CN103654718A - Image processing apparatus and image processing method - Google Patents
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Abstract
The present invention relates to an image processing apparatus and an image processing method. For appropriately obtaining and providing a tomographic image and a layer thickness map in a short period of time regardless of involuntary eye movement, when the tomographic image is to be obtained in a specific scan pattern, a 3D tomographic image is first obtained by 3D scan, and then a tomographic image of a desired part is extracted from the image in accordance with the specific scan pattern. Further, based on the obtained 3D tomographic image, a sector for layer thickness may display, a main scanning line, and a sub-scanning line which are displayed on a fundus image, are set movable, and tomographic images taken along both the scanning lines after the movement are obtained. The sector having a center corresponding to the intersection between those scanning lines and the layer thickness map are recalculated and displayed so as to follow the intersection.
Description
Technical field
The present invention relates to method and apparatus that a kind of image obtaining for the Ophthalmologic apparatus to being configured to that tested eye is observed, made a video recording and measures processes with and program.
Background technology
At present, there is optical various types of ophthalmological instrument.For example, as for observing the optical instrument of eyes, use such as front eye shooting instrument, fundus camera, confocal scanning laser ophthalmoscope (scanning laser ophthalmoscope: various instruments SLO) etc.Especially, utilizing the interference of multi-wavelength light to carry out the optical fault picture pick-up device of optical coherence tomography (OCT), is to obtain with high-resolution the equipment of the faultage image of sample.Due to this reason, the ophthalmological instrument using as the retina training in outpatient service field, optical fault picture pick-up device is becoming indispensable equipment.Hereinafter optical fault picture pick-up device is called to OCT equipment.
OCT equipment can be divided into the measurement light with low coherence reference light and measure light, and with measuring rayed checked property, so that interfere from back light and the reference light of checked property, thus the layer of checked property is measured.In addition, OCT equipment, by scanning survey light on sample, can obtain and have high-resolution faultage image.Therefore, obtain the amphiblestroid faultage image on the optical fundus of tested eye, be widely used for the ophthalmic diagnosis of retina etc.
TOHKEMY 2008-209166 has proposed general Ophthalmologic apparatus, and wherein, OCT moves galvanometer mirror by the scan mode based on operator's appointment and scans optical fundus.
Between to the diagnostic period of tested eye, for example, existence need to the faultage image based on layer of retina etc. obtain each layer at the part of expectation or the thickness of this part vicinity the situation as additional information.Known configurations is for determine the fan-shaped of a plurality of regions at eye fundus image, and shows the average layer thickness in each region in fan-shaped, meets thus the method for above-mentioned needs.
Yet, do not know to show adaptively along with fan-shaped movement the method for faultage image of the position at fan-shaped place, and be difficult to fan-shaped move to given position in the situation that to configuring the layer thickness of this fan-shaped location and the faultage image of this fan-shaped position of configuration compares.
Summary of the invention
In view of said circumstances, made the present invention, the object of the invention is to make when fan-shaped while moving to given position, can be easily at the layer thickness of this fan-shaped location of configuration with configure between the faultage image of this fan-shaped position and compare
In order to address the above problem, according to an aspect of the present invention, provide a kind of image processing equipment, it comprises: eye fundus image obtains parts, for obtaining the eye fundus image of tested eye, calculating unit, the thickness of the subregion for the predetermined layer on optical fundus of calculating described tested eye on described eye fundus image, faultage image obtains parts, for obtaining described optical fundus at the faultage image of described subregion, and display control unit part, for making display unit show described eye fundus image, representing display format and the described faultage image of described subregion, wherein, described image processing equipment also comprises: change parts, for changing the position of the described display format that represents described subregion, described display format shows in described display unit, described faultage image obtains parts and is configured to when representing the described position change of described display format of described subregion, faultage image in the described subregion of the described optical fundus that obtains described tested eye after described position change, described display control unit part is configured to make described display unit to show the described faultage image in described position change described subregion afterwards, replace the described faultage image in described position change described subregion before.
According to an aspect of the present invention, also provide a kind of image processing equipment, it comprises: obtain parts, be included in the faultage image group of a plurality of faultage images that the diverse location place of checked property obtains for obtaining; Form parts, for based on described faultage image group, form be configured to described a plurality of faultage images at least one crossing formation image; Fan-shaped formation parts, for based on described faultage image group, be formed for cutting the fan-shaped of described formation image, and the thickness in described fan-shaped region are shown as figure by the predetermined layer of described checked property; Display control unit part, for making display unit show described formation image and described fan-shaped; Center specified parts, is used to specify the center of described formation image; And align unit, for forming picture centre position and align for cutting the described fan-shaped center of described formation image, described fan-shaped formation parts are configured to according to the alignment of described fan-shaped center, recalculate the thickness of the described predetermined layer that will show as figure, and make described display unit show described figure.
