CN103638596B - A kind of animal vagal stimulation electrode and preparation method thereof - Google Patents
A kind of animal vagal stimulation electrode and preparation method thereof Download PDFInfo
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- CN103638596B CN103638596B CN201310671225.5A CN201310671225A CN103638596B CN 103638596 B CN103638596 B CN 103638596B CN 201310671225 A CN201310671225 A CN 201310671225A CN 103638596 B CN103638596 B CN 103638596B
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Abstract
A kind of animal vagal stimulation electrode, comprise a pair anelectrode and a pair negative electrode, the each freedom of anelectrode, negative electrode two cross sections are that the curling metal silver strip of C font is formed, silver strip is all arranged in a plastic tube, and fluted in inside pipe wall, recess width is identical with silver strip width, silver strip is inlayed completely by biogum and groove, seamless, form circular channel after silver strip fastens up and down, make vagus nerve can be just accommodated therein, and can contact very well.Two silver strip one end in positive and negative electrode be welded to connect separately and after passing tube wall plastic tube outer separately with a wire bonds.Present invention decreases the volume of vagal stimulation electrode, can implant in the animal body such as experimental rabbit, Canis familiaris L., it is neural convenient to be wound around when implanting, not easily injured nerve, effective with nerve contact in vivo, laboratory animal withstand long term exposure, can conduct electricity not perishable for a long time, good with nerve contact conductive effect, reuse effective.
Description
Technical field:
The present invention relates to physical field, particularly relate to electronic installation, particularly a kind of animal vagal stimulation electrode and preparation method thereof for the experiment of toy nerve.
Background technology:
Along with the development of neural electrophysiology, various nerve electric stimulation has been applied to clinical, and achieve good curative effect, especially treat in epilepsy at vagal stimulation (VNS), achieve significant clinical efficacy, but due to human brain particularity and involve the reason of the aspects such as ethics, more difficult acquisition patient cerebral tissue is (even if obtain specimen, the truth that in vitro cerebral tissue is simulated VNS suppression epilepsy is also very unrealistic), therefore need to test in animal (as rabbit and the dog) body easily obtained, carry out the scientific research of being correlated with.But, in prior art, not yet find the Neural stimulation electrodes can implanted in petty action object.
Summary of the invention:
The object of the present invention is to provide a kind of animal vagal stimulation electrode, described this animal vagal stimulation electrode will solve in prior art the technical problem not having appropriate device can carry out irritant test to toy vagus nerve.
This animal vagal stimulation electrode of the present invention, comprise a pair anelectrode and a pair negative electrode, wherein, described anelectrode comprises two the first metal silver strips, described negative electrode comprises two the second metal silver strips, two the first metal silver strips and two the second metal silver strips are all arranged in a plastic tube, in the inwall of described plastic tube, its axial distribution is provided with a first circumferential groove and a second circumferential groove, two the first metal silver strips are curling in C font separately and in the first circumferential groove described in embedding, circular channel is formed between two the first metal silver strips, two the second metal silver strips are curling in C font separately and in the second circumferential groove described in embedding, circular channel is formed between two the second metal silver strips, any one first metal silver strip is equal along the length of plastic tube axis along all circumferential with first groove of length of plastic tube axis, any one second metal silver strip is equal along the length of plastic tube axis along all circumferential with second groove of length of plastic tube axis, all biogum is filled with between any one the first metal silver strip and first circumferential groove, all biogum is filled with between any one the second metal silver strip and second circumferential groove, one end of two the first metal silver strips is all common with first wire bonds at plastic tube through the tube wall of plastic tube, one end of two the second metal silver strips is all common with second wire bonds at plastic tube through the tube wall of plastic tube, mutually insulated between anelectrode and negative electrode is also provided with gap.
Above-mentioned circular channel makes vagus nerve can be just accommodated therein, and can well contact.
Further, two the first metal silver strips are symmetrical arranged, and two the second metal silver strips are symmetrical arranged.
Further, the external side parallel of plastic tube is provided with a pipe fitting, one end of one end of first metal silver strip, one end of the second metal silver strip, one end of the first wire and the second wire all penetrates pipe fitting along the radial direction of described pipe fitting, one end of first metal silver strip all in the inner chamber of pipe fitting with the first wire bonds, one end of the second metal silver strip all in the inner chamber of pipe fitting with the second wire bonds.
Further, the central axis of circular channel of two the first metal silver strip formation and the central axes of plastic tube, the central axis of circular channel of two the second metal silver strip formation and the central axes of plastic tube.
