CN103645451A - Low field nuclear magnetic resonance probe based on printed circuit board helmholtz coil - Google Patents
Low field nuclear magnetic resonance probe based on printed circuit board helmholtz coil Download PDFInfo
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- CN103645451A CN103645451A CN201310661302.9A CN201310661302A CN103645451A CN 103645451 A CN103645451 A CN 103645451A CN 201310661302 A CN201310661302 A CN 201310661302A CN 103645451 A CN103645451 A CN 103645451A
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Abstract
The invention discloses a low field nuclear magnetic resonance probe based on a printed circuit board helmholtz coil. A PCB substrate is taken as a substrate. An upper surface of the PCB substrate is provided with a first bonding pad, a second bonding pad, an upper portion lead wire and an upper portion plane coil. A lower surface of the PCB substrate is provided with a lower portion lead wire and a lower portion plane coil. An outer end of the upper portion plane coil is connected with the first bonding pad through the upper portion lead wire. An outer end of the lower portion plane coil is connected with the lower portion lead wire. An inner end of the upper portion plane coil and an inner end of the lower portion plane coil are connected through a first metalized through hole. The second bonding pad and the lower portion lead wire are connected through a second metalized through hole. A central section of the PCB substrate is provided with a sample through hole which passes through up and down. The nuclear magnetic resonance probe based on PCB helmholtz coil provided in the invention adopts a PCB technology and possesses the following advantages that manufacturing is simple; cost is low; a period is short; mass production can be realized and so on. And a radio-frequency field which is relatively uniform can be generated.
Description
Technical field
The present invention relates to a kind of low-field nuclear magnetic resonance probe based on printed circuit board (PCB) (printed circuit board, PCB) Helmholtz coils.
Background technology
Nuclear magnetic resonance (nuclear magnetic resonance, NMR) technology is compared other analytical technologies, has the advantages that not destroy sample, so the application such as widespread use chemistry, material and medical science.NMR probe based on coil is one of core component of nuclear magnetic resonance apparatus, and the quality of coil development directly has influence on the performance of NMR system.Therefore, domestic and international research institution and business unit are all using coil as an important research and development object.
Research and development is solenoid coil in early days, the main method adopting is that the manual wire that is wound around is made (Peck on kapillary, T.L., et al.Design and analysis of microcoils for NMR microscopy.Journal of Magnetic Resonance Series B, 1995.108 (2): p.114-124.), high and the radio-frequency field good uniformity of coil q, but manual to be wound around the limitation of bringing be can not batch making.For mass and automated production coil, some scholars (Massin, T.L., et al.Planar microcoil-based microfluidic NMR probes.Journal of Magnetic Resonance, 2003.164 (2): p.242-255.) based on glass substrate or silicon substrate, use photoetching and copper electroplating technology, make MEMS (micro electro mechanical system) (micro electro mechanic system, MEMS) planar coil, it has the potentiality that are easy to the integrated advantage of microchannel and reduce cost of manufacture, but planar coil is compared and Helmholtz coils, aspect the uniform radio-frequency field of generation, be still in a disadvantageous position.Therefore, indivedual scholar (Ehrmann, K., et al., Microfabricated solenoids and Helmholtz coils for NMR spectroscopy of mammalian cells.Lab on a Chip, 2007.7 (3): p.373-380.) still take photoetching and copper electroplating technology as basis, make MEMS Helmholtz coils, but technology difficulty is large and the cycle is long, be difficult for repeating making, cost is higher.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of low-field nuclear magnetic resonance based on printed circuit board (PCB) Helmholtz coils probe, solve that difficult making, cost that existing Helmholtz coils exists in making are high, the cycle is long, can not wait in batches problem.
