CN103645312A - Test strip card - Google Patents
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- CN103645312A CN103645312A CN201310570268.4A CN201310570268A CN103645312A CN 103645312 A CN103645312 A CN 103645312A CN 201310570268 A CN201310570268 A CN 201310570268A CN 103645312 A CN103645312 A CN 103645312A
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- 238000012360 testing method Methods 0.000 title claims abstract description 42
- 238000001514 detection method Methods 0.000 claims abstract description 80
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 239000000020 Nitrocellulose Substances 0.000 claims description 10
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 229920001220 nitrocellulos Polymers 0.000 claims description 10
- 239000004033 plastic Substances 0.000 claims description 10
- 229920003023 plastic Polymers 0.000 claims description 10
- 229920000728 polyester Polymers 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 238000007689 inspection Methods 0.000 claims description 8
- 230000000274 adsorptive effect Effects 0.000 claims description 7
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- 239000000084 colloidal system Substances 0.000 claims description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 6
- 239000010931 gold Substances 0.000 claims description 6
- 229910052737 gold Inorganic materials 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 5
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 5
- 229920002301 cellulose acetate Polymers 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
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- 239000006249 magnetic particle Substances 0.000 claims description 5
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- 229910052761 rare earth metal Inorganic materials 0.000 claims description 5
- 150000002910 rare earth metals Chemical class 0.000 claims description 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 4
- 230000005784 autoimmunity Effects 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 238000011109 contamination Methods 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 210000004392 genitalia Anatomy 0.000 claims description 4
- 229940088597 hormone Drugs 0.000 claims description 4
- 239000005556 hormone Substances 0.000 claims description 4
- 239000002117 illicit drug Substances 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
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- 210000002700 urine Anatomy 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
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- Life Sciences & Earth Sciences (AREA)
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- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
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- Cell Biology (AREA)
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- Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
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Abstract
Belonging to the in vitro diagnosis field, the invention in particularly relates to a test strip card with a storage medium (11) for storing a detected object standard curve or coefficient parameter and other information for the detection. The test strip card includes a card box (3) and a test strip (2) inside. The storage medium (11) is mounted on the card box (3). During sample detection, the characteristic signal of a detection band (6) in the test strip (2) is collected by an instrument with a signal detection function, and by combining the instrument, the detected object standard curve or coefficient parameter are read at the same time from the storage medium (11), so that a sample single-component or multicomponent concentration can be calculated. The test strip card for sample detection provided by the invention has the characteristics of simplicity, rapidity, high sensitivity, subjective result, and flexible application, etc.
Description
Technical field
The invention belongs to in-vitro diagnosis field, be specifically related to a kind of self with storage medium 11 standby storage checking matter typical curve or coefficient parameter etc. for detections information, combination there is instrument energy fast detecting sample one-component or the multi-component examination bar card of signal testing function.
Background technology
The immunity-chromatography test strip technology that the colloid gold test strip of take is main representative has now been widely used in the various aspects of immune detection.This technology is simple and quick, and a few minutes just can obtain result.Weak point is: (1) can only qualitative detection sample, and difficulty can realize sample and quantitatively detect, the more difficult sample polycomponent Quantitative detection of realizing.(2) for some antigen or the extremely low sample of antibody content, be difficult to the naked eye judged result, detection sensitivity is low.
Adopting the quantitative checking matter concentration of checking matter standard items typical curve, is the main method of the quantitative sample concentration of current detection field.Standard curve making is technical strong, and process is numerous and diverse, be unable to do without professional and technical personnel.Message area is the storage medium of development recently, as RFID label (claiming again RFID tag), IC chip, magnetic code, bar code etc., for Information Access identification, has now been widely used in the fields such as computing machine, communication, electronics, business, communications and transportation control and management.RFID label, volume is little, and storage information capacity is large, and identification need not manual intervention, the desirable means of Information Access identification especially, but few people use it for biomedical detection field.
For overcoming the deficiencies in the prior art, the invention provides a kind of self with the information (not needing to make again checking matter typical curve when operating personnel detect sample) detections for such as storage medium 11 standby storage checking matter typical curve or coefficient parameter, in conjunction with the instrument with signal testing function, just can realize fast the examination bar card of the quantitative detection of sample single component or polycomponent.The present invention is for sample detection, has easy quick, highly sensitive, the feature such as result is objective.