In order to address the above problem, according to an aspect of the present invention, also provide a kind of image processing method, it comprises: obtain the faultage image group that is included in a plurality of faultage images that the diverse location place of checked property obtains; Based on described faultage image group, form be configured to described a plurality of faultage images at least one crossing formation image; Based on described faultage image group, be formed for cutting the fan-shaped of described formation image, and the thickness in the region being obtained by described fan-shaped cutting is shown as figure by the predetermined layer of described checked property; Make display unit show described formation image and described fan-shaped; And using the formation picture centre position of the designated centers position as described formation image with for cutting the described fan-shaped center of described formation image, align, described fan-shaped formation comprises: according to the alignment of described fan-shaped center, recalculate the thickness of the described predetermined layer that will show as figure, and make described display unit show described figure.
According to embodiments of the invention, can in the area of a room, present part faultage image in short-term, and display layer thickness distribution together with this part faultage image suitably.
According to the description to exemplary embodiment below with reference to accompanying drawing, it is clear that further feature of the present invention will become.
Accompanying drawing explanation
Figure 1A and 1B are according to the structure chart of the OCT equipment of the first embodiment of the present invention.
Fig. 2 A and 2B are the key diagrams that the 3D rendering acquisition methods in the first embodiment is shown.
Fig. 3 is the figure that the camera picture in the first embodiment is shown.
Fig. 4 is the figure that the picture showing after shooting in the first embodiment is shown.
Fig. 5 is the figure that the report picture in the first embodiment is shown.
Fig. 6 is the figure that the report picture in the second embodiment of the present invention is shown.
Fig. 7 A, 7B and 7C are the key diagrams relevant to eye fundus image in the second embodiment.
Fig. 8 A and 8B are the key diagrams relevant to eye fundus image in the second embodiment.
Fig. 9 is that the shooting and the report that illustrate in the first embodiment form the flow chart operating.
Figure 10 is the block diagram that the configuration of the image processing equipment in the first embodiment is shown.
The specific embodiment
The first embodiment
Based on describing the present invention in detail at the embodiment shown in Figure 1A to 10.
The illustrative arrangement of equipment
With reference to Figure 1A, describe according to the illustrative arrangement of the examination of ocular fundus equipment of the present embodiment.
Figure 1A is the side view of Ophthalmologic apparatus.Ophthalmologic apparatus (examination of ocular fundus equipment) 200 comprises optical head 900 and platform portion 950, optical head 900 is for obtaining the measurement optical system of two dimensional image and the faultage image on front eyes image and optical fundus, platform portion 950 be can the xyz direction in Figure 1A on by the movable part for flying optical head that makes of motor (not shown).Base portion 951 comprises beam splitter (describing after a while).
Also the 925 pairs of platform portions of personal computer that are used as the control part of platform portion control, and carry out the formation of faultage image.Memory element 926 is also as examinee's information storage part, and its storage is for obtaining the program of faultage image.Monitor 928 is as display part, and input part 929 provides instruction to personal computer.Particularly, input part 929 comprises keyboard and mouse.Lower jaw keeper 323 keeps examinee's lower jaw and forehead, to impel fixedly eyes (tested eye) of examinee.Outside is used for examinee's eyes admittedly to look depending on lamp 324 admittedly.
With reference to Figure 1B, the measurement optical system of the present embodiment and the structure of beam splitter are described.
First, the inside of 900 of optical heads described.It is relative with tested eye 107 that object lens 135-1 is set to, and the light path 353 that the light path wavelength basis band on its optical axis is branched into light path 351, the fundus observation of OCT optical system and the light path 352 of admittedly using depending on lamp and observes for front eye by the first dichroic mirror 132-1 and the second dichroic mirror 132-2.In lens 135-3 and 135-4, lens 135-3 drives admittedly to look lamp 191 by motor (not shown) and for the focus adjustment of the CCD172 of fundus observation.
Between lens 135-4 and the 3rd dichroic mirror 132-3, configure perforated mirror 303, and light path 352 branches into light path 352 and light path 354.
After perforated mirror 303 in light path 352, the 3rd dichroic mirror 132-3 as mentioned above wavelength basis band, light path 352 is branched into for the light path of the CCD172 of fundus observation with to the light path of admittedly looking lamp 191.
In the centre wavelength of the LED light source 316 of the illumination light that the sensitivity of CCD172 is used with ejaculation fundus observation, the present embodiment, be specially about 780nm corresponding.CCD172 is connected to CCD control part 102.On the other hand, admittedly look lamp 191, generate visible ray, to impel fixedly eyes of examinee.Admittedly be connected to and admittedly look lamp control part 103 depending on lamp 191.
The infrared CCD 171 that lens 135-2 is set in light path 353 and observes for front eye.The sensitivity of CCD171 and front eye observe the illumination light (not shown) of use wavelength, for example about 970nm is corresponding.In addition, in light path 353, configuration image is cut apart prism (not shown).Therefore, can detect 900 of optical heads and as front eye, observe the image of cutting apart in image with respect to tested 107 distance in z direction.
As mentioned above, light path 351 forms OCT optical system, and light path 351 is for obtaining the faultage image on the optical fundus of tested eye 107.XY scanning device 134 scan light on optical fundus.As single mirror, show XY scanning device 134, but XY scanning device 134 is in the enterprising line scanning of 2 direction of principal axis of X and Y.In lens 135-5 and 135-6, by motor (not shown), drive lens 135-5, with regulate from light source 101 penetrate and the light of optical fiber 131-2 by being connected to photo-coupler 131 to the focusing the optical fundus of tested eye 107.Due to this focus adjustment, the image that simultaneously forms light spot shape from the light on the optical fundus of tested eye 107 is to enter the end of optical fiber 131-2.
