CN1036438C - Dental composition and process for preparation thereof - Google Patents

Abstract

Dental composition comprising an anti-osteoporotic agent, an antiphlogistic agent, optionally a natural or synthetic chemotherapeutic agent or local anaesthetic, furthermore one or more known auxiliary agent(s). The invention also relates to a process for the preparation of the above composition.

Description

The preparation method of dentistry combination filling agent

The present invention relates to a kind of preparation method of dental composition.

As everyone knows, dental caries is a kind of very common endemicity epidemic diseases.Veteran dentist knows that obviously if can in time treat, most dental caries is to remain with the method for expectant treatment, needn't pull out.But in clinical position, patient often will be when having a toothache to such an extent that have no patience, and in other words, dental caries develops into and occurs at least just seeking medical advice after a kind of complication.

Toothache is owing to due to the pulp hyperemia, promptly be because the interior nerve of the blood vessel of dental pulp root and blood vessel occurs due to the reversibility inflammation at first; Dental pulp tube chamber narrow, that be close between the sclerine can't expand, so the pressure strong effect of tremulous pulse early stage venous congestion (congestion) phenomenon occurs in vein.Yet, in this stage of pulp hyperemia, still there is the dentin of skim health that both are separated between cavity and the dental pulp, dental caries does not feed through in the dental pulp as yet.

If dental caries continues development, infective inflammation (pulpitis) will appear in the dental pulp.Pulpitis has all kinds, now only narrates its main person.Acute inflammation on the first appearance, dental pulp only is partially damaged, the dentist is devoted to manage to keep the still tooth of survival more.But if the inflammation of dental pulp chronicity, perhaps dental pulp is destroyed fully, and Zhi Liao purpose just transfers the pain that elimination will be treated from now on to so, prevents new complication, makes disease disappear the tooth rehabilitation.

Pulpitis late period, tissue necrosis appears.The downright bad constantly development of dental pulp and tooth.Body is only being supplied good its function of position competence exertion to the anti-mechanism of unloading that infects diffusion.There is good blood flow in periodontal tissue around tooth, so " periodontitis ", the i.e. stage of periodontal tissue's inflammation occur thereupon.At this moment, touch tooth and also can bring out pain; Though pulp necrosis loses sensibility, the conscious pain of patient unbearably.The treatment policy of this moment alleviates patient's misery for controlling acute inflammation as early as possible.After entering chronic phase, should visit in advance other complication take place; For example, inflammation may be diffused in the sclerotin of periodontal, causes pathologic osteoporosis (granuloma, cyst).

The trial that had some to stop above-mentioned various disease to increase the weight of so far.According to Adler and Z á ray Liang Shi report, (dentistry expectant treatment method (Konzerv á l ó fog á sz à t), 172 pages of (medical journals, Budapest, 1972) (Hungarian)), they advocate thoroughly to remove the microorganism in the pulp canal, think that the inflammation of eliminating the dental caries surrounding tissue is very important.Thereby the processing pulp cavity can use the mixture (being generally liquid) of various disinfecting drugs, antibiotics and antiinflammatory.The shortcoming of this method is that curative effect can not be lasting.

People also once attempted using powder or paste (afterwards can be abandoned by removing) to carry out (Fogorvosi Szemle (dentist's comment) 64 volumes, 404 pages of (1971) (Hungarians)) that pulp cavity is handled.This method can not keep long-term efficacy.

Hungarian patent No.167, a kind of disinfectant (being oxidant) or antiinflammatory and/or a kind of antibiotics of containing is used in No. 308 suggestions, adds a kind of gutta percha point that does not have the auxiliary type agent preparation of drug effect again and handles.Antibiotics is selected penicillin, chloromycetin and oxytetracycline for use; The antiinflammatory hydrocortisone.The major defect of this method is in the spinal canal that can only be applied to behind the extirpation of pulp, and the generation of can not resist osteoporosis and complication thereof.

The object of the present invention is to provide a kind of NEW TYPE OF COMPOSITE filler, it can be used to handle dental caries, can cure the inflammation of the infringement of acute, subacute or chronic inflammatory disease, tooth root inflammation and the root of the tooth osseous tissue on every side of dental pulp.

By a large amount of laboratory works, we are surprised to find that, use certain special compatibility, i.e. the cooperation of ipriflavone (7-isopropoxy-isoflavone) and certain antiinflammatory can be used for the Comprehensive Treatment of odontopathy, and obtains good result.According to clinical needs, also can in this compatibility, add chemotherapy drugs, local anesthetic and auxiliary agent commonly used.

The complexing agent that fits in like this is all effective in cure to pulpitis and the periodontitis of each phase.

As mentioned above, involved in the present invention is a kind of novel dentistry combination filling agent.It contains a kind of osteoporosis agent, preferably uses ipriflavone (a kind of anti-inflammation drugs), and adds a kind of natural or synthetic chemistry therapy medicine as required, or local anesthetic, adds one or more auxiliary agents commonly used at last.

