CN111729191B - Small animal vagus nerve stimulation system and manufacturing method thereof - Google Patents
Small animal vagus nerve stimulation system and manufacturing method thereof Download PDFInfo
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- CN111729191B CN111729191B CN202010524069.XA CN202010524069A CN111729191B CN 111729191 B CN111729191 B CN 111729191B CN 202010524069 A CN202010524069 A CN 202010524069A CN 111729191 B CN111729191 B CN 111729191B
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- 230000001681 protective effect Effects 0.000 claims abstract description 45
- 230000000638 stimulation Effects 0.000 claims abstract description 34
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- 239000002184 metal Substances 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 10
- 230000007384 vagal nerve stimulation Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 238000003466 welding Methods 0.000 claims description 7
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 6
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 5
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- 238000009413 insulation Methods 0.000 claims description 3
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000000602 vitallium Substances 0.000 claims description 3
- 238000002788 crimping Methods 0.000 claims description 2
- 238000002513 implantation Methods 0.000 abstract description 9
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- 238000001727 in vivo Methods 0.000 description 7
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0558—Anchoring or fixation means therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37518—Anchoring of the implants, e.g. fixation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention provides an animal vagus nerve stimulation system and a manufacturing method thereof, the system comprises a protective tube formed by a flexible cylindrical plastic tube with an axial opening, wherein surgical sutures are respectively arranged at two sides of the axial opening, the axial opening of the protective tube can be pulled away by pulling the surgical sutures to two sides, and after the protective tube is loosened, the axial opening of the protective tube is restored to the original state; the stimulation contacts of the two hollow semi-ring-shaped metal pieces are that the inner ring is contacted with the vagus nerve, and the outer ring is attached and fixed on the inner wall of the protective tube; and one end of each of the two coating leads penetrates into the hollow position of the stimulating contact and is connected with the stimulating contact, the other end of each of the two coating leads radially penetrates out from the inner wall of the axial middle position of the protective tube, and the penetrated end is connected with the plug connector. The animal vagus nerve stimulating electrode has a simple structure and a small volume, and can be used for vagus nerve stimulation of small animals. The invention has short manufacturing period, simple implantation operation and high reliability, can be implanted into animals for a long time and provides stable electric stimulation.
Description
Technical Field
The invention belongs to the technical field of medical instrument manufacturing, and particularly relates to a small animal vagus nerve stimulation system and a manufacturing method thereof.
Background
Epilepsy is a neurological disorder that results in transient brain dysfunction due to sudden abnormal discharge of brain neurons. The disease has high disability rate, long disease course and recurrent attacks, and seriously threatens the physical and mental health of patients. The vagus nerve stimulation method (Vagus Nerve Stimulation) is to fix the electrode on the vagus nerve, and to perform electrical stimulation on the nerve continuously, so as to cause the change of brain electrical activity and neurotransmitter, thereby achieving the purpose of treating epilepsy. The therapy has the characteristics of non-destructive, reversible and adjustable, and has become one of the important surgical methods for treating epilepsy.
The mechanism of vagal nerve stimulation is a synergistic or trade-off of a number of factors including changes in cerebral blood flow in the brain, functional connection of electroencephalogram, or depletion, blocking of neurotransmitters, etc. At present, the actual action mechanism of vagus nerve stimulation by medical practitioners at home and abroad is not clear. The medical researchers mostly take animals as research objects (rats, mice, rabbits, monkeys, etc.) to simulate the stimulation process by using animal experiment bodies to research the action mechanism of vagal nerve electric stimulation treatment, thereby improving the effect of nerve stimulation and expanding new targets and new indications in the future.
The patent of CN103638596A and CN203647859U discloses an electrode for stimulating the vagus nerve of an animal, but the welding spot structures in the electrode are all required to be protected and insulated in independent plastic pipes, so that the size and the weight of the electrode are increased, the electrode is not applicable to small animals such as mice and the like, the operation of the electrode is difficult during surgical implantation, and the reliability after implantation is poor.
