow.Or because the nursing of newborn piglet is improper, as do not fixed nipple in time after piggy birth, weak piglet eats less than good nipple, causes sucking pig can not meet nutritional need, growth retardation.
Food is stiff: after weaned piglet, daily ration quality is bad, nutritional deficiency, or it is foster with group feeding to be bred as piglet, and hopper is not enough or water is under-supply, and the many food of powerhouse, weak person eats and is in starvation less than enough material, forms cad pig in the course of time.
Sick stiff: the infectious disease that piglet suffers from symptom of diarrhea or organa parenchymatosum does not heal for a long time, form cad pig.
Worm is stiff: the endoparasite and ectoparasites such as roundworm disease, lung filaria, Fasciolopsis, acarid, mange are chronic wasting diseases, and because nutrient consumption amount is excessive, impact is grown, and forms cad pig.
Medicine is stiff: the medium-term and long-term heavy dose of feed adds medicine or plant continues drug abuse, and cause drug induccd to suffer from diarrhoea or the damage of organa parenchymatosum, body is in sub-health state, nutrition digestion absorb or transformation efficiency poor, formation cad pig.
Avoid that inbreeding and male and female pig utilize too early, the material that supplements the nutrients, stomach invigorating expelling parasite, the measure such as Normalization rule medicine and medicated premix can stiff to tire, milk is stiff, food is stiff, worm is stiff, medicine cad pig carries out good control.
Recent year hyperpyrexia disease, No. 5 diseases, transmissible gastroenteritis and epidemic diarrheas popular, make the to fall ill organa parenchymatosum of pig and alimentary canal is subject to grievous injury, except pig mortality causes direct economic loss, the Potential economic losses that the sick cad pig that gets off of surviving after disease is caused also seriously annoyings the development of aquaculture.
Since 2009, prevention gradually occurs with the feed addictive of curing sick cad pig, the patent No. be disclose in the application of CN103272148A, CN102919538A, CN102138648A, CN101836691A, CN102090560A the additive that forms with Chinese herbal medicine compound prescription or Chinese herbal medicine and trace element, multivitamin, amino acid compound preventing with treatment cad pig in application, but due to aspects such as the active component of Chinese herbal medicine own are indefinite, using dosage is large, palatability is poor, be difficult to widely apply in production reality.
For prevention and the sick cad pig for the treatment of need safety, effectively, definite ingredients, easy to operate, the market demand that do not affect pig palatability; the present inventor filters out several natural plant extracts, from protection organa parenchymatosum, recuperating gastrointestinal tract function, raising immunity with strengthen the object that the angle of palatability reaches prevention and therapy cad pig.
Summary of the invention
The present invention adopts haw thorn extract, grape seed extract, Leonurus extract, kudzu root extract, Fructus Chebulae extract, hippophae rhamnoides, siberian Ginseng P.E, Flos Caryophylli extract, cinnamomum cassia extract, by rationally processing and prescription, final purpose is that providing a kind of makes disease cad pig take off stiff plant extract feed additive.
Technical scheme of the present invention be with haw thorn extract, grape seed extract, Leonurus extract, kudzu root extract, Fructus Chebulae extract, hippophae rhamnoides for Main Function thing, promote the recovery of disease cad pig organa parenchymatosum, particularly cardiac function.Siberian Ginseng P.E, Flos Caryophylli extract, cinnamomum cassia extract are secondary role thing, are used for recuperating gastrointestinal tract function and stimulating appetite.This compound composite plant extract feed additive can play good solution deadlock effect for sick cad pig.