Technical scheme: for achieving the above object, the technical solution used in the present invention is:
Low-field nuclear magnetic resonance probe based on printed circuit board (PCB) Helmholtz coils, this probe is usingd PCB substrate as substrate, at the upper surface of PCB substrate, the first pad, the second pad, top lead-in wire and upper plane coil are set, at the lower surface of PCB substrate, bottom lead-in wire and lower flat coil are set; The outer end of described upper plane coil is gone between and is connected with the first pad by top, and the outer end of described lower flat coil is connected with bottom lead-in wire; The inner of the inner of described upper plane coil and lower flat coil is connected by the first plated-through hole, and described the second pad is connected by the second plated-through hole with bottom lead-in wire; The middle part of described PCB substrate is provided with the sample through hole running through up and down, and described sample through hole is positioned at upper plane coil and lower flat coil.
In said structure, the first pad, the second pad, top lead-in wire, upper plane coil, bottom lead-in wire and lower flat coil connect as one, and all can adopt copper product to make, after completing, all right turmeric or gold-plated of the outside surface of copper product, can avoid copper oxidation.
Above-mentioned probe is mainly used in low-field nuclear magnetic resonance field, and concrete applicable operating frequency range is depending on the self-resonant frequency of Helmholtz coils (upper plane coil and lower flat coil); Determining of the thickness of PCB substrate need to be determined in conjunction with the manufacture craft of Helmholtz coils internal diameter and PCB substrate; Helmholtz coils and peripheral resonance matching circuit integrated, can adopt spun gold (or aluminium wire) bonding or Zero-ohm resistor to connect.
During work, by after above-mentioned probe place in circuit, detected fluid sample is put into the kapillary of closed at both ends, then kapillary is directly put in sample through hole and can starts to detect.
Preferably, the material of described PCB substrate is for mainly by glass fibre, insulating material that fabric material and resin do not form, such as FR-4.
Preferably, the planform of described upper plane coil and lower flat coil is spiral circle, square, hexagon, octagon or n limit shape, and described n is even number and is more than or equal to 10, for symmetrical or approach symmetrical shape; Upper plane coil is consistent with the planform of lower flat coil, and internal diameter, live width, thickness, spacing, the number of turn are all identical.
Preferably, the wire of described upper plane coil and lower flat coil trend is contrary, and upper plane coil is consistent with the radio-frequency field direction that lower flat coil produces.
Preferably, the shape of cross section of described sample through hole has symmetry, and it is interior for putting sample hose; Generally be designed to circle, by bore mode, process and make; The internal diameter of sample through hole should approach the internal diameter size of upper plane coil and lower flat coil as much as possible, like this can be so that activity coefficient maximizes.
, there is the limitations such as radio-frequency field is inhomogeneous in beneficial effect: existing nmr probe is made most based on planar coil; The Helmholtz coils that minority is made based on photoetching and electroplating technology, exists that technology difficulty is large, high in cost of production limitation.Nmr probe based on PCB Helmholtz coils provided by the invention, can produce radio-frequency field relatively uniformly; Meanwhile, the present invention adopts PCB technology, have make simple, cost is low, the cycle is short and can mass etc. advantage; Can be applied to realize the sample analysis in low-field nuclear magnetic resonance field, such as imaging, well logging, food security etc.
Accompanying drawing explanation
Fig. 1 is that the axle that waits of structure of the present invention measures intention;
Fig. 2 is the upward view of structure of the present invention;
Fig. 3 is the vertical view of structure of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the present invention is further described.
Be a kind of low-field nuclear magnetic resonance probe based on printed circuit board (PCB) Helmholtz coils as shown in Figure 1, Figure 2 and Figure 3, this probe is usingd PCB substrate 1 as substrate, at the upper surface of PCB substrate 1, the first pad 61, the second pad 62, top lead-in wire 51 and upper plane coil 31 are set, at the lower surface of PCB substrate 1, bottom lead-in wire 52 and lower flat coil 32 are set; The outer end of described upper plane coil 31 is gone between and 51 is connected with the first pad 61 by top, and the outer end of described lower flat coil 32 is connected with bottom lead-in wire 52; The inner of the inner of described upper plane coil 31 and lower flat coil 32 is connected by the first plated-through hole 41, and described the second pad 62 is connected by the second plated-through hole 42 with bottom lead-in wire 52; The middle part of described PCB substrate 1 is provided with the sample through hole 2 running through up and down, and described sample through hole 2 is positioned at upper plane coil 31 and lower flat coil 32.