Disclosure of Invention
The invention provides a small animal vagus nerve stimulation system and a manufacturing method thereof.
In one aspect, the invention provides a small animal vagus nerve stimulation system comprisingA stimulator, a stimulating electricity A pole, wherein: the stimulating electrode comprises a protecting tube, at least two stimulating contacts and at least two coating wires;
the protective tube is a flexible insulating tube which is axially opened;
the stimulation contact is a hollow semi-ring-shaped metal piece, the inner ring is in contact with the vagus nerve, and the outer ring is fixed on the inner wall of the protection tube;
and each coating lead corresponds to one of the stimulation contacts, one end of each coating lead penetrates into the hollow position of the stimulation contact and is connected with the stimulation contact, and the other end of each coating lead penetrates out of the protection tube and is directly or indirectly connected with the stimulator. Further, two sides of the axial opening of the protective tube are respectively provided with a surgical suture, the surgical suture can be pulled to two sides to pull the axial opening of the protective tube open, and after the surgical suture is loosened, the axial opening of the protective tube is restored to the original state.
Further, the center normal direction of the inner circular arcs of the stimulation contacts faces the axial opening position of the protection tube.
Further, the coated wire is indirectly connected with the external stimulator through the plug connector or directly connected with the internal stimulator.
Further, the coated wire is connected with the plug connector or the in-vivo stimulator in a welding or crimping mode.
Further, the stimulator includes a circuit board and a protective housing; the circuit board can output electric signals with different frequencies, pulse widths and amplitudes; the protective shell is arranged outside the circuit board, can isolate the circuit board from the outside and has the function of electric insulation.
Further, a colored marking tape is arranged at the position, which is close to one of the stimulation contacts, outside the protective tube and is used for distinguishing the positive electrode from the negative electrode of the electrode.
Further, the outer diameter of the protection tube is 0.5mm-2mm, the inner diameter is 0.4mm-1.8mm, and the length is 3mm-8mm; the diameter of the inner ring of the stimulation contact is 0.1mm-1mm, the diameter of the outer ring is consistent with the inner diameter of the protection tube, the length of the outer ring is 0.3mm-2mm, and the distance between two adjacent stimulation contacts is 1mm-5mm.
Further, the material of the protective tube is silica gel, polyurethane or polyurethane-silicone rubber copolymer; the material of the stimulating contact is platinum or platinum iridium alloy; the material of the wire in the coated wire is stainless steel, cobalt chromium molybdenum alloy, nickel titanium alloy or platinum iridium alloy.
The invention provides a manufacturing method of a small animal vagus nerve stimulation system, which comprises the following steps: s1, welding the coating wire at a hollow position of the stimulation contact;
s2, fixing the outer ring of the stimulation contact on the inner wall of the protection tube by using biological glue, and ensuring that the circular arc center direction of the inner ring of the stimulation contact faces the axial opening position of the protection tube;
s3, penetrating the other end of the coating wire out of the inner wall of the protection tube along the radial direction, and directly or indirectly connecting with the stimulator.
The animal vagus nerve stimulation system has simple structure and small volume, and can be used for vagus nerve stimulation of small animals, such as mice, rats and the like. The system has the advantages of short manufacturing period, simple implantation operation, high reliability, long-time implantation in animals and stable electric stimulation.
Drawings
FIG. 1 is a schematic diagram of a small animal vagal nerve stimulation system provided by a first embodiment of the present invention;
FIG. 2 is a schematic diagram of a small animal vagal nerve stimulation system provided by a second embodiment of the present invention;
fig. 3 (a) -3 (d) are schematic illustrations of the implantation process of the small animal vagal nerve stimulation system of the present invention.
The reference numerals in the figures illustrate: 110-protective tube, 111-surgical suture, 112-marker band, 113-axial opening, 120-stimulation contact, 130-coated wire, 140-plug, 141-protective gel, 150-in vivo stimulator, 151-circuit board, 152-protective housing, 200-animal vagus nerve, 300-surgical non-absorbable suture
Detailed Description
The present invention will be described in detail below by way of examples with reference to the accompanying drawings.