Summary of the invention
Technical solution of the present invention is as follows:
Examination bar card of the present invention comprises the examination bar 2 of cartridge 3 and Qi Nei.Examination bar 2 comprises that overlap joint is fixed on sample pad 4, label pad 5, analyzing film 7, the adsorptive pads 8 on end liner 1 in turn.Analyzing film 7 has to detect is with 6.Detection is with 6 to be one or more.The upper box face of cartridge 3 is having well 9 corresponding to examination bar sample pad 4 positions.The upper box face of cartridge 3 is having detection window 10 corresponding to examination bar analyzing film 7 positions.One storage medium 11 is installed in cartridge 3.
The a certain target checking matter that the label pad 5 of described examination bar 2 is coated with single labelled substance markers detects relevant single special molecular, or: each target checking matter that is coated with different label correspondence markings detects the potpourri of relevant special molecular.
The detection of described examination bar 2 is coated with a certain target checking matter with 6 and detects another relevant special molecular, or: be coated with the potpourri that each target checking matter detects another relevant special molecular.
The checking matter typical curve that described storage medium 11 stores has various ways available, its include but not limited to checking matter standard items series concentration with
a detect bandbetween corresponding relation curve.Described
a detect bandbe defined as the detection band signal intensity that checking matter standard items series concentration records.
After the adsorptive pads 8 of examination bar 2 of the present invention, can also be overlapped with an examination bar reaction end indicating label 12.Correspondingly, these examination bar reaction end indicating label 12 corresponding positions of its cartridge 3 have view window 13.Described examination bar reaction end indicating label 12 includes but not limited to that color change interval is the pH test paper of 5-9.
The label pad 5 of examination bar 2 of the present invention is glass fibre membrane; The analyzing film 7 of described examination bar 2 is nitrocellulose filter, nylon membrane or cellulose nitrate/cellulose acetate hybrid films; The end liner 1 of described examination bar 2 is polyester or plastic plate; Described cartridge 3 is that polyester, plastics, rigid paper material or other materials are made.
Examination bar of the present invention is stuck in examination bar checking matter and completes after the reaction of examination bar, and the detection that is gathered examination bar 2 in examination bar card by the instrument (as reading bar instrument, fluorescence detector, magnetic signal detector etc.) with signal testing function is read the checking matter typical curve that comes or coefficient parameter simultaneously and calculated and obtain sample single component or polycomponent concentration from storage medium 11 with 6 characteristic signals and in conjunction with this instrument.
The sample to be checked of examination bar card of the present invention can be from clinical or non-clinical blood, body fluid, urine, saliva, genital secretion or other liquid samples or thick sample, wherein, clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, cancer, diabetes, autoimmunity disease etc., and non-clinical sample comprises the sample of food inspection, environment pollution detection, persticide residue detection, biological contamination detection, Biopreparate detection, veterinary science detection, illicit drugs inspection etc.
The present invention has following beneficial effect:
(1) can Quantitative detection sample component.On examination bar card of the present invention, storage medium 11 is installed, this storage medium 11 stores the detection information such as checking matter typical curve or coefficient parameter.When testing sample completes on bar after chromatography reaction in examination, by have the detection that tries bar 2 in the instrument collection examination bar card of signal testing function with 6 characteristic signals and in conjunction with this instrument from storage medium 11 read simultaneously the checking matter typical curve that comes or coefficient parameter fast (in a few minutes) quantitatively obtain sample component concentration.
(2) the examination bar 2 in examination bar card of the present invention, when employing is quantum dot-labeled, can be realized sample polycomponent simultaneously and quick and precisely quantitatively detect.Quantum dot (Quantum Dots, be called for short QDs) be the good spectral signature of a kind of tool of the development nineties in 20th century and the semiconductor nanocrystal of photochemical stability, there is fluorescence radiation efficiency high, exciting line wide ranges, spectral line of emission narrow range, fluorescence lifetime is long, and Stokes displacement is large, particle diameter and biomolecule are close, can multifunction after finishing etc. feature.The quantum dot of different-grain diameter, kind and structure can produce different characteristic wavelength and continue fluorescence peak spectrum, and the characteristic wavelength fluorescence peak spectrum that quantum dot potpourri produces is not overlapping.Adopt different quantum dots mark checking matter respective reaction molecule respectively, its potpourri is coated on the examination bar of examination bar card of the present invention and reacts with testing sample, by mensuration, try bar specific fluorescent signal, quantitative sample polycomponent concentration quick and precisely just in a few minutes.Existing examination bar technology can only qualitative detection sample, can not realize sample and quantitatively detect, and more can not realize sample polycomponent and quantitatively detect.
