CN103638606B - Photo-thermal and optical power therapentic equipment - Google Patents
Photo-thermal and optical power therapentic equipment Download PDFInfo
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- CN103638606B CN103638606B CN201310740459.0A CN201310740459A CN103638606B CN 103638606 B CN103638606 B CN 103638606B CN 201310740459 A CN201310740459 A CN 201310740459A CN 103638606 B CN103638606 B CN 103638606B
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Abstract
The invention discloses a kind of photo-thermal and optical power therapentic equipment, comprise the treatment chamber of sealing and be packaged in laser instrument, heating plate, optical system, blood oxygen instrument, thermal imaging system and the air purifier in described treatment chamber; Described laser instrument Emission Lasers provides light source by described optical system to treatment body, and described optical system is for controlling the spot size of laser with the power density of control light source; Described heating plate is for heating to described treatment chamber, to keep treating the temperature of body; Described blood oxygen instrument changes for the blood oxygen concentration of monitor therapy body; Described thermal imaging system is for detection of part or the bulk temperature for the treatment of body; Described air purifier is for purifying the air in described treatment chamber; On described treatment chamber, be also provided with passage, for input oxygen or anesthetic in described treatment chamber. The present invention, by photo-thermal and optical dynamic therapy combination, can realize the cell in toy or culture plate is carried out to photo-thermal and/or optical dynamic therapy.
Description
Technical field
The present invention relates to a kind of a kind of device of physical therapy, particularly a kind of for to toy tumour orThe photo-thermal that cell in culture plate is treated and optical power therapentic equipment.
Background technology
Traditional operation excision, chemotherapy, radiotherapy or biological therapy obtained outstanding aspect oncotherapyAchievement, but the problems such as its toxic and side effect, MDR are still difficult to overcome. In recent years, transdermal is nearThere is non-invasion and attack, nontoxic, target, efficient because of it in photo-thermal, the optical dynamic therapy of infrared light activated nano materialEtc. advantage and be day by day subject to parent and look at. Photo-thermal therapy refers to the fuel factor of utilizing various pyrogens, by tumor area orWhole body is heated to the effectively temperature for the treatment of, and maintains the regular hour, utilizes normal structure and tumor tissues pairThe difference of temperature tolerance, reaches the methods for the treatment of of can killing off tumor cells not damaging again normal structure. LightMotivation therapy (PhotodynamicTherapy, PDT) be later 1970s come out and closely severalOver year, the one that develops rapidly is for the selective therapy new technology of (blood vessel) proliferative lesion tissue,This therapy is to be different from another after operation, radiotherapy, chemotherapy and immunization therapy completely to study, soonThe developing brand-new therapy of speed, has become one of most active research field in world's treatment and prevention of tumour science. LightDynamic therapy is a kind of is the treatment mould taking the interaction of light, sensitising agent and oxygen as basic disease Local treatmentFormula, by Food and Drug Administration (U.S.FoodandDrugAdministration, FDA)Official approval is applied to the treatment of local tumor. Optical dynamic therapy relates to sensitising agent and is discharged efficient by optical excitationProperty oxygen and singlet oxygen, guiding apoptosis of tumor cells or necrosis. Both at home and abroad at photo-thermal, optical dynamic therapyCarry out a large amount of experiments, but lacked laser and photo-thermal or light power combined treatment toy tumour at presentInstrument and equipment.
Summary of the invention
For solving the existing problem of above-mentioned prior art, the object of the present invention is to provide a kind of laser withThe instrument and equipment of photo-thermal or light power combined treatment toy tumour.
To achieve these goals, the present invention has adopted following technical scheme:
A kind of photo-thermal and optical power therapentic equipment, wherein, comprise the treatment chamber of sealing and be packaged in described inLaser instrument, heating plate, optical system, blood oxygen instrument, thermal imaging system and air cleaning in treatment chamberDevice; Described laser instrument Emission Lasers provides light source, described optical system by described optical system to treatment bodyFor controlling the spot size of laser with the power density of control light source; Described heating plate is used for to described treatmentChamber heating, to keep treating the temperature of body; Described blood oxygen instrument changes for the blood oxygen concentration of monitor therapy body;Described thermal imaging system is for detection of part or the bulk temperature for the treatment of body; Described air purifier is for purifyingAir in described treatment chamber; On described treatment chamber, be also provided with passage, for to described treatment chamberIndoor input oxygen or anesthetic.
Preferably, this device also comprises a computer control system, described computer control system respectively with instituteState laser instrument, heating plate, optical system, blood oxygen instrument, thermal imaging system and air purifier and connect, useIn controlling described laser instrument, heating plate, optical system, blood oxygen instrument, thermal imaging system and air purifier.
Preferably, described laser instrument is also connected with a laser power meter, launches for detection of described laser instrument 3The power of laser.