Next, the structure of the light path, reference optical system and the beam splitter that start from light source 101 is described.
These structures comprise light source 101, mirror 132-4, dispersion compensation glass 115, above-mentioned photo-coupler 131, the single-mode fiber 131-1 to 131-4 that is integrally connected to photo-coupler 131, lens 135-7 and beam splitter 180.
Said modules forms Michelson's interferometer.The light penetrating from light source 101 is split into the measurement light of optical fiber 131-2 side and the reference light of optical fiber 131-3 side by optical fiber 131-1 via photo-coupler 131.
Measure light and by the light path of above-mentioned OCT optical system, irradiate the optical fundus of the tested eye 107 that will observe, and because amphiblestroid reflection and scattering are by same light path arrival photo-coupler 131.
On the other hand, reference light is by optical fiber 131-3, lens 135-7 with in order to mate by measuring the dispersion of light and the dispersion of reference light the dispersion compensation glass 115 arrival mirror 132-4 that insert, and from mirror, 132-4 is reflected.Then, reference light returns by same light path, and arrives photo-coupler 131.
Photo-coupler 131 will measure light and reference light is synthetic, to form interference light.In this case, when measuring the optical path length of light and the optical path length of reference light and substantially equate each other, interfere.In the mode being regulated on optical axis direction by motor and driving mechanism (not shown), keep mirror 132-4, mirror 132-4 can be adjusted to reference to the optical path length of light according to the optical path length of the tested eye 107 measurement light that change.By optical fiber 131-4 by the interference light beam splitter 180 that leads.
In addition, in optical fiber 131-2, for measuring light, polarization adjusting portion 139-1 is set.In optical fiber 131-3, for reference light, polarization adjusting portion 139-2 is set.These polarization adjusting portions have fiber optic loop separately around the part of several times.Should be around the length direction rotation of optical fiber, so that optical fiber distortion around portion.By this way, can regulate and measure light and reference light polarization state separately, and it is matched each other.In this equipment, regulate and measure light and reference light polarization state separately in advance, and it is fixed.
The interference light scioptics 135-8 penetrating from optical fiber 131-4 collimates substantially, and carries out dispersion by diffraction grating 181, with by forming image on lens 135-9 on-line sensor 182.
Next, the periphery of light source 101 is described.Light source 101 is as the super-radiance light emitting diode of general low-coherence light source (SLD).The light penetrating from light source 101 has the centre wavelength of 855nm and the wavelength bandwidth of about 100nm.In this case, the resolution of the faultage image that bandwidth impact will be obtained on optical axis direction, so bandwidth is important parameter.In addition, although selected SLD, do not limit especially the type of light source 101, as long as light source can send low-coherent light, can also use Amplified Spontaneous Emission (ASE) etc.For this centre wavelength, to consider eyes are measured, near infrared light is applicable to.In addition, because therefore the faultage image that centre wavelength impact will be obtained resolution in a lateral direction expect that centre wavelength is possible minimal wave length.Due to these two reasons, as example, centre wavelength is set to 855nm.
Although in the present embodiment, use Michelson's interferometer as interferometer, can use Mach Zehnder interference instrument.In the situation that the light quantity of measuring between light and reference light is poor large, Mach Zehnder interference instrument is used in expectation, and in the situation that light quantity is poor relatively little, Michelson's interferometer is used in expectation.
With reference to the functional block diagram shown in Figure 10, the method that obtains faultage image with examination of ocular fundus equipment 200 is described.Figure 10 is the schematic diagram that the function of personal computer 925 is shown.
Personal computer 925 (particularly, be included in the processor in personal computer 925) for example carry out the program in memory element 926 that is stored in, to be used as image acquiring unit 401, scan control section 402, image forming part 403,3D rendering forming portion 404,3D rendering extraction unit 405 and display control unit 406.
200 pairs of XY scanning devices 134 of examination of ocular fundus equipment are controlled, to obtain the faultage image of expectation part on the optical fundus of tested eye 107.Particularly, 402 pairs of XY scanning devices 134 of scan control section are controlled.
The image processing method that uses examination of ocular fundus equipment 200 is described.When having selected scan mode via input part 929, scan control section 402 is independently controlled XY scanning device 134 with selected scan mode, to carry out raster scanning.Then, the signal of image acquiring unit 401 based on being received by line sensor 182 obtains faultage image.That is to say, by the image acquiring unit 401 that acts on the acquiring unit that obtains faultage image group, obtain the image that is used to form 3D faultage image.Note, XY scanning device 134 is scanning survey light in the x of Fig. 2 A direction, and 182 pairs of the line sensors information from the image pickup scope in the x direction on optical fundus is carried out the imaging of pre-determined number.
