CN103638491A - Formula and preparation of anti-fatigue oral liquid - Google Patents
Formula and preparation of anti-fatigue oral liquid Download PDFInfo
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- CN103638491A CN103638491A CN201310661448.3A CN201310661448A CN103638491A CN 103638491 A CN103638491 A CN 103638491A CN 201310661448 A CN201310661448 A CN 201310661448A CN 103638491 A CN103638491 A CN 103638491A
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Abstract
The invention discloses a formula and a preparation method of an anti-fatigue oral liquid, and relates to a preparation method of a medicine. The preparation method comprises the following steps: crushing radix paeoniae alba, ligusticum wallichii, Chinese-dates, Angelica sinensis, codonopsis pilosula, astragalus membranaceus, fresh ginger and rehmannia to 40-mesh coarse powder and placing the powder in an extraction tank; adding water, heating for reflux extraction, filtering, fetching the filtrate for later use, absorbing by use of macroporous resin, eluting residual impurities by use of distilled water, then, eluting by use of ethanol until the solution is colorless, collecting an eluant, and concentrating the eluant to an extract A for later use at the vacuum degree of 0.01-0.05MPa and the temperature of 50-78 DEG C; then, mixing the extract A with cordyceps sinensis concentrated liquor, adding ethanol, adjusting alcohol to over 70%, standing, extracting the supernate, and concentrating to a refined raw paste; then, filtering, removing a resin gum precipitate and preparing an original liquid; then, adding deionized water to the original liquid to prepare the oral liquid. The anti-fatigue oral liquid is high in clarity and good in stability performance, can be used for fundamentally removing fatigue, and is free from toxic and side effects in long-term administration.
Description
Technical field:
The present invention relates to a kind of preparation method of medicine, be specifically related to a kind of formula and preparation technology of Antifatigue oral liquid.
Background technology:
Fatigue is a kind of very common phenomenon.It can be divided into two types of disease fatigue and non-disease fatigues, if be in general non-disease fatigue can nationality by sleeping, motion, amusement etc. eliminate symptom.And the fatigue of disease is just not all right, we only have by eliminating symptom by Drug therapy.At present, relieving fatigue is except taking this traditional refreshing oneself beverage of glucose, the anti-fatigue effect beverages such as many beverages on market, have also been there is, adopt these mode relieving fatigues, on the one hand easy addiction, on the other hand, it is just by the sensation of the temporary transient relieving fatigues of form such as refreshing oneself, also just cure the symptoms, not the disease, and fundamentally do not reach relieving fatigue.And the anti-fatigue Chinese medicine oral liquid of selling on market, active constituent content is unstable, and impurity is more, affects clarity and the perception of finished product oral liquid.
Summary of the invention:
The formula and the preparation technology that the object of this invention is to provide a kind of Antifatigue oral liquid, its preparation method is simple, the clarity of product is high, stability is good, from regulating the function of human body, natural nutrition composition and the biological active substances that can effectively supplement needed by human body, have strengthening the body resistance, nourish the function of body-building, enhancing human body immunity and resisting fatigue, relieving fatigue fundamentally, long-term taking has no side effect.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions: its formula comprises the Radix Paeoniae Alba of 3-8%, the Rhizoma Chuanxiong of 5-10%, the Fructus Jujubae of 2-5%, the Radix Angelicae Sinensis of 20-30%, the Radix Codonopsis of 20-30%, the Radix Astragali of 20-30%, the Rhizoma Zingiberis Recens of 2-5%, the Radix Rehmanniae Preparata of 5-10%, the Cordyceps extracting solution of 0.3-1%.
The preparation method of described Cordyceps extracting solution is: Cordyceps mycelium is ground to form to powdery, then Cordyceps mycelium powder is put into and injected quantitative clear water extraction pot, be warming up to 90 ℃ and maintain 90 minutes, time can stop extracting; Then after filtering, flame filter press obtains Cordyceps mycelium powder extracting solution; Above-mentioned Cordyceps mycelium powder extracting solution is concentrated through vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, obtains Cordyceps concentrated solution.
