CN103656146A - Traditional Chinese medicine for treating acne and preparation method thereof - Google Patents
Traditional Chinese medicine for treating acne and preparation method thereof Download PDFInfo
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- CN103656146A CN103656146A CN201310716456.3A CN201310716456A CN103656146A CN 103656146 A CN103656146 A CN 103656146A CN 201310716456 A CN201310716456 A CN 201310716456A CN 103656146 A CN103656146 A CN 103656146A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention belongs to the field of traditional Chinese medicines, in particular relates to a traditional Chinese medicine for treating acne and a preparation method thereof. The traditional Chinese medicine is refined by thirteen traditional Chinese medicines of flos farfarae, coptis chinensis, honeysuckle, scutellaria baicalensis, prepared rehmannia root, moutan bark, salvia miltiorrhiza, radix rehmanniae recen, jasmine, radix scrophulariae, thunberg fritillary bulb, cortex mori and selfheal. All the medicines are compatible with each other perfectly to achieve the effect of clearing away heat, relieving poison, cooling blood and activating blood; the traditional Chinese medicine has obvious counteraction effect on the acute and chronic inflammation, has obviously antibacterial effect on the common skin pathogenic bacterium of staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, escherichia coli, pseudomonas aeruginosa and propionibacterium, can obviously reduce the swelling rate of the propionibacterium caused mouse auricle acne model, obviously improves the activity of catalase to achieve the anti-oxidation effect, and has a certain pain relieving effect; the traditional Chinese medicine has the advantages of short treatment course, quick effect and no toxic or side effects, and is a good medicine for treating the acne.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Chinese medicine and preparation method of Acne treatment.
Background technology
Acne Chinese medicine is referred to as rosacea caused by lung-wind, pimples etc., and Chinese medicine is thought: the generation of " acne " and lung stomach are damp and hot in close relations, and lung stomach is damp and hot to be felt ailment said due to cold or exposure again and falls ill.All emptiness of spleen and stomach, or eating and drinking without temperance impairing the spleen and stomach, all can cause dysfunction of the spleen in transportation and transformation; Cross the wine of drinking tea, throw off restraint the product of the greasy fish raw meat of edible oil, all can help heat of wetting, damp-heat gluing each other, stifling women's head-ornaments, cause sebum secretion and cross Sheng, and multiple sense poison is evil, blocks a hair key, makes stagnation of QI-blood, outgoing skin and generate pustule etc.; With the passing of time stagnation of QI and blood, forms cyst, tuberosity.As < < Yizong Jinjian rosacea caused by lung-wind > > " this card is formed by lung meridian heat in blood ".The rule for the treatment of should be with heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation.
Western modern medicine Acne treatment: acne (acne) is a kind of chronic inflammatory disease illness of pilosebaceous unit structure, because sebaceous gland duct and pore stop up, cause sebum secretion smooth due to.Often show as the hair follicle of Head And Face, cervical region and chest and back and the acute festering type of affiliated sebaceous gland thereof and infect, easily expand to subcutaneous tissue.Except pathogenic bacterium, invade outside the golden Portugal bacterium of infection, white Portugal bacterium, sebaceous gland lower floor propionibacterium is also important pathogenic bacterium.Hormonal change in the generation of acne and body, androgen secretion increases, and stimulates sebaceous hyperplasia loose, and smegma increases relevant.Sebaceous gland is subject to the control of hormone completely, and androgen directly stimulates sebaceous cell to produce a large amount of sebums.Testis and entovarial testosterone, the androstanedione in adrenal gland (Androstanedione) and 17-Hormoforin (Dehy-droepiandrosterone) all have this effect, make the movable increase of adolescence gonad, a large amount of sebums of smegma.The common method of western modern medicine Acne treatment all belongs to and taking stopgap measures, and there is no at present satisfied radical cure medicine, and majority can not effect a radical cure.