The invention provides one and can promote disease cad pig organa parenchymatosum functional rehabilitation, the stiff feed addictive of the compound sick cad pig solution of one can nursed one's health again disease cad pig gastrointestinal function and stimulate appetite, it is made up of (each amounts of components is weight portion) following component:
Haw thorn extract 15 ~ 25
Grape seed extract 15 ~ 25
Leonurus extract 10 ~ 15
Kudzu root extract 10 ~ 15
Fructus Chebulae extract 10 ~ 15
Hippophae rhamnoides 10 ~ 15
Siberian Ginseng P.E 8 ~ 12
Flos Caryophylli extract 15 ~ 20
Cinnamomum cassia extract 8 ~ 15
In a preferred embodiment of the invention, the invention provides consisting of (each amounts of components is weight portion) of a kind of compound stiff feed addictive of sick cad pig solution:
Haw thorn extract 20
Grape seed extract 20
Leonurus extract 15
Kudzu root extract 10
Fructus Chebulae extract 10
Hippophae rhamnoides 15
Siberian Ginseng P.E 10
Flos Caryophylli extract 15
Cinnamomum cassia extract 10
In another preferred embodiment of the present invention, the invention provides consisting of (each amounts of components is weight portion) of a kind of compound stiff feed addictive of sick cad pig solution:
Haw thorn extract 25
Grape seed extract 25
Leonurus extract 10
Kudzu root extract 15
Fructus Chebulae extract 10
Hippophae rhamnoides 10
Siberian Ginseng P.E 10
Flos Caryophylli extract 10
Cinnamomum cassia extract 8
Detoxification experiment proves: the stiff feed addictive of compound sick cad pig solution of the present invention adds by 0.15 ~ 0.3 kilogram/1000 kilograms batches, the palatability of feed can be strengthened, promote pig growth, greatly improve and skeletonize state disorderly thick by hair, improve pig immunity.
Therefore, the invention provides the purposes of the stiff feed addictive of compound sick cad pig solution of the present invention in protection organa parenchymatosum, recuperating gastrointestinal tract function, raising immunity and enhancing feed palatability etc.
In a preferred embodiment of the invention, described animal is the pig of each age level.Addition in feed is 0.30 kilogram/1000 kilograms complete diet pellets.
On the other hand, the invention provides the preparation method of the stiff feed addictive of a kind of compound sick cad pig solution.The method comprises the following steps:
(1) haw thorn extract preparation: hawthorn is removed slag, adds the alcohol that volume ratio is 1:5 times 75%, first soaks 0.5 hour, rear backflow twice, 1 hour first time, for the second time half an hour; Merge twice filtrate, centrifugal 20 minutes, collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated.
(2) grape seed extract preparation: grape pip impurity elimination, grind into powder, adding volume ratio is 1:8 water doubly, refluxing extraction 2 hours, collecting by filtration filtrate.In filter residue, again add volume ratio 1:5 water doubly, continue backflow 2 hours.Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated.
(3) Leonurus extract preparation: the impurity elimination of motherwort medicinal material, grind into powder, be the water of 1:10 times amount respectively with volume ratio, 1% hydrochloric acid solution, 95% ethanol, 0.1% ethanol solution hydrochloride extract twice for solvent in the supersonic generator of 59KHz, each 40 minutes, merge extract, collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated.
(4) kudzu root extract preparation: the root of kudzu vine is cleaned, and dries; Pulverize and collect 20 order screenings, 75% alcohol heating reflux extracts twice, each 2 hours, and it is 1:10 times amount that first time adds volume ratio, and it is 1:8 times amount that second time adds volume ratio, all filtrate is merged, evaporate to dryness after filtrate is concentrated.
(5) Fructus Chebulae extract preparation: myrobalan's impurity elimination, grind into powder, adds 70% alcohol-pickled 15 minutes of volume ratio 1:7 times amount, after extract 3 minutes at microwave power 1200W, temperature 60 C, evaporate to dryness after filtrate is concentrated.
(6) hippophae rhamnoides preparation: dry Leaves of Hippophae L is pulverized, crosses 60 mesh sieves, and add volume ratio 1:10 benzinum doubly 45 DEG C of immersions, extract 1.5h with 150r/min concussion, suction filtration, in triplicate, discard extract, filter residue volatilizes naturally.In filter residue, add volume ratio 1:10 65% ethanol doubly, extract 8h at 45 DEG C with 150r/min concussion in controllable temperature shaking table, suction filtration, repeats extraction three times altogether, merges extract, freeze drying.
(7) siberian Ginseng P.E preparation: the impurity elimination of acanthopanax powder, grinding, collects the screenings by 100 mesh sieve sheets.Add volume ratio 1:8 doubly 60% ethanolic solution, refluxing extraction 1 hour, again add in filter residue volume ratio 1:5 doubly 60% ethanol, continue backflow 2 hours.Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated.
(8) Flos Caryophylli extract preparation: cloves is removed slag grindings, adds volume ratio 1:8 doubly 95% ethanol, installs magneton and stir and condenser pipe, 80 DEG C of direct backflow 2 h, decompression distillation removal ethanol.
(9) cinnamomum cassia extract preparation: Chinese cassia tree is removed slag grindings, adds volume ratio 1:5 times of volume 95% ethanol, installs magneton and stirs and condenser pipe, 80 DEG C of direct backflow 3 h, decompression distillation removal ethanol.