Fig. 1 is a schematic diagram of a small animal vagus nerve stimulation system according to a first embodiment of the present invention, wherein the small animal vagus nerve stimulation system includes an animal vagus nerve stimulation electrode, a plug 140, a protective gel 141 and an external stimulator (not shown). The small animal vagus nerve stimulating electrode comprises a protective tube 110, two stimulating contacts 120 and two coated wires 130.
The protective tube 110 is a flexible cylindrical plastic tube having an axial opening 113, with a surgical suture 111 on each side of the opening. Pulling on both sides of the surgical suture 111 pulls the protective tube axial opening 113 open, and the protective tube 110 axial opening returns to its original state after releasing the surgical suture 111. The outer diameter of the protection tube 110 is 0.5-2mm, preferably 1.3mm; the length is 3-8mm, preferably 5mm. The material of the protective tube 110 is silica gel, polyurethane or polyurethane-silicone rubber copolymer, which plays an insulating role.
The two stimulation contacts 120 are hollow semi-annular shaped metallic pieces. The material is platinum or platinum iridium alloy. The stimulating contacts 120 have an inner ring diameter of 0.1-1mm, preferably 0.4mm, and an outer ring diameter corresponding to the inner diameter of the protective tube 110, and an outer ring diameter corresponding to the inner diameter of the protective tube, and the inner diameter of the protective tube 110 is 0.4-1.8 mm, preferably 0.9mm. The distance between the two stimulation contacts 120 is 1-5mm, preferably 3mm; the length of the two stimulation contacts 120 is 0.3mm-2mm, preferably 0.5mm. The inner annulus of the stimulation contact 120 contacts the vagus nerve 200 and the outer annulus fits over and is secured to the inner wall of the protective tube 110. The axes of the two stimulating contacts 120 are coincident with the axis of the protection tube 110, and the center normal direction of the inner circular arc faces the axial opening position of the protection tube 110. The hollow structure of the stimulation contact 120 may accommodate the coated wire 130.
The electrode has two coated wires 130, one end of the two coated wires 130 penetrate into the hollow position of the stimulating contact 120 and are welded with the stimulating contact, and the other end of the two coated wires penetrates out of the inner wall along the radial direction from the axial middle position of the protective tube 110. The end portions after the penetration are welded with the corresponding plug members 140. The wire is made of stainless steel wires, cobalt-chromium-molybdenum alloy wires, nickel-titanium alloy wires, platinum-iridium alloy wires and the like, and can exist in the form of stranded wires or spiral wires so as to improve the integral fatigue resistance of the electrode.
The connector 140 is used to connect to an external stimulator (not shown). The plug 140 may be micro usb male and female, du Bangtou, a terminal, an alligator clip, etc. The exposed contact pin and welding spot area of the plug connector 140 is covered by a protective adhesive 141, which plays an electrical insulation role. The material of the protective paste 141 may be silicone rubber, polyurethane, epoxy resin.
The outer side of the protective tube 110, which is adjacent to the contact on one side, is provided with a colored marking tape 112 for distinguishing the positive electrode from the negative electrode of the electrode, so that the implantation direction of the electrode during operation can be conveniently determined.
Fig. 2 is a schematic diagram of a small animal vagal nerve stimulation system including a small animal vagal nerve stimulation electrode, an integral internal stimulator 150, provided in accordance with a second embodiment of the present invention. The small animal vagus nerve stimulating electrode comprises a protective tube 110, two stimulating contacts 120 and two coated wires 130. The coated lead 130 in this embodiment is directly connected to the in vivo stimulator 150. In this embodiment, the features of the other parts of the electrode are the same as those of the first embodiment.