The Luminance Distribution that certain position to line sensor 182 in x direction obtains is carried out fast fourier transform (FFT), and the linear luminance obtaining by FFT is distributed and is converted to concentration or colouring information.Information after this conversion is called to A sweep image.In order to organize a B scanogram after having obtained a plurality of A sweep images, the scanning position in mobile y direction, and again carry out the scanning in x direction, thus obtain a plurality of B scanograms.That is to say, the diverse location on tested eye obtains a plurality of faultage image T that extend parallel to each other
1to T
n, as faultage image group.Image based on being obtained by image acquiring unit 401,3D rendering forming portion 404 forms the 3D rendering shown in Fig. 2 B.Note, in the present embodiment, obtained and be suitable for n the faultage image that 3D rendering forms, still, for example, can, according to by the resolution of the image that will extract describing after a while, increase or reduce the quantity of the faultage image that will obtain.
Next, 3D rendering extraction unit 405 is extracted the image corresponding with the scan mode of selecting by input part 929.That is to say, in the present invention, 3D rendering extraction unit 405 is as forming unit, and forming unit is for the faultage image group based on comprising a plurality of faultage images that obtain as B scanogram, form be configured to the plurality of faultage image at least one crossing image.Display control unit (unit) 406, according to the preassigned pattern of all patterns as shown in Figure 3 etc., shows the image extracting on display part 928.Image forming part 403 forms eye fundus image based on B scanogram.That is to say, image forming part 403 is corresponding to for obtaining the example of eye fundus image acquiring unit of the eye fundus image of tested eye.In addition, 3D rendering extraction unit 405 is corresponding to for obtaining the example of faultage image acquiring unit of the faultage image on the optical fundus of (fan-shaped) in region.
Fig. 3 is the example of the picture 1000 that will show on display part 928.Picture 1000 comprises front eye observation image 1101, fundus observation image 1201 and tomography observation image 1301.In addition, picture 1000 comprises left eye or right eye selection button 1001.In addition the information 1202 that shows, the scope that represents acquisition faultage image on fundus observation image 1201.
Next, referring to figs. 1A to 9, method and processing method that the use OCT equipment with the present embodiment feature obtains faultage image are described.
Fig. 9 is the flow chart that obtains the method for faultage image.In step S1, in the scan pattern button 1501 from the measurement picture shown in Fig. 3, select scan pattern.Scan pattern comprises Macula (macula lutea) 3D, Glaucoma (glaucoma) 3D and Disc (optic disc) 3D.The in the situation that of switched scan pattern, for each in scan pattern, optimum scanning mode and solid apparent place are set.Scan mode comprises radial scan, cross scan, circular scan and 3D scanning.In the present invention, these modes become be respectively used to obtain the faultage image group comprise a plurality of radial configuration image, comprise two crossing faultage image groups image, comprise the image of cylindrical fault image sets and comprise the working method of the image of a plurality of parallel fault image sets.
In the present embodiment, describe and select radial scan as the situation of scan mode.Note, scan mode is not limited to radial scan, and can select other scan mode.In step S2, press start button 1004, automatically to carry out focus adjustment and alignment adjusting.Thus, prepare to make a video recording.In order to regulate subtly, focus on and alignment, operation slide block 1103, above to move and to regulate the position of optical head 900 in z direction (optical axis direction) with respect to tested eye.In addition, operation slide block 1203 is to carry out focus adjustment, and operation slide block 1302 is with the door position adjustments that is concerned with.Focus adjustment is corresponding to the adjusting of mobile lens 135-3 and 135-5 in the direction of shown arrow in order to regulate focusing with respect to optical fundus.Relevant door regulates corresponding to the faultage image for observation expectation position in faultage image display frame the adjusting of moving lens 132-4 in the direction at shown arrow.Subsequently, in step S3, press shooting push button 1003, to make a video recording.Note, use cursor of mouse 1002 to carry out this button push etc.
In step S4, XY scanning device 134 is carried out 3D scanning.In step S5, the B scanogram based on shown in Fig. 2 A, forms the 3D faultage image body shown in Fig. 2 B.In step S6, as shown in Figure 4, the eye fundus image 2101 show obtaining on picture 2000 and 2201 and faultage image 2301,2303 and 2305.Faultage image 2303 is the faultage images at scanning line 2102 and 2202 places.Scanning line 2102 and 2202 moves along the vertical direction automatically in sweep limits, to show corresponding faultage image.Faultage image 2301 is faultage images of the upper edge of sweep limits, and faultage image 2305 is faultage images of the lower edge of sweep limits.In addition, arrow 2302,2304 and 2306 represents the position of faultage image on eye fundus image (faultage image scope).Note, in the present embodiment, eye fundus image 2101 is SLO images, and eye fundus image 2201 is integral images.In addition, left eye or right eye select button 2001 and left eye or right eye in Fig. 3 to select button 1001 similar, and scan pattern button 2501 is similar with the scan pattern button 1501 in Fig. 3.
In step S7, press OK button 2004 or NG button 2003, when pressing OK button 2004, form report picture 3000 (Fig. 5).
In addition, on faultage image 3201, show the information 3202 of the direction that represents main scanning line 3103, and on faultage image 3301, show the information 3302 of the direction that represents subscan line 3104.Note, represent that the information 3202 of direction of main scanning line 3103 and the information 3302 of the direction of vice scanning line 3104 can not show on faultage image, and may be displayed near faultage image.