(3) in described examination bar card, reagent and material do not relate to active inactivation, can preserve for a long time in room temperature.
Accompanying drawing explanation
Figure l: the plan structure figure of examination bar card preferred version one of the present invention (showing detection line of examination strip adoption in it)
Fig. 2: the side-looking structural drawing of examination bar in the cartridge of examination bar card preferred version one of the present invention (showing detection line of examination strip adoption)
Fig. 3: the plan structure figure of examination bar card preferred version one of the present invention (showing many detection lines of examination strip adoption in it)
Fig. 4: the side-looking structural drawing of examination bar in the cartridge of examination bar card preferred version one of the present invention (showing many detection lines of examination strip adoption)
Fig. 5: the plan structure figure of another preferred version of examination bar card of the present invention (showing detection line of examination strip adoption in it)
Fig. 6: the side-looking structural drawing of examination bar in the cartridge of another preferred version of examination bar card of the present invention (showing detection line of examination strip adoption)
Fig. 7: the plan structure figure of another preferred version of examination bar card of the present invention (showing many detection lines of examination strip adoption in it)
Fig. 8: the side-looking structural drawing of examination bar in the cartridge of another preferred version of examination bar card of the present invention (showing many detection lines of examination strip adoption)
Sequence number is expressed as follows:
1, end liner, 2, examination bar, 3, cartridge, 4, sample pad, 5, label pad, 6, detect band, 7, analyzing film, 8, adsorptive pads, 9, well, 10, detection window, 11, storage medium, 12, examination bar reaction end indicating label, 13, view window.
Embodiment
Embodiment and accompanying drawing thereof are only that those skilled in the art should not limit the scope of the invention with this in order to further illustrate the present invention below.
embodiment mono-
Fig. 1-4 explanation embodiment mono-.Embodiment mono-is one of examination bar card preferred version of the present invention.
In Fig. 1-4, the described examination bar card of described preferred version comprises the examination bar 2 of cartridge 3 and Qi Nei.Described examination bar 2 comprises that overlap joint is fixed on sample pad 4, label pad 5, analyzing film 7, the adsorptive pads 8 on end liner 1 in turn.Analyzing film 7 has to detect is with 6.The upper box face of cartridge 3 is having well 9 corresponding to examination bar sample pad 4 positions.The upper box face of cartridge 3 is having detection window 10 corresponding to examination bar analyzing film 7 positions.One storage medium 11 is installed in cartridge 3.
The a certain target checking matter that the label pad 5 of described examination bar 2 is coated with single labelled substance markers detects relevant single special molecular, or: each target checking matter that is coated with different label correspondence markings detects the potpourri of relevant special molecular.
The detection of described examination bar 2 is with 6 can be one (shown in Fig. 1 and Fig. 2), can be also many (shown in Fig. 3 and Fig. 4).Detection is coated with a certain target checking matter with 6 and detects another relevant special molecular, or: be coated with the potpourri that each target checking matter detects another relevant special molecular.
The checking matter typical curve that described storage medium 11 stores has various ways available, its include but not limited to checking matter standard items series concentration with
a detect bandbetween corresponding relation curve.Described
a detect bandbe defined as the detection band signal intensity that checking matter standard items series concentration records.
The label pad 5 of described examination bar 2 is glass fibre membrane; The analyzing film 7 of described examination bar 2 is nitrocellulose filter, nylon membrane or cellulose nitrate/cellulose acetate hybrid films; The end liner 1 of described examination bar 2 is polyester or plastic plate; Described cartridge 3 is that polyester, plastics, rigid paper material or other materials are made.
Described examination bar 2 is any examination bar, and it includes but not limited to quanta dot mark test bar, colloid gold label examination bar, colloidal selenium marked examination bar, up-converting phosphor substance markers examination bar, nano rare earth fluorescence complex mark test bar, nano magnetic particle mark test bar, time resolution chromatography examination bar, chemiluminescence examination bar.