The preparation method of described anti-fatigue medicament is by the Radix Paeoniae Alba in above-mentioned formula, Rhizoma Chuanxiong, Fructus Jujubae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, Rhizoma Zingiberis Recens and Radix Rehmanniae, be ground into 40 order coarse powder and be placed in extraction pot, adds the water of 6 times of inventorys, heating and refluxing extraction 1-2 hour, filter, get filtrate for later use, above-mentioned filtrate is adsorbed by macroporous resin, with distilled water eluting residual impurity, using 30% ethanol elution to colourless again, collect eluent, is that 0.01-0.05MPa, temperature are 50-78 ℃ by eluent in vacuum, be concentrated into relative density and be 1.1 extractum A, standby; Then extractum A is mixed with the Cordyceps concentrated solution of above-mentioned formula, add 90% ethanol, adjust alcohol to put more than 70%, static, extract supernatant, be concentrated into the refining former cream of d=1.20, then filter, eliminate resin natural gum precipitation, be configured to stock solution, then stock solution is added to deionized water and be configured to oral liquid.
The present invention has following beneficial effect: its preparation method is simple, the clarity of product is high, stability is good, from regulating the function of human body, can effectively supplement natural nutrition composition and the biological active substances of needed by human body, there is strengthening the body resistance, nourish body-building, strengthen the function of human body immunity and resisting fatigue, relieving fatigue fundamentally, long-term taking has no side effect.
The specific embodiment:
This specific embodiment is taked following technical scheme: its formula comprises the Radix Paeoniae Alba of 3-8%, the Rhizoma Chuanxiong of 5-10%, the Fructus Jujubae of 2-5%, the Radix Angelicae Sinensis of 20-30%, the Radix Codonopsis of 20-30%, the Radix Astragali of 20-30%, the Rhizoma Zingiberis Recens of 2-5%, the Radix Rehmanniae Preparata of 5-10%, the Cordyceps extracting solution of 0.3-1%.
The preparation method of described Cordyceps extracting solution is: Cordyceps mycelium is ground to form to powdery, then Cordyceps mycelium powder is put into and injected quantitative clear water extraction pot, be warming up to 90 ℃ and maintain 90 minutes, time can stop extracting; Then after filtering, flame filter press obtains Cordyceps mycelium powder extracting solution; Above-mentioned Cordyceps mycelium powder extracting solution is concentrated through vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, obtains Cordyceps concentrated solution.
The preparation method of described anti-fatigue medicament is by the Radix Paeoniae Alba in above-mentioned formula, Rhizoma Chuanxiong, Fructus Jujubae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, Rhizoma Zingiberis Recens and Radix Rehmanniae, be ground into 40 order coarse powder and be placed in extraction pot, adds the water of 6 times of inventorys, heating and refluxing extraction 1-2 hour, filter, get filtrate for later use, above-mentioned filtrate is adsorbed by macroporous resin, with distilled water eluting residual impurity, using 30% ethanol elution to colourless again, collect eluent, is that 0.01-0.05MPa, temperature are 50-78 ℃ by eluent in vacuum, be concentrated into relative density and be 1.1 extractum A, standby; Then extractum A is mixed with the Cordyceps concentrated solution of above-mentioned formula, add 90% ethanol, adjust alcohol to put more than 70%, static, extract supernatant, be concentrated into the refining former cream of d=1.20, then filter, eliminate resin natural gum precipitation, be configured to stock solution, then stock solution is added to deionized water and be configured to oral liquid.
This specific embodiment has following beneficial effect: its preparation method is simple, the clarity of product is high, stability is good, from regulating the function of human body, can effectively supplement natural nutrition composition and the biological active substances of needed by human body, there is strengthening the body resistance, nourish body-building, strengthen the function of human body immunity and resisting fatigue, relieving fatigue fundamentally, long-term taking has no side effect.