In step S9, by clicking with cursor of mouse (not shown), on eye fundus image 3101, specify given scanning center position 3102.This appointment carrying out as the module region of center designating unit in display control unit 406, wherein, center designating unit is used to specify corresponding with the center that forms image being formed by the forming unit picture centre position that forms.In step S10, obtain the coordinate (x, y) 3102 of the position of appointment in step S9.In step S11, centered by coordinate (x, y) 3102, based on 3D faultage image, form along the faultage image of main scanning line 3103 and 3104 acquisitions of subscan line, be used as forming image.In the present invention, these main scanning lines 3103 correspond respectively to first direction line and the second direction line different from first direction line with subscan line 3104, for determine forming image in the configuration of the extracting position of the corresponding eye fundus image of the plane picture with checked property etc.Main scanning line 3103 intersects with formation image in precalculated position.This precalculated position is corresponding to coordinate (x, y) 3102.In addition, the module region as forming picture position determining unit in display control unit 406 of determining of these lines is carried out, and wherein, forms picture position determining unit for determining first direction line and the second direction line crossing with it.
In step S12,3D faultage image based on forming in step S5, calculate amphiblestroid thickness and using fan-shaped form demonstration as retinal thickness Figure 37 01, and calculate and illustrate retinal nerve fibre layer (RNFL) thickness 3401, the RNFL deviation 3501 based on normal eyes data base (NDB) and the RNFL significance 3601 based on NDB.Note, these calculated example are as undertaken by personal computer 925.That is to say, personal computer 925 is corresponding to the example of computing unit, and computing unit is for calculating the thickness in the predetermined layer on the optical fundus of the tested eye in the subregion of eye fundus image.
In addition,, so that the mode of thickness can be identified by for example color, show RNFL thickness 3401.By the color that shows that 3402 expressions are corresponding with thickness.In addition, in the mode that can identify deviation by for example color, show deviation 3501.By the color that shows that 3502 expressions are corresponding with deviation.In addition, in the mode that can identify significance by for example color, show significance 3601.By the color that shows that 3602 expressions are corresponding with significance.In this case, near the circle papillae in each in RNFL thickness 3401, RNFL deviation 3501 and RNFL significance 3601 is corresponding to retinal thickness Figure 37 01.Note, not with near the circle papillae in each in four partial display RNFL thickness 3401, RNFL deviation 3501 and RNFL significances 3601 of cutting apart, but when forming retinal thickness Figure 37 01, with four parts of cutting apart, calculate each in RNFL thickness 3401, RNFL deviation 3501 and RNFL significance 3601.Note, retinal thickness Figure 37 01 is not limited to be divided into the figure of four parts, and more than can being divided into five parts or three below part.
In step S13, when again having clicked the given position on eye fundus image 3101 with cursor of mouse, again carry out the processing in step S10, S11 and S12, and again calculate faultage image and the retinal thickness figure of specified location.
In addition, for example, when rotating mouse roller in the situation that cursor of mouse is on eye fundus image, main scanning line 3103 and subscan line 3104 be 3102 rotations around scanning center position, and show with it corresponding faultage image 3201 and 3301 together.Note, according to the rotation of main scanning line 3103 and subscan line 3104, in addition according to the rotation direction of mouse roller, the expression information 3202 of direction of main scanning line 3103 and the information 3302 of the direction of vice scanning line 3104 can be rotated similarly.By this way, when faultage image obtain position while rotating, grasp and on eye fundus image 3101, which direction to have obtained the relevant information of faultage image along and become easily, this is difficult to grasp under conventional situation.
Note, the rotation direction of main scanning line 3103 and subscan line 3104 can be any one clockwise and counterclockwise.
In addition, on the eye fundus image 3101 in Fig. 5, dot tomography image pickup scope, the rotation according to mouse roller in the scope being illustrated by the broken lines of main scanning line 3103 and subscan line 3104 is moved.Note, in the rectangle image pickup scope being illustrated by the broken lines, the length of the faultage image that can obtain when main scanning line 3103 or subscan line 3104 are positioned on the diagonal of image pickup scope, is greater than the length of the faultage image that can obtain when main scanning line 3103 or subscan line 3104 are positioned at the cornerwise position that is different from image pickup scope.Therefore, the length of main scanning line 3103 and subscan line 3104 is set to during turning not change.Alternatively, can main scanning line 3103 and the length of subscan line 3104 be set to depend on the scope being illustrated by the broken lines, and when faultage image is elongated, can not show the end of faultage image, to show consistently the faultage image with essentially identical length.In addition, alternatively, can main scanning line 3103 and the length of subscan line 3104 be set to depend on the scope being illustrated by the broken lines, and when faultage image is elongated, can be with according to viewing area and the mode of minification shows faultage image, or can increase viewing area itself.
Note, eye fundus image 3101 can be the image by 3D faultage image integration is obtained, or can be SLO image.
Note, below carrying out as the module region in the image forming part 403 of fan-shaped forming unit: form fan-shapedly in the specified location corresponding with forming image for faultage image, and the predetermined layer based on faultage image group demonstration checked property is at the figure of the thickness in the fan-shaped region cutting out.In addition, fan-shaped forming unit is according to the alignment of fan-shaped center, recalculate the thickness of the predetermined layer such as layer of retina etc. that will show as figure, and display control unit 406 shows together with faultage image and recalculates result on display part 928.