When described examination bar card is used for sample detection, fluid sample is applied in the well 9 of examination bar card, until examination bar 2 in it, complete after reaction, the detection that is gathered examination bar 2 in examination bar card by the instrument (as reading bar instrument, fluorescence detector, magnetic signal detector etc.) with signal testing function is read the checking matter typical curve that comes or coefficient parameter simultaneously and is calculated and obtain sample single component or polycomponent concentration from examination bar card storage medium 11 with 6 characteristic signals and in conjunction with this instrument.
The sample to be checked of described examination bar card can be from clinical or non-clinical blood, body fluid, urine, saliva, genital secretion or other liquid samples or thick sample, wherein, clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, cancer, diabetes, autoimmunity disease etc., and non-clinical sample comprises the sample of food inspection, environment pollution detection, persticide residue detection, biological contamination detection, Biopreparate detection, veterinary science detection, illicit drugs inspection etc.
embodiment bis-
Fig. 5-8 explanation embodiment bis-.Embodiment bis-is another preferred version of examination bar card of the present invention.
In Fig. 5-8, the described examination bar card of described preferred version comprises the examination bar 2 of cartridge 3 and Qi Nei.Described examination bar 2 comprises that overlap joint is fixed on sample pad 4, label pad 5, analyzing film 7, adsorptive pads 8, the examination bar reaction end indicating label 12 on end liner 1 in turn.Analyzing film 7 has to detect is with 6.The upper box face of cartridge 3 is having well 9 corresponding to examination bar sample pad 4 positions.The upper box face of cartridge 3 is having detection window 10 corresponding to examination bar analyzing film 7 positions.The upper box face of cartridge 3 is having view window 13 corresponding to examination bar reaction end indicating label 12 positions.One storage medium 11 is installed in cartridge 3.
The a certain target checking matter that the label pad 5 of described examination bar 2 is coated with single labelled substance markers detects relevant single special molecular, or: each target checking matter that is coated with different label correspondence markings detects the potpourri of relevant special molecular.
The detection of described examination bar 2 is with 6 can be one (shown in Fig. 5 and Fig. 6), can be also many (shown in Fig. 7 and Fig. 8).Detection is coated with a certain target checking matter with 6 and detects another relevant special molecular, or: be coated with the potpourri that each target checking matter detects another relevant special molecular.
Described examination bar reaction end indicating label 12 includes but not limited to that color change interval is the pH test paper of 5-9.During sample detection, the examination bar reaction end indicating label 12 of examination on bar can develop the color according to the pH condition of examination bar reaction, to point out examination bar reactant whether fully to ooze to move past to detect, is with 6, and whether the reaction of prompting examination bar is abundant, and whether its testing result is effective.
The checking matter typical curve that described storage medium 11 stores has various ways available, its include but not limited to checking matter standard items series concentration with
a detect bandbetween corresponding relation curve.Described
a detect bandbe defined as the detection band signal intensity that checking matter standard items series concentration records.
The label pad 5 of described examination bar 2 is glass fibre membrane; The analyzing film 7 of described examination bar 2 is nitrocellulose filter, nylon membrane or cellulose nitrate/cellulose acetate hybrid films; The end liner 1 of described examination bar 2 is polyester or plastic plate; Described cartridge 3 is that polyester, plastics, rigid paper material or other materials are made.
Described examination bar 2 is any examination bar, and it includes but not limited to quanta dot mark test bar, colloid gold label examination bar, colloidal selenium marked examination bar, up-converting phosphor substance markers examination bar, nano rare earth fluorescence complex mark test bar, nano magnetic particle mark test bar, time resolution chromatography examination bar, chemiluminescence examination bar.
When described examination bar card is used for sample detection, fluid sample is applied in the well 9 of examination bar card, examination bar reaction end indicating label 12 indication examination bars 2 until examination bar 2 in it complete after reaction, and the detection that is gathered examination bar 2 in examination bar card by the instrument (as reading bar instrument, fluorescence detector, magnetic signal detector etc.) with signal testing function is read the checking matter typical curve that comes or coefficient parameter simultaneously and calculated and obtain sample single component or polycomponent concentration from examination bar card storage medium 11 with 6 characteristic signals and in conjunction with this instrument.