Embodiment: by 5% the Radix Paeoniae Alba, 7% Rhizoma Chuanxiong, 2.5% Fructus Jujubae, 25% Radix Angelicae Sinensis, 25% Radix Codonopsis, 25% Radix Astragali, 2.5% Rhizoma Zingiberis Recens, 7.5% Radix Rehmanniae Preparata is ground into 40 order coarse powder and is placed in extraction pot, the water that adds 6 times of inventorys, heating and refluxing extraction 1.5 hours, filter, get filtrate for later use, above-mentioned filtrate is adsorbed by macroporous resin, with distilled water eluting residual impurity, use again 30% ethanol elution to colourless, collect eluent, by eluent, in vacuum, be 0.03MPa, temperature is 65 ℃, be concentrated into relative density and be 1.1 extractum A, standby, then extractum A is mixed with 0.5% Cordyceps concentrated solution, add 90% ethanol, adjust alcohol to put more than 70%, static, extract supernatant, be concentrated into the refining former cream of d=1.20, then filter, eliminate resin natural gum precipitation, be configured to stock solution, then stock solution is added to deionized water and be configured to oral liquid.
Claims (3)
1. the formula of an Antifatigue oral liquid, it is characterized in that the Radix Paeoniae Alba that its formula comprises 3-8%, the Rhizoma Chuanxiong of 5-10%, the Fructus Jujubae of 2-5%, the Radix Angelicae Sinensis of 20-30%, the Radix Codonopsis of 20-30%, the Radix Astragali of 20-30%, the Rhizoma Zingiberis Recens of 2-5%, the Radix Rehmanniae Preparata of 5-10%, the Cordyceps extracting solution of 0.3-1%.
2. the formula of a kind of Antifatigue oral liquid according to claim 1 and preparation technology, the preparation method that it is characterized in that described Cordyceps extracting solution is: Cordyceps mycelium is ground to form to powdery, again Cordyceps mycelium powder is put into and injected quantitative clear water extraction pot, be warming up to 90 ℃ and maintain 90 minutes, in time, can stop extracting; Then after filtering, flame filter press obtains Cordyceps mycelium powder extracting solution, above-mentioned Cordyceps mycelium powder extracting solution is concentrated through vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, obtains Cordyceps concentrated solution.
3. the preparation technology of a kind of Antifatigue oral liquid according to claim 1, the preparation method that it is characterized in that it is by the Radix Paeoniae Alba in formula, Rhizoma Chuanxiong, Fructus Jujubae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, Rhizoma Zingiberis Recens and Radix Rehmanniae, being ground into 40 order coarse powder is placed in extraction pot, the water that adds 6 times of inventorys, heating and refluxing extraction 1-2 hour, filter, get filtrate for later use, above-mentioned filtrate is adsorbed by macroporous resin, with distilled water eluting residual impurity, use again 30% ethanol elution to colourless, collect eluent, by eluent, in vacuum, be 0.01-0.05MPa, temperature is 50-78 ℃, be concentrated into relative density and be 1.1 extractum A, standby, then extractum A is mixed with the Cordyceps concentrated solution of above-mentioned formula, add 90% ethanol, adjust alcohol to put more than 70%, static, extract supernatant, be concentrated into the refining former cream of d=1.20, then filter, eliminate resin natural gum precipitation, be configured to stock solution, then stock solution is added to deionized water and be configured to oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310661448.3A CN103638491A (en) | 2013-12-10 | 2013-12-10 | Formula and preparation of anti-fatigue oral liquid |
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| CN201310661448.3A CN103638491A (en) | 2013-12-10 | 2013-12-10 | Formula and preparation of anti-fatigue oral liquid |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1151699A (en) * | 1994-06-30 | 1997-06-11 | 明治乳业株式会社 | Health compsn. |
| CN1270047A (en) * | 1999-04-14 | 2000-10-18 | 陈江辉 | A tonic tea product and its preparation method |
| CN102319351A (en) * | 2011-09-22 | 2012-01-18 | 王璐 | Blood enriching and qi replenishing health-care product |
-
2013
- 2013-12-10 CN CN201310661448.3A patent/CN103638491A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1151699A (en) * | 1994-06-30 | 1997-06-11 | 明治乳业株式会社 | Health compsn. |
| CN1270047A (en) * | 1999-04-14 | 2000-10-18 | 陈江辉 | A tonic tea product and its preparation method |
| CN102319351A (en) * | 2011-09-22 | 2012-01-18 | 王璐 | Blood enriching and qi replenishing health-care product |
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Application publication date: 20140319 |