Summary of the invention
The present invention has overcome technical deficiency, and a kind of Chinese medicine and preparation method of Acne treatment is provided.The Chinese medicine of Acne treatment of the present invention, by following component, be prepared from, all in weight portion: 7.7～13.8 parts of Flos Farfaraees, 3.5～6.3 parts of Rhizoma Coptidis, 5.5～10.3 parts of Flos Loniceraes, 5.5～10.3 parts of Radix Scutellariaes, 5.5～10.3 parts of Radix Rehmanniae Preparata, 5.5～10.3 parts of Cortex Moutans, 5.5～10.3 parts of Radix Salviae Miltiorrhizaes, 5.5～10.3 parts of Radix Rehmanniae, 5.5～10.3 parts of Fructus Gardeniaes, 5.5～10.3 parts of Radix Scrophulariaes, 3.8～6.9 parts of Bulbus Fritillariae Thunbergiis, 5.5～10.3 parts of Cortex Mori, 5.5～10.3 parts of Spica Prunellaes.
The Chinese medicine of Acne treatment of the present invention, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 6 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Rehmanniae, 9 parts of Fructus Gardeniaes, 9 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 8 parts of Cortex Mori, 10 parts of Spica Prunellaes.
The Chinese medicine of Acne treatment of the present invention, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 8 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Rehmanniae, 10 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 9 parts of Cortex Mori, 9 parts of Spica Prunellaes.
The Chinese medicine of Acne treatment of the present invention, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 7 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Rehmanniae, 7 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 5 parts of Bulbus Fritillariae Thunbergiis, 7 parts of Cortex Mori, 9 parts of Spica Prunellaes.
Chinese medicine of the present invention is mainly formed by Flos Farfarae, Rhizoma Coptidis, Flos Lonicerae, Radix Scutellariae, Radix Rehmanniae Preparata, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Fructus Gardeniae, Radix Scrophulariae, Bulbus Fritillariae Thunbergii, Cortex Mori, Spica Prunellae 13 taste purification of tcm, and its dosage form comprises capsule, tablet and granule.Prescription solution: be monarch drug with Flos Farfarae, Rhizoma Coptidis heat-clearing and toxic substances removing; With Flos Lonicerae, Radix Scutellariae, Radix Rehmanniae Preparata, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Fructus Gardeniae, Radix Scrophulariae heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, it is ministerial drug; With Bulbus Fritillariae Thunbergii, Spica Prunellae, Cortex Mori dissipating depression of QI eliminating stagnation, eliminating the pathogens from the lung dampness removing, be adjuvant altogether.All medicine compatibilities, bring out the best in each other above, amount to the effect of heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, and Chinese medicine cures mainly rosacea caused by lung-wind, pimples etc., and western medicine is applicable to acne.
The Chinese medicine of Acne treatment of the present invention, its preparation method is:
(1) by ingredients weight parts, get 30～70% dry sterilizations of Bulbus Fritillariae Thunbergii total amount, be ground into fine powder, sieve, standby;
(2) get remaining Bulbus Fritillariae Thunbergii and decoct with water and extract three times by said components weight portion all the other the 12 taste Chinese medicines such as Flos Farfarae of withdrawing the money; the decocting that adds for the first time 4～7 times of amounts of whole extraction medical material weight boils 2 hours; adding for the second time 3～6 times of water gagings of whole extraction medical material weight decocts 1.5 hours; adding for the third time 2～4 times of water gagings of whole extraction medical material weight decocts 1.0 hours; collecting decoction, filters or/and standing;
(3) get filtrate or/and supernatant is condensed into thick paste, dry, pulverize into fine powder, sieve;
(4) add above-mentioned Bulbus Fritillariae Thunbergii fine powder to mix, granulate or do not granulate, be packed into capsule and obtain capsule or add the pharmaceutic adjuvant compacting of granulating or do not granulate and obtain in flakes tablet or add pharmaceutic adjuvant granulation and obtain granule.
Pharmaceutic adjuvant is generally: starch, dextrin, lactose, microcrystalline Cellulose, sucrose, stearic acid, magnesium stearate etc., its kind and consumption need the amount doesn't matter according to preparation object and technique.