Further, the periphery of the first wire and the second wire is outer is separately surrounded by insulating barrier.
Further, one end of the first wire and the second wire is provided with connector separately.
Further, plastic tube is made up of the semicircle column jeckets docking bonding that two are cut open vertically.
Further, the diameter of plastic tube is 3 millimeters, distance between first metal silver strip and the second metal silver strip is 3 millimeters, the bare area of any one the first metal silver strip and the bare area of any one the second metal silver strip are 6 square millimeters, and the diameter of the circular channel that the diameter of the circular channel that the first metal silver strip is formed and the second metal silver strip are formed is 1 millimeter.
Present invention also offers a kind of method preparing above-mentioned animal vagal stimulation electrode, described method comprises: embed in the groove on two semicolumn plastic tube walls cut open vertically respectively by the first metal silver strip and the second metal silver strip, with biogum, the first metal silver strip and the second metal silver strip and tube wall are fixed, the one end the first metal silver strip and the second metal silver strip being passed tube wall with respectively with the first wire be arranged on a pipe fitting and the second wire bonds.
Operation principle of the present invention is: with 10% chloral hydrate 3.5ml intraperitoneal injection of anesthesia experimental rabbit, head cervical shaves hair, rabbit dorsal position is fixed on and dissects on plate, cervical region median incision, expose left side bilateral common carotid artery sheath, be separated Following Vagus Nerve and be about 1cm, animal vagal stimulation electrode of the present invention is placed in nerve trunk also fixing, electrode all stops with rabbit and insulate except the position contacted with nerve trunk, cause outside neck skin of back along subcutaneous moving under water, be connected to together with EEG electrode in the circumscription socket of insulation, and be fixed on skull with dental cement, operation is all carried out under aseptic condition, postoperatively give antibiotic (penicillium sp mycin) prevention infection.Then rabbit is fixed on stereotactic apparatus, along the long otch of crown midline incision about 2 cm, be separated periosteum, fontanel before and after exposing, EEG electrode is fixed on skull, finally the connector of animal vagal stimulation electrode of the present invention is connected with electroencephalogramrecording recording electrode head end insert division, with dental cement, Du Pont's head is fixed on rabbit head.Operation is all carried out under aseptic condition, postoperatively gives penicillin 40000 unit lumbar injection prevention infection for three days on end, and single cage raising recovery 1 week.
The present invention compares with prior art, and its effect is actively with obvious.Present invention decreases the volume of vagal stimulation electrode, can implant in experimental rabbit daughter, rabbit can withstand long term exposure preferably, when to the electricity irritation of rabbit row, this electrode can well conductive electric current, and in vivo can conduct electricity for a long time and not easily be corroded, it is neural convenient to be wound around when implanting, not easily injured nerve, reach the effect of conducting electricity with nerve contact simultaneously, conductive effect is good, effective with nerve contact in vivo, can reuse.
Accompanying drawing illustrates:
Fig. 1 is the structural representation of animal vagal stimulation electrode of the present invention.
Fig. 2 is the radial structure schematic diagram of the plastic tube in animal vagal stimulation electrode of the present invention.
Detailed description of the invention:
Embodiment 1:
As depicted in figs. 1 and 2, animal vagal stimulation electrode of the present invention, comprise a pair anelectrode and a pair negative electrode, wherein, described anelectrode comprises two the first metal silver strips 1, described negative electrode comprises two the second metal silver strips 2, two the first metal silver strips 1 and two the second metal silver strips 2 are all arranged in a plastic tube 3, in the inwall of described plastic tube 3, its axial distribution is provided with a first circumferential groove and a second circumferential groove, two the first metal silver strips 1 are curling in C font separately and in the first circumferential groove described in embedding, circular channel is formed between two the first metal silver strips 1, two the second metal silver strips 2 are curling in C font separately and in the second circumferential groove described in embedding, circular channel is formed between two the second metal silver strips 2, any one first metal silver strip 1 is equal along the length of plastic tube 3 axis along all circumferential with first groove of length of plastic tube 3 axis, any one second metal silver strip 2 is equal along the length of plastic tube 3 axis along all circumferential with second groove of length of plastic tube 3 axis, all biogum is filled with between any one the first metal silver strip 1 and first circumferential groove, all biogum is filled with between any one the second metal silver strip 2 and second circumferential groove, one end of two the first metal silver strips 1 all through plastic tube 3 tube wall and jointly weld with first wire 4 at plastic tube 3, one end of two the second metal silver strips 2 all through plastic tube 3 tube wall and jointly weld with second wire 6 at plastic tube 3, mutually insulated between anelectrode and negative electrode is also provided with gap.