The external stimulator or the internal stimulator 150 includes a circuit board 151 and a protective case 152, and the circuit board 151 can output an electric signal with a fixed frequency, pulse width and amplitude. In the first embodiment described above, the plug 140 is connected to the external stimulator; in the second embodiment, one end of the coated wire 130 passing out of the protection tube is soldered to the circuit board 151. The protective case 152 is outside the circuit board 151, and can isolate the circuit board 151 from the outside, thereby functioning as an electrical insulation.As in the second embodiment Liquid isolation from circuit board 151. The material of the protective housing 152 is silicone rubber, polyurethane, epoxy resin, etc.
The invention also provides a manufacturing method of the small animal vagus nerve system, which comprises the following steps: the coating lead 130 is welded at the hollow position of the contact 120 by laser, and the outer ring of the contact 120 is fixedly attached to the inner wall of the protection tube 110 by using biological glue, so that the circular arc center direction of the inner ring of the contact 120 faces the axial opening position of the protection tube 110. The other end of the coated wire 130 is radially penetrated from the axial middle position of the protection tube 110 and welded or crimped with the socket connector 140. The exposed part of the pin of the plug connector and the welding spot are coated by the protective adhesive 141, so that the mutual insulation between the positive electrode and the negative electrode is ensured. The external stimulator is detachably connected to the hub 140. In the absence of the connector 140, the other end of the coated wire 130 is connected to the in vivo stimulator 150, and the coated wire 130 is directly welded or crimped to the in vivo stimulator 150 in such a manner that the connection is not detachable.
Fig. 3 is a schematic representation of the implantation process of the small animal vagal nerve stimulation system of the present invention. The implantation method of the stimulation system is as follows: step 1, after anesthesia of the small animals, a median incision of the neck is performed, a left carotid sheath is exposed, and vagal nerve trunk is separated by about 1cm; step 2, the surgical suture 111 of the electrode protecting tube 110 is pulled in the direction indicated by the arrow in fig. 3 (a), the axial opening 113 is pulled, and the inner rings of the two stimulation contacts 120 are exposed in the state in which the electrode axial opening 113 is pulled as shown in fig. 3 (b). Step 3, the vagus nerve 200 is placed within the protective tube 110 and in contact with the inner ring of the stimulation contacts 120, as shown in fig. 3 (c). At step 4, the surgical suture 111 is loosened and the protective tube 110 is restored to its original shape, confirming that the protective tube 110 completely covers the vagus nerve 200. Two surgical non-absorbable sutures 300 are then used to secure the electrode in place on the vagus nerve 200, as shown in fig. 3 (d), with the two contacts 120 being tied separately on the outside of the protective tube 110. Finally, the plug 140 is submerged subcutaneously into the neck of a small animal, such as a rat, and the plug is secured to the skull of the animal with dental cement. After the connector 140 is connected with the external stimulator, the electrical signal can be transmitted to the vagus nerve of the small animal. If the coated lead 130 is directly connected to the in vivo stimulator 150, the in vivo stimulator 150 may be placed and fixed subcutaneously on the back or abdomen of the animal.
The present invention is not limited to the preferred embodiments, and any changes or substitutions that would be apparent to one skilled in the art within the scope of the present invention are intended to be included in the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.
Claims (7)
1. A small animal vagal nerve stimulation system comprising a stimulator, a stimulation electrode, wherein: the stimulating electrode comprises a protecting tube, at least two stimulating contacts and at least two coating wires; it is characterized in that the method comprises the steps of,
the protection tube is a flexible insulating tube with an axial opening, the outer diameter is 0.5mm-2mm, the inner diameter is 0.4mm-1.8mm, and the length is 3mm-8mm; two sides of the axial opening of the protective tube are respectively provided with a surgical suture, the surgical suture can be pulled to two sides to pull the axial opening of the protective tube open, and after the surgical suture is loosened, the axial opening of the protective tube is restored to the original state;
the stimulation contact is a hollow semi-ring-shaped metal piece, the middle structure can accommodate the coating wire, the inner ring is in contact with the vagus nerve, the outer ring is bonded and fixed on the inner wall of the protection tube through biological glue, and the normal direction of the center of the circular arc of the inner ring faces the axial opening position of the protection tube; the diameter of the inner ring of the stimulation contact is 0.1mm-1mm, the diameter of the outer ring is consistent with the inner diameter of the protection tube, the length of the outer ring is 0.3mm-2mm, and the distance between two adjacent stimulation contacts is 1mm-5mm;
each of the coated wires corresponds to one of the stimulation contacts, one end of each of the coated wires penetrates through the hollow position of the stimulation contact and is welded with the stimulation contact by laser, and the other end of each of the coated wires penetrates out of the inner wall from the axial middle position of the protective tube along the radial direction and is directly or indirectly connected with the stimulator.