Pharmacodynamic study
To treatment by Chinese herbs acne of the present invention, adopt randomized single blind trial to carry out clinical observation on the therapeutic effect.Clinical data: treatment by Chinese herbs group 120 examples of the present invention, 16～34 years old age, average 21.94 ± 3.91 years old; The course of disease 1 week～14 years, average 3.3 ± 3.14 years; Clinical weight classification I degree 62 examples, II degree 43 examples, III degree 10 examples, IV degree 5 examples.Observational technique: adopt open trial to observe, before and after record patient medication, disease situation of change, carries out rank scores statistics, carry out weekly clinical observation and record once, and all before and after treatment, do routine blood test and hepatic and renal function inspection, the untoward reaction that observation may occur, statistics curative effect after 4 weeks.Therapeutic outcome: Chinese medicine of the present invention to homeliness type acne (curing mainly pyretic toxicity syndrome of blood stasis) have that remarkable therapeutical effect, clinical cure rate are 33.33%, obvious effective rate is 27.5%, total effective rate is 88.33%.Untoward reaction: do not observe serious adverse reaction, before and after all patient treatments, routine blood test and hepatic and renal function, without abnormal change, illustrate that Chinese medicine of the present invention is safe and reliable, untoward reaction is very little.
The invention has the beneficial effects as follows: Chinese medicine of the present invention is prepared from by Flos Farfarae, Rhizoma Coptidis, Flos Lonicerae, Radix Scutellariae, Radix Rehmanniae Preparata, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Fructus Gardeniae, Radix Scrophulariae, Bulbus Fritillariae Thunbergii, Cortex Mori, Spica Prunellae 13 taste raw material of Chinese medicine, all medicine compatibilities above, bring out the best in each other, amount to the effect of heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation; Chinese medicine of the present invention has remarkable antagonism to Acute and chronic inflammation, common Bacteria skin infection staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, escherichia coli, bacillus pyocyaneus, propionibacterium are had to significant antibacterial action, can significantly reduce propionibacterium and cause rat auricle Acne Model swelling rate, significantly improve catalatic vigor and Wheat Protein, and also have certain analgesic activity; The advantage such as Chinese medicine of the present invention has short treating period, instant effect, have no side effect is the good medicine of Acne treatment.
The specific embodiment
Below by embodiment, further illustrate the present invention.
Embodiment 1
The Chinese medicine of Acne treatment of the present invention, is prepared from by following component, all in weight portion:
8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 6 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Rehmanniae, 9 parts of Fructus Gardeniaes, 9 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 8 parts of Cortex Mori, 10 parts of Spica Prunellaes.
The Chinese medicine of Acne treatment of the present invention, its preparation method is:
(1) Bulbus Fritillariae Thunbergii 4Kg, gets 35% dry sterilization of total amount, is ground into fine powder, sieves, standby;
(2) get remaining Bulbus Fritillariae Thunbergii and Flos Farfarae 8Kg, Rhizoma Coptidis 4Kg, Flos Lonicerae 6Kg, Radix Scutellariae 6Kg, Radix Rehmanniae Preparata 6Kg, Cortex Moutan 6Kg, Radix Salviae Miltiorrhizae 10Kg, Radix Rehmanniae 10Kg, Fructus Gardeniae 9Kg, Radix Scrophulariae 9Kg, Cortex Mori 8Kg, all the other 12 taste Chinese medicines of Spica Prunellae 10Kg decoct with water and extract three times; the decocting that adds for the first time 4 times of amounts of whole extraction medical material weight boils 2 hours; adding for the second time 4 times of water gagings of whole extraction medical material weight decocts 1.5 hours; adding for the third time 2 times of water gagings of whole extraction medical material weight decocts 1.0 hours; collecting decoction, filters or/and standing;
(3) get filtrate or/and supernatant is condensed into thick paste, dry, pulverize into fine powder, sieve;
(4) add above-mentioned Bulbus Fritillariae Thunbergii fine powder to mix, granulate or do not granulate, be packed into capsule and obtain capsule or add the pharmaceutic adjuvant compacting of granulating or do not granulate and obtain in flakes tablet or add pharmaceutic adjuvant granulation and obtain granule.