In the present embodiment, when scanning optical fundus, under scan mode, all carry out 3D scanning arbitrarily, therefore can from 3D faultage image, extract the faultage image of expectation part.Traditionally, existence is only being obtained under the scan mode of the faultage image obtaining along invisible scanning line (radial scan, circular scan, cross scan etc.), cannot obtained the situation of expecting faultage image partly, but in these cases, can easily regenerate any one in these faultage images as forming image.Note, forming image can be the single faultage image obtaining along certain line.In addition,, no matter selected which scan mode, all carry out 3D scanning, so the track of scanning line is constant.Therefore, can eliminate the fluctuation of depending on that consolidating of scanning line looks.
That is to say, use above-mentioned configuration, no matter selected which scan mode, all carry out 3D scanning, to obtain 3D faultage image, and can extract the faultage image of this scan mode.Traditionally, the situation of the faultage image of the part that cannot obtain expectation under the scan mode of the faultage image obtaining along invisible scanning line (radial scan, circular scan, cross scan etc.) is only being obtained in existence, but can easily regenerate in these cases, the faultage image of expectation part.In addition, under any scan mode, all carry out 3D scanning, so the track of scanning line is constant.Therefore, can eliminate the fluctuation of depending on that consolidating of scanning line looks.
The second embodiment
The second embodiment of the present invention and the first embodiment utilize the identical method of obtaining faultage image, but different aspect report picture.Note, the report picture that show is the difference according to selected scan pattern in the picture of Fig. 3 for example.For example, Fig. 5 shows the report picture while having selected papillae image pickup mode in scan pattern button 1501.In addition, for example, Fig. 6 shows the report picture while having selected macula lutea image pickup mode in scan pattern button 1501.Report picture 4000 shown in Fig. 6 comprises eye fundus image 4101.On eye fundus image 4101, show main scanning line 4103, subscan line 4104 and fan-shaped 4105.Note, showing that under the original state of report picture 4000, for example, mate with the center of tomography image pickup scope at fan-shaped 4105 center.In addition, the intersection point 4102 between main scanning line 4103 and subscan line 4104 for example mates with fan-shaped 4105 center.Report picture 4000 comprises main scanning line faultage image 4301 as the faultage image corresponding with main scanning line 4103, as subscan line faultage image 4401 and thickness chart 4701 with the corresponding faultage image of subscan line 4104.Note, fan-shaped 4105 shape is not limited to the shape shown in Fig. 6, and can be other shape.Note, equally in a second embodiment, function and the function shown in Figure 10 of personal computer are substantially similar, therefore omit its detailed description.
Equally in a second embodiment, according to the flow chart of the method for obtaining faultage image shown in Fig. 9, obtain faultage image.On report picture 4000 as shown in Figure 6, show the faultage image obtaining.That is to say, display control unit 406 is corresponding to the example of indicative control unit, and indicative control unit is for making display unit show display format and the faultage image in eye fundus image, expression region.
Now, be described in main scanning line 4103, the subscan line 4104 and fan-shaped 4105 showing on the eye fundus image corresponding with the plane picture of checked property 4101.When the initial position from Fig. 7 A is clicked given scanning center position with cursor of mouse, as shown in Figure 7 B, fan-shaped 4105 the intersection point between main scanning line 4103 and subscan line 4104 with for cutting under the state that fan-shaped 4105 center of this formation image matches each other, move.That is to say that the movement along with fan-shaped 4105 changes the faultage image showing on report picture 4000.In addition, such as the input part 929 of cursor of mouse etc., corresponding to the example that changes unit, wherein, change unit for changing the position of the display format that is illustrated in region shown on display unit.As shown in Figure 7 B, the movement along with fan-shaped 4105, main scanning line 4103 and subscan line 4104 move.Therefore, when representing the position change of display format in this region, the faultage image in the region of the optical fundus that obtains tested eye as the 3D rendering extraction unit 405 of faultage image acquiring unit after position change.Then, indicative control unit makes display unit display position change the faultage image in region afterwards, replaces the faultage image in position change region before.
In addition, when as shown in Fig. 7 C, while selecting and dragging main scanning line 4103 and subscan line 4104 by using cursor of mouse to click, fan-shapedly do not move, but main scanning line 4103 and subscan line 4104 can move.When watching the main scanning line faultage image 4301 and subscan line faultage image 4401 corresponding with main scanning line 4103 and subscan line 4104 difference, main scanning line 4103 and subscan line 4104 move.By this way, can make main scanning line 4103 and subscan line 4104 be positioned at the most recessed position of fovea centralis, find exactly thus the center of fovea centralis.
At this moment, when clicking the intersection point between main scanning line and subscan line with cursor of mouse, mate with the intersection point between main scanning line 4103 and subscan line 4104 at fan-shaped center, therefore can be by the fan-shaped center that moves to exactly fovea centralis.Like this, the center that the fovea centralis of can take is thickness chart, obtains retinal thickness Figure 47 01 accurately, and this is useful for retinal diagnosis.That is to say, display control unit 406 shows predetermined layer for fan-shaped the cut image of cutting image, is amphiblestroid thickness in the present embodiment on display part 928.In addition, the appointment of the configuration to this image that comprises faultage image in eye fundus image, the module region as position specifying unit in display control unit 406 is carried out.