(10) material above-mentioned steps obtained ratio mixing by weight.
Haw thorn extract 15 ~ 25
Grape seed extract 15 ~ 25
Leonurus extract 10 ~ 15
Kudzu root extract 10 ~ 15
Fructus Chebulae extract 10 ~ 15
Hippophae rhamnoides 10 ~ 15
Siberian Ginseng P.E 8 ~ 12
Flos Caryophylli extract 15 ~ 20
Cinnamomum cassia extract 8 ~ 15
In a preferred embodiment of the invention, wherein the ratio by weight described in step (9) is mixed into:
Haw thorn extract 20
Grape seed extract 20
Leonurus extract 15
Kudzu root extract 10
Fructus Chebulae extract 10
Hippophae rhamnoides 15
Siberian Ginseng P.E 10
Flos Caryophylli extract 15
Cinnamomum cassia extract 10
In another preferred embodiment of the present invention, wherein the ratio by weight described in step (9) is mixed into:
Haw thorn extract 25
Grape seed extract 25
Leonurus extract 10
Kudzu root extract 15
Fructus Chebulae extract 10
Hippophae rhamnoides 10
Siberian Ginseng P.E 10
Flos Caryophylli extract 10
Cinnamomum cassia extract 8.
advantage of the present invention
Additive of the present invention forms through Crushing of Ultrafine, extraction, the processes such as concentrated, has that raw material sources are extensive, bioavailability is high, a feature of nontoxic, noresidue, overcomes the shortcoming that Chinese herbal medicine addition is large, active component is indefinite, agreeable to the taste type is not good.These plant extracts composite, provides the stiff feed addictive of a kind of compound sick cad pig solution, plays the organa parenchymatosum of protection cad pig, recuperating gastrointestinal tract function, raising immunity and strengthens the effect of the aspects such as feed palatability.
Below in conjunction with embodiment, the specific embodiment of the present invention is described further.Following examples only for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment
the preparation of embodiment 1 plant extracts
1. haw thorn extract preparation: hawthorn is removed slag, adds the alcohol that volume ratio is 1:5 times 75%, first soaks 0.5 hour, rear backflow twice, 1 hour first time, for the second time half an hour.Merge twice filtrate, centrifugal 20 minutes, collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated.
2. grape seed extract preparation: grape pip impurity elimination, grind into powder, adding volume ratio is 1:8 water doubly, refluxing extraction 2 hours, collecting by filtration filtrate.In filter residue, again add volume ratio 1:5 water doubly, continue backflow 2 hours.Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated.
3. Leonurus extract preparation: the impurity elimination of motherwort medicinal material, grind into powder, extract twice in the supersonic generator of 59KHz for solvent with the water of volume ratio 1:10 times amount, 1% hydrochloric acid solution, 95% ethanol, 0.1% ethanol solution hydrochloride respectively, each 40 minutes, merge extract, collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated.
4. kudzu root extract preparation: the root of kudzu vine is cleaned, and dries; Pulverize and collect 20 order screenings, 75% alcohol heating reflux extracts twice, each 2 hours, and first time adds volume ratio 1:10 times amount, and second time adds volume ratio 1:8 times amount, filters.All filtrate is merged, evaporate to dryness after filtrate is concentrated.
5. Fructus Chebulae extract preparation: myrobalan's impurity elimination, grind into powder, adds 70% alcohol-pickled 15 minutes of volume ratio 1:7 times amount, after extract 3 minutes at microwave power 1200W, temperature 60 C, evaporate to dryness after filtrate is concentrated.
6. hippophae rhamnoides preparation: dry Leaves of Hippophae L is pulverized, crosses 60 mesh sieves, and add volume ratio 1:10 benzinum doubly 45 DEG C of immersions, extract 1.5h with 150r/min concussion, suction filtration, in triplicate, discard extract, filter residue volatilizes naturally.In filter residue, add volume ratio 1:10 65% ethanol doubly, extract 8h at 45 DEG C with 150r/min concussion in controllable temperature shaking table, suction filtration, repeats extraction three times altogether, merges extract, freeze drying.
7. siberian Ginseng P.E preparation: the impurity elimination of acanthopanax powder, grinding, collects the screenings by 100 mesh sieve sheets.Add volume ratio 1:8 doubly 60% ethanolic solution, refluxing extraction 1 hour, again add in filter residue volume ratio 1:5 doubly 60% ethanol, continue backflow 2 hours.Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated.