The material of described PCB substrate 1 is for mainly by glass fibre, insulating material that fabric material and resin do not form, and this case adopts FR-4.
The planform of described upper plane coil 31 and lower flat coil 32 is spiral circle, square, hexagon, octagon or n limit shape, and described n is even number and is more than or equal to 10; Upper plane coil 31 is consistent with the planform of lower flat coil 32, and internal diameter, live width, thickness, spacing, the number of turn are all identical; In this case, upper plane coil 31 is identical with the geomery of lower flat coil 32, is circle, but wire trend is contrary.
The shape of cross section of described sample through hole 2 has symmetry, and this case has adopted circular configuration, and the internal diameter of its sample through hole is slightly less than the internal diameter of upper plane coil 31 and lower flat coil 32, allows as far as possible activity coefficient maximize.
The low-field nuclear magnetic resonance probe based on printed circuit board (PCB) Helmholtz coils that this case provides, a kind of making and use procedure are as follows:
(1) theoretical according to classical signal to noise ratio (S/N ratio), and in conjunction with the geometric parameter of Maxwell Ansoft Software for Design Helmholtz coils (upper plane coil 31 and lower flat coil 32), another according to the thickness of the feature Design PCB substrate 1 of PCB technique;
(2) according to the geometric parameter of design, on CAD or CAXA software, draw the planimetric map of upper plane coil 31 and lower flat coil 32, then two planimetric maps are imported to successively to the circuit diagram drafting that Protel DXP software carries out Helmholtz coils, then adopt PCB technology to carry out the processing and fabricating of Helmholtz coils;
(3) Helmholtz coils of making is put into network analyzer (containing electric impedance analyzer), the electrical quantity of test Helmholtz coils, and according to the electrical quantity design resonance matching circuit of Helmholtz coils, the general L-type that adopts, by resonance matching, low the NMR probe based on PCB Helmholtz coils is matched to 50 Ω;
(4) the NMR probe after resonance matching is put into main field environment, and NMR probe is connected to the switch board part of NMR system by non-magnetic coaxial wire, the software debugging NMR by computing machine pops one's head in, and NMR is popped one's head in and is adjusted to optimum Working;
(5) tested liquid sample is put into kapillary, kapillary is sealed at both ends, after sealing, kapillary sample is directly put into sample through hole 2; If sample is solid-state, depending on its sample size and sample through hole 2 sizes, when sample through hole 2 is larger, can directly solid sample be put into sample through hole, sample through hole compared with hour, solid sample is divided into fraction and puts into sample through hole 2;
(6) sample produces macroscopical magnetization vector (or atomic nucleus system thermal equilibrium state of microcosmic) under the magnetization of main field, PCB Helmholtz coils produces radio-frequency field under the excitation of radio-frequency pulse, radio-frequency field and main field vertical generation relaxation phenomena mutually; While having radio-frequency (RF) excited, there is flop phenomenon and turn to 90 ° in magnetization vector, during without radio-frequency (RF) excited, magnetization vector returns original thermal equilibrium state, from 90 °, revert to again 0 °, in this regression process (term claims relaxation), PCB Helmholtz coils cutting magnetic line produces free induction decay (free induction decay, FID) signal; And the FID signal receiving just can obtain corresponding nuclear magnetic resonance time-domain signal or frequency-region signal by low noise amplification, detection and Fourier transform, by these NMR signal, just can carry out structure analysis and Components identification to sample.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (5)
1. the low-field nuclear magnetic resonance based on printed circuit board (PCB) Helmholtz coils is popped one's head in, it is characterized in that: this probe is usingd PCB substrate (1) as substrate, at the upper surface of PCB substrate (1), the first pad (61), the second pad (62), top lead-in wire (51) and upper plane coil (31) are set, at the lower surface of PCB substrate (1), bottom go between (52) and lower flat coil (32) are set; The outer end of described upper plane coil (31) by top go between (51) be connected with the first pad (61), the outer end of described lower flat coil (32) and bottom lead-in wire (52) is connected; The inner of the inner of described upper plane coil (31) and lower flat coil (32) is connected by the first plated-through hole (41), and described the second pad (62) is connected by the second plated-through hole (42) with bottom lead-in wire (52); The middle part of described PCB substrate (1) is provided with the sample through hole (2) running through up and down, and described sample through hole (2) is positioned at upper plane coil (31) and lower flat coil (32).