Note, subscan line faultage image 4401 forms based on main scanning line faultage image 4301, therefore compares with main scanning line faultage image 4301, and the picture quality of subscan line faultage image 4401 is conventionally deteriorated.In some cases, by watching this faultage image, be difficult to find exactly the center of fovea centralis.In these cases, can use the auxiliary fault line 4302 showing on main scanning line faultage image 4301, to find exactly the center of fovea centralis.Auxiliary fault line 4302 is positioned at the position of fault identical with subscan line 4104, when auxiliary fault line 4302 moves, and subscan line 4104 and 4502 associated with itly mobile.In order to obtain exactly retinal thickness Figure 47 01, when watching main scanning line faultage image 4301, move main scanning line 4103, to find the most recessed position of fovea centralis, then, mobile auxiliary fault line 4302, so that auxiliary fault line 4302 is positioned at the most recessed position of fovea centralis.At this moment, when clicking the intersection point between main scanning line 4103 and subscan line 4104 with cursor of mouse, for fan-shaped 4105 the center of cutting eye fundus image or forming image, mate with the intersection point between main scanning line and subscan line.Therefore, can be by fan-shaped 4105 centers that move to exactly fovea centralis.That is to say, fan-shaped, main scanning line and subscan line are followed each other.At this moment, do not need subscan line faultage image 4401, therefore can not show subscan line faultage image 4401.In addition, when not showing subscan line faultage image 4401, can be in showing the region of subscan line faultage image 4401, in the mode of amplifying, show near the faultage image fovea centralis of main scanning line faultage image 4301, and can show auxiliary fault line 4302.Like this, can find more accurately the center of fovea centralis.Note, can on report picture 4000, switch be set, for the demonstration of subscan line faultage image 4401 is switched to and do not shown.In addition the deviation of RNFL or the cromogram of significance that, eye fundus image 4501 shows based on NDB.When pressing retinal thickness switching push button 4605, eye fundus image 4601 is at layer of retina,pigment epithelium (RPE), photoreceptor internal segment/acromere (IS/OS) and (retinal nerve fibre layer: RNFL)+(ganglion cell layer: GCL)+(inner molecular layer: switch thickness chart between thickness chart IPL), and show corresponding thickness chart as cromogram.Note, when auxiliary fault line 4402 moves, main scanning line 4103 and 4503 can be associated with it mobile.In this case, show that 4106,4504 and 4604 represent the color with respect to the value of thickness etc.
The example that subscan line 4104 and 4502 moves associated with itly in the above-described embodiments, has been described when auxiliary fault line 4302 moves.Alternatively, for example, when subscan line 4104 moves, auxiliary fault line 4302 and subscan line 4502 are associated with itly mobile.That is to say, auxiliary fault line 4302 can move with subscan line 4104 and 4502 with being associated with each other.Auxiliary fault line 4402 can be mobile similarly with main scanning line 4103 and 4503 with being associated with each other.In addition, main scanning line 4603 and subscan line 4602 can move with auxiliary fault line 4402 and auxiliary fault line 4302 respectively explicitly.
Fig. 8 A and 8B show variation.As shown in Fig. 8 A and 8B, main scanning line and fan-shaped integrated each other, and subscan line moves independently.When watching faultage image, integrated main scanning line and fan-shaped moving into place in the most recessed position of fovea centralis each other.Then, the auxiliary fault line in faultage image moves into place in the most recessed position of fovea centralis.By this way, equally can be by the fan-shaped center that moves to exactly fovea centralis.
Other embodiment
In addition, the present invention can also realize by carrying out following processing.That is to say, pack processing is containing be provided for realizing the software (program) of the function of above-described embodiment to system or equipment via network or various storage medium, and the computer (or CPU, MPU etc.) of system or equipment is read and performing a programme.
The invention is not restricted to above-described embodiment, can without departing from the spirit of the invention within the scope, to the present invention, carry out various distortion or change.For example, in the above-described embodiments, having described checked property is the situation of eyes, but the present invention can also be applied to the measuring object such as the skin outside eyes and organ etc.In this case, the present invention has the aspect as the medical apparatus and instruments such as the endoscope outside Ophthalmologic apparatus etc.Therefore, expectation the present invention is understood to take the checkout facility that Ophthalmologic apparatus is example, and tested eye is understood to an aspect of checked property.
Although reference example embodiment describes the present invention, should be appreciated that and the invention is not restricted to disclosed exemplary embodiment.The scope of claims meets the widest explanation, so that it contains all this distortion, equivalent structure and function.
Claims (9)
1. an image processing equipment, it comprises:
Eye fundus image obtains parts, for obtaining the eye fundus image of tested eye;
Calculating unit, the thickness of the subregion for the predetermined layer on optical fundus of calculating described tested eye on described eye fundus image;
Faultage image obtains parts, for obtaining described optical fundus at the faultage image of described subregion; And
Display control unit part, for making display unit show described eye fundus image, described faultage image and representing the display format of described subregion;
Wherein, described image processing equipment also comprises:
Change parts, for changing the position of the described display format that represents described subregion, wherein, described display format shows in described display unit,
Described faultage image obtains parts and is configured in the situation that represent the position change of the described display format of described subregion, the faultage image in the described subregion of the optical fundus that obtains described tested eye after described position change,
Described display control unit part is configured to make described display unit to show the described faultage image in described position change described subregion afterwards, replaces the described faultage image in described position change described subregion before.