8. Flos Caryophylli extract preparation: cloves is removed slag grindings, adds volume ratio 1:8 doubly 95% ethanol, installs magneton and stir and condenser pipe, 80 DEG C of direct backflow 2 h, decompression distillation removal ethanol.
Prepared by cinnamomum cassia extract: Chinese cassia tree is removed slag grindings, adds volume ratio 1:5 doubly 95% ethanol, installs magneton and stir and condenser pipe, 80 DEG C of direct backflow 3 h, decompression distillation removal ethanol.
the preparation of embodiment 2 plant extracts compound additive
Plant extracts embodiment 1 prepared is by following weight:
Haw thorn extract 20
Grape seed extract 20
Leonurus extract 15
Kudzu root extract 10
Fructus Chebulae extract 10
Hippophae rhamnoides 15
Siberian Ginseng P.E 10
Flos Caryophylli extract 15
Cinnamomum cassia extract 10
Above-mentioned each component mixing, obtains plant extracts additive of the present invention.
the preparation of embodiment 3 plant extracts compound additive
Plant extracts embodiment 1 prepared is by following weight:
Haw thorn extract 25
Grape seed extract 25
Leonurus extract 10
Kudzu root extract 15
Fructus Chebulae extract 10
Hippophae rhamnoides 10
Siberian Ginseng P.E 10
Flos Caryophylli extract 10
Cinnamomum cassia extract 8
Above-mentioned each component mixing, obtains plant extracts additive of the present invention.
embodiment 4 detoxification is tested
1. test Ration Compound and experimental animal
with reference to swine rearing standard, preparation and the suitable basal diet of piglet nutrition concentration, the formula of basal diet and nutritional labeling be not in table 1,2.
Table 1. basal diet formula table
Corn GB3 47
Popcorn 14.6
Wheat bran 5
Crack rice 5
Soybean oil 1
Dregs of beans 46% 18
Expanded soybean 6
Piglet specific enzyme 0.01
Calcium monohydrogen phosphate 0.7
Stone flour 1
Salt 0.3
Mould inhibitor 0.05
Antioxidant 0.02
Lysine 98% 0.2
Threonine 98% 0.06
Methionine 98% 0.04
Choline Chloride 0.08
1% piglet premix 1
Consumption adds up to 100.06
Table 2. basal diet nutrient component meter
Digestible energy (MCAL) 3.23
Crude protein 16.7
Lysine 0.93
Egg adds Guang 0.54
Calcium 0.58
Available phosphorus 0.32
Threonine 0.62
Methionine 0.31
experimental animal
Select to survive after hyperpyrexia disease the 100 age in days cad pigs got off, be divided into A, B two groups, A group 10 pig average weights are 24.52 ± 0.9 kilograms, B group 10 pig average weights are 24.20 ± 1.1 kilograms; The cad pig of 120 ages in days is divided into C, D two groups, and C group 10 pig average weights are 37.8 ± 1.3 kilograms, D group 10 pig average weights are 36.2 ± 1.8 kilograms; Close according to corresponding body weight between process, the principle of genetic mechanism for crop uniform distribution using A, C as basal diet group of feeding, B, D, as experimental group (basal diet adds 300 grams of plant extracts/ton daily ration), often organize injection ivermectin on pretreatment and carry out conventional expelling parasite.
2 results
Table 3 growth of growing-finishing pigs performance table
Note: the female different person of colleague's data shoulder marking-up represents significant difference (P<0.05), lower same.
Table 4 growth of growing-finishing pigs performance table
Note: the female different person of colleague's data shoulder marking-up represents significant difference (P<0.05), lower same
Experimental result illustrates: the pig of adding the experimental group of plant extracts compound additive of the present invention is similar to control group body weight when testing beginning, at the end of experiment, body weight is obviously greater than control group, significant difference, illustrate that this plant extracts compound additive can effectively make disease cad pig de-stiff, reach the object of normal growth.