2. low-field nuclear magnetic resonance based on printed circuit board (PCB) Helmholtz coils probe according to claim 1, is characterized in that: the material of described PCB substrate (1) is for mainly by glass fibre, insulating material that fabric material and resin do not form.
3. the low-field nuclear magnetic resonance based on printed circuit board (PCB) Helmholtz coils according to claim 1 is popped one's head in, it is characterized in that: the planform of described upper plane coil (31) and lower flat coil (32) is spiral circle, square, hexagon, octagon or n limit shape, and described n is even number and is more than or equal to 10; Upper plane coil (31) is consistent with the planform of lower flat coil (32), and internal diameter, live width, thickness, spacing, the number of turn are all identical.
4. the low-field nuclear magnetic resonance probe based on printed circuit board (PCB) Helmholtz coils according to claim 1, is characterized in that: the wire trend of described upper plane coil (31) and lower flat coil (32) is contrary.
5. the low-field nuclear magnetic resonance probe based on printed circuit board (PCB) Helmholtz coils according to claim 1, is characterized in that: the shape of cross section of described sample through hole (2) has symmetry.
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| CN105513747A (en) * | 2014-10-14 | 2016-04-20 | 三星电机株式会社 | Chip electronic component and board having the same |
| CN105761881A (en) * | 2016-05-20 | 2016-07-13 | 浙江求缺科技有限公司 | Planar winding coil for double-column magnetic core structure |
| CN105842269A (en) * | 2016-06-13 | 2016-08-10 | 东南大学 | Device for integrating nuclear magnetic resonance (NMR) magnet and probe |
| CN106067372A (en) * | 2016-05-20 | 2016-11-02 | 浙江求缺科技有限公司 | A kind of multilayer planar winding coil method for designing being applicable to twin columns core structure |
| CN108226830A (en) * | 2018-01-05 | 2018-06-29 | 重庆大学 | A kind of resonant element and its array structure for being used to strengthen RF energy |
| CN109826618A (en) * | 2019-01-10 | 2019-05-31 | 中国石油天然气集团有限公司 | A kind of NMR RF coil that can be used under high-salinity mud Drilling Fluid Conditions |
| CN110007259A (en) * | 2018-01-04 | 2019-07-12 | 布鲁克碧奥斯平股份公司 | NMR shimming system |
| WO2022155451A1 (en) * | 2021-01-15 | 2022-07-21 | Hyperfine, Inc. | Radio frequency coil magnetic resonance imaging |
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| CN110007259A (en) * | 2018-01-04 | 2019-07-12 | 布鲁克碧奥斯平股份公司 | NMR shimming system |
| CN108226830A (en) * | 2018-01-05 | 2018-06-29 | 重庆大学 | A kind of resonant element and its array structure for being used to strengthen RF energy |
| CN109826618A (en) * | 2019-01-10 | 2019-05-31 | 中国石油天然气集团有限公司 | A kind of NMR RF coil that can be used under high-salinity mud Drilling Fluid Conditions |
| CN109826618B (en) * | 2019-01-10 | 2022-06-03 | 中国石油天然气集团有限公司 | Nuclear magnetic resonance radio frequency coil capable of being used under high-salinity mud drilling fluid condition |
| WO2022155451A1 (en) * | 2021-01-15 | 2022-07-21 | Hyperfine, Inc. | Radio frequency coil magnetic resonance imaging |
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Application publication date: 20140319 |