Embodiment 2
The Chinese medicine of Acne treatment of the present invention, is prepared from by following composition, all in weight portion:
8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 8 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Rehmanniae, 10 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 9 parts of Cortex Mori, 9 parts of Spica Prunellaes.
The Chinese medicine for the treatment of seat skin ulcer of the present invention, its preparation method is:
(1) Bulbus Fritillariae Thunbergii 4Kg, gets 50% dry sterilization of its total amount, is ground into fine powder, sieves, standby;
(2) get remaining Bulbus Fritillariae Thunbergii and Flos Farfarae 8Kg, Rhizoma Coptidis 4Kg, Flos Lonicerae 6Kg, Radix Scutellariae 6Kg, Radix Rehmanniae Preparata 6Kg, Cortex Moutan 8Kg, Radix Salviae Miltiorrhizae 9Kg, Radix Rehmanniae 9Kg, Fructus Gardeniae 10Kg, Radix Scrophulariae 7Kg, Cortex Mori 9Kg, all the other 12 taste Chinese medicines of Spica Prunellae 9Kg decoct with water and extract three times; the decocting that adds for the first time 5 times of amounts of whole extraction medical material weight boils 2 hours; adding for the second time 4 times of water gagings of whole extraction medical material weight decocts 1.5 hours; adding for the third time 3 times of water gagings of whole extraction medical material weight decocts 1.0 hours; collecting decoction, filters or/and standing;
(3) get filtrate or/and supernatant is condensed into thick paste, dry, pulverize into fine powder, sieve;
(4) add above-mentioned Bulbus Fritillariae Thunbergii fine powder to mix, granulate or do not granulate, be packed into capsule and obtain capsule or add the pharmaceutic adjuvant compacting of granulating or do not granulate and obtain in flakes tablet or add pharmaceutic adjuvant granulation and obtain granule.
Embodiment 3
The Chinese medicine of the Acne treatment of invention, is prepared from by following composition, all in weight portion:
8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 7 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Rehmanniae, 7 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 5 parts of Bulbus Fritillariae Thunbergiis, 7 parts of Cortex Mori, 9 parts of Spica Prunellaes.
The Chinese medicine for the treatment of seat skin ulcer of the present invention, its preparation method is:
(1) Bulbus Fritillariae Thunbergii 5Kg, gets 70% dry sterilization of total amount, is ground into fine powder, sieves, standby;
(2) get remaining Bulbus Fritillariae Thunbergii and Flos Farfarae 8Kg, Rhizoma Coptidis 4Kg, Flos Lonicerae 6Kg, Radix Scutellariae 6Kg, Radix Rehmanniae Preparata 6Kg, Cortex Moutan 7Kg, Radix Salviae Miltiorrhizae 9Kg, Radix Rehmanniae 7Kg, Fructus Gardeniae 7Kg, Radix Scrophulariae 7Kg, Cortex Mori 7Kg, all the other 12 taste Chinese medicines of Spica Prunellae 9Kg decoct with water and extract three times; the decocting that adds for the first time 7 times of amounts of whole extraction medical material weight boils 2 hours; adding for the second time 6 times of water gagings of whole extraction medical material weight decocts 1.5 hours; adding for the third time 4 times of water gagings of whole extraction medical material weight decocts 1.0 hours; collecting decoction, filters or/and standing;
(3) get filtrate or/and supernatant is condensed into thick paste, dry, pulverize into fine powder, sieve;
(4) add above-mentioned Bulbus Fritillariae Thunbergii fine powder to mix, granulate or do not granulate, be packed into capsule and obtain capsule or add the pharmaceutic adjuvant compacting of granulating or do not granulate and obtain in flakes tablet or add pharmaceutic adjuvant granulation and obtain granule.