Claims (2)
1., by haw thorn extract, grape seed extract, Leonurus extract, kudzu root extract, Fructus Chebulae extract, hippophae rhamnoides, siberian Ginseng P.E, Flos Caryophylli extract, the de-deadlock plant extract feed additive of the compounded sick cad pig of cinnamomum cassia extract proportioning, it is as follows that it prepares feature:
Prepared by haw thorn extract: hawthorn is removed slag, and adds the alcohol that volume ratio is 1:5 times 75%, first soaks 0.5 hour, rear backflow twice, 1 hour first time, for the second time half an hour; Merge twice filtrate, centrifugal 20 minutes, collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated;
Prepared by grape seed extract: grape pip impurity elimination, grind into powder, and adding volume ratio is 1:8 water doubly, refluxing extraction 2 hours, collecting by filtration filtrate; In filter residue, again add volume ratio 1:5 water doubly, continue backflow 2 hours; Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated;
Prepared by Leonurus extract: the impurity elimination of motherwort medicinal material, grind into powder; be the water of 1:10 times amount respectively with volume ratio, 1% hydrochloric acid solution, 95% ethanol, 0.1% ethanol solution hydrochloride extract twice for solvent in the supersonic generator of 59KHz; each 40 minutes; merge extract; collecting by filtration filtrate, evaporate to dryness after filtrate is concentrated;
Prepared by kudzu root extract: the root of kudzu vine is cleaned, and dries; Pulverize and collect 20 order screenings; 75% alcohol heating reflux extracts twice, each 2 hours, and first time adds volume ratio 1:10 times amount, and second time adds volume ratio 1:8 times amount, all filtrate is merged, evaporate to dryness after filtrate is concentrated;
Prepared by Fructus Chebulae extract: myrobalan's impurity elimination, grind into powder, adds 70% alcohol-pickled 15 minutes of volume ratio 1:7 times amount, after extract 3 minutes at microwave power 1200W, temperature 60 C, evaporate to dryness after filtrate is concentrated;
Prepared by hippophae rhamnoides: dry Leaves of Hippophae L is pulverized, and crosses 60 mesh sieves, and add volume ratio 1:10 benzinum doubly 45 DEG C of immersions, extract 1.5h, suction filtration with 150r/min concussion, in triplicate, discard extract, filter residue volatilizes naturally; In filter residue, add volume ratio 1:10 65% ethanol doubly, extract 8h at 45 DEG C with 150r/min concussion in controllable temperature shaking table, suction filtration, repeats extraction three times altogether, merges extract, freeze drying;
Prepared by siberian Ginseng P.E: the impurity elimination of acanthopanax powder, grinding, collects the screenings by 100 mesh sieve sheets; Add volume ratio 1:8 doubly 60% ethanolic solution, refluxing extraction 1 hour, again add in filter residue volume ratio 1:5 doubly 60% ethanol, continue backflow 2 hours; Collecting by filtration filtrate, discards filter residue merging filtrate, evaporate to dryness after filtrate is concentrated;
Prepared by Flos Caryophylli extract: cloves is removed slag grindings, and adding volume ratio is 1:8 doubly 95% ethanol, installs magneton and stirs and condenser pipe, 80 DEG C of direct backflow 2 h, decompression distillation removal ethanol;
Prepared by cinnamomum cassia extract: Chinese cassia tree is removed slag grindings, adds volume ratio 1:5 doubly 95% ethanol, installs magneton and stir and condenser pipe, 80 DEG C of direct backflow 3 h, decompression distillation removal ethanol;
Plant extracts above-mentioned steps obtained mixes by following weight ratio:
Haw thorn extract 15 ~ 25
Grape seed extract 15 ~ 25
Leonurus extract 10 ~ 15
Kudzu root extract 10 ~ 15
Fructus Chebulae extract 10 ~ 15
Hippophae rhamnoides 10 ~ 15
Siberian Ginseng P.E 8 ~ 12
Flos Caryophylli extract 15 ~ 20
Cinnamomum cassia extract 8 ~ 15.
2. the de-deadlock plant extract feed additive of sick cad pig according to claim 1, its weight portion consists of:
Haw thorn extract 20
Grape seed extract 20
Leonurus extract 15
Kudzu root extract 10
Fructus Chebulae extract 10
Hippophae rhamnoides 15
Siberian Ginseng P.E 10
Flos Caryophylli extract 15
Cinnamomum cassia extract 10.
3. the de-deadlock plant extract feed additive of sick cad pig according to claim 1, its weight portion consists of:
Haw thorn extract 25
Grape seed extract 25
Leonurus extract 10
Kudzu root extract 15
Fructus Chebulae extract 10
Hippophae rhamnoides 10
Siberian Ginseng P.E 10
Flos Caryophylli extract 10
Cinnamomum cassia extract 8.
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