Preferably, described treatment body is the cell in toy or culture plate.
Preferably, the wave-length coverage of the laser of described laser instrument transmitting is 600～1400nm, and watt level is0.1～10W。
Preferably, the power density that is irradiated to the light source of described treatment body is 0.1～10W/cm2。
Preferably, this therapeutic system carries out photo-thermal and optical dynamic therapy to described treatment body simultaneously.
The present invention has following beneficial effect:
The present invention, by photo-thermal and optical dynamic therapy combination, can realize the cell in toy or culture plate is dividedDo not carry out photo-thermal or optical dynamic therapy or carry out photo-thermal and optical dynamic therapy simultaneously, in the process for the treatment ofCan change by the blood oxygen concentration of blood oxygen instrument Real-Time Monitoring treatment body; Detect and control in real time by thermal imaging systemTreat part or the bulk temperature of body; This apparatus structure is simple, low cost of manufacture.
Brief description of the drawings
The photo-thermal that Fig. 1 provides for the present invention's one specific embodiment and the structural representation of optical power therapentic equipment.
Reference numeral:
1-computer control system, 2-treats chamber, 201-passage, 3-laser instrument, 301-laser power meter,4-heating plate, 5-optical system, 6-blood oxygen instrument, 7-thermal imaging system, 8-air purifier.
Detailed description of the invention
In order to set forth better technical characterstic of the present invention and structure, carry out below in conjunction with embodiment and accompanying drawing thereofDescribe in detail.
As previously mentioned, the present invention, for solving the existing problem of prior art, provides a kind of laser and lightThe instrument and equipment of heat or light power combined treatment toy tumour. As shown in Figure 1, the light that the present embodiment providesLight and heat power therapentic equipment comprise computer control system 1, sealing treatment chamber 2 and be packaged in described inThe laser instrument 3 for the treatment of in chamber 2, heating plate 4, optical system 5, blood oxygen instrument 6, thermal imaging system 7 withAnd air purifier 8. Described computer control system 1 respectively with described laser instrument 3, heating plate 4, opticsSystem 5, blood oxygen instrument 6, thermal imaging system 7 and air purifier 8 connect, for controlling described laser instrument3, heating plate 4, optical system 5, blood oxygen instrument 6, thermal imaging system 7 and air purifier 8. Described sharpLight device 3 Emission Lasers are irradiated to treatment body (cell in toy or culture plate) by described optical system 5Upper, provide light source to treatment body, described optical system 5 for the spot size of controlling laser to control light sourcePower density, wherein, described laser instrument 3 is also connected with a laser power meter 301, for detection of laser instrumentThe power of 3 Emission Lasers, then adjust by optical system 5, to reach needed power density. InstituteState heating plate 4 for heating to described treatment chamber 2, to keep treating the temperature of body. Described blood oxygen instrument 6Blood oxygen concentration for Real-Time Monitoring treatment body changes, and indirectly reflects the effect of optical dynamic therapy. Described heat becomesPicture system 7 is for detection of part or the bulk temperature for the treatment of body. Described air purifier 8 is for described in purifyingAir in treatment chamber 2, in the present embodiment, described air purifier 8 is activated carbon air purifier.On described treatment chamber 2, be also provided with passage 201, for to the interior input oxygen of described treatment chamber 2 or fiber cropsLiquor-saturated dose; In the time that toy is treated, connect anesthetic by passage, so that toy is anaesthetized;Or in the time carrying out optical dynamic therapy, input oxygen by passage, to regulate the blood oxygen in petty action object denseDegree.
In the present invention, the wave-length coverage of the laser that described laser instrument 3 is launched is 600～1400nm, and power is largeLittle scope is 0.1～10W; The scope that is irradiated to the power density size of the light source of described treatment body is0.1～10W/cm2. Wherein, in the time carrying out photo-thermal therapy, the scope of the power density size of light source is0.3～10W/cm2; In the time carrying out optical dynamic therapy, the scope of the power density size of light source is 0.1～5W/cm2。The laser instrument that can have a continuous wavelength by installation obtains the light source of different wave length, also can be by changingLaser instrument obtains the light source of different wave length.
Introduce below and adopt photo-thermal provided by the invention and optical power therapentic equipment to carry out respectively light light and heat powerThe object lesson for the treatment of.