Claims (6)
1. the Chinese medicine of an Acne treatment, it is characterized in that, by following component, be prepared from, all in weight portion: 7.7～13.8 parts of Flos Farfaraees, 3.5～6.3 parts of Rhizoma Coptidis, 5.5～10.3 parts of Flos Loniceraes, 5.5～10.3 parts of Radix Scutellariaes, 5.5～10.3 parts of Radix Rehmanniae Preparata, 5.5～10.3 parts of Cortex Moutans, 5.5～10.3 parts of Radix Salviae Miltiorrhizaes, 5.5～10.3 parts of Radix Rehmanniae, 5.5～10.3 parts of Fructus Gardeniaes, 5.5～10.3 parts of Radix Scrophulariaes, 3.8～6.9 parts of Bulbus Fritillariae Thunbergiis, 5.5～10.3 parts of Cortex Mori, 5.5～10.3 parts of Spica Prunellaes.
2. the Chinese medicine of Acne treatment as claimed in claim 1, it is characterized in that, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 6 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Rehmanniae, 9 parts of Fructus Gardeniaes, 9 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 8 parts of Cortex Mori, 10 parts of Spica Prunellaes.
3. the Chinese medicine of Acne treatment as claimed in claim 1, it is characterized in that, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 8 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Rehmanniae, 10 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 4 parts of Bulbus Fritillariae Thunbergiis, 9 parts of Cortex Mori, 9 parts of Spica Prunellaes.
4. the Chinese medicine of Acne treatment as claimed in claim 1, it is characterized in that, by following component, be prepared from, all in weight portion: 8 parts of Flos Farfaraees, 4 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 6 parts of Radix Rehmanniae Preparata, 7 parts of Cortex Moutans, 9 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Rehmanniae, 7 parts of Fructus Gardeniaes, 7 parts of Radix Scrophulariaes, 5 parts of Bulbus Fritillariae Thunbergiis, 7 parts of Cortex Mori, 9 parts of Spica Prunellaes.
5. the Chinese medicine for the treatment of seat skin ulcer as claimed in claim 1, is characterized in that, dosage form can be capsule, tablet or granule.
6. the preparation method of Acne treatment Chinese medicine as claimed in claim 1, is characterized in that, concrete steps are as follows: (1) gets 30～70% dry sterilizations of Bulbus Fritillariae Thunbergii total amount by ingredients weight parts, be ground into fine powder, sieves, standby; (2) get remaining Bulbus Fritillariae Thunbergii and all the other the 12 taste Chinese medicines such as Flos Farfarae of withdrawing the money by ingredients weight parts decoct with water and extract three times; the decocting that adds for the first time 4～7 times of amounts of whole extraction medical material weight boils 2 hours; adding for the second time 3～6 times of water gagings of whole extraction medical material weight decocts 1.5 hours; adding for the third time 2～4 times of water gagings of whole extraction medical material weight decocts 1.0 hours; collecting decoction, filters or/and standing;
(3) get filtrate or/and supernatant is condensed into thick paste, dry, pulverize into fine powder, sieve;
(4) add above-mentioned Bulbus Fritillariae Thunbergii fine powder to mix, granulate or do not granulate, be packed into capsule obtain capsule or add pharmaceutic adjuvant granulate or do not granulate compacting in blocks tablet or add pharmaceutic adjuvant granulation and obtain granule.
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| CN201310716456.3A CN103656146A (en) | 2013-12-21 | 2013-12-21 | Traditional Chinese medicine for treating acne and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108042695A (en) * | 2017-12-30 | 2018-05-18 | 朱增伟 | Treat the Chinese medicine preparation of acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN101322799A (en) * | 2008-08-07 | 2008-12-17 | 田建生 | Chinese medicine for treating acne and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN101322799A (en) * | 2008-08-07 | 2008-12-17 | 田建生 | Chinese medicine for treating acne and preparation thereof |
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| 达文慧等: "滋肾疏肝汤治疗中年女性痤疮80例", 《现代中医药》 * |
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| CN108042695A (en) * | 2017-12-30 | 2018-05-18 | 朱增伟 | Treat the Chinese medicine preparation of acne |
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Application publication date: 20140326 |