Above-mentioned circular channel makes vagus nerve can be just accommodated therein, and can well contact.
Further, two the first metal silver strips 1 are symmetrical arranged, and two the second metal silver strips 2 are symmetrical arranged.
Further, the external side parallel of plastic tube 3 is provided with a pipe fitting 5, one end of first metal silver strip 1, one end of the second metal silver strip 2, one end of the first wire 4 and one end of the second wire 6 all penetrate pipe fitting 5 along the radial direction of described pipe fitting 5, one end of first metal silver strip 1 is all welded with the first wire 4 in the inner chamber of pipe fitting 5, and one end of the second metal silver strip 2 is all welded with the second wire 6 in the inner chamber of pipe fitting 5.
Further, the central axis of circular channel of two the first metal silver strip 1 formation and the central axes of plastic tube 3, the central axis of circular channel of two the second metal silver strip 2 formation and the central axes of plastic tube 3.
Further, the periphery of the first wire 4 and the second wire 6 is outer is separately surrounded by insulating barrier.
Further, one end of the first wire 4 and the second wire 6 is provided with connector separately.
Further, plastic tube 3 is made up of the semicircle column jeckets docking bonding that two are cut open vertically.
Further, the diameter of plastic tube 3 is 3 millimeters, distance between first metal silver strip 1 and the second metal silver strip 2 is 3 millimeters, the bare area of any one the first metal silver strip 1 and the bare area of any one the second metal silver strip 2 are 6 square millimeters, and the diameter of the circular channel that the diameter of the circular channel that the first metal silver strip 1 is formed and the second metal silver strip 2 are formed is 1 millimeter.
Present invention also offers a kind of method preparing above-mentioned animal vagal stimulation electrode, described method comprises: embed in the groove on two semicolumn plastic tube walls cut open vertically respectively by the first metal silver strip 1 and the second metal silver strip 2, with biogum, the first metal silver strip 1 and the second metal silver strip 2 are fixed with tube wall, the one end the first metal silver strip 1 and the second metal silver strip 2 being passed tube wall with weld with the first wire 4 be arranged on pipe fitting 5 and the second wire 6 respectively.
The operation principle of the present embodiment is: with 10% chloral hydrate 3.5ml intraperitoneal injection of anesthesia experimental rabbit, head cervical shaves hair, rabbit dorsal position is fixed on and dissects on plate, cervical region median incision, expose left side bilateral common carotid artery sheath, be separated Following Vagus Nerve and be about 1cm, animal vagal stimulation electrode of the present invention is placed in nerve trunk also fixing, electrode all stops with rabbit and insulate except the position contacted with nerve trunk, cause outside neck skin of back along subcutaneous moving under water, be connected to together with EEG electrode in the circumscription socket of insulation, and be fixed on skull with dental cement, operation is all carried out under aseptic condition, postoperatively give antibiotic (penicillium sp mycin) prevention infection.Then rabbit is fixed on stereotactic apparatus, along the long otch of crown midline incision about 2 cm, be separated periosteum, fontanel before and after exposing, EEG electrode is fixed on skull, finally the connector of animal vagal stimulation electrode of the present invention is connected with electroencephalogramrecording recording electrode head end insert division, with dental cement, Du Pont's head is fixed on rabbit head.Operation is all carried out under aseptic condition, postoperatively gives penicillin 40000 unit lumbar injection prevention infection for three days on end, and single cage raising recovery 1 week.
Claims (9)
1. an animal vagal stimulation electrode, comprise a pair anelectrode and a pair negative electrode, it is characterized in that: described anelectrode comprises two the first metal silver strips, described negative electrode comprises two the second metal silver strips, two the first metal silver strips and two the second metal silver strips are all arranged in a plastic tube, in the inwall of described plastic tube, its axial distribution is provided with a first circumferential groove and a second circumferential groove, two the first metal silver strips are curling in C font separately and in the first circumferential groove described in embedding, circular channel is formed between two the first metal silver strips, two the second metal silver strips are curling in C font separately and in the second circumferential groove described in embedding, circular channel is formed between two the second metal silver strips, any one first metal silver strip is equal along the length of plastic tube axis along all circumferential with first groove of length of plastic tube axis, any one second metal silver strip is equal along the length of plastic tube axis along all circumferential with second groove of length of plastic tube axis, all biogum is filled with between any one the first metal silver strip and first circumferential groove, all biogum is filled with between any one the second metal silver strip and second circumferential groove, one end of two the first metal silver strips is all common with first wire bonds at plastic tube through the tube wall of plastic tube, one end of two the second metal silver strips is all common with second wire bonds at plastic tube through the tube wall of plastic tube, mutually insulated between anelectrode and negative electrode is also provided with gap.