The invention still further relates to the preparation method of above-mentioned dentistry combination filling agent.By preparation method of the present invention, iprifavone with 0.1～30% (weight), the anti-inflammation drugs of～15% 0.5 (weight), preferably use tramcinolone (triamcinolone), and add one or more natural or synthetic chemistry therapy medicines as required, or local anesthetic, add the blending of dentistry usual auxiliaries at last again and form.For example, the synthetic chemistry therapy medicine select for use sulfonamides or trimethoprim (2,4-diaminourea-5-(3 ', 4 ', 5 '-the trimethoxy benzyl) pyrimidine); The native chemical therapy medicine is selected doxycycline alkali (antibiotics a kind of) or its esters chemical compound for use; Local anesthetic (necessary when for example modulating the protective coating of tooth stump) can be selected lignocaine for use.In sulfa drugs, be good with Huang An Jia Ji oxazole especially.Auxiliary agent commonly used during dentistry is clinical has zinc oxide, calcium oxide, bismuth oxide, titanium dioxide, acetaminol, epoxy resin and dental paint vehicle etc.

If in the dentistry filler, use several active high materials simultaneously, tend to cause beyond thought, particularly advantageous consequence.

Broad-spectrum antibiotic can be eliminated the pathogenic bacterium that cause inflammation.Yet use antibiotics that other pathological processes of inflammation are not had therapeutical effect separately.

Anti-inflammation drugs, for example tramcinolone has tangible influence to the pathological process of inflammation: it suppresses the generation of edema, stops the progress of other pathological processes of inflammation, and alleviating pain pauses development of inflammation rapidly.But this type of medicine strengthens the activity of osteoclast, causes osteoporosis, for example use the complexing agent filling spinal canal of fluorine-containing hydroxyl prednisolone behind the extirpation of pulp after, induced osteoporosis usually, this is well-known.

A kind of composition in the combination filling agent that we formulate, be that ipriflavone has special synergism to the previously described therapeutic effect of two kinds of compositions in addition: both be when being used alone, it also has the enhanced effect of the caused osteoclast activity of antagonism steroid anti-inflammation drugs except that the osteoporotic effect of inhibition is arranged.

Above-mentioned three kinds of active substance are suitably concocted, promptly be can be made into various effective dentistry fillers, pulpitis, periodontitis in order to treat each phase are preserved tooth.

Maximum characteristics of the present invention are that this kind complexing agent can be applied to various types of dental disorders.Its indication is as follows:

When (1) treating pulp hyperemia or acute partial pulpitis, use the cement (cement) that contains the above-mentioned compounded agent of 0.1～10% (is good with 0.7～2%), filling is in the nearly dental pulp wall place in the hole, chamber that has made.Medicine infiltrates dental pulp from this, and pain is alleviated rapidly, and inflammation disappears.Doxycycline (being an example of above-mentioned chemotherapeutic agent) is then put aside in tooth, brings into play drug effect over a long time.Owing to the effect of ipriflavone, being expected subsequently, the president goes out newborn dentine in addition.

(2) during the chronic completeness pulpitis of treatment, should divide two steps to handle.At first treat by above-mentioned (1) item; After treating that toothache disappears, eliminate the spinal canal content, prevent the inflammation diffusion.Two steps of the mat woven of fine bamboo strips handle by following (3) described method.

When (3) treating periodontitis, " treatment paste " (interpolation proper assistant) inserted in the treated clean and dry spinal canal in front.Anti-inflammation drugs and antibacterials will be brought into play effectiveness rapidly, and pain is expected to alleviate thereupon.

(4) life-time service contains osteoporosis agent " treatment paste " complication of preventing parodontitis in advance, also can alleviate the complication that has occurred, and the osteoporosis (diffusivity osteitis, granuloma, cyst) that has occurred is recovered gradually.After treating the bone damage complete obiteration, with containing osteoporosis agent and X line developing materials and carrier, but the complexing agent that does not contain antibiotics is done last filling to the root pipe.

Below only lift some examples and specify the present invention, but be not construed as limiting the invention.

The preparation method of example 1 " treatment cement "

With doxycycline (doxycyclin hyclate) 2 gram, tramcinolone 0.8 gram, ipriflavone 2 grams, zinc oxide 80 grams, calcium oxide (component " A ") 15.2 grams, with acetaminol (component " B ") in proportion intermingling make.

The preparation method of example 2 another kinds " treatment cement "

Its modulator approach is described identical with example 1, but replaces doxycycline with trimethoprim 2.2 grams.

The preparation method that example 3 is used for dental pulp tube chamber disinfectant " treatment use paste " restrains ipriflavone 0.2 gram, after zinc oxide 10 restrains and mix, calls in an amount of acetaminol with doxycycline alkali 0.2 gram, tramcinolone 0.08, make paste.

Example 4

Another kind is used for the preparation method of dental pulp tube chamber disinfectant " treatment paste "

Its modulator approach is identical with example 3 described methods, but replaces the doxycycline alkali with Huang An Jia Ji oxazole.

Example 5

The preparation method of " root canal filling agent "

With ipriflavone 0.5 grams add an amount of epoxy resin and are modulated into paste with after tramcinolone 0.1 gram, bismuth oxide 4.0 grams, titanium dioxide 2.0 grams, zinc oxide 3.4 restrain and mix.

Example 6

Be used to protect the preparation method of " covering composition " of tooth stump

After ipriflavone 0.3 gram, tramcinolone 0.1 gram and the 0.2 gram mixing of lignocaine alkali, be dissolved in 5 milliliters of acetone.Use this solution and can form the single or multiple lift cover layer at the tooth stump.

Claims (2)

1. the preparation method of dentistry combination filling agent is characterized in that this method is that 7-isopropoxy isoflavone 0.1-30% (weight) and tramcinolone 0.5-15% (weight) are mixed with the dentistry usual auxiliaries.

2. the preparation method of the dentistry combination filling agent of claim 1 is characterized in that adding doxycycline or its salt or lignocaine.