2. an image processing equipment, it comprises:
Obtain parts, for obtaining, be included in the faultage image group of a plurality of faultage images that the diverse location place of checked property obtains;
Form parts, for based on described faultage image group, form be configured to described a plurality of faultage images at least one crossing formation image;
Fan-shaped formation parts, for based on described faultage image group, be formed for cutting the fan-shaped of described formation image, and the thickness in described fan-shaped region are shown as figure by the predetermined layer of described checked property;
Display control unit part, for making display unit show described formation image and described fan-shaped;
Center specified parts, is used to specify the center of described formation image; And
Align unit, for by the center of described formation image with for cutting the described fan-shaped center of described formation image, align,
Described fan-shaped formation parts are configured to, according to the alignment of described fan-shaped center, recalculate the thickness of the described predetermined layer that will be shown as figure, and make described display unit show described figure.
3. image processing equipment according to claim 2, wherein, described formation parts be configured to form using in hypograph any one as described formation image: comprise the faultage image group of a plurality of radial configuration image, comprise columned faultage image group image, comprise the image and the image that comprises a plurality of parallel faultage image groups of two crossing faultage image groups, wherein, any one in described image is configured in the region that obtains described faultage image group.
4. according to the image processing equipment described in claim 2 or 3, wherein, also comprise: form picture position determining means, for determine in precalculated position with described formation image crossing with determine described formation image configuration first direction line and with the crossing second direction line of described first direction line.
5. image processing equipment according to claim 3, wherein, also comprise: form picture position determining means, for determine in precalculated position with described formation image crossing with determine described formation image configuration first direction line and with the crossing second direction line of described first direction line
Described precalculated position comprises with any one the center in hypograph: described in comprise the faultage image group of a plurality of radial configuration image, described in comprise columned faultage image group image, described in comprise two crossing faultage image groups image with described in comprise the image of a plurality of parallel faultage image groups.
6. image processing equipment according to claim 2, wherein, also comprises: position specifying part part, and for specify the configuration of described formation image at the plane picture of described checked property,
Wherein, described display control unit part be configured to make described display unit in the described plane picture of described checked property, show first direction line, with the crossing second direction line of described first direction line with for cutting the fan-shaped of described plane picture,
Wherein, described first direction line in direction, equal described checked property acquisition described formation image layer, and
Wherein, described align unit is configured to make described first direction line and described second direction line to follow for cutting the described fan-shaped of described plane picture.
7. image processing equipment according to claim 6, wherein, described position specifying part part is configured to the center based on described formation image, specifies the configuration of described formation image.
8. image processing equipment according to claim 6, wherein, described display control unit part is configured to:
Make described display unit show described second direction line in the faultage image obtaining along described first direction line; And
Make described display unit show described first direction line in the faultage image obtaining along described second direction line.
9. an image processing method, it comprises:
Obtain the faultage image group that is included in a plurality of faultage images that the diverse location place of checked property obtains;
Based on described faultage image group, form be configured to described a plurality of faultage images at least one crossing formation image;
Based on described faultage image group, be formed for cutting the fan-shaped of described formation image, and the thickness in the region being obtained by described fan-shaped cutting is shown as figure by the predetermined layer of described checked property;
Make display unit show described formation image and described fan-shaped; And
Using the formation picture centre position of the designated centers position as described formation image with for cutting the described fan-shaped center of described formation image, align,
Described fan-shaped formation comprises: according to the alignment of described fan-shaped center, recalculate the thickness of the described predetermined layer that will be shown as figure, and make described display unit show described figure.
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| JP (1) | JP6188296B2 (en) |
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| JP6160809B2 (en) * | 2013-01-23 | 2017-07-12 | 株式会社ニデック | Ophthalmic photographing apparatus and photographing control program |
| JP6464565B2 (en) * | 2014-03-31 | 2019-02-06 | 株式会社ニデック | Fundus photographing device |
| JP6635716B2 (en) * | 2015-08-27 | 2020-01-29 | キヤノン株式会社 | Display control device, display control method and program |
| EP3655748B1 (en) | 2017-07-18 | 2023-08-09 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
| JP7135346B2 (en) * | 2018-03-06 | 2022-09-13 | 株式会社ニデック | OCT data processor and OCT data processing program |
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| GB2507394A (en) | 2014-04-30 |
| GB201315281D0 (en) | 2013-10-09 |
| CN103654718B (en) | 2016-05-04 |
| JP2014045901A (en) | 2014-03-17 |
| KR20140029255A (en) | 2014-03-10 |
| KR101581310B1 (en) | 2015-12-31 |
| US9125561B2 (en) | 2015-09-08 |
| US20140063451A1 (en) | 2014-03-06 |
| JP6188296B2 (en) | 2017-08-30 |
| DE102013217112A1 (en) | 2014-03-06 |
| GB2507394B (en) | 2015-04-22 |
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