1, toy photo-thermal therapy
First open after the air 10min in activated carbon air purifier 8 purification treatment chambers 2, little oldInject the CG 200 μ L of 50 μ g/mL in mouse tumour, mouselet be placed on the heating plate 4 of 37 DEG C,And keep this temperature by heating plate 4 heating, passage 201 is aimed in the nostril of mouselet, by passage201 connect Anesthesia machine anaesthetizes mouselet. Open laser instrument 3, the sharp light wavelength that laser instrument 3 is launchedFor 808nm, regulating the power of laser instrument is 4W, and regulating the spot size of laser by optical system 5 is 4cm2，The light source power density that makes to be irradiated to mouselet knub position is 1W/cm2, simultaneously by laser power meter 301Measure the power step calibration of going forward side by side. Observe little by the thermal imaging system 7 being connected with computer control system 1The variations in temperature of mouse and knub position.
2, toy optical dynamic therapy
First open after the air 10min in activated carbon air purifier 8 purification treatment chambers 2, little oldIn mouse tumour, inject the CG 200 μ L of 50 μ g/mL, then at mouselet lumbar injection amobarbitalMouselet is anaesthetized, mouselet is placed on the heating plate 4 of 37 DEG C, and protect by heating plate 4 heatingHold this temperature, passage 201 is aimed in the nostril of mouselet, input oxygen from passage 201 and strengthen mouse bodyInterior blood oxygen concentration. Open laser instrument 3, the sharp light wavelength that laser instrument 3 is launched is 670nm, regulates laserThe power of device is 2W, and regulating the spot size of laser by optical system 5 is 4cm2, make to be irradiated to little oldThe light source power density of mouse knub position is 0.5W/cm2, measure power by laser power meter 301 close simultaneouslySpend the step calibration of going forward side by side. Observe mouselet and tumour by the blood oxygen instrument 6 being connected with computer control system 1The variation of the blood oxygen concentration of position.
3, petty action object light power-photo-thermal therapy
First open after the air 10min in activated carbon air purifier 8 purification treatment chambers 2, little oldIn mouse tumour, inject the CG 200 μ L of 50 μ g/mL, then at mouselet lumbar injection amobarbitalMouselet is anaesthetized, mouselet is placed on the heating plate 4 of 37 DEG C, and protect by heating plate 4 heatingHold this temperature, passage 201 is aimed in the nostril of mouselet, input oxygen from passage 201 and strengthen mouse bodyInterior blood oxygen concentration. Open laser instrument 3, the sharp light wavelength that laser instrument 3 is launched is 670nm, regulates laserThe power of device is 2W, and regulating the spot size of laser by optical system 5 is 4cm2, make to be irradiated to little oldThe light source power density of mouse knub position is 0.5W/cm2, measure power by laser power meter 301 close simultaneouslySpend the step calibration of going forward side by side. Observe mouselet and tumour by the blood oxygen instrument 6 being connected with computer control system 1The variation of the blood oxygen concentration of position. Observe little by the thermal imaging system 7 being connected with computer control system 1The variations in temperature of mouse and knub position.
4, cell photo-thermal therapy
First MCF-7 breast cancer cell (in culture medium, CG concentration is 50 μ g/mL) is added to cultivationIn plate, culture plate is placed on the heating plate 4 of 37 DEG C, and keeps these temperature by heating plate 4 heating, beatDrive laser instrument 3, the sharp light wavelength that laser instrument 3 is launched is 808nm, and regulating the power of laser instrument is 10W, logicalCrossing the spot size that optical system 5 regulates laser is 1cm2, make to be irradiated to the light source power of culture plate positionDensity is 10W/cm2, measure the power step calibration of going forward side by side by laser power meter 301 simultaneously. By with calculatingThe thermal imaging system 7 that machine control system 1 connects is observed the variations in temperature in culture plate.
5, cell optical dynamic therapy
First MCF-7 breast cancer cell (in culture medium, CG concentration is 50 μ g/mL) is added to cultivationIn plate, culture plate is placed on the heating plate 4 of 37 DEG C, and keeps these temperature by heating plate 4 heating, beatDrive laser instrument 3, the sharp light wavelength that laser instrument 3 is launched is 980nm, and regulating the power of laser instrument is 1W, passes throughIt is 10cm that optical system 5 regulates the spot size of laser2, make to be irradiated to the light source power of culture plate positionDensity is 0.1W/cm2, measure the power step calibration of going forward side by side by laser power meter 301 simultaneously. By with meterThe blood oxygen instrument 6 that calculation machine control system 1 connects is observed the variation of oxygen concentration.
In sum, the present invention, by photo-thermal and optical dynamic therapy combination, can realize toy or culture plateIn cell carry out respectively photo-thermal or optical dynamic therapy, treatment process in can supervise in real time by blood oxygen instrumentThe blood oxygen concentration of surveying treatment body changes; Detect in real time part or the bulk temperature for the treatment of body by thermal imaging system;This apparatus structure is simple, low cost of manufacture.