2. animal vagal stimulation electrode as claimed in claim 1, it is characterized in that: two the first metal silver strips are symmetrical arranged, two the second metal silver strips are symmetrical arranged.
3. animal vagal stimulation electrode as claimed in claim 1, it is characterized in that: the external side parallel of plastic tube is provided with a pipe fitting, one end of one end of first metal silver strip, one end of the second metal silver strip, one end of the first wire and the second wire all penetrates pipe fitting along the radial direction of described pipe fitting, one end of first metal silver strip all in the inner chamber of pipe fitting with the first wire bonds, one end of the second metal silver strip all in the inner chamber of pipe fitting with the second wire bonds.
4. animal vagal stimulation electrode as claimed in claim 1, it is characterized in that: the central axis of circular channel of two the first metal silver strip formation and the central axes of plastic tube, the central axis of circular channel of two the second metal silver strip formation and the central axes of plastic tube.
5. animal vagal stimulation electrode as claimed in claim 1, is characterized in that: the periphery of the first wire and the second wire is outer is separately surrounded by insulating barrier.
6. animal vagal stimulation electrode as claimed in claim 1, is characterized in that: one end of the first wire and the second wire is provided with connector separately.
7. animal vagal stimulation electrode as claimed in claim 1, is characterized in that: plastic tube docks bonding by two semicircle column jeckets cut open vertically and forms.
8. animal vagal stimulation electrode as claimed in claim 1, it is characterized in that: the diameter of plastic tube is 3 millimeters, distance between first metal silver strip and the second metal silver strip is 3 millimeters, the bare area of any one the first metal silver strip and the bare area of any one the second metal silver strip are 6 square millimeters, and the diameter of the circular channel that the diameter of the circular channel that the first metal silver strip is formed and the second metal silver strip are formed is 1 millimeter.
9. prepare the method for animal vagal stimulation electrode as claimed in claim 1 for one kind, it is characterized in that: the first metal silver strip and the second metal silver strip are embedded in the groove on two semicolumn plastic tube walls cut open vertically respectively, with biogum, the first metal silver strip and the second metal silver strip and tube wall are fixed, the one end the first metal silver strip and the second metal silver strip being passed tube wall with respectively with the first wire be arranged on a pipe fitting and the second wire bonds.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310671225.5A CN103638596B (en) | 2013-12-11 | 2013-12-11 | A kind of animal vagal stimulation electrode and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310671225.5A CN103638596B (en) | 2013-12-11 | 2013-12-11 | A kind of animal vagal stimulation electrode and preparation method thereof |
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| CN103638596A CN103638596A (en) | 2014-03-19 |
| CN103638596B true CN103638596B (en) | 2015-10-21 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103989467A (en) * | 2014-05-22 | 2014-08-20 | 侯月梅 | Animal neck neural signal continuous recording model and recording method |
| CN105078443B (en) * | 2015-07-09 | 2019-01-11 | 新疆医科大学第一附属医院 | Flush type nerve signal recording device and its application method |
| CN111729191B (en) * | 2020-06-10 | 2023-09-26 | 北京品驰医疗设备有限公司 | Small animal vagus nerve stimulation system and manufacturing method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091983A (en) * | 1993-01-28 | 1994-09-14 | 株式会社白寿生科学研究所 | Electric potential therapeutic apparatus |
| US5857957A (en) * | 1997-03-04 | 1999-01-12 | Lin; Vernon Wen-Hau | Functional magentic stimulation of the expiratory muscles |
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2013
- 2013-12-11 CN CN201310671225.5A patent/CN103638596B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091983A (en) * | 1993-01-28 | 1994-09-14 | 株式会社白寿生科学研究所 | Electric potential therapeutic apparatus |
| US5857957A (en) * | 1997-03-04 | 1999-01-12 | Lin; Vernon Wen-Hau | Functional magentic stimulation of the expiratory muscles |
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| CN103638596A (en) | 2014-03-19 |
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Granted publication date: 20151021 Termination date: 20161211 |