2. A small animal vagus nerve stimulation system according to claim 1, wherein: the coating lead is indirectly connected with the external stimulator through the plug connector or directly connected with the internal stimulator.
3. A small animal vagus nerve stimulation system according to claim 2, wherein: the coated wire is connected with the plug connector or the internal stimulator in a welding or crimping mode.
4. A small animal vagus nerve stimulation system according to claim 2, wherein: the stimulator comprises a circuit board and a protective shell; the circuit board can output electric signals with different frequencies, pulse widths and amplitudes; the protective shell is arranged outside the circuit board, can isolate the circuit board from the outside and has the function of electric insulation.
5. A small animal vagus nerve stimulation system according to claim 1, wherein: and a colored marking belt is arranged at the position, which is close to one of the stimulation contacts, outside the protective tube and is used for distinguishing the positive electrode from the negative electrode of the electrode.
6. A small animal vagus nerve stimulation system according to claim 1, wherein:
the material of the protective tube is silica gel, polyurethane or polyurethane-silicone rubber copolymer;
the material of the stimulating contact is platinum or platinum iridium alloy;
the material of the wire in the coated wire is stainless steel, cobalt chromium molybdenum alloy, nickel titanium alloy or platinum iridium alloy.
7. A method of making a small animal vagal nerve stimulation system according to any one of claims 1-6, wherein:
s1, laser welding the coated wire at a hollow position of the stimulation contact;
s2, fixedly attaching the outer ring of the stimulating contact to the inner wall of the protection tube by using biological glue, and ensuring that the normal direction of the circular arc center of the inner ring of the stimulating contact is towards the axial opening position of the protection tube;
s3, the other end of the coating wire penetrates out of the inner wall from the axial middle position of the protection tube along the radial direction and is directly or indirectly connected with the stimulator.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010524069.XA CN111729191B (en) | 2020-06-10 | 2020-06-10 | Small animal vagus nerve stimulation system and manufacturing method thereof |
| PCT/CN2020/141951 WO2021248895A1 (en) | 2020-06-10 | 2020-12-31 | Animal vagus nerve stimulation system and manufacturing method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010524069.XA CN111729191B (en) | 2020-06-10 | 2020-06-10 | Small animal vagus nerve stimulation system and manufacturing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN111729191A CN111729191A (en) | 2020-10-02 |
| CN111729191B true CN111729191B (en) | 2023-09-26 |
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| CN202010524069.XA Active CN111729191B (en) | 2020-06-10 | 2020-06-10 | Small animal vagus nerve stimulation system and manufacturing method thereof |
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| CN (1) | CN111729191B (en) |
| WO (1) | WO2021248895A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111729191B (en) * | 2020-06-10 | 2023-09-26 | 北京品驰医疗设备有限公司 | Small animal vagus nerve stimulation system and manufacturing method thereof |
| CN113769270A (en) * | 2021-09-07 | 2021-12-10 | 北京品驰医疗设备有限公司 | Implantable nerve stimulator suitable for human neck |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202777459U (en) * | 2012-06-29 | 2013-03-13 | 杨小玉 | Sacral nerve anterior root electrical stimulation system |
| CN103211589A (en) * | 2006-07-10 | 2013-07-24 | 瓦高希有限公司 | Method and apparatus for measuring activity in the peripheral nervous system |
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| CN111729191A (en) | 2020-10-02 |
| WO2021248895A1 (en) | 2021-12-16 |
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