It should be noted that, in this article, the relational terms such as the first and second grades be only used for byEntity or operation and another entity or operating space separate, and not necessarily require or imply theseBetween entity or operation, there is relation or the order of any this reality. And term " comprises ", " bagContaining " or its any other variant be intended to contain comprising of nonexcludability, thereby make to comprise a series of key elementsProcess, method, article or equipment not only comprise those key elements, but also comprise and clearly not listingOther key elements, or be also included as the intrinsic key element of this process, method, article or equipment. ?In the absence of more restrictions, the key element being limited by statement " comprising ... ", and be not precluded within bagDraw together in process, method, article or the equipment of described key element and also have other identical element.
Although the present invention is described in detail and shows with reference to its exemplary embodiment, this areaThose of ordinary skill should be appreciated that, in the feelings that do not depart from the spirit and scope of the present invention that are defined by the claimsUnder condition, can carry out to it various changes of form and details.
Claims (7)
1. photo-thermal and an optical power therapentic equipment, is characterized in that, comprises the treatment chamber (2) of sealingAnd be packaged in laser instrument (3) in described treatment chamber (2), heating plate (4), optical system (5),Blood oxygen instrument (6), thermal imaging system (7) and air purifier (8); Described laser instrument (3) transmitting swashsLight provides light source by described optical system (5) to treatment body, and described optical system (5) is sharp for controllingThe spot size of light is to control the power density of light source; Described heating plate (4) is for giving described treatment chamber (2)Heating, to keep treating the temperature of body; Described blood oxygen instrument (6) changes for the blood oxygen concentration of monitor therapy body;Described thermal imaging system (7) is for detection of part or the bulk temperature for the treatment of body; Described air purifier (8)Be used for purifying the air in described treatment chamber (2); On described treatment chamber (2), be also provided with passage(201), for input oxygen or anesthetic in described treatment chamber (2);
Wherein, described treatment body is the cell in toy or culture plate.
2. photo-thermal according to claim 1 and optical power therapentic equipment, is characterized in that, this device alsoComprise a computer control system (1), described computer control system (1) respectively with described laser instrument (3),Heating plate (4), optical system (5), blood oxygen instrument (6), thermal imaging system (7) and air purifier (8)Connect, for control described laser instrument (3), heating plate (4), optical system (5), blood oxygen instrument (6),Thermal imaging system (7) and air purifier (8).
3. photo-thermal according to claim 2 and optical power therapentic equipment, is characterized in that, described laserDevice (3) is also connected with a laser power meter (301), for detection of described laser instrument (3) Emission LasersPower.
4. photo-thermal according to claim 1 and optical power therapentic equipment, is characterized in that, described laserThe wave-length coverage of the laser of device (3) transmitting is 600～1400nm, and watt level is 0.1～10W.
5. photo-thermal according to claim 1 and optical power therapentic equipment, is characterized in that, is irradiated to instituteThe power density of stating the light source for the treatment of body is 0.1～10W/cm2。
6. photo-thermal according to claim 1 and optical power therapentic equipment, is characterized in that, described airClarifier (8) is activated carbon air purifier.
7. photo-thermal according to claim 1 and optical power therapentic equipment, is characterized in that, this treatment dressPutting is the device that described treatment body is carried out simultaneously to photo-thermal and optical dynamic therapy.
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| CN103920248B (en) * | 2014-04-29 | 2016-05-25 | 北京理工大学 | A kind of synchronizable optical power therapentic equipment |
| CN104398238A (en) * | 2014-11-26 | 2015-03-11 | 深圳先进技术研究院 | Laser nano-optic diagnosing and treating apparatus |
| CN105148411B (en) * | 2015-09-08 | 2018-03-06 | 黄勇 | Verify experimental provision and application of the near infrared light to AD therapy effect |
| US11391634B2 (en) * | 2019-02-12 | 2022-07-19 | Accure Acne, Inc. | Temperature sensing apparatus for use with a photo-thermal targeted treatment system and associated methods |
| CN109771076A (en) * | 2019-03-11 | 2019-05-21 | 绍兴文理学院 | A kind of instrument for light adjuvant treatment experiment |
| CN110201312A (en) * | 2019-07-10 | 2019-09-06 | 中国人民解放军陆军军医大学第一附属医院 | Device based on infrared ray dynamic therapy different type tumour or cell |
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| NL1035971C (en) * | 2008-09-23 | 2010-03-24 | Nucletron Bv | Assembly for performing brachytherapy treatment of tumour tissue in an animal body. |
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Effective date of registration: 20201216 Address after: 519000 12-storey factory building of Zone A, No. 1 Gangle Road, Tangjiawan Town, Zhuhai High-tech Zone, Guangdong Province Patentee after: ZHUHAI INSTITUTE OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES Co.,Ltd. Address before: 1068 No. 518055 Guangdong city in Shenzhen Province, Nanshan District City Xili University School Avenue Patentee before: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY |
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