The sample to be checked of described examination bar card can be from clinical or non-clinical blood, body fluid, urine, saliva, genital secretion or other liquid samples or thick sample, wherein, clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, cancer, diabetes, autoimmunity disease etc., and non-clinical sample comprises the sample of food inspection, environment pollution detection, persticide residue detection, biological contamination detection, Biopreparate detection, veterinary science detection, illicit drugs inspection etc.
It is pointed out that examination bar card of the present invention can also have other to improve, as it is upper outside except being arranged on the cartridge 3 of examination bar card with the storage medium 11 of information to store detection such as checking matter typical curve, also can be directly installed on that examination bar card is interior to be tried on bar 2; Based on same principle of the present invention, the examination bar in cartridge 3 also can be expanded and replace with biochip (comprising antigen-antibody chip, protein chip, nucleic acid chip, micro-fluidic chip) etc.Therefore, every to any other technical scheme that is equal to replacement or equivalent transformation formation of examination bar card employing of the present invention, all drop in the protection domain of the claims in the present invention.
Claims (3)
1. one kind is tried bar card, comprise cartridge (3) and the examination bar (2) in it, examination bar (2) comprises that overlap joint is fixed on the sample pad (4) on end liner (1) in turn, label pad (5), analyzing film (7), adsorptive pads (8), analyzing film (7) has the band of detection (6), detecting band (6) is one or more, the upper box face of cartridge (3) is having well (9) corresponding to examination bar sample pad (4) position, the upper box face of cartridge (3) is having detection window (10) corresponding to examination bar analyzing film (7) position, it is characterized in that: a storage medium (11) is also installed in described cartridge (3),
The a certain target checking matter that the label pad (5) of described examination bar (2) is coated with single labelled substance markers detects relevant single special molecular, or: each target checking matter that is coated with different label correspondence markings detects the potpourri of relevant special molecular; The detection band (6) of described examination bar (2) is coated with a certain target checking matter and detects another relevant special molecular, or: be coated with the potpourri that each target checking matter detects another relevant special molecular;
Storage medium (11) in described cartridge (3) comprises RFID label, IC chip, magnetic code or bar code;
Described storage medium (11) stores with batch examination bar (2) the checking matter typical curve that quantitatively sample concentration is used or coefficient parameter, examination bar lot number, tries bar effect phase, storage medium password, clinical indices reference value, Shi Tiao production firm information, and can read in measurand identity information, tester's information, sample title, sample number into spectrum, detection date, testing result information;
The checking matter typical curve that described storage medium (11) stores has various ways available, it comprise checking matter standard items series concentration with
a detect bandbetween corresponding relation curve; Described
a detect bandbe defined as the detection band signal intensity that checking matter standard items series concentration records;
The label pad (5) of described examination bar (2) is glass fibre membrane; The analyzing film (7) of described examination bar (2) is nitrocellulose filter, nylon membrane or cellulose nitrate/cellulose acetate hybrid films; The end liner (1) of described examination bar (2) is polyester or plastic plate; Described cartridge (3) is that polyester, plastics or rigid paper material are made;
Described examination bar (2) is any examination bar, and it comprises quanta dot mark test bar, colloid gold label examination bar, colloidal selenium marked examination bar, up-converting phosphor substance markers examination bar, nano rare earth fluorescence complex mark test bar, nano magnetic particle mark test bar, time resolution chromatography examination bar, chemiluminescence examination bar;
During sample detection, the instrument collection with signal testing function tries examination bar (2) in bar card and detects the characteristic signal of band (6) the checking matter typical curve simultaneously reading from storage medium (11) in conjunction with this instrument or coefficient parameter and calculate acquisition sample single component or polycomponent concentration.
2. an examination bar card as claimed in claim 1, is characterized in that: the adsorptive pads (8) of wherein said examination bar (2) is also overlapped with an examination bar reaction end indicating label (12) afterwards; This examination bar reaction end indicating label (12) corresponding position of its cartridge (3) has view window (13);
Described examination bar reaction end indicating label (12) comprises that color change interval is the pH test paper of 5-9;
The a certain target checking matter that the label pad (5) of described examination bar (2) is coated with single labelled substance markers detects relevant single special molecular, or: each target checking matter that is coated with different label correspondence markings detects the potpourri of relevant special molecular; The detection band (6) of described examination bar (2) is coated with a certain target checking matter and detects another relevant special molecular, or: be coated with the potpourri that each target checking matter detects another relevant special molecular;
Storage medium (11) in described cartridge (3) comprises RFID label, IC chip, magnetic code or bar code;
Described storage medium (11) stores with batch examination bar (2) the checking matter typical curve that quantitatively sample concentration is used or coefficient parameter, examination bar lot number, tries bar effect phase, storage medium password, clinical indices reference value, Shi Tiao production firm information, and can read in measurand identity information, tester's information, sample title, sample number into spectrum, detection date, testing result information;
The checking matter typical curve that described storage medium (11) stores has various ways available, it comprise checking matter standard items series concentration with
a detect bandbetween corresponding relation curve; Described
a detect bandbe defined as the detection band signal intensity that checking matter standard items series concentration records;
The label pad (5) of described examination bar (2) is glass fibre membrane; The analyzing film (7) of described examination bar (2) is nitrocellulose filter, nylon membrane or cellulose nitrate/cellulose acetate hybrid films; The end liner (1) of described examination bar (2) is polyester or plastic plate; Described cartridge (3) is that polyester, plastics or rigid paper material are made;
Described examination bar (2) is any examination bar, and it comprises quanta dot mark test bar, colloid gold label examination bar, colloidal selenium marked examination bar, up-converting phosphor substance markers examination bar, nano rare earth fluorescence complex mark test bar, nano magnetic particle mark test bar, time resolution chromatography examination bar, chemiluminescence examination bar;
During sample detection, try bar reaction end indicating label (12) and indicate sample on examination bar (2), to complete after the reaction of examination bar, by the instrument collection with signal testing function, tried to try in bar card the characteristic signal of bar (2) detection band (6) the checking matter typical curve simultaneously reading from storage medium (11) in conjunction with this instrument or coefficient parameter and calculate to obtain sample single component or polycomponent concentration.
3. an examination bar card as claimed in claim 1 or 2, it is characterized in that: sample to be checked is from clinical or non-clinical blood, body fluid, urine, saliva, genital secretion or other liquid samples or thick sample, wherein, clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, cancer, diabetes, autoimmunity disease, and non-clinical sample comprises that food inspection, environment pollution detection, persticide residue detection, biological contamination detection, Biopreparate detection, veterinary science detect, the sample of illicit drugs inspection.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310570268.4A CN103645312A (en) | 2013-11-16 | 2013-11-16 | Test strip card |
| PCT/CN2014/090852 WO2015070749A1 (en) | 2013-11-16 | 2014-11-11 | Test strip card |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310570268.4A CN103645312A (en) | 2013-11-16 | 2013-11-16 | Test strip card |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103645312A true CN103645312A (en) | 2014-03-19 |
Family
ID=50250563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310570268.4A Pending CN103645312A (en) | 2013-11-16 | 2013-11-16 | Test strip card |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103645312A (en) |
| WO (1) | WO2015070749A1 (en) |
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| WO2015070704A1 (en) * | 2013-11-13 | 2015-05-21 | 成都领御生物技术有限公司 | Test bar card |
| WO2015070700A1 (en) * | 2013-11-12 | 2015-05-21 | 成都领御生物技术有限公司 | Quantum dot-labeled test strip card |
| WO2015070699A1 (en) * | 2013-11-12 | 2015-05-21 | 成都领御生物技术有限公司 | Quantum dot-labeled test strip card |
| WO2015070749A1 (en) * | 2013-11-16 | 2015-05-21 | 成都领御生物技术有限公司 | Test strip card |
| CN104794520A (en) * | 2015-05-07 | 2015-07-22 | 杭州博圣生物技术有限公司 | Biological sample information carrying card, management system and realization method thereof |
| CN105510609A (en) * | 2015-11-26 | 2016-04-20 | 宁波美康保生生物医学工程有限公司 | In vitro test piece and application method thereof |
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| Publication number | Publication date |
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| WO2015070749A1 (en) | 2015-05-21 |
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Application publication date: 20140319 |